DOI record:
{
"DOI": "10.1093/nutrit/nuad105",
"ISSN": [
"0029-6643",
"1753-4887"
],
"URL": "http://dx.doi.org/10.1093/nutrit/nuad105",
"abstract": "<jats:title>Abstract</jats:title>\n <jats:sec>\n <jats:title>Context</jats:title>\n <jats:p>Coronavirus disease 2019 (COVID-19) could induce the “cytokine storm” due to overactivation of immune system and accompanied by acute respiratory distress syndrome as a serious complication. Vitamin C has been effective in improving lung function of patients by reducing inflammation.</jats:p>\n </jats:sec>\n <jats:sec>\n <jats:title>Objective</jats:title>\n <jats:p>The aim was to explore the therapeutic effects of high-dose vitamin C supplementation for patients with COVID-19 using meta-analysis.</jats:p>\n </jats:sec>\n <jats:sec>\n <jats:title>Data Sources</jats:title>\n <jats:p>Published studies were searched from PubMed, Cochrane Library, Web of Science, EMBASE, and China National Knowledge Infrastructure databases up to August 2022 using the terms “vitamin C” and “COVID-19”. Data analyses were performed independently by 2 researchers using the PRISMA guidelines.</jats:p>\n </jats:sec>\n <jats:sec>\n <jats:title>Data Extraction</jats:title>\n <jats:p>Heterogeneity between the included studies was assessed using I2 statistics. When I2 ≥50%, the random-effects model was used; otherwise, a fixed-effects model was applied. Stata 14.0 software was used to pool data by standardized mean differences (SMDs) with 95% CIs or odds ratios (ORs) with 95% CIs.</jats:p>\n </jats:sec>\n <jats:sec>\n <jats:title>Data Analysis</jats:title>\n <jats:p>The 14 studies had a total of 751 patients and 1583 control participants in 7 randomized controlled trials and 7 retrospective studies. The vitamin C supplement significantly increased ferritin (SMD = 0.272; 95% CI: 0.059 to 0.485; P = 0.012) and lymphocyte count levels (SMD = 0.376; 95% CI: 0.153 to 0.599; P = 0.001) in patients with COVID-19. Patients administered vitamin C in the length of intensive care unit staying (SMD = 0.226; 95% CI: 0.073 to 0.379; P = 0.004). Intake of vitamin C prominently alleviate disease aggravation (OR = 0.344, 95%CI: 0.135 to 0.873, P = 0.025).</jats:p>\n </jats:sec>\n <jats:sec>\n <jats:title>Conclusions</jats:title>\n <jats:p>High-dose vitamin C supplementation can alleviate inflammatory response and hinder the aggravation of COVID-19.</jats:p>\n </jats:sec>",
"author": [
{
"ORCID": "http://orcid.org/0000-0002-6134-1592",
"affiliation": [
{
"name": "Department of Environmental Health, School of Public Health, Zhengzhou University, Environment and Health Innovation Team , Zhengzhou, Henan, China"
}
],
"authenticated-orcid": false,
"family": "Sun",
"given": "Lei",
"sequence": "first"
},
{
"affiliation": [
{
"name": "Department of Environmental Health, School of Public Health, Zhengzhou University, Environment and Health Innovation Team , Zhengzhou, Henan, China"
}
],
"family": "Zhao",
"given": "Jia-Hao",
"sequence": "additional"
},
{
"affiliation": [
{
"name": "Department of Environmental Health, School of Public Health, Zhengzhou University, Environment and Health Innovation Team , Zhengzhou, Henan, China"
}
],
"family": "Fan",
"given": "Wen-Yi",
"sequence": "additional"
},
{
"affiliation": [
{
"name": "Department of Environmental Health, School of Public Health, Zhengzhou University, Environment and Health Innovation Team , Zhengzhou, Henan, China"
