Analgesics
Antiandrogens
Antihistamines
Azvudine
Bromhexine
Budesonide
Colchicine
Conv. Plasma
Curcumin
Famotidine
Favipiravir
Fluvoxamine
Hydroxychlor..
Ivermectin
Lifestyle
Melatonin
Metformin
Minerals
Molnupiravir
Monoclonals
Naso/orophar..
Nigella Sativa
Nitazoxanide
PPIs
Paxlovid
Quercetin
Remdesivir
Thermotherapy
Vitamins
More

Other
Feedback
Home
Top
Results
Abstract
All antiandrogen studies
Meta analysis
 
Feedback
Home
next
study
previous
study
c19early.org COVID-19 treatment researchAntiandrogensAntiandrogens (more..)
Melatonin Meta
Metformin Meta
Antihistamines Meta
Azvudine Meta Molnupiravir Meta
Bromhexine Meta
Budesonide Meta
Colchicine Meta Nigella Sativa Meta
Conv. Plasma Meta Nitazoxanide Meta
Curcumin Meta PPIs Meta
Famotidine Meta Paxlovid Meta
Favipiravir Meta Quercetin Meta
Fluvoxamine Meta Remdesivir Meta
Hydroxychlor.. Meta Thermotherapy Meta
Ivermectin Meta

All Studies   Meta Analysis    Recent:   

A Phase 2 Trial of the Effect of Antiandrogen Therapy on COVID-19 Outcome: No Evidence of Benefit, Supported by Epidemiology and In Vitro Data

Welén et al., European Urology, doi:10.1016/j.eururo.2021.12.013, NCT04475601
Dec 2021  
  Post
  Facebook
Share
  Source   PDF   All Studies   Meta AnalysisMeta
Mortality 2% Improvement Relative Risk Mortality (b) 11% Mortality (c) -151% ICU admission -28% ICU admission (b) 13% ICU admission (c) 21% Hospitalization -23% Hospitalization (b) -24% Hospitalization (c) -40% Antiandrogens for COVID-19  Welén et al.  Prophylaxis Is prophylaxis with antiandrogens beneficial for COVID-19? Retrospective 5,338 patients in Sweden Higher ICU admission (p=0.28) and hospitalization (p=0.094), not sig. c19early.org Welén et al., European Urology, December 2021 Favorsvarious Favorscontrol 0 0.5 1 1.5 2+
7th treatment shown to reduce risk in September 2020
 
*, now with p = 0.000000056 from 49 studies.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,500+ studies for 81 treatments. c19early.org
Retrospective 7,894 COVID+ prostate cancer patients, analyzing patients on antiandrogen treatment, ADT, and ADT + abiraterone acetate or enzalutamide, showing mixed results and higher mortality for ADT + abiraterone acetate or enzalutamide.
This paper also includes a small RCT which is listed separately, and an In Vitro HBEC study showing no significant differences (p = 0.084). The supplementary data is not currently available. NCT04475601 (history).
For discussion of issues with this study see1-4.
risk of death, 2.0% lower, HR 0.98, p = 0.94, treatment 21 of 358 (5.9%), control 167 of 4,980 (3.4%), adjusted per study, antiandrogen treatment.
risk of death, 11.0% lower, HR 0.89, p = 0.66, treatment 20 of 334 (6.0%), control 167 of 4,980 (3.4%), adjusted per study, ADT.
risk of death, 151.0% higher, HR 2.51, p < 0.001, treatment 24 of 152 (15.8%), control 167 of 4,980 (3.4%), adjusted per study, ADT and abiraterone acetate or enzalutamide.
risk of ICU admission, 28.0% higher, HR 1.28, p = 0.28, treatment 24 of 358 (6.7%), control 216 of 4,980 (4.3%), adjusted per study, antiandrogen treatment.
risk of ICU admission, 13.0% lower, HR 0.87, p = 0.62, treatment 16 of 334 (4.8%), control 216 of 4,980 (4.3%), adjusted per study, ADT.
risk of ICU admission, 21.0% lower, HR 0.79, p = 0.60, treatment 6 of 152 (3.9%), control 216 of 4,980 (4.3%), adjusted per study, ADT and abiraterone acetate or enzalutamide.
risk of hospitalization, 23.0% higher, HR 1.23, p = 0.09, treatment 126 of 358 (35.2%), control 1,108 of 4,980 (22.2%), adjusted per study, antiandrogen treatment.
risk of hospitalization, 24.0% higher, HR 1.24, p = 0.09, treatment 126 of 334 (37.7%), control 1,108 of 4,980 (22.2%), adjusted per study, ADT.
risk of hospitalization, 40.0% higher, HR 1.40, p = 0.06, treatment 66 of 152 (43.4%), control 1,108 of 4,980 (22.2%), adjusted per study, ADT and abiraterone acetate or enzalutamide.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Welén et al., 14 Dec 2021, retrospective, Sweden, peer-reviewed, 27 authors, trial NCT04475601 (history). Contact: andreas.josefsson@umu.se.
