Analgesics
Antiandrogens
Azvudine
Bromhexine
Budesonide
Colchicine
Conv. Plasma
Curcumin
Famotidine
Favipiravir
Fluvoxamine
Hydroxychlor..
Ivermectin
Lifestyle
Melatonin
Metformin
Minerals
Molnupiravir
Monoclonals
Naso/orophar..
Nigella Sativa
Nitazoxanide
Paxlovid
Quercetin
Remdesivir
Thermotherapy
Vitamins
More

Other
Feedback
Home
Top
Results
Abstract
All vitamin C studies
Meta analysis
 
Feedback
Home
next
study
previous
study
c19early.org COVID-19 treatment researchVitamin CVitamin C (more..)
Melatonin Meta
Metformin Meta
Azvudine Meta
Bromhexine Meta Molnupiravir Meta
Budesonide Meta
Colchicine Meta
Conv. Plasma Meta Nigella Sativa Meta
Curcumin Meta Nitazoxanide Meta
Famotidine Meta Paxlovid Meta
Favipiravir Meta Quercetin Meta
Fluvoxamine Meta Remdesivir Meta
Hydroxychlor.. Meta Thermotherapy Meta
Ivermectin Meta

All Studies   Meta Analysis    Recent:   

Therapeutic effects of high-dose vitamin C supplementation in patients with COVID-19: a meta-analysis

Sun et al., Nutrition Reviews, doi:10.1093/nutrit/nuad105
Sep 2023  
  Post
  Facebook
Share
  Source   PDF   All Studies   Meta AnalysisMeta
Progression 66% Improvement Relative Risk Vitamin C for COVID-19  Sun et al.  META ANALYSIS c19early.org Favorsvitamin C Favorscontrol 0 0.5 1 1.5 2+
Vitamin C for COVID-19
6th treatment shown to reduce risk in September 2020
 
*, now with p = 0.000000038 from 71 studies, recognized in 12 countries.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,300+ studies for 77 treatments. c19early.org
Meta analysis of 14 studies showing lower COVID-19 progression with high-dose vitamin C treatment.
6 meta analyses show significant improvements with vitamin C for mortality1-4, progression5, severity1, and cases6.
Currently there are 71 vitamin C for COVID-19 studies, showing 19% lower mortality [9‑27%], 9% lower ventilation [-12‑27%], 14% lower ICU admission [3‑24%], 19% lower hospitalization [6‑30%], and 3% fewer cases [-16‑19%].
risk of progression, 65.6% lower, OR 0.34, p = 0.03, RR approximated with OR.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Sun et al., 8 Sep 2023, peer-reviewed, 13 authors.
This PaperVitamin CAll
{ 'indexed': {'date-parts': [[2023, 9, 9]], 'date-time': '2023-09-09T04:50:03Z', 'timestamp': 1694235003185}, 'reference-count': 49, 'publisher': 'Oxford University Press (OUP)', 'license': [ { 'start': { 'date-parts': [[2023, 9, 8]], 'date-time': '2023-09-08T00:00:00Z', 'timestamp': 1694131200000}, 'content-version': 'vor', 'delay-in-days': 0, 'URL': 'https://academic.oup.com/pages/standard-publication-reuse-rights'}], 'funder': [ { 'DOI': '10.13039/501100001809', 'name': 'National Natural Scientific Foundation of China', 'doi-asserted-by': 'crossref', 'award': ['82003400']}, { 'name': 'Science and Technology Program of Henan Province', 'award': ['232102311079', '212102310622']}], 'content-domain': {'domain': [], 'crossmark-restriction': False}, 'abstract': '<jats:title>Abstract</jats:title>\n' ' <jats:sec>\n' ' <jats:title>Context</jats:title>\n' ' <jats:p>Coronavirus disease 2019 (COVID-19) could induce the\xa0“cytokine ' 'storm” due to overactivation of immune system and accompanied by acute respiratory distress ' 'syndrome as a serious complication. Vitamin\u2009C has been effective in improving lung ' 'function of patients by reducing inflammation.