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In-silico screening and in-vitro assay show the antiviral effect of Indomethacin against SARS-CoV-2

Chakraborty et al., Computers in Biology and Medicine, doi:10.1016/j.compbiomed.2022.105788
Jun 2022  
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Vitamin A for COVID-19
42nd treatment shown to reduce risk in June 2023, now with p = 0.021 from 14 studies.
Lower risk for recovery and cases.
No treatment is 100% effective. Protocols combine treatments.
5,100+ studies for 109 treatments. c19early.org
In Silico study predicting indomethacin and vitamin A can bind critical host and viral proteins for SARS-CoV-2 interaction, and may be able to compensate for gene expressions changes related to SARS-CoV-2.
10 preclinical studies support the efficacy of vitamin A for COVID-19:
Vitamin A has been identified by the European Food Safety Authority (EFSA) as having sufficient evidence for a causal relationship between intake and optimal immune system function10-12. Vitamin A has potent antiviral activity against SARS-CoV-2 in both human cell lines and human organoids of the lower respiratory tract (active metabolite all-trans retinoic acid, ATRA)7, is predicted to bind critical host and viral proteins for SARS-CoV-2 and may compensate for gene expression changes related to SARS-CoV-21-3, may be beneficial for COVID-19 via antiviral, anti-inflammatory, and immunomodulatory effects according to network pharmacology analysis4, reduces barrier compromise caused by TNF-α in Calu-3 cells6, inhibits mouse coronavirus replication9, may stimulate innate immunity by activating interferon responses in an IRF3-dependent manner (ATRA)9, may reduce excessive inflammation induced by SARS-CoV-21, shows SARS-CoV-2 antiviral activity In Vitro1,5,8, is effective against multiple SARS-CoV-2 variants in Calu-3 cells8, and inhibits the entry and replication of SARS-CoV-2 via binding to ACE2 / 3CLpro / RdRp / helicase / 3′-to-5′ exonuclease1.
Study covers indomethacin and vitamin A.
Chakraborty et al., 30 Jun 2022, peer-reviewed, 11 authors. Contact: yashahasija@dtu.ac.in, amitghosh@iitkgp.ac.in, amitk@bt.iitkgp.ac.in.
In Silico studies are an important part of preclinical research, however results may be very different in vivo.
This PaperVitamin AAll
In-silico screening and in-vitro assay show the antiviral effect of Indomethacin against SARS-CoV-2
Rajkumar Chakraborty, Gourab Bhattacharje, Joydeep Baral, Bharat Manna, Jayati Mullick, Basavaraj S Mathapati, Priya Abraham, Yasha Hasija, Amit Ghosh, Amit Kumar Das
Computers in Biology and Medicine, doi:10.1016/j.compbiomed.2022.105788
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused the worldwide spread of coronavirus disease 19 , and till now, it has caused death to more than 6.2 million people. Although various vaccines and drug candidates are being tested globally with limited to moderate success, a comprehensive therapeutic cure is yet to be achieved. In this study, we applied computational drug repurposing methods complemented with the analyses of the already existing gene expression data to find better therapeutics in treatment and recovery. Primarily, we identified the most crucial proteins of SARS-CoV-2 and host human cells responsible for viral infection and host response. An in-silico screening of the existing drugs was performed against the crucial proteins for SARS-CoV-2 infection, and a few existing drugs were shortlisted. Further, we analyzed the gene expression data of SARS-CoV-2 in human lung epithelial cells and investigated the molecules that can reverse the cellular mRNA expression profiles in the diseased state. LINCS L1000 and Comparative Toxicogenomics Database (CTD) were utilized to obtain two sets of compounds that can be used to counter SARS-CoV-2 infection from the gene expression perspective. Indomethacin, a nonsteroidal anti-inflammatory drug (NSAID), and Vitamin-A were found in two sets of compounds, and in the in-silico screening of existing drugs to treat SARS-CoV-2. Our in-silico findings on Indomethacin were further successfully validated by in-vitro testing in Vero CCL-81 cells with an IC 50 of 12 μM. Along with these findings, we briefly discuss the possible roles of Indomethacin and Vitamin-A to counter the SARS-CoV-2 infection in humans.
Appendix A. Supplementary data Supplementary data to this article can be found online at https://doi. org/10.1016/j.compbiomed.2022.105788.
References
Abd El-Mageed, In silico evaluation of different flavonoids from medicinal plants for their potency against SARS-CoV-2, Biologics
Abdellatif, New indomethacin analogs as selective COX-2 inhibitors: synthesis, COX-1/2 inhibitory activity, anti-inflammatory, ulcerogenicity, histopathological, and docking studies, Arch. Pharm
Abo Elmaaty, Computational insights on the potential of some NSAIDs for treating COVID-19: priority set and lead optimization, Molecules
Aibana, Impact of vitamin A and carotenoids on the risk of tuberculosis progression, Clin. Infect. Dis
Al-Horani, Kar, Potential anti-SARS-CoV-2 therapeutics that target the post-entry stages of the viral life cycle: a comprehensive review, Viruses
Al-Saleh, Essential metals, vitamins and antioxidant enzyme activities in COVID-19 patients and their potential associations with the disease severity, Biometals
Alkotaji, Al-Zidan, Indomethacin, Can it counteract bradykinin effects in COVID-19 patients?, Curr. Pharmacol. Rep
Amici, Indomethacin has a potent antiviral activity against SARS coronavirus, Antivir. Ther
Amici, Inhibition of viral protein translation by indomethacin in vesicular stomatitis virus infection: role of eIF2alpha kinase PKR, Cell Microbiol
Armstrong, The IUPHAR/BPS Guide to PHARMACOLOGY in 2020: extending immunopharmacology content and introducing the IUPHAR/MMV Guide to MALARIA PHARMACOLOGY, Nucleic Acids Res
Baby, Targeting SARS-CoV-2 main protease: a computational drug repurposing study, Arch. Med. Res
Bhardwaj, Bioactive molecules of tea as potential inhibitors for RNAdependent RNA polymerase of SARS-CoV-2, Front. Med
Bhardwaj, Identification of bioactive molecules from tea plant as SARS-CoV-2 main protease inhibitors, J. Biomol. Struct. Dyn, doi:10.1080/07391102.2020.1766572/SUPPL_FILE/TBSD_A_1766572_SM5637.PDF