}
],
"family": "Feng",
"given": "Bo",
"sequence": "additional"
},
{
"affiliation": [
{
"name": "Department of Environmental Health, School of Public Health, Zhengzhou University, Environment and Health Innovation Team , Zhengzhou, Henan, China"
}
],
"family": "Liu",
"given": "Wen-Wen",
"sequence": "additional"
},
{
"affiliation": [
{
"name": "Jinshui District Center for Disease Control and Prevention , Zhengzhou, Henan, China"
}
],
"family": "Chen",
"given": "Rui-Qin",
"sequence": "additional"
},
{
"affiliation": [
{
"name": "Department of Environmental Health, School of Public Health, Zhengzhou University, Environment and Health Innovation Team , Zhengzhou, Henan, China"
}
],
"family": "Ban",
"given": "Chuang",
"sequence": "additional"
},
{
"affiliation": [
{
"name": "Department of Environmental Health, School of Public Health, Zhengzhou University, Environment and Health Innovation Team , Zhengzhou, Henan, China"
}
],
"family": "Dang",
"given": "Ao-Gui",
"sequence": "additional"
},
{
"affiliation": [
{
"name": "Department of Environmental Health, School of Public Health, Zhengzhou University, Environment and Health Innovation Team , Zhengzhou, Henan, China"
}
],
"family": "Wang",
"given": "Miao",
"sequence": "additional"
},
{
"affiliation": [
{
"name": "Department of Environmental Health, School of Public Health, Zhengzhou University, Environment and Health Innovation Team , Zhengzhou, Henan, China"
}
],
"family": "Luo",
"given": "Kang-Ting",
"sequence": "additional"
},
{
"affiliation": [
{
"name": "Department of Environmental Health, School of Public Health, Zhengzhou University, Environment and Health Innovation Team , Zhengzhou, Henan, China"
}
],
"family": "Zhou",
"given": "Guo-Yu",
"sequence": "additional"
},
{
"affiliation": [
{
"name": "Department of Environmental Health, School of Public Health, Zhengzhou University, Environment and Health Innovation Team , Zhengzhou, Henan, China"
}
],
"family": "Yu",
"given": "Fang-Fang",
"sequence": "additional"
},
{
"ORCID": "http://orcid.org/0000-0002-9659-7993",
"affiliation": [
{
"name": "Department of Environmental Health, School of Public Health, Zhengzhou University, Environment and Health Innovation Team , Zhengzhou, Henan, China"
}
],
"authenticated-orcid": false,
"family": "Ba",
"given": "Yue",
"sequence": "additional"
}
],
"container-title": "Nutrition Reviews",
"content-domain": {
"crossmark-restriction": false,
"domain": []
},
"created": {
"date-parts": [
[
2023,
9,
8
]
],
"date-time": "2023-09-08T15:58:42Z",
"timestamp": 1694188722000
},
"deposited": {
"date-parts": [
[
2023,
9,
8
]
],
"date-time": "2023-09-08T15:58:59Z",
"timestamp": 1694188739000
},
"funder": [
{
"DOI": "10.13039/501100001809",
"award": [
"82003400"
],
"doi-asserted-by": "crossref",
"name": "National Natural Scientific Foundation of China"
},
{
"award": [
"232102311079",
"212102310622"
],
"name": "Science and Technology Program of Henan Province"
}
],
"indexed": {
"date-parts": [
[
2023,
9,
9
]
],
"date-time": "2023-09-09T04:50:03Z",
"timestamp": 1694235003185
},
"is-referenced-by-count": 0,
"issued": {
"date-parts": [
[
2023,
9,
8
]
]
},
"language": "en",
"license": [
{
"URL": "https://academic.oup.com/pages/standard-publication-reuse-rights",
"content-version": "vor",
"delay-in-days": 0,
"start": {
"date-parts": [
[
2023,
9,
8
]
],
"date-time": "2023-09-08T00:00:00Z",