</jats:p>\n' ' </jats:sec>\n' ' <jats:sec>\n' ' <jats:title>Objective</jats:title>\n' ' <jats:p>The aim was to explore the therapeutic effects of high-dose ' 'vitamin\u2009C supplementation for patients with COVID-19 using meta-analysis.</jats:p>\n' ' </jats:sec>\n' ' <jats:sec>\n' ' <jats:title>Data Sources</jats:title>\n' ' <jats:p>Published studies were searched from PubMed, Cochrane Library, Web ' 'of Science, EMBASE, and China National Knowledge Infrastructure databases up to August 2022 ' 'using the terms “vitamin\u2009C” and “COVID-19”. Data analyses were performed independently ' 'by 2 researchers using the PRISMA guidelines.</jats:p>\n' ' </jats:sec>\n' ' <jats:sec>\n' ' <jats:title>Data Extraction</jats:title>\n' ' <jats:p>Heterogeneity between the included studies was assessed using I2 ' 'statistics. When I2 ≥50%, the random-effects model was used; otherwise, a fixed-effects model ' 'was applied. Stata 14.0 software was used to pool data by standardized mean differences ' '(SMDs) with 95% CIs or odds ratios (ORs) with 95% CIs.</jats:p>\n' ' </jats:sec>\n' ' <jats:sec>\n' ' <jats:title>Data Analysis</jats:title>\n' ' <jats:p>The 14 studies had a total of 751 patients and 1583 control ' 'participants in 7 randomized controlled trials and 7 retrospective studies. The vitamin\u2009' 'C supplement significantly increased ferritin (SMD\u2009=\u20090.272; 95% CI: 0.059 to 0.485; ' 'P\u2009=\u20090.012) and lymphocyte count levels (SMD\u2009=\u20090.376; 95% CI: 0.153 to ' '0.599; P\u2009=\u20090.001) in patients with COVID-19. Patients administered vitamin\u2009C ' 'in the length of intensive care unit staying (SMD\u2009=\u20090.226; 95% CI: 0.073 to 0.379; ' 'P\u2009=\u20090.004). Intake of vitamin\u2009C prominently alleviate disease aggravation ' '(OR\u2009=\u20090.344, 95%CI: 0.135 to 0.873, P\u2009=\u20090.025).</jats:p>\n' ' </jats:sec>\n' ' <jats:sec>\n' ' <jats:title>Conclusions</jats:title>\n' ' <jats:p>High-dose vitamin\u2009C supplementation can alleviate inflammatory ' 'response and hinder the aggravation of COVID-19.</jats:p>\n' ' </jats:sec>', 'DOI': '10.1093/nutrit/nuad105', 'type': 'journal-article', 'created': {'date-parts': [[2023, 9, 8]], 'date-time': '2023-09-08T15:58:42Z', 'timestamp': 1694188722000}, 'source': 'Crossref', 'is-referenced-by-count': 0, 'title': 'Therapeutic effects of high-dose vitamin C supplementation in patients with COVID-19: a ' 'meta-analysis', 'prefix': '10.1093', 'author': [ { 'ORCID': 'http://orcid.org/0000-0002-6134-1592', 'authenticated-orcid': False, 'given': 'Lei', 'family': 'Sun', 'sequence': 'first', 'affiliation': [ { 'name': 'Department of Environmental Health, School of Public Health, ' 'Zhengzhou University, Environment and Health Innovation Team , ' 'Zhengzhou, Henan, China'}]}, { 'given': 'Jia-Hao', 'family': 'Zhao', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Environmental Health, School of Public Health, ' 'Zhengzhou University, Environment and Health Innovation Team , ' 'Zhengzhou, Henan, China'}]}, { 'given': 'Wen-Yi', 'family': 'Fan', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Environmental Health, School of Public Health, ' 'Zhengzhou University, Environment and Health Innovation Team , ' 