Blanco-Melo, Imbalanced host response to SARS-CoV-2 drives development of COVID-19, Cell
Bourinbaiar, The non-steroidal anti-inflammatory drug, indomethacin, as an inhibitor of HIV replication, FEBS Lett
Calum, Non-steroidal anti-inflammatory drugs, prostaglandins, and COVID-19, Br. J. Pharmacol
Chong, An appraisal of the current scenario in vaccine research for COVID-19, Viruses
Choudhari, Development of an in vitro transcribed RNA as positive control for laboratory diagnosis of SARS-CoV-2 in India, Indian J. Med. Res
Daniel, Effect of indomethacin on Epstein-Barr virus early antigen induction, Cancer Res
Davis, The comparative Toxicogenomics database: update 2019, Nucleic Acids Res
Desantis, Indomethacin-based PROTACs as pan-coronavirus antiviral agents, Eur. J. Med. Chem
Fu, Optimization of metabolomic data processing using NOREVA, Nat. Protoc
Fu, VARIDT 2.0: structural variability of drug transporter, Nucleic Acids Res
Gao, Structure of the RNA-dependent RNA polymerase from COVID-19 virus, Science
Gaziano, Immunomodulatory agents as potential therapeutic or preventive strategies for COVID-19, Eur. Rev. Med. Pharmacol. Sci
Ghosh, Chloropyridinyl esters of nonsteroidal anti-inflammatory agents and related derivatives as potent SARS-CoV-2 3CL protease inhibitors, Molecules
Gomeni, Model based approach for estimating the dosage regimen of indomethacin a potential antiviral treatment of patients infected with SARS CoV-2, J. Pharmacokinet. Pharmacodyn
Gordon, A SARS-CoV-2-human protein-protein interaction map reveals drug targets and potential drug-repurposing, Nature
Harvey, SARS-CoV-2 variants, spike mutations and immune escape, Nat. Rev. Microbiol
Huang, Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China, Lancet
Huang, Role of vitamin A in the immune system, J. Clin. Med
Kiani, In vitro assessment of the antiviral activity of Ketotifen, indomethacin and naproxen, alone and in combination, against SARS-CoV-2, Viruses
Kim, Crystal structure of Nsp15 endoribonuclease NendoU from SARS-CoV-2, Protein Sci
Kirchner, Molecular insights into arrhythmogenic right ventricular cardiomyopathy caused by plakophilin-2 missense mutations, Circ. Cardiovasc. Genet
Ko, Comparative analysis of antiviral efficacy of FDA-approved drugs against SARS-CoV-2 in human lung cells, J. Med. Virol
Kristensen, Crystal structure of the G3BP2 NTF2-like domain in complex with a canonical FGDF motif peptide, Biochem. Biophys. Res. Commun
Krymchantowski, Indomethacin for refractory COVID or post-COVID headache: a retrospective study, Acta Neurol. Belg
Kumar, A multi-targeted approach to identify potential flavonoids against three targets in the SARS-CoV-2 life cycle, Comput. Biol. Med
Kumar, Role of vitamins and minerals as immunity boosters in COVID-19, Inflammopharmacology
Lad, Comparison of the Heme-free and -bound Crystal Structures of Human Heme Oxygenase-1, J. Biol. Chem, doi:10.1074/jbc.M211450200
Lan, Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor, Nature
Li, A comprehensive review of the global efforts on COVID-19 vaccine development, ACS Cent. Sci
Li, Therapeutic target database update 2018: enriched resource for facilitating bench-to-clinic research of targeted therapeutics, Nucleic Acids Res
Lionta, Structure-based virtual screening for drug discovery: principles, applications and recent advances, Curr. Top. Med. Chem
Liu, The role of cyclooxygenase in multiplication and reactivation of HSV-1 in vestibular ganglion neurons, Sci. World J
Lundgren, Hwang, Wu, Han, Role of spectral counting in quantitative proteomics, Expert Rev. Proteomics
Mahi, Najafabadi, Pilarczyk, GREIN: an interactive web platform for Re-analyzing GEO RNA-seq data, Sci. Rep
Marx, Structural variations in the catalytic and ubiquitin-associated domains of microtubule-associated protein/Microtubule affinity regulating kinase (MARK) 1 and MARK2, J. Biol. Chem
Mawson, Croft, Gonzalez-Fernandez, Liver damage and exposure to toxic concentrations of endogenous retinoids in the pathogenesis of COVID-19 disease: hypothesis, Viral Immunol
Mcmillan, A tail of two sites: a bipartite mechanism for recognition of notch ligands by mind bomb E3 ligases, Mol. Cell
Meerloo, Cell sensitivity assays, Methods Mol. Biol
Mody, Identification of 3-chymotrypsin like protease (3CLPro) inhibitors as potential anti-SARS-CoV-2 agents, Commun. Biol
Morita, All-trans retinoic acid exhibits antiviral effect against SARS-CoV-2 by inhibiting 3CLpro activity, Viruses
Morris, Autodock4 and AutoDockTools4: automated docking with selective receptor flexibility, J. Comput. Chem
Mugusi, Vitamin A status of patients presenting with pulmonary tuberculosis and asymptomatic HIV-infected individuals, Dar es Salaam, Tanzania, Int. J. Tubercul. Lung Dis
Murphy, Conformational instability of the MARK3 UBA domain compromises ubiquitin recognition and promotes interaction with the adjacent kinase domain, Proc. Natl. Acad. Sci. U.S.A, doi:10.1073/pnas.070301210
Mäkelä, Inhibition of serum phospholipase-A2 in acute pancreatitis by pharmacological agents in vitro, Scand. J. Clin. Lab. Invest
O'boyle, Open Babel: an open chemical toolbox, J. Cheminf
Oh, Network pharmacology approach to decipher signaling pathways associated with target proteins of NSAIDs against COVID-19, Sci. Rep
Pdb -2b4y, Crystal structure of human sirtuin homolog 5
Pdb -2f8a, Crystal structure of the selenocysteine to glycine mutant of human glutathione peroxidase 1
Protease, Angiotensin-converting enzyme 2 (6M0J: Chain A) [47] Kinase and Ubiquitinassociated domains of MARK3/Par-1, 2QNJ
Rafi, Combination of QSAR, molecular docking, molecular dynamic simulation and MM-PBSA: analogues of lopinavir and favipiravir as potential drug candidates against COVID-19, J. Biomol. Struct. Dyn
Ravichandran, An open label randomized clinical trial of Indomethacin for mild and moderate hospitalised Covid-19 patients, Sci. Rep
Rcsb Pdb -, Crystal structure of the NTF2 domain of Ras GTPase-activating protein-binding protein 1
Redondo, SARS-CoV-2 accessory proteins in viral pathogenesis: knowns and unknowns, Front. Immunol
Rehman, COVID-19 challenges and its therapeutics, Biomed. Pharmacother