"timestamp": 1694131200000
}
}
],
"link": [
{
"URL": "https://academic.oup.com/nutritionreviews/advance-article-pdf/doi/10.1093/nutrit/nuad105/51442062/nuad105.pdf",
"content-type": "application/pdf",
"content-version": "vor",
"intended-application": "syndication"
},
{
"URL": "https://academic.oup.com/nutritionreviews/advance-article-pdf/doi/10.1093/nutrit/nuad105/51442062/nuad105.pdf",
"content-type": "unspecified",
"content-version": "vor",
"intended-application": "similarity-checking"
}
],
"member": "286",
"original-title": [],
"prefix": "10.1093",
"published": {
"date-parts": [
[
2023,
9,
8
]
]
},
"published-online": {
"date-parts": [
[
2023,
9,
8
]
]
},
"publisher": "Oxford University Press (OUP)",
"reference": [
{
"DOI": "10.1016/j.jaci.2020.04.006",
"article-title": "Risk factors for severity and mortality in adult COVID-19 inpatients in Wuhan",
"author": "Li",
"doi-asserted-by": "crossref",
"first-page": "110",
"journal-title": "J Allergy Clin Immunol",
"key": "2023090814453546700_nuad105-B1",
"volume": "146",
"year": "2020"
},
{
"DOI": "10.1016/j.bios.2020.112752",
"article-title": "COVID-19 diagnosis—a review of current methods",
"author": "Yuce",
"doi-asserted-by": "crossref",
"first-page": "112752",
"journal-title": "Biosens Bioelectron",
"key": "2023090814453546700_nuad105-B2",
"volume": "172",
"year": "2021"
},
{
"DOI": "10.1016/j.jinf.2020.03.041",
"article-title": "Clinical characteristics of coronavirus disease 2019 (COVID-19) in China: a systematic review and meta-analysis",
"author": "Fu",
"doi-asserted-by": "crossref",
"first-page": "656",
"journal-title": "J Infect",
"key": "2023090814453546700_nuad105-B3",
"volume": "80",
"year": "2020"
},
{
"DOI": "10.1007/s11684-020-0767-8",
"article-title": "Coronavirus disease 2019 (COVID-19): a clinical update",
"author": "Zhou",
"doi-asserted-by": "crossref",
"first-page": "126",
"journal-title": "Front Med",
"key": "2023090814453546700_nuad105-B4",
"volume": "14",
"year": "2020"
},
{
"DOI": "10.1007/s40995-021-01244-8",
"article-title": "Clinical characteristics of coronavirus disease 2019 (COVID-19): a comparison between laboratory-confirmed and clinically suspected patients",
"author": "Li",
"doi-asserted-by": "crossref",
"first-page": "81",
"journal-title": "Iran J Sci Technol Trans A Sci",
"key": "2023090814453546700_nuad105-B5",
"volume": "46",
"year": "2022"
},
{
"DOI": "10.3390/jcm11164896",
"article-title": "COVID-19-related ARDS: key mechanistic features and treatments",
"author": "Selickman",
"doi-asserted-by": "crossref",
"first-page": "4896",
"journal-title": "J Clin Med",
"key": "2023090814453546700_nuad105-B6",
"volume": "11",
"year": "2022"
},
{
"DOI": "10.1016/S0140-6736(20)30183-5",
"article-title": "Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China",
"author": "Huang",
"doi-asserted-by": "crossref",
"first-page": "497",
"journal-title": "Lancet",
"key": "2023090814453546700_nuad105-B7",
"volume": "395",
"year": "2020"
},
{
"DOI": "10.1186/s12985-022-01814-1",
"article-title": "COVID-19 infection: an overview on cytokine storm and related interventions",
"author": "Montazersaheb",
"doi-asserted-by": "crossref",
"first-page": "92",
"journal-title": "Virol J",
"key": "2023090814453546700_nuad105-B8",
"volume": "19",
"year": "2022"
},
{
"DOI": "10.3389/fmed.2020.559811",
"article-title": "Vitamin C and COVID-19",
"author": "Hemila",