'Zhengzhou, Henan, China'}]}, { 'given': 'Bo', 'family': 'Feng', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Environmental Health, School of Public Health, ' 'Zhengzhou University, Environment and Health Innovation Team , ' 'Zhengzhou, Henan, China'}]}, { 'given': 'Wen-Wen', 'family': 'Liu', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Environmental Health, School of Public Health, ' 'Zhengzhou University, Environment and Health Innovation Team , ' 'Zhengzhou, Henan, China'}]}, { 'given': 'Rui-Qin', 'family': 'Chen', 'sequence': 'additional', 'affiliation': [ { 'name': 'Jinshui District Center for Disease Control and Prevention , ' 'Zhengzhou, Henan, China'}]}, { 'given': 'Chuang', 'family': 'Ban', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Environmental Health, School of Public Health, ' 'Zhengzhou University, Environment and Health Innovation Team , ' 'Zhengzhou, Henan, China'}]}, { 'given': 'Ao-Gui', 'family': 'Dang', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Environmental Health, School of Public Health, ' 'Zhengzhou University, Environment and Health Innovation Team , ' 'Zhengzhou, Henan, China'}]}, { 'given': 'Miao', 'family': 'Wang', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Environmental Health, School of Public Health, ' 'Zhengzhou University, Environment and Health Innovation Team , ' 'Zhengzhou, Henan, China'}]}, { 'given': 'Kang-Ting', 'family': 'Luo', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Environmental Health, School of Public Health, ' 'Zhengzhou University, Environment and Health Innovation Team , ' 'Zhengzhou, Henan, China'}]}, { 'given': 'Guo-Yu', 'family': 'Zhou', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Environmental Health, School of Public Health, ' 'Zhengzhou University, Environment and Health Innovation Team , ' 'Zhengzhou, Henan, China'}]}, { 'given': 'Fang-Fang', 'family': 'Yu', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Environmental Health, School of Public Health, ' 'Zhengzhou University, Environment and Health Innovation Team , ' 'Zhengzhou, Henan, China'}]}, { 'ORCID': 'http://orcid.org/0000-0002-9659-7993', 'authenticated-orcid': False, 'given': 'Yue', 'family': 'Ba', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Environmental Health, School of Public Health, ' 'Zhengzhou University, Environment and Health Innovation Team , ' 'Zhengzhou, Henan, China'}]}], 'member': '286', 'published-online': {'date-parts': [[2023, 9, 8]]}, 'reference': [ { 'key': '2023090814453546700_nuad105-B1', 'doi-asserted-by': 'crossref', 'first-page': '110', 'DOI': '10.1016/j.jaci.2020.04.006', 'article-title': 'Risk factors for severity and mortality in adult COVID-19 inpatients in ' 'Wuhan', 'volume': '146', 'author': 'Li', 'year': '2020', 'journal-title': 'J Allergy Clin Immunol'}, { 'key': '2023090814453546700_nuad105-B2', 'doi-asserted-by': 'crossref', 'first-page': '112752', 'DOI': '10.1016/j.bios.2020.112752', 'article-title': 'COVID-19 diagnosis—a review of current methods', 'volume': '172', 'author': 'Yuce', 'year': '2021', 'journal-title': 'Biosens Bioelectron'}, { 'key': '2023090814453546700_nuad105-B3', 'doi-asserted-by': 'crossref', 'first-page': '656', 'DOI': '10.1016/j.jinf.2020.03.041', 'article-title': 'Clinical characteristics of coronavirus