Impact of uricosurics on mortality outcomes in patients with COVID-19: a systematic review and meta-analysis of randomized controlled trials

DOI record: { "DOI": "10.1093/ijpp/riae003", "ISSN": [ "0961-7671", "2042-7174" ], "URL": "http://dx.doi.org/10.1093/ijpp/riae003", "abstract": "<jats:title>Abstract</jats:title>\n <jats:sec>\n <jats:title>Objectives</jats:title>\n <jats:p>To determine risks associated with uricosurics in COVID-19 patients.</jats:p>\n </jats:sec>\n <jats:sec>\n <jats:title>Methods</jats:title>\n <jats:p>A systematic review and meta-analysis was conducted by systematically searching electronic databases.</jats:p>\n </jats:sec>\n <jats:sec>\n <jats:title>Key findings</jats:title>\n <jats:p>The pooled analysis of the included trials revealed that the use of uricosurics was not associated with the risk of mortality (pooled odds ratio [OR] = 1.03, 95% confidence interval [CI]: 0.94–1.12). However, there is a potential mortality benefit associated with the use of ascorbic acid (pooled OR = 0.78, 95% CI: 0.65–0.94).</jats:p>\n </jats:sec>\n <jats:sec>\n <jats:title>Conclusions</jats:title>\n <jats:p>The findings confirmed the safety of uricosurics in COVID-19 patients, despite their potential to cause uric acid excretion, which may possess antioxidant properties.</jats:p>\n </jats:sec>", "author": [ { "ORCID": "http://orcid.org/0000-0002-8186-2926", "affiliation": [ { "name": "School of Pharmacy, International Medical University , Kuala Lumpur , Malaysia" } ], "authenticated-orcid": false, "family": "Kow", "given": "Chia Siang", "sequence": "first" }, { "ORCID": "http://orcid.org/0000-0001-5390-7026", "affiliation": [ { "name": "School of Pharmacy, Monash University Malaysia , Bandar Sunway , Selangor , Malaysia" } ], "authenticated-orcid": false, "family": "Ramachandram", "given": "Dinesh Sangarran", "sequence": "additional" }, { "ORCID": "http://orcid.org/0000-0002-4058-2215", "affiliation": [ { "name": "School of Applied Sciences, University of Huddersfield , United Kingdom" } ], "authenticated-orcid": false, "family": "Hasan", "given": "Syed Shahzad", "sequence": "additional" }, { "ORCID": "http://orcid.org/0000-0002-3754-1690", "affiliation": [ { "name": "School of Pharmacy, International Medical University , Kuala Lumpur , Malaysia" } ], "authenticated-orcid": false, "family": "Thiruchelvam", "given": "Kaeshaelya", "sequence": "additional" } ], "container-title": "International Journal of Pharmacy Practice", "content-domain": { "crossmark-restriction": false, "domain": [] }, "created": { "date-parts": [ [ 2024, 1, 25 ] ], "date-time": "2024-01-25T13:42:45Z", "timestamp": 1706190165000 }, "deposited": { "date-parts": [ [ 2024, 3, 5 ] ], "date-time": "2024-03-05T03:14:43Z", "timestamp": 1709608483000 }, "indexed": { "date-parts": [ [ 2024, 3, 5 ] ], "date-time": "2024-03-05T03:43:20Z", "timestamp": 1709610200304 }, "is-referenced-by-count": 0, "issued": { "date-parts": [ [ 2024, 3, 4 ] ] }, "language": "en", "license": [ { "URL": "https://creativecommons.org/licenses/by/4.0/", "content-version": "vor", "delay-in-days": 0, "start": { "date-parts": [ [ 2024, 3, 4 ] ], "date-time": "2024-03-04T00:00:00Z", "timestamp": 1709510400000 } } ], "link": [ { "URL": "https://academic.oup.com/ijpp/advance-article-pdf/doi/10.1093/ijpp/riae003/56832744/riae003.pdf", "content-type": "application/pdf", "content-version": "vor", "intended-application": "syndication" }, { "URL": "https://academic.oup.com/ijpp/advance-article-pdf/doi/10.1093/ijpp/riae003/56832744/riae003.pdf", "content-type": "unspecified", "content-version": "vor", "intended-application": "similarity-checking" } ], "member": "286", "original-title": [], "prefix": "10.1093", "published": { "date-parts": [ [ 2024, 3, 4 ] ] }, "published-online": { "date-parts": [ [ 2024, 3, 4 ] ] }, "publisher": "Oxford University Press (OUP)", "reference": [ { "article-title": "Inflammation related to association of low uric acid and progression to severe disease in patients hospitalized for non-severe Coronavirus disease 2019", "author": "Kurajoh", "first-page": "854", "key": "2024030503142663800_CIT0001", "volume-title": "Biomedicines", "year": "2023" }, { "article-title": "Uric acid: the oxidant-antioxidant paradox", "author": "Sautin", "first-page": "608", "key": "2024030503142663800_CIT0002", "volume-title": "Nucleos Nucleot Nucl Acids", "year": "2010" }, { "DOI": "10.1186/s13054-021-03616-3", "article-title": "Serum uric acid, disease severity and outcomes in COVID-19", "author": "Dufour", "doi-asserted-by": "crossref", "first-page": "212", "journal-title": "Crit Care", "key": "2024030503142663800_CIT0003", "volume": "25", "year": "2021" }, { "article-title": "Gout and the risk of COVID-19 diagnosis and death in the UK Biobank: a population-based study", "author": "Topless", "first-page": "e274", "key": "2024030503142663800_CIT0004", "volume-title": "Lancet Rheumatol", "year": "2022" }, { "DOI": "10.1007/s10787-023-01200-5", "article-title": "The effect of vitamin C on the risk of mortality in patients with COVID-19: a systematic review and meta-analysis of randomized controlled trials", "author": "Kow", "doi-asserted-by": "crossref", "first-page": "3357", "journal-title": "Inflammopharmacology", "key": "2024030503142663800_CIT0005", "volume": "31", "year": "2023" } ], "reference-count": 5, "references-count": 5, "relation": {}, "resource": { "primary": { "URL": "https://academic.oup.com/ijpp/advance-article/doi/10.1093/ijpp/riae003/7619074" } }, "score": 1, "short-title": [], "source": "Crossref", "subject": [ "Public Health, Environmental and Occupational Health", "Health Policy", "Pharmaceutical Science", "Pharmacy" ], "subtitle": [], "title": "Impact of uricosurics on mortality outcomes in patients with COVID-19: a systematic review and meta-analysis of randomized controlled trials", "type": "journal-article" }