This PaperAntiandrogensAll
{ 'indexed': {'date-parts': [[2024, 3, 28]], 'date-time': '2024-03-28T10:40:13Z', 'timestamp': 1711622413583}, 'reference-count': 24, 'publisher': 'Elsevier BV', 'issue': '3', 'license': [ { 'start': { 'date-parts': [[2022, 3, 1]], 'date-time': '2022-03-01T00:00:00Z', 'timestamp': 1646092800000}, 'content-version': 'tdm', 'delay-in-days': 0, 'URL': 'https://www.elsevier.com/tdm/userlicense/1.0/'}, { 'start': { 'date-parts': [[2021, 12, 15]], 'date-time': '2021-12-15T00:00:00Z', 'timestamp': 1639526400000}, 'content-version': 'vor', 'delay-in-days': 0, 'URL': 'http://creativecommons.org/licenses/by-nc-nd/4.0/'}], 'content-domain': { 'domain': [ 'clinicalkey.jp', 'clinicalkey.com', 'clinicalkey.es', 'clinicalkey.com.au', 'clinicalkey.fr', 'elsevier.com', 'sciencedirect.com'], 'crossmark-restriction': True}, 'published-print': {'date-parts': [[2022, 3]]}, 'DOI': '10.1016/j.eururo.2021.12.013', 'type': 'journal-article', 'created': { 'date-parts': [[2021, 12, 15]], 'date-time': '2021-12-15T22:42:54Z', 'timestamp': 1639608174000}, 'page': '285-293', 'update-policy': 'http://dx.doi.org/10.1016/elsevier_cm_policy', 'source': 'Crossref', 'is-referenced-by-count': 38, 'title': 'A Phase 2 Trial of the Effect of Antiandrogen Therapy on COVID-19 Outcome: No Evidence of ' 'Benefit, Supported by Epidemiology and In Vitro Data', 'prefix': '10.1016', 'volume': '81', 'author': [ {'given': 'Karin', 'family': 'Welén', 'sequence': 'first', 'affiliation': []}, {'given': 'Ebba', 'family': 'Rosendal', 'sequence': 'additional', 'affiliation': []}, {'given': 'Magnus', 'family': 'Gisslén', 'sequence': 'additional', 'affiliation': []}, {'given': 'Annasara', 'family': 'Lenman', 'sequence': 'additional', 'affiliation': []}, {'given': 'Eva', 'family': 'Freyhult', 'sequence': 'additional', 'affiliation': []}, { 'given': 'Osvaldo', 'family': 'Fonseca-Rodríguez', 'sequence': 'additional', 'affiliation': []}, {'given': 'Daniel', 'family': 'Bremell', 'sequence': 'additional', 'affiliation': []}, {'given': 'Johan', 'family': 'Stranne', 'sequence': 'additional', 'affiliation': []}, {'given': 'Åse Östholm', 'family': 'Balkhed', 'sequence': 'additional', 'affiliation': []}, {'given': 'Katarina', 'family': 'Niward', 'sequence': 'additional', 'affiliation': []}, {'given': 'Johanna', 'family': 'Repo', 'sequence': 'additional', 'affiliation': []}, {'given': 'David', 'family': 'Robinsson', 'sequence': 'additional', 'affiliation': []}, {'given': 'Anna J.', 'family': 'Henningsson', 'sequence': 'additional', 'affiliation': []}, {'given': 'Johan', 'family': 'Styrke', 'sequence': 'additional', 'affiliation': []}, {'given': 'Martin', 'family': 'Angelin', 'sequence': 'additional', 'affiliation': []}, {'given': 'Elisabeth', 'family': 'Lindquist', 'sequence': 'additional', 'affiliation': []}, {'given': 'Annika', 'family': 'Allard', 'sequence': 'additional', 'affiliation': []}, {'given': 'Miriam', 'family': 'Becker', 'sequence': 'additional', 'affiliation': []}, {'given': 'Stina', 'family': 'Rudolfsson', 'sequence': 'additional', 'affiliation': []}, {'given': 'Robert', 'family': 'Buckland', 'sequence': 'additional', 'affiliation': []}, { 'given': 'Camilla Thellenberg', 'family': 'Carlsson', 'sequence': 'additional', 'affiliation': []}, {'given': 'Anders', 'family': 'Bjartell', 'sequence': 'additional', 'affiliation': []}, {'given': 'Anna C.', 'family': 'Nilsson', 'sequence': 'additional', 'affiliation': []}, {'given': 