disease 2019 (COVID-19) in ' 'China: a systematic review and meta-analysis', 'volume': '80', 'author': 'Fu', 'year': '2020', 'journal-title': 'J Infect'}, { 'key': '2023090814453546700_nuad105-B4', 'doi-asserted-by': 'crossref', 'first-page': '126', 'DOI': '10.1007/s11684-020-0767-8', 'article-title': 'Coronavirus disease 2019 (COVID-19): a clinical update', 'volume': '14', 'author': 'Zhou', 'year': '2020', 'journal-title': 'Front Med'}, { 'key': '2023090814453546700_nuad105-B5', 'doi-asserted-by': 'crossref', 'first-page': '81', 'DOI': '10.1007/s40995-021-01244-8', 'article-title': 'Clinical characteristics of coronavirus disease 2019 (COVID-19): a ' 'comparison between laboratory-confirmed and clinically suspected ' 'patients', 'volume': '46', 'author': 'Li', 'year': '2022', 'journal-title': 'Iran J Sci Technol Trans A Sci'}, { 'key': '2023090814453546700_nuad105-B6', 'doi-asserted-by': 'crossref', 'first-page': '4896', 'DOI': '10.3390/jcm11164896', 'article-title': 'COVID-19-related ARDS: key mechanistic features and treatments', 'volume': '11', 'author': 'Selickman', 'year': '2022', 'journal-title': 'J Clin Med'}, { 'key': '2023090814453546700_nuad105-B7', 'doi-asserted-by': 'crossref', 'first-page': '497', 'DOI': '10.1016/S0140-6736(20)30183-5', 'article-title': 'Clinical features of patients infected with 2019 novel coronavirus in ' 'Wuhan, China', 'volume': '395', 'author': 'Huang', 'year': '2020', 'journal-title': 'Lancet'}, { 'key': '2023090814453546700_nuad105-B8', 'doi-asserted-by': 'crossref', 'first-page': '92', 'DOI': '10.1186/s12985-022-01814-1', 'article-title': 'COVID-19 infection: an overview on cytokine storm and related ' 'interventions', 'volume': '19', 'author': 'Montazersaheb', 'year': '2022', 'journal-title': 'Virol J'}, { 'key': '2023090814453546700_nuad105-B9', 'doi-asserted-by': 'crossref', 'first-page': '559811', 'DOI': '10.3389/fmed.2020.559811', 'article-title': 'Vitamin C and COVID-19', 'volume': '7', 'author': 'Hemila', 'year': '2020', 'journal-title': 'Front Med (Lausanne)'}, { 'key': '2023090814453546700_nuad105-B10', 'doi-asserted-by': 'crossref', 'first-page': '300', 'DOI': '10.1186/s13054-017-1891-y', 'article-title': 'Hypovitaminosis C and vitamin C deficiency in critically ill patients ' 'despite recommended enteral and parenteral intakes', 'volume': '21', 'author': 'Carr', 'year': '2017', 'journal-title': 'Crit Care'}, { 'key': '2023090814453546700_nuad105-B11', 'doi-asserted-by': 'crossref', 'first-page': '7180', 'DOI': '10.4049/jimmunol.165.12.7180', 'article-title': 'Vitamin C inhibits NF-kappa B activation by TNF via the activation of ' 'p38 mitogen-activated protein kinase', 'volume': '165', 'author': 'Bowie', 'year': '2000', 'journal-title': 'J Immunol.'}, { 'key': '2023090814453546700_nuad105-B12', 'doi-asserted-by': 'crossref', 'first-page': '574029', 'DOI': '10.3389/fimmu.2020.574029', 'article-title': 'The long history of vitamin C: from prevention of the common cold to ' 'potential aid in the treatment of COVID-19', 'volume': '11', 'author': 'Cerullo', 'year': '2020', 'journal-title': 'Front Immunol.'