Therapeutic effects of high-dose vitamin C supplementation in patients with COVID-19: a meta-analysis

Sun et al., Nutrition Reviews, doi:10.1093/nutrit/nuad105

Sep 2023

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Meta analysis of 14 studies showing lower COVID-19 progression with high-dose vitamin C treatment.

5 meta analyses show significant improvements with vitamin C for mortality Bhowmik, Kow, Olczak-Pruc, progression Sun, severity Bhowmik, and cases Xu.

Currently there are 64 vitamin C for COVID-19 studies, showing 20% lower mortality [10‑29%], 16% lower ventilation [-1‑31%], 15% lower ICU admission [2‑26%], 16% lower hospitalization [4‑27%], and 6% more cases [-13‑30%].

1. Bhowmik et al., Impact of high-dose vitamin C on the mortality, severity, and duration of hospital stay in COVID-19 patients: A meta-analysis, Health Science Reports, doi:10.1002/hsr2.762.wiley.com, doi.org.

2. Kow et al., The effect of vitamin C on the risk of mortality in patients with COVID-19: a systematic review and meta-analysis of randomized controlled trials, Inflammopharmacology, doi:10.1007/s10787-023-01200-5.springer.com, doi.org.

3. Olczak-Pruc et al., Vitamin C Supplementation for the Treatment of COVID-19: A Systematic Review and Meta-Analysis, Nutrients, doi:10.3390/nu14194217.mdpi.com, doi.org.

4. Sun et al., Therapeutic effects of high-dose vitamin C supplementation in patients with COVID-19: a meta-analysis, Nutrition Reviews, doi:10.1093/nutrit/nuad105.oup.com, doi.org.

5. Xu et al., Association of Oral or Intravenous Vitamin C Supplementation with Mortality: A Systematic Review and Meta-Analysis, Nutrients, doi:10.3390/nu15081848.mdpi.com, doi.org.

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risk of progression, 65.6% lower, OR 0.34, p = 0.03, RR approximated with OR.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates

Sun et al., 8 Sep 2023, peer-reviewed, 13 authors.

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