"doi-asserted-by": "crossref",
"first-page": "559811",
"journal-title": "Front Med (Lausanne)",
"key": "2023090814453546700_nuad105-B9",
"volume": "7",
"year": "2020"
},
{
"DOI": "10.1186/s13054-017-1891-y",
"article-title": "Hypovitaminosis C and vitamin C deficiency in critically ill patients despite recommended enteral and parenteral intakes",
"author": "Carr",
"doi-asserted-by": "crossref",
"first-page": "300",
"journal-title": "Crit Care",
"key": "2023090814453546700_nuad105-B10",
"volume": "21",
"year": "2017"
},
{
"DOI": "10.4049/jimmunol.165.12.7180",
"article-title": "Vitamin C inhibits NF-kappa B activation by TNF via the activation of p38 mitogen-activated protein kinase",
"author": "Bowie",
"doi-asserted-by": "crossref",
"first-page": "7180",
"journal-title": "J Immunol.",
"key": "2023090814453546700_nuad105-B11",
"volume": "165",
"year": "2000"
},
{
"DOI": "10.3389/fimmu.2020.574029",
"article-title": "The long history of vitamin C: from prevention of the common cold to potential aid in the treatment of COVID-19",
"author": "Cerullo",
"doi-asserted-by": "crossref",
"first-page": "574029",
"journal-title": "Front Immunol.",
"key": "2023090814453546700_nuad105-B12",
"volume": "11",
"year": "2020"
},
{
"DOI": "10.5492/wjccm.v6.i1.85",
"article-title": "Intravenous vitamin C as adjunctive therapy for enterovirus/rhinovirus induced acute respiratory distress syndrome",
"author": "Fowler Iii",
"doi-asserted-by": "crossref",
"first-page": "85",
"journal-title": "World J Crit Care Med",
"key": "2023090814453546700_nuad105-B13",
"volume": "6",
"year": "2017"
},
{
"DOI": "10.1186/1479-5876-12-32",
"article-title": "Phase I safety trial of intravenous ascorbic acid in patients with severe sepsis",
"author": "Fowler",
"doi-asserted-by": "crossref",
"first-page": "32",
"journal-title": "J Transl Med",
"key": "2023090814453546700_nuad105-B14",
"volume": "12",
"year": "2014"
},
{
"DOI": "10.3390/nu11040708",
"article-title": "Vitamin C can shorten the length of stay in the ICU: a meta-analysis",
"author": "Hemila",
"doi-asserted-by": "crossref",
"first-page": "708",
"journal-title": "Nutrients",
"key": "2023090814453546700_nuad105-B15",
"volume": "11",
"year": "2019"
},
{
"DOI": "10.3390/nu13041172",
"article-title": "Vitamin C in the treatment of COVID-19",
"author": "Milani",
"doi-asserted-by": "crossref",
"first-page": "1162",
"journal-title": "Nutrients",
"key": "2023090814453546700_nuad105-B16",
"volume": "13",
"year": "2021"
},
{
"DOI": "10.1016/j.recesp.2021.06.016",
"article-title": "The PRISMA 2020 statement: an updated guideline for reporting systematic reviews",
"author": "Page",
"doi-asserted-by": "crossref",
"first-page": "790",
"journal-title": "Rev Esp Cardiol (Engl Ed)",
"key": "2023090814453546700_nuad105-B17",
"volume": "74",
"year": "2021"
},
{
"article-title": "The role of vitamin C as adjuvant therapy in COVID-19",
"author": "Kumari",
"first-page": "e11779",
"journal-title": "Cureus",
"key": "2023090814453546700_nuad105-B18",
"volume": "12",
"year": "2020"
},
{
"DOI": "10.1186/s13613-020-00792-3",
"article-title": "Pilot trial of high-dose vitamin C in critically ill COVID-19 patients",
"author": "Zhang",
"doi-asserted-by": "crossref",
"first-page": "5",
"journal-title": "Ann Intensive Care",
"key": "2023090814453546700_nuad105-B19",
"volume": "11",
"year": "2021"
},
{
"DOI": "10.1186/s40001-021-00490-1",