}, { 'key': '2023090814453546700_nuad105-B13', 'doi-asserted-by': 'crossref', 'first-page': '85', 'DOI': '10.5492/wjccm.v6.i1.85', 'article-title': 'Intravenous vitamin C as adjunctive therapy for enterovirus/rhinovirus ' 'induced acute respiratory distress syndrome', 'volume': '6', 'author': 'Fowler Iii', 'year': '2017', 'journal-title': 'World J Crit Care Med'}, { 'key': '2023090814453546700_nuad105-B14', 'doi-asserted-by': 'crossref', 'first-page': '32', 'DOI': '10.1186/1479-5876-12-32', 'article-title': 'Phase I safety trial of intravenous ascorbic acid in patients with ' 'severe sepsis', 'volume': '12', 'author': 'Fowler', 'year': '2014', 'journal-title': 'J Transl Med'}, { 'key': '2023090814453546700_nuad105-B15', 'doi-asserted-by': 'crossref', 'first-page': '708', 'DOI': '10.3390/nu11040708', 'article-title': 'Vitamin C can shorten the length of stay in the ICU: a meta-analysis', 'volume': '11', 'author': 'Hemila', 'year': '2019', 'journal-title': 'Nutrients'}, { 'key': '2023090814453546700_nuad105-B16', 'doi-asserted-by': 'crossref', 'first-page': '1162', 'DOI': '10.3390/nu13041172', 'article-title': 'Vitamin C in the treatment of COVID-19', 'volume': '13', 'author': 'Milani', 'year': '2021', 'journal-title': 'Nutrients'}, { 'key': '2023090814453546700_nuad105-B17', 'doi-asserted-by': 'crossref', 'first-page': '790', 'DOI': '10.1016/j.recesp.2021.06.016', 'article-title': 'The PRISMA 2020 statement: an updated guideline for reporting ' 'systematic reviews', 'volume': '74', 'author': 'Page', 'year': '2021', 'journal-title': 'Rev Esp Cardiol (Engl Ed)'}, { 'key': '2023090814453546700_nuad105-B18', 'first-page': 'e11779', 'article-title': 'The role of vitamin C as adjuvant therapy in COVID-19', 'volume': '12', 'author': 'Kumari', 'year': '2020', 'journal-title': 'Cureus'}, { 'key': '2023090814453546700_nuad105-B19', 'doi-asserted-by': 'crossref', 'first-page': '5', 'DOI': '10.1186/s13613-020-00792-3', 'article-title': 'Pilot trial of high-dose vitamin C in critically ill COVID-19 patients', 'volume': '11', 'author': 'Zhang', 'year': '2021', 'journal-title': 'Ann Intensive Care'}, { 'key': '2023090814453546700_nuad105-B20', 'doi-asserted-by': 'crossref', 'first-page': '20', 'DOI': '10.1186/s40001-021-00490-1', 'article-title': 'Safety and effectiveness of high-dose vitamin C in patients with ' 'COVID-19: a randomized open-label clinical trial', 'volume': '26', 'author': 'JamaliMoghadamSiahkali', 'year': '2021', 'journal-title': 'Eur J Med Res'}, { 'key': '2023090814453546700_nuad105-B21', 'doi-asserted-by': 'crossref', 'first-page': '7020', 'DOI': '10.18632/aging.202557', 'article-title': 'The efficiency and safety of high-dose vitamin C in patients with ' 'COVID-19: a retrospective cohort study', 'volume': '13', 'author': 'Gao', 'year': '2021', 'journal-title': 'Aging (Albany NY)'}, { 'key': '2023090814453546700_nuad105-B22', 'doi-asserted-by': 'crossref', 'first-page': '638556', 'DOI': '10.3389/fphar.2021.638556', 'article-title': 'High dose intravenous vitamin C for preventing the disease aggravation ' 'of moderate COVID-19 pneumonia. A retrospective propensity matched ' 'before-after study', 'volume': '12', 'author': 'Zhao', 'year': '2021', 'journal-title': 'Front Pharmacol'}, { 'key': '2023090814453546700_nuad105-B23', 'doi-asserted-by': 'crossref', 'first-page': 'e210369', 'DOI': '10.1001/jamanetworkopen.2021.0369', 'article-title': 'Effect of high-dose zinc and ascorbic acid supplementation vs