'Clas', 'family': 'Ahlm', 'sequence': 'additional', 'affiliation': []}, {'given': 'Anne-Marie Fors', 'family': 'Connolly', 'sequence': 'additional', 'affiliation': []}, {'given': 'Anna K.', 'family': 'Överby', 'sequence': 'additional', 'affiliation': []}, {'given': 'Andreas', 'family': 'Josefsson', 'sequence': 'additional', 'affiliation': []}], 'member': '78', 'reference': [ { 'key': '10.1016/j.eururo.2021.12.013_b0005', 'doi-asserted-by': 'crossref', 'first-page': '6317', 'DOI': '10.1038/s41467-020-19741-6', 'article-title': 'Male sex identified by global COVID-19 meta-analysis as a risk factor ' 'for death and ITU admission', 'volume': '11', 'author': 'Peckham', 'year': '2020', 'journal-title': 'Nat Commun'}, { 'key': '10.1016/j.eururo.2021.12.013_b0010', 'doi-asserted-by': 'crossref', 'first-page': '430', 'DOI': '10.1038/s41586-020-2521-4', 'article-title': 'Factors associated with COVID-19-related death using OpenSAFELY', 'volume': '584', 'author': 'Williamson', 'year': '2020', 'journal-title': 'Nature'}, { 'key': '10.1016/j.eururo.2021.12.013_b0015', 'doi-asserted-by': 'crossref', 'unstructured': 'Ghazizadeh Z, Majd H, Richter M, et al. Androgen regulates SARS-CoV-2 ' 'receptor levels and is associated with severe COVID-19 symptoms in men. ' 'BioRxiv preprint. https://doi.org/10.1101/2020.05.12.091082', 'DOI': '10.1101/2020.05.12.091082'}, { 'key': '10.1016/j.eururo.2021.12.013_b0020', 'doi-asserted-by': 'crossref', 'first-page': '4068', 'DOI': '10.1038/s41467-021-24342-y', 'article-title': 'The antiandrogen enzalutamide downregulates TMPRSS2 and reduces ' 'cellular entry of SARS-CoV-2 in human lung cells', 'volume': '12', 'author': 'Leach', 'year': '2021', 'journal-title': 'Nat Commun'}, { 'key': '10.1016/j.eururo.2021.12.013_b0025', 'doi-asserted-by': 'crossref', 'first-page': '14', 'DOI': '10.1016/j.mce.2009.12.022', 'article-title': 'Androgen receptor and androgen-dependent gene expression in lung', 'volume': '317', 'author': 'Mikkonen', 'year': '2010', 'journal-title': 'Mol Cell Endocrinol'}, { 'key': '10.1016/j.eururo.2021.12.013_b0030', 'article-title': 'Sex hormones promote opposite effects on ACE and ACE2 activity, ' 'hypertrophy and cardiac contractility in spontaneously hypertensive ' 'rats', 'volume': '10', 'author': 'Dalpiaz', 'year': '2015', 'journal-title': 'PLoS One'}, { 'key': '10.1016/j.eururo.2021.12.013_b0035', 'doi-asserted-by': 'crossref', 'first-page': '1040', 'DOI': '10.1016/j.annonc.2020.04.479', 'article-title': 'Androgen-deprivation therapies for prostate cancer and risk of ' 'infection by SARS-CoV-2: a population-based study (N = 4532)', 'volume': '31', 'author': 'Montopoli', 'year': '2020', 'journal-title': 'Ann Oncol'}, { 'key': '10.1016/j.eururo.2021.12.013_b0040', 'doi-asserted-by': 'crossref', 'first-page': '1419', 'DOI': '10.1016/j.annonc.2020.06.023', 'article-title': 'Does androgen deprivation therapy protect against severe complications ' 'from COVID-19?', 'volume': '31', 'author': 'Patel', 'year': '2020', 'journal-title': 'Ann Oncol'}, { 'key': '10.1016/j.eururo.2021.12.013_b0045', 'doi-asserted-by': 'crossref', 'first-page': '680', 'DOI': '10.1016/j.jaad.2020.05.079', 'article-title': 'Androgenetic alopecia present in the majority of hospitalized COVID-19 ' 'patients: the “Gabrin sign”', 'volume': '83', 'author': 'Wambier', 'year': '2020', 'journal-title': 'J Am Acad Dermatol'}, { 'key': '10.1016/j.eururo.2021.12.013_b0050', 