"article-title": "Safety and effectiveness of high-dose vitamin C in patients with COVID-19: a randomized open-label clinical trial",
"author": "JamaliMoghadamSiahkali",
"doi-asserted-by": "crossref",
"first-page": "20",
"journal-title": "Eur J Med Res",
"key": "2023090814453546700_nuad105-B20",
"volume": "26",
"year": "2021"
},
{
"DOI": "10.18632/aging.202557",
"article-title": "The efficiency and safety of high-dose vitamin C in patients with COVID-19: a retrospective cohort study",
"author": "Gao",
"doi-asserted-by": "crossref",
"first-page": "7020",
"journal-title": "Aging (Albany NY)",
"key": "2023090814453546700_nuad105-B21",
"volume": "13",
"year": "2021"
},
{
"DOI": "10.3389/fphar.2021.638556",
"article-title": "High dose intravenous vitamin C for preventing the disease aggravation of moderate COVID-19 pneumonia. A retrospective propensity matched before-after study",
"author": "Zhao",
"doi-asserted-by": "crossref",
"first-page": "638556",
"journal-title": "Front Pharmacol",
"key": "2023090814453546700_nuad105-B22",
"volume": "12",
"year": "2021"
},
{
"DOI": "10.1001/jamanetworkopen.2021.0369",
"article-title": "Effect of high-dose zinc and ascorbic acid supplementation vs usual care on symptom length and reduction among ambulatory patients with SARS-CoV-2 infection: the COVID A to Z randomized clinical trial",
"author": "Thomas",
"doi-asserted-by": "crossref",
"first-page": "e210369",
"journal-title": "JAMA Netw Open",
"key": "2023090814453546700_nuad105-B23",
"volume": "4",
"year": "2021"
},
{
"DOI": "10.1038/s41598-021-96703-y",
"article-title": "Ascorbic acid as an adjunctive therapy in critically ill patients with COVID-19: a propensity score matched study",
"author": "Al Sulaiman",
"doi-asserted-by": "crossref",
"first-page": "17648",
"journal-title": "Sci Rep",
"key": "2023090814453546700_nuad105-B24",
"volume": "11",
"year": "2021"
},
{
"DOI": "10.1186/s13063-021-05795-4",
"article-title": "The effect of supplementation with vitamins A, B, C, D, and E on disease severity and inflammatory responses in patients with COVID-19: a randomized clinical trial",
"author": "Beigmohammadi",
"doi-asserted-by": "crossref",
"first-page": "802",
"journal-title": "Trials",
"key": "2023090814453546700_nuad105-B25",
"volume": "22",
"year": "2021"
},
{
"article-title": "Efficacy of high dose vitamin C, melatonin and zinc in Iranian patients with acute respiratory syndrome due to coronavirus infection: a pilot randomized trial",
"author": "Darban",
"first-page": "164",
"journal-title": "J Cell Mol Anesth",
"key": "2023090814453546700_nuad105-B26",
"volume": "6",
"year": "2020"
},
{
"DOI": "10.1177/08971900211015052",
"article-title": "Use of intravenous vitamin C in critically ill patients with COVID-19 infection",
"author": "Li",
"doi-asserted-by": "crossref",
"first-page": "60",
"journal-title": "J Pharm Pract",
"key": "2023090814453546700_nuad105-B27",
"volume": "36",
"year": "2023"
},
{
"article-title": "Effect of high-dose intravenous vitamin C on prognosis in patients with SARS-CoV-2 pneumonia",
"author": "Suna",
"first-page": "356",
"journal-title": "Med Clin (Engl Ed)",
"key": "2023090814453546700_nuad105-B28",
"volume": "158",
"year": "2021"
},
{
"DOI": "10.1515/med-2021-0361",
"article-title": "No significant benefit of moderate-dose vitamin C on severe COVID-19 cases",
"author": "Zheng",
"doi-asserted-by": "crossref",
"first-page": "1403",