usual ' 'care on symptom length and reduction among ambulatory patients with ' 'SARS-CoV-2 infection: the COVID A to Z randomized clinical trial', 'volume': '4', 'author': 'Thomas', 'year': '2021', 'journal-title': 'JAMA Netw Open'}, { 'key': '2023090814453546700_nuad105-B24', 'doi-asserted-by': 'crossref', 'first-page': '17648', 'DOI': '10.1038/s41598-021-96703-y', 'article-title': 'Ascorbic acid as an adjunctive therapy in critically ill patients with ' 'COVID-19: a propensity score matched study', 'volume': '11', 'author': 'Al Sulaiman', 'year': '2021', 'journal-title': 'Sci Rep'}, { 'key': '2023090814453546700_nuad105-B25', 'doi-asserted-by': 'crossref', 'first-page': '802', 'DOI': '10.1186/s13063-021-05795-4', 'article-title': 'The effect of supplementation with vitamins A, B, C, D, and E on ' 'disease severity and inflammatory responses in patients with COVID-19: ' 'a randomized clinical trial', 'volume': '22', 'author': 'Beigmohammadi', 'year': '2021', 'journal-title': 'Trials'}, { 'key': '2023090814453546700_nuad105-B26', 'first-page': '164', 'article-title': 'Efficacy of high dose vitamin C, melatonin and zinc in Iranian patients ' 'with acute respiratory syndrome due to coronavirus infection: a pilot ' 'randomized trial', 'volume': '6', 'author': 'Darban', 'year': '2020', 'journal-title': 'J Cell Mol Anesth'}, { 'key': '2023090814453546700_nuad105-B27', 'doi-asserted-by': 'crossref', 'first-page': '60', 'DOI': '10.1177/08971900211015052', 'article-title': 'Use of intravenous vitamin C in critically ill patients with COVID-19 ' 'infection', 'volume': '36', 'author': 'Li', 'year': '2023', 'journal-title': 'J Pharm Pract'}, { 'key': '2023090814453546700_nuad105-B28', 'first-page': '356', 'article-title': 'Effect of high-dose intravenous vitamin C on prognosis in patients with ' 'SARS-CoV-2 pneumonia', 'volume': '158', 'author': 'Suna', 'year': '2021', 'journal-title': 'Med Clin (Engl Ed)'}, { 'key': '2023090814453546700_nuad105-B29', 'doi-asserted-by': 'crossref', 'first-page': '1403', 'DOI': '10.1515/med-2021-0361', 'article-title': 'No significant benefit of moderate-dose vitamin C on severe COVID-19 ' 'cases', 'volume': '16', 'author': 'Zheng', 'year': '2021', 'journal-title': 'Open Med (Wars)'}, { 'key': '2023090814453546700_nuad105-B30', 'doi-asserted-by': 'crossref', 'first-page': '717816', 'DOI': '10.3389/fimmu.2021.717816', 'article-title': 'The effect of vitamin C on pathological parameters and survival ' 'duration of critically ill coronavirus disease 2019 patients: a ' 'randomized clinical trial', 'volume': '12', 'author': 'Majidi', 'year': '2021', 'journal-title': 'Front Immunol'}, { 'key': '2023090814453546700_nuad105-B31', 'doi-asserted-by': 'crossref', 'first-page': '814587', 'DOI': '10.3389/fmed.2022.814587', 'article-title': 'Effect of vitamin C on clinical outcomes of critically ill patients ' 'with COVID-19: an observational study and subsequent meta-analysis', 'volume': '9', 'author': 'Gavrielatou', 'year': '2022', 'journal-title': 'Front Med (Lausanne)'}, { 'key': '2023090814453546700_nuad105-B32', 'doi-asserted-by': 'crossref', 'first-page': '603', 'DOI': '10.1007/s10654-010-9491-z', 'article-title': 'Critical evaluation of the Newcastle-Ottawa scale for the assessment of ' 'the quality of nonrandomized