Rosas-Lemus, High-resolution structures of the SARS-CoV-2 2'-Omethyltransferase reveal strategies for structure-based inhibitor design, Sci. Signal
Ross, Stephensen, Vitamin A and retinoids in antiviral responses, Faseb. J
Saier, The transporter classification database (TCDB): 2021 update, Nucleic Acids Res
Sanders, Pharmacologic treatments for coronavirus disease 2019 (COVID-19): a review, JAMA
Sapkal, Inactivated COVID-19 vaccine BBV152/COVAXIN effectively neutralizes recently emerged B.1.1.7 variant of SARS-CoV-2, J. Trav. Med
Sarohan, A novel hypothesis for COVID-19 pathogenesis: retinol depletion and retinoid signaling disorder, Cell. Signal
Sharma, An in-silico evaluation of different bioactive molecules of tea for their inhibition potency against non structural protein-15 of SARS-CoV-2, Food Chem
Shekhar, Indomethacin: an exploratory study of antiviral mechanism and host-pathogen interaction in COVID-19, Expert Rev. Anti Infect. Ther
Shen, Structures of human insulin-degrading enzyme reveal a new substrate recognition mechanism, Nature
Shimizu, Structure-based analysis of the guanine nucleotide exchange factor SmgGDS reveals armadillo-repeat motifs and key regions for activity and GTPase binding, J. Biol. Chem, doi:10.1074/jbc.M117.792556
Sigrist, New and continuing developments at PROSITE, Nucleic Acids Res
Singh, In-silico evaluation of bioactive compounds from tea as potential SARS-CoV-2 nonstructural protein 16 inhibitors, J. Tradl. Complement. Med
Spike, Human glutathione peroxidase 1 (2F8A) [70] Catalytic and ubiquitinassociated domains of MARK1/PAR-1 (2HAK) [56] Papain like protease (6W9C) [73] NTF2 domain of Ras GTPaseactivating protein-binding protein (3Q90), Human Heme Oxygenase
Stark, BioGRID: a general repository for interaction datasets, Nucleic Acids Res
Tang, ANPELA: analysis and performance assessment of the label-free quantification workflow for metaproteomic studies, Briefings Bioinf
Tang, Simultaneous improvement in the precision, accuracy, and robustness of label-free proteome quantification by optimizing data manipulation chains, Mol. Cell. Proteomics
Tarighi, A review of potential suggested drugs for coronavirus disease (COVID-19) treatment, Eur. J. Pharmacol
Tepasse, Vitamin A plasma levels in COVID-19 patients: a prospective multicenter study and hypothesis, Nutrients
Tian, CASTp 3.0: computed atlas of surface topography of proteins, Nucleic Acids Res
Tomasa-Irriguible, Low levels of few micronutrients may impact COVID-19 disease progression: an observational study on the first wave, Metabolites
Trasino, A role for retinoids in the treatment of COVID-19?, Clin. Exp. Pharmacol. Physiol
Trott, Autodock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading, J. Comput. Chem
Turrubiates-Hernández, The involvement of vitamin A in the production of secretory IgA in the respiratory epithelium for potential protection against SARS-CoV-2 infection, Rev. Alerg. Mex
Vane, Botting, Mechanism of action of anti-inflammatory drugs, Int. J. Tissue React
Vane, Botting, Mechanism of action of nonsteroidal anti-inflammatory drugs, Am. J. Med
Vlieg-Boerstra, Nutrient supplementation for prevention of viral respiratory tract infections in healthy subjects: a systematic review and metaanalysis, Allergy
Voelkle, Prevalence of micronutrient deficiencies in patients hospitalized with COVID-19: an observational cohort study, Nutrients
Vries, A comparative analysis of SARS-CoV-2 antivirals characterizes 3CL pro inhibitor PF-00835231 as a potential new treatment for COVID-19, J. Virol
Wang, COVID-19 drug repurposing: a review of computational screening methods, clinical trials, and protein interaction assays, Med. Res. Rev
Wang, L1000FWD: fireworks visualization of drug-induced transcriptomic signatures, Bioinformatics
Wang, Therapeutic target database 2020: enriched resource for facilitating research and early development of targeted therapeutics, Nucleic Acids Res
Wei, Kao, Lu, A web-based text mining tool for assisting biocuration, Nucleic Acids Res
Wolbach, Howe, Tissue changes following deprivation of fat-soluble A vitamin, Nutr. Rev
Xiaolu, On the origin and continuing evolution of SARS-CoV-2, Natl. Sci. Rev
Xu, Gao, Wu, Selinger, Zhou, None, bioRxiv, doi:10.1101/2020.04.01.017624
Yadav, Kumar, Global emergence of SARS-CoV-2 variants: new foresight needed for improved vaccine efficacy, Lancet Infect. Dis
Yadav, Neutralization of Beta and Delta variant with sera of COVID-19 recovered cases and vaccines of inactivated COVID-19 vaccine BBV152/Covaxin, J. Trav. Med
Yan, Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2, Science
Yang, A novel bioinformatics approach to identify the consistently wellperforming normalization strategy for current metabolomic studies, Briefings Bioinf
Yang, NOREVA: enhanced normalization and evaluation of time-course and multi-class metabolomic data, Nucleic Acids Res
Yin, INTEDE: interactome of drug-metabolizing enzymes, Nucleic Acids Res
Yuan, A highly conserved cryptic epitope in the receptor binding domains of SARS-CoV-2 and SARS-CoV, Science
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Med.'}, { 'issue': '5', 'key': '10.1016/j.compbiomed.2022.105788_bib15', 'doi-asserted-by': 'crossref', 'first-page': '1036', 'DOI': '10.1016/j.cell.2020.04.026', 'article-title': 'Imbalanced host response to SARS-CoV-2 drives development of COVID-19', 'volume': '181', 'author': 'Blanco-Melo', 'year': '2020', 'journal-title': 'Cell'}, { 'issue': '1', 'key': '10.1016/j.compbiomed.2022.105788_bib16', 'doi-asserted-by': 'crossref', 'first-page': '85', 'DOI': '10.1016/0014-5793(95)00057-G', 'article-title': 'The non-steroidal anti-inflammatory drug, indomethacin, as an inhibitor ' 'of HIV replication', 'volume': '360', 'author': 'Bourinbaiar', 'year': '1995', 'journal-title': 'FEBS Lett.'}, { 'issue': '21', 'key': '10.1016/j.compbiomed.2022.105788_bib17', 'doi-asserted-by': 'crossref', 'first-page': '4899', 'DOI': '10.1111/bph.15206', 'article-title': 'Non-steroidal anti-inflammatory drugs, prostaglandins, and COVID-19', 'volume': '177', 'author': 'Calum', 'year': '2020', 'journal-title': 'Br. J. Pharmacol.'}, { 'issue': '7', 'key': '10.1016/j.compbiomed.2022.105788_bib18', 'doi-asserted-by': 'crossref', 'first-page': '1397', 'DOI': '10.3390/v13071397', 'article-title': 'An appraisal of the current scenario in vaccine research for COVID-19', 'volume': '13', 'author': 'Chong', 'year': '2021', 'journal-title': 'Viruses'}, { 'issue': '2–3', 'key': '10.1016/j.compbiomed.2022.105788_bib19', 'first-page': '251', 'article-title': 'Development of an in vitro transcribed RNA as positive control for ' 'laboratory diagnosis of SARS-CoV-2 in India', 'volume': '151', 'author': 'Choudhari', 'year': '2020', 'journal-title': 'Indian J. Med. Res.'}, { 'key': '10.1016/j.compbiomed.2022.105788_bib20', 'doi-asserted-by': 'crossref', 'first-page': 'D506', 'DOI': '10.1093/nar/gky1049', 'article-title': 'UniProt: a worldwide hub of protein knowledge', 'volume': '47', 'author': 'Consortium', 'year': '2019', 'journal-title': 'Nucleic Acids Res.'}, { 'issue': '3', 'key': '10.1016/j.compbiomed.2022.105788_bib21', 'first-page': '981', 'article-title': 'Effect of indomethacin on Epstein-Barr virus early antigen induction', 'volume': '44', 'author': 'Daniel', 'year': '2021', 'journal-title': 'Cancer Res.'}, { 'issue': 'D1', 'key': '10.1016/j.compbiomed.2022.105788_bib22', 'doi-asserted-by': 'crossref', 'first-page': 'D948', 'DOI': '10.1093/nar/gky868', 'article-title': 'The comparative Toxicogenomics database: update 2019', 'volume': '47', 'author': 'Davis', 'year': '2019', 'journal-title': 'Nucleic Acids Res.'}, { 'key': '10.1016/j.compbiomed.2022.105788_bib23', 'doi-asserted-by': 'crossref', 'DOI': '10.1016/j.ejmech.2021.113814', 'article-title': 'Indomethacin-based PROTACs as pan-coronavirus antiviral agents', 'volume': '226', 'author': 'Desantis', 'year': '2021', 'journal-title': 'Eur. J. Med. Chem.'}, { 'key': '10.1016/j.compbiomed.2022.105788_bib24', 'doi-asserted-by': 'crossref', 'DOI': '10.1128/JVI.01819-20', 'article-title': 'A comparative analysis of SARS-CoV-2 antivirals characterizes 3CL pro ' 'inhibitor PF-00835231 as a potential new treatment for COVID-19', 'volume': '95', 'author': 'de Vries', 'year': '2021', 'journal-title': 'J. Virol.'}, {'key': '10.1016/j.compbiomed.2022.105788_bib25', 'author': 'DrugBank'}, { 'issue': '1', 'key': '10.1016/j.compbiomed.2022.105788_bib27', 'doi-asserted-by': 'crossref', 'first-page': '129', 'DOI': '10.1038/s41596-021-00636-9', 'article-title': 'Optimization of metabolomic data processing using NOREVA', 'volume': '17', 'author': 'Fu', 'year': '2022', 'journal-title': 'Nat. Protoc.'}, { 'key': '10.1016/j.compbiomed.2022.105788_bib28', 'doi-asserted-by': 'crossref', 'first-page': 'D1417', 'DOI': '10.1093/nar/gkab1013', 'article-title': 'VARIDT 2.0: structural variability of drug transporter', 'volume': '50', 'author': 'Fu', 'year': '2022', 'journal-title': 'Nucleic Acids Res.'}, { 'key': '10.1016/j.compbiomed.2022.105788_bib29', 'doi-asserted-by': 'crossref', 'first-page': '779', 'DOI': '10.1126/science.abb7498', 'article-title': 'Structure of the RNA-dependent RNA polymerase from COVID-19 virus', 'volume': '368', 'author': 'Gao', 'year': '2020', 'journal-title': 'Science'}, { 'key': '10.1016/j.compbiomed.2022.105788_bib30', 'first-page': '4174', 'article-title': 'Immunomodulatory agents as potential therapeutic or preventive ' 'strategies for COVID-19', 'volume': '25', 'author': 'Gaziano', 'year': '2021', 'journal-title': 'Eur. Rev. Med. Pharmacol. Sci.'}, { 'issue': '19', 'key': '10.1016/j.compbiomed.2022.105788_bib31', 'doi-asserted-by': 'crossref', 'first-page': '5782', 'DOI': '10.3390/molecules26195782', 'article-title': 'Chloropyridinyl esters of nonsteroidal anti-inflammatory agents and ' 'related derivatives as potent SARS-CoV-2 3CL protease inhibitors', 'volume': '26', 'author': 'Ghosh', 'year': '2021', 'journal-title': 'Molecules'}, { 'key': '10.1016/j.compbiomed.2022.105788_bib32', 'doi-asserted-by': 'crossref', 'first-page': '189', 'DOI': '10.1007/s10928-020-09690-4', 'article-title': 'Model based approach for estimating the dosage regimen of indomethacin ' 'a potential antiviral treatment of patients infected with SARS CoV-2', 'volume': '47', 'author': 'Gomeni', 'year': '2020', 'journal-title': 'J. Pharmacokinet. Pharmacodyn.'}, { 'key': '10.1016/j.compbiomed.2022.105788_bib33', 'doi-asserted-by': 'crossref', 'article-title': 'A SARS-CoV-2-human protein-protein interaction map reveals drug targets ' 'and potential drug-repurposing', 'author': 'Gordon', 'year': '2020', 'journal-title': 'Nature', 'DOI': '10.1038/s41586-020-2286-9'}, {'key': '10.1016/j.compbiomed.2022.105788_bib34', 'author': 'GSE147507'}, { 'key': '10.1016/j.compbiomed.2022.105788_bib35', 'doi-asserted-by': 'crossref', 'first-page': '409', 'DOI': '10.1038/s41579-021-00573-0', 'article-title': 'SARS-CoV-2 variants, spike mutations and immune escape', 'volume': '19', 'author': 'Harvey', 'year': '2021', 'journal-title': 'Nat. Rev. Microbiol.'}, { 'issue': '10223', 'key': '10.1016/j.compbiomed.2022.105788_bib36', 'doi-asserted-by': 'crossref', 'first-page': '497', 'DOI': '10.1016/S0140-6736(20)30183-5', 'article-title': 'Clinical features of patients infected with 2019 novel coronavirus in ' 'Wuhan, China', 'volume': '395', 'author': 'Huang', 'year': '2020', 'journal-title': 'Lancet'}, { 'issue': '9', 'key': '10.1016/j.compbiomed.2022.105788_bib37', 'first-page': '7', 'article-title': 'Role of vitamin A in the immune system', 'volume': '258', 'author': 'Huang', 'year': '2018', 'journal-title': 'J. Clin. Med.'}, { 'issue': '4', 'key': '10.1016/j.compbiomed.2022.105788_bib38', 'doi-asserted-by': 'crossref', 'first-page': '558', 'DOI': '10.3390/v13040558', 'article-title': 'In vitro assessment of the antiviral activity of Ketotifen, ' 'indomethacin and naproxen, alone and in combination, against SARS-CoV-2', 'volume': '13', 'author': 'Kiani', 'year': '2021', 'journal-title': 'Viruses'}, { 'key': '10.1016/j.compbiomed.2022.105788_bib39', 'doi-asserted-by': 'crossref', 'first-page': '1596', 'DOI': '10.1002/pro.3873', 'article-title': 'Crystal structure of Nsp15 endoribonuclease NendoU from SARS-CoV-2', 'volume': '29', 'author': 'Kim', 'year': '2020', 'journal-title': 'Protein Sci.'}, { 'key': '10.1016/j.compbiomed.2022.105788_bib40', 'doi-asserted-by': 'crossref', 'first-page': '400', 'DOI': '10.1161/CIRCGENETICS.111.961854', 'article-title': 'Molecular insights into arrhythmogenic right ventricular cardiomyopathy ' 'caused by plakophilin-2 missense mutations', 'volume': '5', 'author': 'Kirchner', 'year': '2012', 'journal-title': 'Circ. Cardiovasc. Genet.'}, { 'key': '10.1016/j.compbiomed.2022.105788_bib41', 'doi-asserted-by': 'crossref', 'first-page': '53', 'DOI': '10.1016/j.bbrc.2015.09.123', 'article-title': 'Crystal structure of the G3BP2 NTF2-like domain in complex with a ' 'canonical FGDF motif peptide', 'volume': '467', 'author': 'Kristensen', 'year': '2015', 'journal-title': 'Biochem. Biophys. Res. Commun.'}, { 'issue': '3', 'key': '10.1016/j.compbiomed.2022.105788_bib42', 'doi-asserted-by': 'crossref', 'first-page': '1403', 'DOI': '10.1002/jmv.26397', 'article-title': 'Comparative analysis of antiviral efficacy of FDA-approved drugs ' 'against SARS-CoV-2 in human lung cells', 'volume': '93', 'author': 'Ko', 'year': '2021', 'journal-title': 'J. Med. Virol.'}, { 'key': '10.1016/j.compbiomed.2022.105788_bib43', 'first-page': '1', 'article-title': 'Indomethacin for refractory COVID or post-COVID headache: a ' 'retrospective study', 'volume': '21', 'author': 'Krymchantowski', 'year': '2021', 'journal-title': 'Acta Neurol. Belg.'}, { 'issue': '4', 'key': '10.1016/j.compbiomed.2022.105788_bib44', 'doi-asserted-by': 'crossref', 'first-page': '1001', 'DOI': '10.1007/s10787-021-00826-7', 'article-title': 'Role of vitamins and minerals as immunity boosters in COVID-19', 'volume': '29', 'author': 'Kumar', 'year': '2021', 'journal-title': 'Inflammopharmacology'}, { 'key': '10.1016/j.compbiomed.2022.105788_bib45', 'doi-asserted-by': 'crossref', 'DOI': '10.1016/j.compbiomed.2022.105231', 'article-title': 'A multi-targeted approach to identify potential flavonoids against ' 'three targets in the SARS-CoV-2 life cycle', 'volume': '142', 'author': 'Kumar', 'year': '2022', 'journal-title': 'Comput. Biol. Med.'}, { 'key': '10.1016/j.compbiomed.2022.105788_bib47', 'doi-asserted-by': 'crossref', 'first-page': '215', 'DOI': '10.1038/s41586-020-2180-5', 'article-title': 'Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ' 'ACE2 receptor', 'volume': '581', 'author': 'Lan', 'year': '2020', 'journal-title': 'Nature'}, { 'key': '10.1016/j.compbiomed.2022.105788_bib48', 'doi-asserted-by': 'crossref', 'first-page': 'D1121', 'DOI': '10.1093/nar/gkx1076', 'article-title': 'Therapeutic target database update 2018: enriched resource for ' 'facilitating bench-to-clinic research of targeted therapeutics', 'volume': '46', 'author': 'Li', 'year': '2018', 'journal-title': 'Nucleic Acids Res.'}, { 'issue': '4', 'key': '10.1016/j.compbiomed.2022.105788_bib49', 'doi-asserted-by': 'crossref', 'first-page': '512', 'DOI': '10.1021/acscentsci.1c00120', 'article-title': 'A comprehensive review of the global efforts on COVID-19 vaccine ' 'development', 'volume': '7', 'author': 'Li', 'year': '2021', 'journal-title': 'ACS Cent. Sci.'}, { 'issue': '16', 'key': '10.1016/j.compbiomed.2022.105788_bib50', 'doi-asserted-by': 'crossref', 'first-page': '1923', 'DOI': '10.2174/1568026614666140929124445', 'article-title': 'Structure-based virtual screening for drug discovery: principles, ' 'applications and recent advances', 'volume': '14', 'author': 'Lionta', 'year': '2014', 'journal-title': 'Curr. Top. Med. Chem.'}, { 'key': '10.1016/j.compbiomed.2022.105788_bib51', 'article-title': 'The role of cyclooxygenase in multiplication and reactivation of HSV-1 ' 'in vestibular ganglion neurons', 'author': 'Liu', 'year': '2014', 'journal-title': 'Sci. World J.'}, { 'key': '10.1016/j.compbiomed.2022.105788_bib53', 'doi-asserted-by': 'crossref', 'first-page': '39', 'DOI': '10.1586/epr.09.69', 'article-title': 'Role of spectral counting in quantitative proteomics', 'volume': '7', 'author': 'Lundgren', 'year': '2010', 'journal-title': 'Expert Rev. Proteomics'}, { 'issue': '5', 'key': '10.1016/j.compbiomed.2022.105788_bib54', 'doi-asserted-by': 'crossref', 'first-page': '401', 'DOI': '10.3109/00365519709084587', 'article-title': 'Inhibition of serum phospholipase-A2 in acute pancreatitis by ' 'pharmacological agents in vitro', 'volume': '57', 'author': 'Mäkelä', 'year': '1997', 'journal-title': 'Scand. J. Clin. Lab. Invest.'}, { 'key': '10.1016/j.compbiomed.2022.105788_bib55', 'doi-asserted-by': 'crossref', 'first-page': '7580', 'DOI': '10.1038/s41598-019-43935-8', 'article-title': 'GREIN: an interactive web platform for Re-analyzing GEO RNA-seq data', 'volume': '9', 'author': 'Mahi', 'year': '2019', 'journal-title': 'Sci. Rep.'}, { 'key': '10.1016/j.compbiomed.2022.105788_bib56', 'doi-asserted-by': 'crossref', 'first-page': '27586', 'DOI': '10.1074/jbc.M604865200', 'article-title': 'Structural variations in the catalytic and ubiquitin-associated domains ' 'of microtubule-associated protein/Microtubule affinity regulating ' 'kinase (MARK) 1 and MARK2', 'volume': '281', 'author': 'Marx', 'year': '2006', 'journal-title': 'J. Biol. Chem.'}, { 'key': '10.1016/j.compbiomed.2022.105788_bib57', 'doi-asserted-by': 'crossref', 'first-page': '376', 'DOI': '10.1089/vim.2020.0330', 'article-title': 'Liver damage and exposure to toxic concentrations of endogenous ' 'retinoids in the pathogenesis of COVID-19 disease: hypothesis', 'volume': '34', 'author': 'Mawson', 'year': '2021', 'journal-title': 'Viral Immunol.'}, { 'key': '10.1016/j.compbiomed.2022.105788_bib58', 'doi-asserted-by': 'crossref', 'first-page': '912', 'DOI': '10.1016/j.molcel.2015.01.019', 'article-title': 'A tail of two sites: a bipartite mechanism for recognition of notch ' 'ligands by mind bomb E3 ligases', 'volume': '57', 'author': 'McMillan', 'year': '2015', 'journal-title': 'Mol. Cell'}, { 'key': '10.1016/j.compbiomed.2022.105788_bib59', 'doi-asserted-by': 'crossref', 'first-page': '237', 'DOI': '10.1007/978-1-61779-080-5_20', 'article-title': 'Cell sensitivity assays', 'volume': '731', 'author': 'Meerloo', 'year': '2011', 'journal-title': 'Methods Mol. Biol.'}, { 'issue': '1 4', 'key': '10.1016/j.compbiomed.2022.105788_bib61', 'first-page': '1', 'article-title': 'Identification of 3-chymotrypsin like protease (3CLPro) inhibitors as ' 'potential anti-SARS-CoV-2 agents', 'volume': '4', 'author': 'Mody', 'year': '2021', 'journal-title': 'Commun. Biol.'