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0 0.5 1 1.5 2+ Improvement -40% Improvement Relative Risk Improvement (b) -36% Improvement (c) -64% Favipiravir  Adhikari et al.  EARLY TREATMENT  RCT Is early treatment with favipiravir beneficial for COVID-19? RCT 70 patients in Nepal (May - October 2020) Worse improvement with favipiravir (not stat. sig., p=0.57) Adhikari et al., Int. J. Infectious Di.., Mar 2022 Favors favipiravir Favors control

Efficacy of Favipiravir in treatment of mild & moderate COVID-19 infection in Nepal: a multi-center, randomized, open-labelled, phase III clinical trial

Adhikari et al., International Journal of Infectious Diseases, doi:10.1016/j.ijid.2021.12.109
Mar 2022  
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Preliminary report for an RCT in Nepal with 38 favipiravir patients and 32 control patients, showing no significant differences. There were no serious side effects.
risk of no improvement, 40.4% higher, RR 1.40, p = 0.57, treatment 10 of 38 (26.3%), control 6 of 32 (18.8%), all.
risk of no improvement, 36.3% higher, RR 1.36, p = 0.75, treatment 8 of 27 (29.6%), control 5 of 23 (21.7%), mild cases.
risk of no improvement, 63.6% higher, RR 1.64, p = 1.00, treatment 2 of 11 (18.2%), control 1 of 9 (11.1%), moderate cases.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Adhikari et al., 1 Mar 2022, Randomized Controlled Trial, Nepal, peer-reviewed, 12 authors, study period May 2020 - October 2020.
This PaperFavipiravirAll
High SARS-CoV-2 attack rates among asymptomatic hospital workers from Ecuador
D C Morales Jadan, A P Vallejo Janeta, M A Garcia Bereguiain
International Journal of Infectious Diseases, doi:10.1016/j.ijid.2021.12.107
Purpose: To determine the SARS-CoV-2 risk of infection in Ecuadorian hospital. This study aims to describe the SARS-CoV-2 attacks rate and viral loads among patient care workers and other staff from Ecuadorian hospitals during the first wave of COVID-19 pandemic. Methods & Materials: : Study design and setting. We carried out a cross-sectional study to describe the attack rate of SARS-CoV-2 infection among patient care workers (physicians, nurses and nursing assistants) and other healthcare personnel (administrative and services staff) from 9 hospitals of the Andean and Costal Regions of Ecuador from May to October 2020. Sample collection, RNA Extraction and RT-qPCR for SARS-CoV-2 diagnosis using the CDC protocol. The samples were processed in the BSL2 certified molecular biology laboratory at Universidad de Las Americas. Nasopharyngeal swabs were collected on 0.5mL TE pH 8 buffer for SARS-CoV-2 diagnosis by RT-qPCR following an adapted version of the CDC protocol. Statistical analysis. Chi cuadrado with the statistic program SPSS Results: A total of 1243 patient care workers and 428 of other healthcare staff were tested for SARS-CoV-2 infection. The SARS-CoV-2 attack rate was 12% (145/1243) for patient care workers and 19% (80/428) for other healthcare personnel, being this difference statistically significant (p < 0.05). For each hospital, the following SARS-CoV-2 attack rates were obtained for patient care workers and other staff: 35% and 50% in "Hogar ABEI", 21% and 26% in "Clínica Nuestra Señora de Guadalupe", 15% and 18% in "Hospital de Atención Integral al Adulto Mayor", 5% and 11% in "Hospital de Especialidades Eugenio Espejo", 12% and 22% in "Hospital Geriátrico Dr. Bolívar Arguello", 13% and 22% in "Hospital Dr. Gustavo Domínguez", 22% and 12% in "Hospital General Dr. Napoleón Dávila", 9% and 14% in "Hospital Pablo Arturo" and 5% and 13% in "Hospital San Francisco de Quito". Moreover, we found 47 individuals (19 among patient care workers and 28 among other staff) with viral loads larger than 10 8 copies/mL that may be considered super spreaders. Conclusion: Ecuadorian hospital workers at a high-risk group for SARS-CoV-2 infection. Regular SARS-CoV-2 testing should be mandatory for this group as even asymptomatic SARS-CoV-2 super spreaders can be detected.
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