'doi-asserted-by': 'crossref', 'first-page': '1417', 'DOI': '10.1016/j.annonc.2020.06.015', 'article-title': 'Androgen deprivation and SARS-CoV-2 in men with prostate cancer', 'volume': '31', 'author': 'Koskinen', 'year': '2020', 'journal-title': 'Ann Oncol'}, { 'key': '10.1016/j.eururo.2021.12.013_b0055', 'doi-asserted-by': 'crossref', 'first-page': '1245', 'DOI': '10.1016/0895-4356(94)90129-5', 'article-title': 'Validation of a combined comorbidity index', 'volume': '47', 'author': 'Charlson', 'year': '1994', 'journal-title': 'J Clin Epidemiol'}, { 'key': '10.1016/j.eururo.2021.12.013_b0060', 'doi-asserted-by': 'crossref', 'first-page': '373', 'DOI': '10.1016/0021-9681(87)90171-8', 'article-title': 'A new method of classifying prognostic comorbidity in longitudinal ' 'studies: development and validation', 'volume': '40', 'author': 'Charlson', 'year': '1987', 'journal-title': 'J Chronic Dis'}, { 'key': '10.1016/j.eururo.2021.12.013_b0065', 'doi-asserted-by': 'crossref', 'first-page': '21', 'DOI': '10.2147/CLEP.S282475', 'article-title': 'Adaptation of the Charlson comorbidity index for register-based ' 'research in Sweden', 'volume': '13', 'author': 'Ludvigsson', 'year': '2021', 'journal-title': 'Clin Epidemiol'}, { 'key': '10.1016/j.eururo.2021.12.013_b0070', 'doi-asserted-by': 'crossref', 'first-page': '1057', 'DOI': '10.1007/s40262-015-0283-1', 'article-title': 'Pharmacokinetic drug interaction studies with enzalutamide', 'volume': '54', 'author': 'Gibbons', 'year': '2015', 'journal-title': 'Clin Pharmacokinet'}, { 'key': '10.1016/j.eururo.2021.12.013_b0075', 'doi-asserted-by': 'crossref', 'first-page': '693', 'DOI': '10.1056/NEJMoa2021436', 'article-title': 'Dexamethasone in hospitalized patients with Covid-19', 'volume': '384', 'author': 'RECOVERY Collaborative Group', 'year': '2021', 'journal-title': 'N Engl J Med'}, { 'key': '10.1016/j.eururo.2021.12.013_b0080', 'doi-asserted-by': 'crossref', 'unstructured': 'Lyon M, Li J, Cullen J, et al. 5α-Reductase inhibitors are associated ' 'with reduced risk of SARS-CoV-2 infection: a matched-pair, ' 'registry-based analysis. J Urol. In press. ' 'https://doi.org/10.1097/ju.0000000000002180.', 'DOI': '10.1097/JU.0000000000002180'}, { 'key': '10.1016/j.eururo.2021.12.013_b0085', 'article-title': 'Proxalutamide significantly accelerates viral clearance and reduces ' 'time to clinical remission in patients with mild to moderate COVID-19: ' 'results from a randomized, double-blinded, placebo-controlled trial', 'volume': '13', 'author': 'Cadegiani', 'year': '2021', 'journal-title': 'Cureus'}, { 'key': '10.1016/j.eururo.2021.12.013_b0090', 'article-title': 'Targeting transcriptional regulation of SARS-CoV-2 entry factors ACE2 ' 'and TMPRSS2', 'volume': '118', 'author': 'Qiao', 'year': '2020', 'journal-title': 'Proc Natl Acad Sci U S A'}, { 'key': '10.1016/j.eururo.2021.12.013_b0095', 'doi-asserted-by': 'crossref', 'first-page': '866', 'DOI': '10.1038/s41467-021-21171-x', 'article-title': 'Distinct mechanisms for TMPRSS2 expression explain organ-specific ' 'inhibition of SARS-CoV-2 infection by enzalutamide', 'volume': '12', 'author': 'Li', 'year': '2021', 'journal-title': 'Nat Commun'}, { 'key': '10.1016/j.eururo.2021.12.013_b0100', 'doi-asserted-by': 'crossref', 'DOI': '10.3389/fmed.2021.668698', 'article-title': 'Proxalutamide reduces the rate of hospitalization for COVID-19 male ' 'outpatients: a randomized double-blinded placebo-controlled trial', 'volume': '8', 'author': 'McCoy', 'year': '2021', 'journal-title': 'Front Med'}, { 'key': '10.1016/j.eururo.2021.12.013_b0105', 'doi-asserted-by': 'crossref', 'first-page': '437', 'DOI': '10.1038/s41586-020-2355-0', 'article-title': 'Viral and host factors related to the clinical outcome of COVID-19', 'volume': '583', 'author': 'Zhang', 'year': '2020', 'journal-title': 'Nature'}, { 'key': '10.1016/j.eururo.2021.12.013_b0110', 'unstructured': 'Karimi A, Nowroozi A, Alilou S, Amini E. Effects of androgen deprivation ' 'therapy on COVID-19 in patients with prostate cancer: a systematic ' 'review and meta-analysis. Urol J. In press. ' 'https://doi.org/10.22037/uj.v18i.6691.'}, { 'key': '10.1016/j.eururo.2021.12.013_b0115', 'doi-asserted-by': 'crossref', 'first-page': '4046', 'DOI': '10.1158/1078-0432.CCR-16-2339', 'article-title': 'A phase I/Ib Study of enzalutamide alone and in combination with ' 'endocrine therapies in women with advanced breast cancer', 'volume': '23', 'author': 'Schwartzberg', 'year': '2017', 'journal-title': 'Clin Cancer Res'}, { 'key': '10.1016/j.eururo.2021.12.013_b0120', 'doi-asserted-by': 'crossref', 'first-page': '2428', 'DOI': '10.1093/cid/ciaa644', 'article-title': 'Simulation of the clinical and pathological manifestations of ' 'coronavirus disease 2019 (COVID-19) in golden Syrian hamster model: ' 'implications for disease pathogenesis and transmissibility', 'volume': '71', 'author': 'Chan', 'year': '2020', 'journal-title': 'Clin Infect Dis'}], 'container-title': 'European Urology', 'original-title': [], 'language': 'en', 'link': [ { 'URL': 'https://api.elsevier.com/content/article/PII:S0302283821022247?httpAccept=text/xml', 'content-type': 'text/xml', 'content-version': 'vor', 'intended-application': 'text-mining'}, { 'URL': 'https://api.elsevier.com/content/article/PII:S0302283821022247?httpAccept=text/plain', 'content-type': 'text/plain', 'content-version': 'vor', 'intended-application': 'text-mining'}], 'deposited': { 'date-parts': [[2022, 2, 26]], 'date-time': '2022-02-26T03:38:20Z', 'timestamp': 1645846700000}, 'score': 1, 'resource': {'primary': {'URL': 'https://linkinghub.elsevier.com/retrieve/pii/S0302283821022247'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2022, 3]]}, 'references-count': 24, 'journal-issue': {'issue': '3', 'published-print': {'date-parts': [[2022, 3]]}}, 'alternative-id': ['S0302283821022247'], 'URL': 'http://dx.doi.org/10.1016/j.eururo.2021.12.013', 'relation': {}, 'ISSN': ['0302-2838'], 'subject': ['Urology'], 'container-title-short': 'European Urology', 'published': {'date-parts': [[2022, 3]]}, 'assertion': [ {'value': 'Elsevier', 'name': 'publisher', 'label': 'This article is maintained by'}, { 'value': 'A Phase 2 Trial of the Effect of Antiandrogen Therapy on COVID-19 Outcome: No ' 'Evidence of Benefit, Supported by Epidemiology and In Vitro Data', 'name': 'articletitle', 'label': 'Article Title'}, {'value': 'European Urology', 'name': 'journaltitle', 'label': 'Journal Title'}, { 'value': 'https://doi.org/10.1016/j.eururo.2021.12.013', 'name': 'articlelink', 'label': 'CrossRef DOI link to publisher maintained version'}, {'value': 'article', 'name': 'content_type', 'label': 'Content Type'}, { 'value': '© 2021 The Authors. Published by Elsevier B.V. on behalf of European ' 'Association of Urology.', 'name': 'copyright', 'label': 'Copyright'}]}
Loading..
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop   
Submit