}, { 'key': '10.1016/j.compbiomed.2022.105788_bib62', 'doi-asserted-by': 'crossref', 'DOI': '10.3390/v13081669', 'article-title': 'All-trans retinoic acid exhibits antiviral effect against SARS-CoV-2 by ' 'inhibiting 3CLpro activity', 'volume': '13', 'author': 'Morita', 'year': '2021', 'journal-title': 'Viruses'}, { 'key': '10.1016/j.compbiomed.2022.105788_bib63', 'doi-asserted-by': 'crossref', 'first-page': '2785', 'DOI': '10.1002/jcc.21256', 'article-title': 'Autodock4 and AutoDockTools4: automated docking with selective receptor ' 'flexibility', 'volume': '16', 'author': 'Morris', 'year': '2009', 'journal-title': 'J. Comput. Chem.'}, { 'key': '10.1016/j.compbiomed.2022.105788_bib64', 'first-page': '804', 'article-title': 'Vitamin A status of patients presenting with pulmonary tuberculosis and ' 'asymptomatic HIV-infected individuals, Dar es Salaam, Tanzania', 'volume': '7', 'author': 'Mugusi', 'year': '2003', 'journal-title': 'Int. J. Tubercul. Lung Dis.'}, { 'key': '10.1016/j.compbiomed.2022.105788_bib65', 'doi-asserted-by': 'crossref', 'first-page': '33', 'DOI': '10.1186/1758-2946-3-33', 'article-title': 'Open Babel: an open chemical toolbox', 'volume': '3', 'author': "O'Boyle", 'year': '2011', 'journal-title': 'J. Cheminf.'}, { 'issue': '1', 'key': '10.1016/j.compbiomed.2022.105788_bib66', 'doi-asserted-by': 'crossref', 'first-page': '9606', 'DOI': '10.1038/s41598-021-88313-5', 'article-title': 'Network pharmacology approach to decipher signaling pathways associated ' 'with target proteins of NSAIDs against COVID-19', 'volume': '11', 'author': 'Oh', 'year': '2021', 'journal-title': 'Sci. Rep.'}, { 'key': '10.1016/j.compbiomed.2022.105788_bib67', 'doi-asserted-by': 'crossref', 'DOI': '10.1016/j.biopha.2021.112015', 'article-title': 'COVID-19 challenges and its therapeutics', 'volume': '142', 'author': 'Rehman', 'year': '2021', 'journal-title': 'Biomed. Pharmacother.'}, { 'issue': '8', 'key': '10.1016/j.compbiomed.2022.105788_bib68', 'doi-asserted-by': 'crossref', 'first-page': '3711', 'DOI': '10.1080/07391102.2020.1850355', 'article-title': 'Combination of QSAR, molecular docking, molecular dynamic simulation ' 'and MM-PBSA: analogues of lopinavir and favipiravir as potential drug ' 'candidates against COVID- 19', 'volume': '40', 'author': 'Rafi', 'year': '2022', 'journal-title': 'J. Biomol. Struct. Dyn.'}, { 'issue': '1 12', 'key': '10.1016/j.compbiomed.2022.105788_bib69', 'first-page': '1', 'article-title': 'An open label randomized clinical trial of Indomethacin for mild and ' 'moderate hospitalised Covid-19 patients', 'volume': '12', 'author': 'Ravichandran', 'year': '2022', 'journal-title': 'Sci. Rep.'}, { 'key': '10.1016/j.compbiomed.2022.105788_bib75', 'doi-asserted-by': 'crossref', 'first-page': '2698', 'DOI': '10.3389/fimmu.2021.708264', 'article-title': 'SARS-CoV-2 accessory proteins in viral pathogenesis: knowns and ' 'unknowns', 'volume': '12', 'author': 'Redondo', 'year': '2021', 'journal-title': 'Front. Immunol.'}, { 'key': '10.1016/j.compbiomed.2022.105788_bib76', 'doi-asserted-by': 'crossref', 'DOI': '10.1126/scisignal.abe1202', 'article-title': 'High-resolution structures of the SARS-CoV-2 2’- O-methyltransferase ' 'reveal strategies for structure-based inhibitor design', 'volume': '13', 'author': 'Rosas-Lemus', 'year': '2020', 'journal-title': 'Sci. Signal.'}, { 'issue': '9', 'key': '10.1016/j.compbiomed.2022.105788_bib77', 'doi-asserted-by': 'crossref', 'first-page': '979', 'DOI': '10.1096/fasebj.10.9.8801180', 'article-title': 'Vitamin A and retinoids in antiviral responses', 'volume': '10', 'author': 'Ross', 'year': '1996', 'journal-title': 'Faseb. J.'}, { 'key': '10.1016/j.compbiomed.2022.105788_bib78', 'doi-asserted-by': 'crossref', 'first-page': 'D461', 'DOI': '10.1093/nar/gkaa1004', 'article-title': 'The transporter classification database (TCDB): 2021 update', 'volume': '49', 'author': 'Saier', 'year': '2021', 'journal-title': 'Nucleic Acids Res.'}, { 'issue': '18', 'key': '10.1016/j.compbiomed.2022.105788_bib79', 'first-page': '1824', 'article-title': 'Pharmacologic treatments for coronavirus disease 2019 (COVID-19): a ' 'review', 'volume': '323', 'author': 'Sanders', 'year': '2020', 'journal-title': 'JAMA'}, { 'issue': '4', 'key': '10.1016/j.compbiomed.2022.105788_bib80', 'doi-asserted-by': 'crossref', 'DOI': '10.1093/jtm/taab051', 'article-title': 'Inactivated COVID-19 vaccine BBV152/COVAXIN effectively neutralizes ' 'recently emerged B.1.1.7 variant of SARS-CoV-2', 'volume': '28', 'author': 'Sapkal', 'year': '2021', 'journal-title': 'J. Trav. Med.'}, { 'key': '10.1016/j.compbiomed.2022.105788_bib81', 'doi-asserted-by': 'crossref', 'DOI': '10.1016/j.cellsig.2021.110121', 'article-title': 'A novel hypothesis for COVID-19 pathogenesis: retinol depletion and ' 'retinoid signaling disorder', 'volume': '87', 'author': 'Sarohan', 'year': '2021', 'journal-title': 'Cell. Signal.'}, { 'key': '10.1016/j.compbiomed.2022.105788_bib82', 'article-title': 'An in-silico evaluation of different bioactive molecules of tea for ' 'their inhibition potency against non structural protein-15 of ' 'SARS-CoV-2', 'volume': '346', 'author': 'Sharma', 'year': '2020', 'journal-title': 'Food Chem.'}, { 'key': '10.1016/j.compbiomed.2022.105788_bib83', 'first-page': '1', 'article-title': 'Indomethacin: an exploratory study of antiviral mechanism and ' 'host-pathogen interaction in COVID-19', 'volume': '17', 'author': 'Shekhar', 'year': '2021', 'journal-title': 'Expert Rev. Anti Infect. Ther.'}, { 'key': '10.1016/j.compbiomed.2022.105788_bib84', 'doi-asserted-by': 'crossref', 'first-page': '870', 'DOI': '10.1038/nature05143', 'article-title': 'Structures of human insulin-degrading enzyme reveal a new substrate ' 'recognition mechanism', 'volume': '443', 'author': 'Shen', 'year': '2006', 'journal-title': 'Nature'}, { 'issue': '32', 'key': '10.1016/j.compbiomed.2022.105788_bib85', 'doi-asserted-by': 'crossref', 'first-page': '13441', 'DOI': '10.1074/jbc.M117.792556', 'article-title': 'Structure-based analysis of the guanine nucleotide exchange factor ' 'SmgGDS reveals armadillo-repeat motifs and key regions for activity and ' 'GTPase binding', 'volume': '292', 'author': 'Shimizu', 'year': '2017', 'journal-title': 'J. Biol. Chem.'