studies in meta-analyses', 'volume': '25', 'author': 'Stang', 'year': '2010', 'journal-title': 'Eur J Epidemiol'}, { 'key': '2023090814453546700_nuad105-B33', 'doi-asserted-by': 'crossref', 'first-page': 'd5928', 'DOI': '10.1136/bmj.d5928', 'article-title': "The Cochrane Collaboration's tool for assessing risk of bias in " 'randomised trials', 'volume': '343', 'author': 'Higgins', 'year': '2011', 'journal-title': 'BMJ'}, { 'key': '2023090814453546700_nuad105-B34', 'first-page': '135', 'article-title': 'Estimating the sample mean and standard deviation from the sample size, ' 'median, range and/or interquartile range', 'author': 'Wan', 'year': '2014'}, { 'key': '2023090814453546700_nuad105-B35', 'doi-asserted-by': 'crossref', 'first-page': '106239', 'DOI': '10.1016/j.rmed.2020.106239', 'article-title': 'Pulmonary pathology of ARDS in COVID-19: a pathological review for ' 'clinicians', 'volume': '176', 'author': 'Batah', 'year': '2021', 'journal-title': 'Respir Med'}, { 'key': '2023090814453546700_nuad105-B36', 'doi-asserted-by': 'crossref', 'first-page': '15', 'DOI': '10.1186/s40560-020-0432-y', 'article-title': 'Vitamin C may reduce the duration of mechanical ventilation in ' 'critically ill patients: a meta-regression analysis', 'volume': '8', 'author': 'Hemilä', 'year': '2020', 'journal-title': 'J Intensive Care'}, { 'key': '2023090814453546700_nuad105-B37', 'doi-asserted-by': 'crossref', 'first-page': '846', 'DOI': '10.1007/s00134-020-05991-x', 'article-title': 'Clinical predictors of mortality due to COVID-19 based on an analysis ' 'of data of 150 patients from Wuhan, China', 'volume': '46', 'author': 'Ruan', 'year': '2020', 'journal-title': 'Intensive Care Med'}, { 'key': '2023090814453546700_nuad105-B38', 'doi-asserted-by': 'crossref', 'first-page': '104357', 'DOI': '10.1016/j.jcv.2020.104357', 'article-title': 'Epidemiology and clinical features of COVID-19: a review of current ' 'literature', 'volume': '127', 'author': 'Siordia', 'year': '2020', 'journal-title': 'J Clin Virol'}, {'key': '2023090814453546700_nuad105-B39', 'author': 'Ahmed'}, { 'key': '2023090814453546700_nuad105-B40', 'doi-asserted-by': 'crossref', 'first-page': '1239', 'DOI': '10.1001/jama.2020.2648', 'article-title': 'Characteristics of and important lessons from the coronavirus disease ' '2019 (COVID-19) outbreak in China: summary of a report of 72314 cases ' 'from the Chinese Center for Disease Control and Prevention', 'volume': '323', 'author': 'Wu', 'year': '2020', 'journal-title': 'JAMA'}, { 'key': '2023090814453546700_nuad105-B41', 'doi-asserted-by': 'crossref', 'first-page': '1054', 'DOI': '10.1016/S0140-6736(20)30566-3', 'article-title': 'Clinical course and risk factors for mortality of adult inpatients with ' 'COVID-19 in Wuhan, China: a retrospective cohort study', 'volume': '395', 'author': 'Zhou', 'year': '2020', 'journal-title': 'Lancet'}, { 'key': '2023090814453546700_nuad105-B42', 'doi-asserted-by': 'crossref', 'first-page': '1261', 'DOI': '10.1001/jama.2019.11825', 'article-title': 'Effect of vitamin C infusion on organ failure and biomarkers of ' 'inflammation and vascular injury in patients with sepsis and severe ' 'acute respiratory failure: the CITRIS-ALI randomized clinical trial', 'volume': '322', 'author': 'Fowler', 'year': '2019', 