"journal-title": "Open Med (Wars)",
"key": "2023090814453546700_nuad105-B29",
"volume": "16",
"year": "2021"
},
{
"DOI": "10.3389/fimmu.2021.717816",
"article-title": "The effect of vitamin C on pathological parameters and survival duration of critically ill coronavirus disease 2019 patients: a randomized clinical trial",
"author": "Majidi",
"doi-asserted-by": "crossref",
"first-page": "717816",
"journal-title": "Front Immunol",
"key": "2023090814453546700_nuad105-B30",
"volume": "12",
"year": "2021"
},
{
"DOI": "10.3389/fmed.2022.814587",
"article-title": "Effect of vitamin C on clinical outcomes of critically ill patients with COVID-19: an observational study and subsequent meta-analysis",
"author": "Gavrielatou",
"doi-asserted-by": "crossref",
"first-page": "814587",
"journal-title": "Front Med (Lausanne)",
"key": "2023090814453546700_nuad105-B31",
"volume": "9",
"year": "2022"
},
{
"DOI": "10.1007/s10654-010-9491-z",
"article-title": "Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses",
"author": "Stang",
"doi-asserted-by": "crossref",
"first-page": "603",
"journal-title": "Eur J Epidemiol",
"key": "2023090814453546700_nuad105-B32",
"volume": "25",
"year": "2010"
},
{
"DOI": "10.1136/bmj.d5928",
"article-title": "The Cochrane Collaboration's tool for assessing risk of bias in randomised trials",
"author": "Higgins",
"doi-asserted-by": "crossref",
"first-page": "d5928",
"journal-title": "BMJ",
"key": "2023090814453546700_nuad105-B33",
"volume": "343",
"year": "2011"
},
{
"article-title": "Estimating the sample mean and standard deviation from the sample size, median, range and/or interquartile range",
"author": "Wan",
"first-page": "135",
"key": "2023090814453546700_nuad105-B34",
"year": "2014"
},
{
"DOI": "10.1016/j.rmed.2020.106239",
"article-title": "Pulmonary pathology of ARDS in COVID-19: a pathological review for clinicians",
"author": "Batah",
"doi-asserted-by": "crossref",
"first-page": "106239",
"journal-title": "Respir Med",
"key": "2023090814453546700_nuad105-B35",
"volume": "176",
"year": "2021"
},
{
"DOI": "10.1186/s40560-020-0432-y",
"article-title": "Vitamin C may reduce the duration of mechanical ventilation in critically ill patients: a meta-regression analysis",
"author": "Hemilä",
"doi-asserted-by": "crossref",
"first-page": "15",
"journal-title": "J Intensive Care",
"key": "2023090814453546700_nuad105-B36",
"volume": "8",
"year": "2020"
},
{
"DOI": "10.1007/s00134-020-05991-x",
"article-title": "Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China",
"author": "Ruan",
"doi-asserted-by": "crossref",
"first-page": "846",
"journal-title": "Intensive Care Med",
"key": "2023090814453546700_nuad105-B37",
"volume": "46",
"year": "2020"
},
{
"DOI": "10.1016/j.jcv.2020.104357",
"article-title": "Epidemiology and clinical features of COVID-19: a review of current literature",
"author": "Siordia",
"doi-asserted-by": "crossref",
"first-page": "104357",
"journal-title": "J Clin Virol",
"key": "2023090814453546700_nuad105-B38",
"volume": "127",
"year": "2020"
},
{
"author": "Ahmed",
"key": "2023090814453546700_nuad105-B39"
},
{
"DOI": "10.1001/jama.2020.2648",
"article-title": "Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: summary of a report of 72314 cases from the Chinese Center for Disease Control and Prevention",
"author": "Wu",
"doi-asserted-by": "crossref",
"first-page": "1239",