}, { 'key': '10.1016/j.compbiomed.2022.105788_bib86', 'doi-asserted-by': 'crossref', 'first-page': 'D344', 'DOI': '10.1093/nar/gks1067', 'article-title': 'New and continuing developments at PROSITE', 'volume': '41', 'author': 'Sigrist', 'year': '2012', 'journal-title': 'Nucleic Acids Res.'}, { 'key': '10.1016/j.compbiomed.2022.105788_bib87', 'doi-asserted-by': 'crossref', 'first-page': '35', 'DOI': '10.1016/j.jtcme.2021.05.005', 'article-title': 'In-silico evaluation of bioactive compounds from tea as potential ' 'SARS-CoV-2 nonstructural protein 16 inhibitors', 'volume': '12', 'author': 'Singh', 'year': '2022', 'journal-title': 'J. Tradl. Complement. Med.'}, { 'key': '10.1016/j.compbiomed.2022.105788_bib88', 'doi-asserted-by': 'crossref', 'DOI': '10.1093/nar/gkj109', 'article-title': 'BioGRID: a general repository for interaction datasets', 'volume': '34', 'author': 'Stark', 'year': '2006', 'journal-title': 'Nucleic Acids Res.'}, { 'key': '10.1016/j.compbiomed.2022.105788_bib89', 'doi-asserted-by': 'crossref', 'first-page': '1683', 'DOI': '10.1074/mcp.RA118.001169', 'article-title': 'Simultaneous improvement in the precision, accuracy, and robustness of ' 'label-free proteome quantification by optimizing data manipulation ' 'chains', 'volume': '18', 'author': 'Tang', 'year': '2019', 'journal-title': 'Mol. Cell. Proteomics'}, { 'key': '10.1016/j.compbiomed.2022.105788_bib90', 'doi-asserted-by': 'crossref', 'first-page': '621', 'DOI': '10.1093/bib/bby127', 'article-title': 'ANPELA: analysis and performance assessment of the label-free ' 'quantification workflow for metaproteomic studies', 'volume': '21', 'author': 'Tang', 'year': '2020', 'journal-title': 'Briefings Bioinf.'}, { 'key': '10.1016/j.compbiomed.2022.105788_bib91', 'doi-asserted-by': 'crossref', 'DOI': '10.1016/j.ejphar.2021.173890', 'article-title': 'A review of potential suggested drugs for coronavirus disease ' '(COVID-19) treatment', 'volume': '895', 'author': 'Tarighi', 'year': '2021', 'journal-title': 'Eur. J. Pharmacol.'}, { 'key': '10.1016/j.compbiomed.2022.105788_bib92', 'doi-asserted-by': 'crossref', 'first-page': '2173', 'DOI': '10.3390/nu13072173', 'article-title': 'Vitamin A plasma levels in COVID-19 patients: a prospective multicenter ' 'study and hypothesis', 'volume': '13', 'author': 'Tepasse', 'year': '2021', 'journal-title': 'Nutrients'}, { 'issue': 'W1', 'key': '10.1016/j.compbiomed.2022.105788_bib93', 'doi-asserted-by': 'crossref', 'first-page': 'W363', 'DOI': '10.1093/nar/gky473', 'article-title': 'CASTp 3.0: computed atlas of surface topography of proteins', 'volume': '46', 'author': 'Tian', 'year': '2018', 'journal-title': 'Nucleic Acids Res.'}, { 'key': '10.1016/j.compbiomed.2022.105788_bib94', 'doi-asserted-by': 'crossref', 'unstructured': 'Tianhong Xu, Xuejuan Gao, Zengbin Wu, Douglas W. Selinger, Zichen Zhou, ' 'bioRxiv 2020.04.01.017624; doi: ' 'https://doi.org/10.1101/2020.04.01.017624.', 'DOI': '10.1101/2020.04.01.017624'}, { 'key': '10.1016/j.compbiomed.2022.105788_bib95', 'doi-asserted-by': 'crossref', 'DOI': '10.3390/metabo11090565', 'article-title': 'Low levels of few micronutrients may impact COVID-19 disease ' 'progression: an observational study on the first wave', 'volume': '11', 'author': 'Tomasa-Irriguible', 'year': '2021', 'journal-title': 'Metabolites'}, { 'key': '10.1016/j.compbiomed.2022.105788_bib96', 'first-page': '1765', 'article-title': 'A role for retinoids in the treatment of COVID-19?', 'volume': '47', 'author': 'Trasino', 'year': '2020', 'journal-title': 'Clin. Exp. Pharmacol. Physiol.'}, { 'issue': '2', 'key': '10.1016/j.compbiomed.2022.105788_bib97', 'first-page': '455', 'article-title': 'Autodock Vina: improving the speed and accuracy of docking with a new ' 'scoring function, efficient optimization, and multithreading', 'volume': '31', 'author': 'Trott', 'year': '2010', 'journal-title': 'J. Comput. Chem.'}, { 'key': '10.1016/j.compbiomed.2022.105788_bib98', 'first-page': '185', 'article-title': '[The involvement of vitamin A in the production of secretory IgA in the ' 'respiratory epithelium for potential protection against SARS-CoV-2 ' 'infection]', 'volume': '68', 'author': 'Turrubiates-Hernández', 'year': '2021', 'journal-title': 'Rev. Alerg. Mex.'}, { 'issue': '3A', 'key': '10.1016/j.compbiomed.2022.105788_bib99', 'doi-asserted-by': 'crossref', 'first-page': '2S', 'DOI': '10.1016/S0002-9343(97)00203-9', 'article-title': 'Mechanism of action of nonsteroidal anti-inflammatory drugs', 'volume': '104', 'author': 'Vane', 'year': '1998', 'journal-title': 'Am. J. Med.'}, { 'issue': '1', 'key': '10.1016/j.compbiomed.2022.105788_bib100', 'first-page': '3‐15', 'article-title': 'Mechanism of action of anti-inflammatory drugs', 'volume': '20', 'author': 'Vane', 'year': '1998', 'journal-title': 'Int. J. Tissue React.'}, { 'key': '10.1016/j.compbiomed.2022.105788_bib101', 'doi-asserted-by': 'crossref', 'DOI': '10.1111/all.15136', 'article-title': 'Nutrient supplementation for prevention of viral respiratory tract ' 'infections in healthy subjects: a systematic review and meta-analysis', 'volume': '77', 'author': 'Vlieg- Boerstra', 'year': '2022', 'journal-title': 'Allergy'}, { 'key': '10.1016/j.compbiomed.2022.105788_bib102', 'doi-asserted-by': 'crossref', 'first-page': '1862', 'DOI': '10.3390/nu14091862', 'article-title': 'Prevalence of micronutrient deficiencies in patients hospitalized with ' 'COVID-19: an observational cohort study', 'volume': '14', 'author': 'Voelkle', 'year': '2022', 'journal-title': 'Nutrients'}, { 'issue': '1', 'key': '10.1016/j.compbiomed.2022.105788_bib103', 'doi-asserted-by': 'crossref', 'first-page': '5', 'DOI': '10.1002/med.21728', 'article-title': 'COVID-19 drug repurposing: a review of computational screening methods, ' 'clinical trials, and protein interaction assays', 'volume': '41', 'author': 'Wang', 'year': '2021', 'journal-title': 'Med. Res. Rev.'}, { 'key': '10.1016/j.compbiomed.2022.105788_bib104', 'first-page': 'D1031', 'article-title': 'Therapeutic target database 2020: enriched resource for facilitating ' 'research and early development of targeted therapeutics', 'volume': '48', 'author': 'Wang', 'year': '2020', 'journal-title': 'Nucleic Acids Res.'