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0 0.5 1 1.5 2+ Improvement -40% Improvement Relative Risk Improvement (b) -36% Improvement (c) -64% Adhikari et al. Favipiravir for COVID-19 RCT EARLY Is early treatment with favipiravir beneficial for COVID-19? RCT 70 patients in Nepal Worse improvement with favipiravir (not stat. sig., p=0.57) Adhikari et al., Int. J. Infectious Diseases, doi:10.1016/j.ijid.2021.12.109 Favors favipiravir Favors control
Efficacy of Favipiravir in treatment of mild & moderate COVID-19 infection in Nepal: a multi-center, randomized, open-labelled, phase III clinical trial
Adhikari et al., International Journal of Infectious Diseases, doi:10.1016/j.ijid.2021.12.109
Adhikari et al., Efficacy of Favipiravir in treatment of mild & moderate COVID-19 infection in Nepal: a multi-center,.., International Journal of Infectious Diseases, doi:10.1016/j.ijid.2021.12.109
Mar 2022   Source   PDF  
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Preliminary report for an RCT in Nepal with 38 favipiravir patients and 32 control patients, showing no significant differences. There were no serious side effects.
risk of no improvement, 40.4% higher, RR 1.40, p = 0.57, treatment 10 of 38 (26.3%), control 6 of 32 (18.8%), all.
risk of no improvement, 36.3% higher, RR 1.36, p = 0.75, treatment 8 of 27 (29.6%), control 5 of 23 (21.7%), mild cases.
risk of no improvement, 63.6% higher, RR 1.64, p = 1.00, treatment 2 of 11 (18.2%), control 1 of 9 (11.1%), moderate cases.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Adhikari et al., 1 Mar 2022, Randomized Controlled Trial, Nepal, peer-reviewed, 12 authors.
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Abstract: IMED abstracts 2021 International Journal of Infectious Diseases 116 (2022) S1–S130 PS05.15 (844) Purpose: Coronavirus disease (COVID-19) outbreak has causes life-changing impacts such as new environmental policies, slowdown of world economy and impact on global health and society. Police officers are among the front liners who continue to bravely fight this pandemic. As the frontline in managing the COVID-19 pandemic, police officers are at high risk for many forms of psychological problems which includes anxiety and depression. It is reported that a total of 60 officers from the New York Police Department died from suicide due to mental health disturbance and approximately 95 police officers in China died on the frontline of fighting this outbreak. Thus, it is important to provide appropriate mental health services and to be able to do such, there is the need to understand the psychological risk factors and their subsequent needs during pandemic. The main purpose of this study is to identify the impact of COVID-19 pandemic to mental health of Malaysian police officers. Methods & Materials: Police Stress Questionnaires (PSQ) was used to measure the police-specific stressors related with COVID19. Meanwhile, Depression Anxiety Stress Scale (DASS-21) questionnaires use to determine the prevalence of occupational stress among police officers. Results: It is found that the highest percentage reported of 41.1% moderate depression, 45% of moderate anxiety and 31.8% moderate stress among the respondents. Lack of resources, unequal sharing of work responsibilities, inadequate equipment and high risk to COVID-19 infection are associated with depression, anxiety and stress among police officers. There is significant correlation between COVID-19 stressors and level of depression, anxiety and stress among the police officers with direct correlation. Conclusion: Majority of the police officers suffer moderate to severe depression, anxiety and stress during COVID-19 pandemic. Identified stressors from the study help to develop best practices and offers recommendations for policing when handling pandemic in future. High SARS-CoV-2 attack rates among asymptomatic hospital workers from Ecuador D.C. Morales Jadan ∗, A.P. Vallejo Janeta, M.A. Garcia Bereguiain Universidad de Las Américas, Quito, Pichincha, Ecuador Purpose: To determine the SARS-CoV-2 risk of infection in Ecuadorian hospital. This study aims to describe the SARS-CoV-2 attacks rate and viral loads among patient care workers and other staff from Ecuadorian hospitals during the first wave of COVID-19 pandemic. Methods & Materials: : Study design and setting. We carried out a cross-sectional study to describe the attack rate of SARS-CoV-2 infection among patient care workers (physicians, nurses and nursing assistants) and other healthcare personnel (administrative and services staff) from 9 hospitals of the Andean and Costal Regions of Ecuador from May to October 2020. Sample collection, RNA Extraction and RT-qPCR for SARS-CoV-2 diagnosis using the CDC protocol. The samples were processed in the BSL2 certified molecular biology laboratory at Universidad de Las Americas. Nasopharyngeal swabs were collected on 0.5mL TE pH 8 buffer for SARS-CoV-2 diagnosis by RT-qPCR following an adapted version of the CDC protocol. Statistical analysis. Chi cuadrado with the statistic program SPSS Results: A total of 1243 patient care workers and 428 of other healthcare staff were tested for SARS-CoV-2 infection. The SARSCoV-2..
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