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Therapeutic effects of high-dose vitamin C supplementation in patients with COVID-19: a meta-analysis

Sun et al., Nutrition Reviews, doi:10.1093/nutrit/nuad105

Sep 2023

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Vitamin C for COVID-19

6th treatment shown to reduce risk in September 2020

^*, now known with p = 0.000000087 from 70 studies, recognized in 11 countries.

Lower risk for mortality, ICU admission, hospitalization, and recovery.

No treatment is 100% effective. Protocols combine complementary and synergistic treatments. ^* >10% efficacy in meta analysis with ≥3 clinical studies.

4,100+ studies for 60+ treatments. c19early.org

Meta analysis of 14 studies showing lower COVID-19 progression with high-dose vitamin C treatment.

6 meta analyses show significant improvements with vitamin C for mortality Bhowmik, Kow, Kow (B), Olczak-Pruc, progression Sun, severity Bhowmik, and cases Xu.

Currently there are 70 vitamin C for COVID-19 studies, showing 19% lower mortality [9‑27%], 9% lower ventilation [-12‑27%], 14% lower ICU admission [3‑24%], 19% lower hospitalization [6‑30%], and 4% more cases [-13‑25%].

1. Bhowmik et al., Impact of high-dose vitamin C on the mortality, severity, and duration of hospital stay in COVID-19 patients: A meta-analysis, Health Science Reports, doi:10.1002/hsr2.762.wiley.com, doi.org.

2. Kow et al., The effect of vitamin C on the risk of mortality in patients with COVID-19: a systematic review and meta-analysis of randomized controlled trials, Inflammopharmacology, doi:10.1007/s10787-023-01200-5.springer.com, doi.org.

3. Kow (B) et al., Impact of uricosurics on mortality outcomes in patients with COVID-19: a systematic review and meta-analysis of randomized controlled trials, International Journal of Pharmacy Practice, doi:10.1093/ijpp/riae003.oup.com, doi.org.

4. Olczak-Pruc et al., Vitamin C Supplementation for the Treatment of COVID-19: A Systematic Review and Meta-Analysis, Nutrients, doi:10.3390/nu14194217.mdpi.com, doi.org.

5. Sun et al., Therapeutic effects of high-dose vitamin C supplementation in patients with COVID-19: a meta-analysis, Nutrition Reviews, doi:10.1093/nutrit/nuad105.oup.com, doi.org.

6. Xu et al., Association of Oral or Intravenous Vitamin C Supplementation with Mortality: A Systematic Review and Meta-Analysis, Nutrients, doi:10.3390/nu15081848.mdpi.com, doi.org.

Important missing comments or errors? Let us know.

risk of progression, 65.6% lower, OR 0.34, p = 0.03, RR approximated with OR.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates

Sun et al., 8 Sep 2023, peer-reviewed, 13 authors.

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Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.

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