"journal-title": "JAMA",
"key": "2023090814453546700_nuad105-B40",
"volume": "323",
"year": "2020"
},
{
"DOI": "10.1016/S0140-6736(20)30566-3",
"article-title": "Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study",
"author": "Zhou",
"doi-asserted-by": "crossref",
"first-page": "1054",
"journal-title": "Lancet",
"key": "2023090814453546700_nuad105-B41",
"volume": "395",
"year": "2020"
},
{
"DOI": "10.1001/jama.2019.11825",
"article-title": "Effect of vitamin C infusion on organ failure and biomarkers of inflammation and vascular injury in patients with sepsis and severe acute respiratory failure: the CITRIS-ALI randomized clinical trial",
"author": "Fowler",
"doi-asserted-by": "crossref",
"first-page": "1261",
"journal-title": "JAMA",
"key": "2023090814453546700_nuad105-B42",
"volume": "322",
"year": "2019"
},
{
"DOI": "10.3390/nu13041154",
"article-title": "Feasibility of vitamin C in the treatment of post viral fatigue with focus on long COVID, based on a systematic review of IV vitamin C on fatigue",
"author": "Vollbracht",
"doi-asserted-by": "crossref",
"first-page": "1154",
"journal-title": "Nutrients",
"key": "2023090814453546700_nuad105-B43",
"volume": "13",
"year": "2021"
},
{
"DOI": "10.1056/NEJMoa2002032",
"article-title": "Clinical characteristics of coronavirus disease 2019 in China",
"author": "Guan",
"doi-asserted-by": "crossref",
"first-page": "1708",
"journal-title": "N Engl J Med",
"key": "2023090814453546700_nuad105-B44",
"volume": "382",
"year": "2020"
},
{
"DOI": "10.1007/s43440-020-00176-1",
"article-title": "Overview of the possible role of vitamin C in management of COVID-19",
"author": "Abobaker",
"doi-asserted-by": "crossref",
"first-page": "1517",
"journal-title": "Pharmacol Rep",
"key": "2023090814453546700_nuad105-B45",
"volume": "72",
"year": "2020"
},
{
"DOI": "10.1177/014107680710001109",
"article-title": "Vitamin C may affect lung infections",
"author": "Hemilä",
"doi-asserted-by": "crossref",
"first-page": "495",
"journal-title": "J R Soc Med",
"key": "2023090814453546700_nuad105-B46",
"volume": "100",
"year": "2007"
},
{
"DOI": "10.3947/ic.2020.52.2.224",
"article-title": "Reply: vitamin C as a possible therapy for COVID-19",
"author": "Kim",
"doi-asserted-by": "crossref",
"first-page": "224",
"journal-title": "Infect Chemother",
"key": "2023090814453546700_nuad105-B47",
"volume": "52",
"year": "2020"
},
{
"article-title": "Vitamin C pharmacokinetics: implications for oral and intravenous use",
"author": "Padayatty",
"first-page": "533",
"key": "2023090814453546700_nuad105-B48"
},
{
"DOI": "10.1073/pnas.93.8.3704",
"article-title": "Vitamin C pharmacokinetics in healthy volunteers: evidence for a recommended dietary allowance",
"author": "Levine",
"doi-asserted-by": "crossref",
"first-page": "3704",
"journal-title": "Proc Natl Acad Sci USA",
"key": "2023090814453546700_nuad105-B49",
"volume": "93",
"year": "1996"
}
],
"reference-count": 49,
"references-count": 49,
"relation": {},
"resource": {
"primary": {
"URL": "https://academic.oup.com/nutritionreviews/advance-article/doi/10.1093/nutrit/nuad105/7264250"
}
},
"score": 1,
"short-title": [],
"source": "Crossref",
"subject": [
"Nutrition and Dietetics",
"Medicine (miscellaneous)"
],
"subtitle": [],
"title": "Therapeutic effects of high-dose vitamin C supplementation in patients with COVID-19: a meta-analysis",
"type": "journal-article"
}
