Conv. Plasma
Nigella Sativa

All favipiravir studies
Meta analysis
study COVID-19 treatment researchFavipiravirFavipiravir (more..)
Melatonin Meta
Metformin Meta
Azvudine Meta
Bromhexine Meta Molnupiravir Meta
Budesonide Meta
Colchicine Meta
Conv. Plasma Meta Nigella Sativa Meta
Curcumin Meta Nitazoxanide Meta
Famotidine Meta Paxlovid Meta
Favipiravir Meta Quercetin Meta
Fluvoxamine Meta Remdesivir Meta
Hydroxychlor.. Meta Thermotherapy Meta
Ivermectin Meta

All Studies   Meta Analysis    Recent:   

Early antiviral and supervisory dexamethasone treatment improve clinical outcomes of nonsevere COVID-19 patients

Sitasuwan et al., Medicine, doi:10.1097/MD.0000000000031681
Nov 2022  
  Source   PDF   All Studies   Meta AnalysisMeta
Retrospective 1,940 outpatients in Thailand, showing lower risk of clinical deterioration with early vs. late favipiravir treatment.
Sitasuwan et al., 11 Nov 2022, retrospective, Thailand, peer-reviewed, mean age 42.1, 23 authors, study period July 2021 - November 2021. Contact:
This PaperFavipiravirAll
Early antiviral and supervisory dexamethasone treatment improve clinical outcomes of nonsevere COVID-19 patients
MD a Tullaya Sitasuwan, MD, PhD a , Pochamana Phisalprapa, MD a , Weerachai Srivanichakorn, MD a , Chaiwat Washirasaksiri, MD a , Chonticha Auesomwang, MD a , Rungsima Tinmanee, MD a , Naruemit Sayabovorn, MD, PhD Methee Chayakulkeeree, MD b , Pakpoom Phoompoung, MD c , Korapat Mayurasakorn, PhD Nitat Sookrung, MD, PhD Anchalee Tungtrongchitr, MD f , Rungsima Wanitphakdeedecha, MD g , Saipin Muangman, MD h , Sansnee Senawong, PhD Watip Tangjittipokin, MD i , Gornmigar Sanpawitayakul, BNS Diana Woradetsittichai, MD a , Pongpol Nimitpunya, Chayanis Kositamongkol, MD a , Visit Vamvanij Cherdchai Nopmaneejumruslers, Visit Vamvanij, MD k , Thanet Chaisathaphol
Medicine, doi:10.1097/md.0000000000031681
This study aimed to evaluate the efficacy of early antiviral treatment in preventing clinical deterioration in asymptomatic or mildly symptomatic severe acute respiratory syndrome coronavirus 2 infected (COVID-19) patients in home isolation and to share our experiences with the ambulatory management of nonsevere COVID-19 patients. This retrospective study included mild COVID-19 adult patients confirmed by real-time reverse transcription-polymerase chain reaction. They received care via an ambulatory management strategy between July 2021 and November 2021. Demographic data, clinical progression, and outcomes were collected. Both descriptive and inferential statistics were performed to illustrate the cohort's characteristic and outcomes of the study. Univariable and multivariable logistic regression models were employed to investigate the associations between clinical factors and disease progression. A total of 1940 patients in the Siriraj home isolation system met the inclusion criteria. Their mean age was 42.1 ± 14.9 years, with 14.2% older than 60 years, 54.3% female, and 7.1% with a body weight ≥ 90 kg. Only 115 patients (5.9%) had deterioration of clinical symptoms. Two-thirds of these could be managed at home by dexamethasone treatment under physician supervision; however, 38 of the 115 patients (2.0% of the study cohort) needed hospitalization. Early favipiravir outpatient treatment (≤ 5 days from onset of symptoms) in nonsevere COVID-19 patients was significantly associated with a lower rate of symptom deterioration than late favipiravir treatment (50 [4.6%] vs 65 [7.5%] patients, respectively; P = .008; odds ratio 1.669; 95% confidence interval, 1.141-2.441). The unfavorable prognostic factors for symptom deterioration were advanced age, body weight ≥ 90 kg, unvaccinated status, higher reverse transcription-polymerase chain reaction cycle threshold, and late favipiravir treatment. The early delivery of essential treatment, including antiviral and supervisory dexamethasone, to ambulatory nonsevere COVID-19 patients yielded favorable outcomes during the COVID-19 pandemic in Thailand. Abbreviations: ARI = acute respiratory infection, CI = confidence interval, COVID-19 = coronavirus disease 2019, IQR = interquartile range, OR = odds ratio, RT-PCR = reverse transcription-polymerase chain reaction, Si-home = Siriraj home isolation system.
Ayaz, Dizman, Metan, Out-patient management of patients with COVID-19 on home isolation, Infez Med
Baughman, Hirschberg, Lucas, Pandemic care through collaboration: lessons from a COVID-19 field hospital, J Am Med Dir Assoc
Cai, Yang, Liu, Experimental treatment with Favipiravir for COVID-19: an open-label control study, Engineering
Cdc, Team, Preliminary estimates of the prevalence of selected underlying health conditions among patients with Coronavirus disease 2019 -United States, February 12, MMWR Morb Mortal Wkly Rep
Chuah, Chow, Hor, Efficacy of early treatment with favipiravir on disease progression among high risk COVID-19 patients: a randomized, open-label clinical trial, Clin Infect Dis
Delang, Abdelnabi, Neyts, Favipiravir as a potential countermeasure against neglected and emerging RNA viruses, Antiviral Res
Doi, Hibino, Hase, A prospective, randomized, open-label trial of early versus late favipiravir therapy in hospitalized patients with COVID-19, Antimicrob Agents Chemother
Fujii, Ibe, Ishigo, Early favipiravir treatment was associated with early defervescence in non-severe COVID-19 patients, J Infect Chemother
Gallo Marin, Aghagoli, Lavine, Predictors of COVID-19 severity: a literature review, Rev Med Virol
Horby, Lim, Dexamethasone in hospitalized patients with Covid-19, N Engl J Med
Ivashchenko, Dmitriev, Vostokova, AVIFAVIR for treatment of patients with moderate Coronavirus disease 2019 (COVID-19): interim results of a phase II/III multicenter randomized clinical trial, Clin Infect Dis
Izzedine, Jhaveri, Perazella, COVID-19 therapeutic options for patients with kidney disease, Kidney Int
Kwok, Adam, Ho, Obesity: a critical risk factor in the COVID-19 pandemic, Clin Obes
Long, Chavez, Carius, Clinical update on COVID-19 for the emergency and critical care clinician: Medical management, Am J Emerg Med
Mccullough, Kelly, Ruocco, Pathophysiological basis and rationale for early outpatient treatment of SARS-CoV-2 (COVID-19) infection, Am J Med
Procter, Ross, Pickard, Clinical outcomes after early ambulatory multidrug therapy for high-risk SARS-CoV-2 (COVID-19) infection, Rev Cardiovasc Med
Rao, Manissero, Steele, A systematic review of the clinical utility of cycle threshold values in the context of COVID-19, Infect Dis Ther
Shinkai, