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Colchicine for COVID-19: real-time meta analysis of 56 studies

Covid Analysis

Jul 2024

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Colchicine for COVID-19

5th treatment shown to reduce risk in September 2020

^*, now with p = 0.00000031 from 56 studies.

Lower risk for mortality, ICU admission, hospitalization, and recovery.

No treatment is 100% effective. Protocols combine treatments. ^* >10% efficacy, ≥3 studies.

4,500+ studies for 81 treatments. c19early.org

Statistically significant lower risk is seen for mortality, ICU admission, hospitalization, and recovery. 26 studies from 26 independent teams in 15 countries show significant improvements.

Meta analysis using the most serious outcome reported shows 27% [18‑36%] lower risk. Results are similar for higher quality and peer-reviewed studies and worse for Randomized Controlled Trials. Clinical outcomes suggest benefit while viral and case outcomes do not, consistent with an intervention that aids the immune system or recovery but may have limited antiviral effects. Early treatment is more effective than late treatment.

Results are robust — in exclusion sensitivity analysis 22 of 56 studies must be excluded to avoid finding statistically significant efficacy in pooled analysis.

RCT results are less favorable, however they are dominated by the very late stage RECOVERY RCT which is not generalizable to earlier usage.

No treatment or intervention is 100% effective. All practical, effective, and safe means should be used based on risk/benefit analysis. Multiple treatments are typically used in combination, and other treatments are more effective.

All data to reproduce this paper and sources are in the appendix. 10 other meta analyses show significant improvements with colchicine for mortality1-8, oxygen therapy8, hospitalization9, and severity10.

10 meta analyses show significant improvements with colchicine for mortality1-8, oxygen therapy8, hospitalization9, and severity10.

Important missing comments or errors? Let us know.

1. Zein et al., Effect of colchicine on mortality in patients with COVID-19 – A systematic review and meta-analysis, Diabetes & Metabolic Syndrome: Clinical Research & Reviews, doi:10.1016/j.dsx.2022.102395.sciencedirect.com, doi.org.

2. Rai et al., The Potential Role of Colchicine in Reducing Mortality and Mechanical Ventilation Rates in COVID-19 Infection: A Meta-analysis, Journal of Advances in Medicine and Medical Research, doi:10.9734/jammr/2022/v34i2031503.journaljammr.com, doi.org.

3. Elshafei et al., Colchicine use might be associated with lower mortality in COVID‐19 patients: A meta‐analysis, European Journal of Clinical Investigation, doi:10.1111/eci.13645.wiley.com, doi.org.

4. Lien et al., Repurposing Colchicine in Treating Patients with COVID-19: A Systematic Review and Meta-Analysis, Life, doi:10.3390/life11080864.mdpi.com, doi.org.

5. Danjuma et al., Does Colchicine Reduce Mortality in Patients with Covid-19 Clinical Syndrome? An Umbrella Review of Published Meta-Analyses, Elsevier BV, doi:10.2139/ssrn.4447127.ssrn.com, doi.org.

6. Salah et al., Meta-analysis of the Effect of Colchicine on Mortality and Mechanical Ventilation in COVID-19, The American Journal of Cardiology, doi:10.1016/j.amjcard.2021.02.005.sciencedirect.com, doi.org.

7. Golpour et al., The effectiveness of Colchicine as an anti-inflammatory drug in the treatment of coronavirus disease 2019: Meta-analysis, International Journal of Immunopathology and Pharmacology, doi:10.1177/20587384211031763.sagepub.com, doi.org.

8. Elshiwy et al., The role of colchicine in the management of COVID-19: a meta-analysis, BMC Pulmonary Medicine, doi:10.1186/s12890-024-03001-0.biomedcentral.com, doi.org.

9. Kow et al., The effect of colchicine on mortality outcome and duration of hospital stay in patients with COVID‐19: A meta‐analysis of randomized trials, Immunity, Inflammation and Disease, doi:10.1002/iid3.562.wiley.com, doi.org.

10. Yasmin et al., Safety and efficacy of colchicine in COVID-19 patients: A systematic review and meta-analysis of randomized control trials, PLOS ONE, doi:10.1371/journal.pone.0266245.plos.org, doi.org.

Covid Analysis et al., Jul 2024, preprint, 1 author.

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Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.

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