Impact of uricosurics on mortality outcomes in patients with COVID-19: a systematic review and meta-analysis of randomized controlled trials

{ 'indexed': {'date-parts': [[2024, 3, 5]], 'date-time': '2024-03-05T03:43:20Z', 'timestamp': 1709610200304}, 'reference-count': 5, 'publisher': 'Oxford University Press (OUP)', 'license': [ { 'start': { 'date-parts': [[2024, 3, 4]], 'date-time': '2024-03-04T00:00:00Z', 'timestamp': 1709510400000}, 'content-version': 'vor', 'delay-in-days': 0, 'URL': 'https://creativecommons.org/licenses/by/4.0/'}], 'content-domain': {'domain': [], 'crossmark-restriction': False}, 'abstract': '<jats:title>Abstract</jats:title>\n' ' <jats:sec>\n' ' <jats:title>Objectives</jats:title>\n' ' <jats:p>To determine risks associated with uricosurics in COVID-19 ' 'patients.</jats:p>\n' ' </jats:sec>\n' ' <jats:sec>\n' ' <jats:title>Methods</jats:title>\n' ' <jats:p>A systematic review and meta-analysis was conducted by ' 'systematically searching electronic databases.</jats:p>\n' ' </jats:sec>\n' ' <jats:sec>\n' ' <jats:title>Key findings</jats:title>\n' ' <jats:p>The pooled analysis of the included trials revealed that the use of ' 'uricosurics was not associated with the risk of mortality (pooled odds ratio [OR] = 1.03, 95% ' 'confidence interval [CI]: 0.94–1.12). However, there is a potential mortality benefit ' 'associated with the use of ascorbic acid (pooled OR = 0.78, 95% CI: 0.65–0.94).</jats:p>\n' ' </jats:sec>\n' ' <jats:sec>\n' ' <jats:title>Conclusions</jats:title>\n' ' <jats:p>The findings confirmed the safety of uricosurics in COVID-19 ' 'patients, despite their potential to cause uric acid excretion, which may possess antioxidant ' 'properties.</jats:p>\n' ' </jats:sec>', 'DOI': '10.1093/ijpp/riae003', 'type': 'journal-article', 'created': {'date-parts': [[2024, 1, 25]], 'date-time': '2024-01-25T13:42:45Z', 'timestamp': 1706190165000}, 'source': 'Crossref', 'is-referenced-by-count': 0, 'title': 'Impact of uricosurics on mortality outcomes in patients with COVID-19: a systematic review and ' 'meta-analysis of randomized controlled trials', 'prefix': '10.1093', 'author': [ { 'ORCID': 'http://orcid.org/0000-0002-8186-2926', 'authenticated-orcid': False, 'given': 'Chia Siang', 'family': 'Kow', 'sequence': 'first', 'affiliation': [ { 'name': 'School of Pharmacy, International Medical University , Kuala ' 'Lumpur , Malaysia'}]}, { 'ORCID': 'http://orcid.org/0000-0001-5390-7026', 'authenticated-orcid': False, 'given': 'Dinesh Sangarran', 'family': 'Ramachandram', 'sequence': 'additional', 'affiliation': [ { 'name': 'School of Pharmacy, Monash University Malaysia , Bandar Sunway , ' 'Selangor , Malaysia'}]}, { 'ORCID': 'http://orcid.org/0000-0002-4058-2215', 'authenticated-orcid': False, 'given': 'Syed Shahzad', 'family': 'Hasan', 'sequence': 'additional', 'affiliation': [ { 'name': 'School of Applied Sciences, University of Huddersfield , United ' 'Kingdom'}]}, { 'ORCID': 'http://orcid.org/0000-0002-3754-1690', 'authenticated-orcid': False, 'given': 'Kaeshaelya', 'family': 'Thiruchelvam', 'sequence': 'additional', 'affiliation': [ { 'name': 'School of Pharmacy, International Medical University , Kuala ' 'Lumpur , Malaysia'}]}], 'member': '286', 'published-online': {'date-parts': [[2024, 3, 4]]}, 'reference': [ { 'key': '2024030503142663800_CIT0001', 'first-page': '854', 'article-title': 'Inflammation related to association of low uric acid and progression to ' 'severe disease in patients hospitalized for non-severe Coronavirus ' 'disease 2019', 'volume-title': 'Biomedicines', 'author': 'Kurajoh', 'year': '2023'}, { 'key': '2024030503142663800_CIT0002', 'first-page': '608', 'article-title': 'Uric acid: the oxidant-antioxidant paradox', 'volume-title': 'Nucleos Nucleot Nucl Acids', 'author': 'Sautin', 'year': '2010'}, { 'key': '2024030503142663800_CIT0003', 'doi-asserted-by': 'crossref', 'first-page': '212', 'DOI': '10.1186/s13054-021-03616-3', 'article-title': 'Serum uric acid, disease severity and outcomes in COVID-19', 'volume': '25', 'author': 'Dufour', 'year': '2021', 'journal-title': 'Crit Care'}, { 'key': '2024030503142663800_CIT0004', 'first-page': 'e274', 'article-title': 'Gout and the risk of COVID-19 diagnosis and death in the UK Biobank: a ' 'population-based study', 'volume-title': 'Lancet Rheumatol', 'author': 'Topless', 'year': '2022'}, { 'key': '2024030503142663800_CIT0005', 'doi-asserted-by': 'crossref', 'first-page': '3357', 'DOI': '10.1007/s10787-023-01200-5', 'article-title': 'The effect of vitamin C on the risk of mortality in patients with ' 'COVID-19: a systematic review and meta-analysis of randomized ' 'controlled trials', 'volume': '31', 'author': 'Kow', 'year': '2023', 'journal-title': 'Inflammopharmacology'}], 'container-title': 'International Journal of Pharmacy Practice', 'original-title': [], 'language': 'en', 'link': [ { 'URL': 'https://academic.oup.com/ijpp/advance-article-pdf/doi/10.1093/ijpp/riae003/56832744/riae003.pdf', 'content-type': 'application/pdf', 'content-version': 'vor', 'intended-application': 'syndication'}, { 'URL': 'https://academic.oup.com/ijpp/advance-article-pdf/doi/10.1093/ijpp/riae003/56832744/riae003.pdf', 'content-type': 'unspecified', 'content-version': 'vor', 'intended-application': 'similarity-checking'}], 'deposited': { 'date-parts': [[2024, 3, 5]], 'date-time': '2024-03-05T03:14:43Z', 'timestamp': 1709608483000}, 'score': 1, 'resource': { 'primary': { 'URL': 'https://academic.oup.com/ijpp/advance-article/doi/10.1093/ijpp/riae003/7619074'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2024, 3, 4]]}, 'references-count': 5, 'URL': 'http://dx.doi.org/10.1093/ijpp/riae003', 'relation': {}, 'ISSN': ['0961-7671', '2042-7174'], 'subject': [ 'Public Health, Environmental and Occupational Health', 'Health Policy', 'Pharmaceutical Science', 'Pharmacy'], 'published': {'date-parts': [[2024, 3, 4]]}}