Efficacy of Favipiravir in treatment of mild & moderate COVID-19 infection in Nepal: a multi-center, randomized, open-labelled, phase III clinical trial
Adhikari et al.
, Efficacy of Favipiravir in treatment of mild & moderate COVID-19 infection in Nepal: a multi-center,..
, International Journal of Infectious Diseases, doi:10.1016/j.ijid.2021.12.109
Preliminary report for an RCT in Nepal with 38 favipiravir patients and 32 control patients, showing no significant differences. There were no serious side effects.
risk of no improvement, 40.4% higher, RR 1.40, p = 0.57, treatment 10 of 38 (26.3%), control 6 of 32 (18.8%), all.
risk of no improvement, 36.3% higher, RR 1.36, p = 0.75, treatment 8 of 27 (29.6%), control 5 of 23 (21.7%), mild cases.
risk of no improvement, 63.6% higher, RR 1.64, p = 1.00, treatment 2 of 11 (18.2%), control 1 of 9 (11.1%), moderate cases.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Adhikari et al., 1 Mar 2022, Randomized Controlled Trial, Nepal, peer-reviewed, 12 authors.
Abstract: IMED abstracts 2021
International Journal of Infectious Diseases 116 (2022) S1–S130
Purpose: Coronavirus disease (COVID-19) outbreak has causes
life-changing impacts such as new environmental policies, slowdown of world economy and impact on global health and society.
Police oﬃcers are among the front liners who continue to bravely
ﬁght this pandemic. As the frontline in managing the COVID-19
pandemic, police oﬃcers are at high risk for many forms of psychological problems which includes anxiety and depression. It is
reported that a total of 60 oﬃcers from the New York Police Department died from suicide due to mental health disturbance and
approximately 95 police oﬃcers in China died on the frontline of
ﬁghting this outbreak. Thus, it is important to provide appropriate mental health services and to be able to do such, there is the
need to understand the psychological risk factors and their subsequent needs during pandemic. The main purpose of this study is
to identify the impact of COVID-19 pandemic to mental health of
Malaysian police oﬃcers.
Methods & Materials: Police Stress Questionnaires (PSQ) was
used to measure the police-speciﬁc stressors related with COVID19. Meanwhile, Depression Anxiety Stress Scale (DASS-21) questionnaires use to determine the prevalence of occupational stress
among police oﬃcers.
Results: It is found that the highest percentage reported of
41.1% moderate depression, 45% of moderate anxiety and 31.8%
moderate stress among the respondents. Lack of resources, unequal
sharing of work responsibilities, inadequate equipment and high
risk to COVID-19 infection are associated with depression, anxiety and stress among police oﬃcers. There is signiﬁcant correlation between COVID-19 stressors and level of depression, anxiety
and stress among the police oﬃcers with direct correlation.
Conclusion: Majority of the police oﬃcers suffer moderate to
severe depression, anxiety and stress during COVID-19 pandemic.
Identiﬁed stressors from the study help to develop best practices
and offers recommendations for policing when handling pandemic
High SARS-CoV-2 attack rates among
asymptomatic hospital workers from Ecuador
D.C. Morales Jadan ∗, A.P. Vallejo Janeta,
M.A. Garcia Bereguiain
Universidad de Las Américas, Quito, Pichincha,
Purpose: To determine the SARS-CoV-2 risk of infection in
Ecuadorian hospital. This study aims to describe the SARS-CoV-2
attacks rate and viral loads among patient care workers and other
staff from Ecuadorian hospitals during the ﬁrst wave of COVID-19
Methods & Materials: : Study design and setting. We carried out
a cross-sectional study to describe the attack rate of SARS-CoV-2
infection among patient care workers (physicians, nurses and nursing assistants) and other healthcare personnel (administrative and
services staff) from 9 hospitals of the Andean and Costal Regions
of Ecuador from May to October 2020.
Sample collection, RNA Extraction and RT-qPCR for SARS-CoV-2 diagnosis using the CDC protocol. The samples were processed in the
BSL2 certiﬁed molecular biology laboratory at Universidad de Las
Americas. Nasopharyngeal swabs were collected on 0.5mL TE pH 8
buffer for SARS-CoV-2 diagnosis by RT-qPCR following an adapted
version of the CDC protocol.
Statistical analysis. Chi cuadrado with the statistic program SPSS
Results: A total of 1243 patient care workers and 428 of other
healthcare staff were tested for SARS-CoV-2 infection. The SARSCoV-2..
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