'journal-title': 'JAMA'}, { 'key': '2023090814453546700_nuad105-B43', 'doi-asserted-by': 'crossref', 'first-page': '1154', 'DOI': '10.3390/nu13041154', 'article-title': 'Feasibility of vitamin C in the treatment of post viral fatigue with ' 'focus on long COVID, based on a systematic review of IV vitamin C on ' 'fatigue', 'volume': '13', 'author': 'Vollbracht', 'year': '2021', 'journal-title': 'Nutrients'}, { 'key': '2023090814453546700_nuad105-B44', 'doi-asserted-by': 'crossref', 'first-page': '1708', 'DOI': '10.1056/NEJMoa2002032', 'article-title': 'Clinical characteristics of coronavirus disease 2019 in China', 'volume': '382', 'author': 'Guan', 'year': '2020', 'journal-title': 'N Engl J Med'}, { 'key': '2023090814453546700_nuad105-B45', 'doi-asserted-by': 'crossref', 'first-page': '1517', 'DOI': '10.1007/s43440-020-00176-1', 'article-title': 'Overview of the possible role of vitamin C in management of COVID-19', 'volume': '72', 'author': 'Abobaker', 'year': '2020', 'journal-title': 'Pharmacol Rep'}, { 'key': '2023090814453546700_nuad105-B46', 'doi-asserted-by': 'crossref', 'first-page': '495', 'DOI': '10.1177/014107680710001109', 'article-title': 'Vitamin C may affect lung infections', 'volume': '100', 'author': 'Hemilä', 'year': '2007', 'journal-title': 'J R Soc Med'}, { 'key': '2023090814453546700_nuad105-B47', 'doi-asserted-by': 'crossref', 'first-page': '224', 'DOI': '10.3947/ic.2020.52.2.224', 'article-title': 'Reply: vitamin C as a possible therapy for COVID-19', 'volume': '52', 'author': 'Kim', 'year': '2020', 'journal-title': 'Infect Chemother'}, { 'key': '2023090814453546700_nuad105-B48', 'first-page': '533', 'article-title': 'Vitamin C pharmacokinetics: implications for oral and intravenous use', 'author': 'Padayatty'}, { 'key': '2023090814453546700_nuad105-B49', 'doi-asserted-by': 'crossref', 'first-page': '3704', 'DOI': '10.1073/pnas.93.8.3704', 'article-title': 'Vitamin C pharmacokinetics in healthy volunteers: evidence for a ' 'recommended dietary allowance', 'volume': '93', 'author': 'Levine', 'year': '1996', 'journal-title': 'Proc Natl Acad Sci USA'}], 'container-title': 'Nutrition Reviews', 'original-title': [], 'language': 'en', 'link': [ { 'URL': 'https://academic.oup.com/nutritionreviews/advance-article-pdf/doi/10.1093/nutrit/nuad105/51442062/nuad105.pdf', 'content-type': 'application/pdf', 'content-version': 'vor', 'intended-application': 'syndication'}, { 'URL': 'https://academic.oup.com/nutritionreviews/advance-article-pdf/doi/10.1093/nutrit/nuad105/51442062/nuad105.pdf', 'content-type': 'unspecified', 'content-version': 'vor', 'intended-application': 'similarity-checking'}], 'deposited': { 'date-parts': [[2023, 9, 8]], 'date-time': '2023-09-08T15:58:59Z', 'timestamp': 1694188739000}, 'score': 1, 'resource': { 'primary': { 'URL': 'https://academic.oup.com/nutritionreviews/advance-article/doi/10.1093/nutrit/nuad105/7264250'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2023, 9, 8]]}, 'references-count': 49, 'URL': 'http://dx.doi.org/10.1093/nutrit/nuad105', 'relation': {}, 'ISSN': ['0029-6643', '1753-4887'], 'subject': ['Nutrition and Dietetics', 'Medicine (miscellaneous)'], 'published': {'date-parts': [[2023, 9, 8]]}}
Loading..
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop   
Submit