}, { 'issue': '12', 'key': '10.1016/j.compbiomed.2022.105788_bib105', 'doi-asserted-by': 'crossref', 'first-page': '2150', 'DOI': '10.1093/bioinformatics/bty060', 'article-title': 'L1000FWD: fireworks visualization of drug-induced transcriptomic ' 'signatures', 'volume': '34', 'author': 'Wang', 'year': '2018', 'journal-title': 'Bioinformatics (Oxford, England)'}, { 'key': '10.1016/j.compbiomed.2022.105788_bib106', 'doi-asserted-by': 'crossref', 'first-page': 'W518', 'DOI': '10.1093/nar/gkt441', 'article-title': 'A web-based text mining tool for assisting biocuration', 'volume': '41', 'author': 'Wei', 'year': '2013', 'journal-title': 'Nucleic Acids Res.'}, { 'key': '10.1016/j.compbiomed.2022.105788_bib107', 'first-page': '753', 'article-title': 'Tissue changes following deprivation of fat-soluble A vitamin', 'volume': '42', 'author': 'Wolbach', 'year': '1925', 'journal-title': 'Nutr. Rev.'}, { 'issue': '6', 'key': '10.1016/j.compbiomed.2022.105788_bib108', 'first-page': '1012', 'article-title': 'On the origin and continuing evolution of SARS-CoV-2', 'volume': '7', 'author': 'Xiaolu', 'year': '2021', 'journal-title': 'Natl. Sci. Rev.'}, { 'issue': '7', 'key': '10.1016/j.compbiomed.2022.105788_bib109', 'doi-asserted-by': 'crossref', 'first-page': 'taab104', 'DOI': '10.1093/jtm/taab104', 'article-title': 'Neutralization of Beta and Delta variant with sera of COVID-19 ' 'recovered cases and vaccines of inactivated COVID-19 vaccine ' 'BBV152/Covaxin', 'volume': '28', 'author': 'Yadav', 'year': '2021', 'journal-title': 'J. Trav. Med.'}, { 'key': '10.1016/j.compbiomed.2022.105788_bib110', 'doi-asserted-by': 'crossref', 'first-page': '298', 'DOI': '10.1016/S1473-3099(21)00687-3', 'article-title': 'Global emergence of SARS-CoV-2 variants: new foresight needed for ' 'improved vaccine efficacy', 'volume': '22', 'author': 'Yadav', 'year': '2022', 'journal-title': 'Lancet Infect. Dis.'}, { 'key': '10.1016/j.compbiomed.2022.105788_bib111', 'doi-asserted-by': 'crossref', 'first-page': '1444', 'DOI': '10.1126/science.abb2762', 'article-title': 'Structural basis for the recognition of SARS-CoV-2 by full-length human ' 'ACE2', 'volume': '367', 'author': 'Yan', 'year': '2020', 'journal-title': 'Science'}, { 'key': '10.1016/j.compbiomed.2022.105788_bib112', 'doi-asserted-by': 'crossref', 'first-page': 'W436', 'DOI': '10.1093/nar/gkaa258', 'article-title': 'NOREVA: enhanced normalization and evaluation of time-course and ' 'multi-class metabolomic data', 'volume': '48', 'author': 'Yang', 'year': '2020', 'journal-title': 'Nucleic Acids Res.'}, { 'key': '10.1016/j.compbiomed.2022.105788_bib113', 'doi-asserted-by': 'crossref', 'first-page': '2142', 'DOI': '10.1093/bib/bbz137', 'article-title': 'A novel bioinformatics approach to identify the consistently ' 'well-performing normalization strategy for current metabolomic studies', 'volume': '21', 'author': 'Yang', 'year': '2020', 'journal-title': 'Briefings Bioinf.'}, { 'key': '10.1016/j.compbiomed.2022.105788_bib114', 'doi-asserted-by': 'crossref', 'first-page': 'D1233', 'DOI': '10.1093/nar/gkaa755', 'article-title': 'INTEDE: interactome of drug-metabolizing enzymes', 'volume': '49', 'author': 'Yin', 'year': '2021', 'journal-title': 'Nucleic Acids Res.'}, { 'key': '10.1016/j.compbiomed.2022.105788_bib115', 'doi-asserted-by': 'crossref', 'first-page': '630', 'DOI': '10.1126/science.abb7269', 'article-title': 'A highly conserved cryptic epitope in the receptor binding domains of ' 'SARS-CoV-2 and SARS-CoV', 'volume': '368', 'author': 'Yuan', 'year': '2020', 'journal-title': 'Science'}, { 'issue': '36', 'key': '10.1016/j.compbiomed.2022.105788_bib116', 'doi-asserted-by': 'crossref', 'first-page': '14336', 'DOI': '10.1073/pnas.0703012104', 'article-title': 'Conformational instability of the MARK3 UBA domain compromises ' 'ubiquitin recognition and promotes interaction with the adjacent kinase ' 'domain', 'volume': '104', 'author': 'Murphy', 'year': '2007', 'journal-title': 'Proc. Natl. Acad. Sci. U.S.A.'}, { 'issue': '10', 'key': '10.1016/j.compbiomed.2022.105788_bib117', 'doi-asserted-by': 'crossref', 'first-page': '7834', 'DOI': '10.1074/jbc.M211450200', 'article-title': 'Comparison of the Heme-free and -bound Crystal Structures of Human Heme ' 'Oxygenase-1', 'volume': '278', 'author': 'Lad', 'year': '2003', 'journal-title': 'J. Biol. Chem.'}], 'container-title': 'Computers in Biology and Medicine', 'original-title': [], 'language': 'en', 'link': [ { 'URL': 'https://api.elsevier.com/content/article/PII:S0010482522005558?httpAccept=text/xml', 'content-type': 'text/xml', 'content-version': 'vor', 'intended-application': 'text-mining'}, { 'URL': 'https://api.elsevier.com/content/article/PII:S0010482522005558?httpAccept=text/plain', 'content-type': 'text/plain', 'content-version': 'vor', 'intended-application': 'text-mining'}], 'deposited': { 'date-parts': [[2022, 7, 9]], 'date-time': '2022-07-09T13:49:27Z', 'timestamp': 1657374567000}, 'score': 1, 'resource': {'primary': {'URL': 'https://linkinghub.elsevier.com/retrieve/pii/S0010482522005558'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2022, 8]]}, 'references-count': 107, 'alternative-id': ['S0010482522005558'], 'URL': 'http://dx.doi.org/10.1016/j.compbiomed.2022.105788', 'relation': {}, 'ISSN': ['0010-4825'], 'subject': ['Health Informatics', 'Computer Science Applications'], 'container-title-short': 'Computers in Biology and Medicine', 'published': {'date-parts': [[2022, 8]]}, 'assertion': [ {'value': 'Elsevier', 'name': 'publisher', 'label': 'This article is maintained by'}, { 'value': 'In-silico screening and in-vitro assay show the antiviral effect of ' 'Indomethacin against SARS-CoV-2', 'name': 'articletitle', 'label': 'Article Title'}, { 'value': 'Computers in Biology and Medicine', 'name': 'journaltitle', 'label': 'Journal Title'}, { 'value': 'https://doi.org/10.1016/j.compbiomed.2022.105788', 'name': 'articlelink', 'label': 'CrossRef DOI link to publisher maintained version'}, {'value': 'article', 'name': 'content_type', 'label': 'Content Type'}, { 'value': '© 2022 Elsevier Ltd. 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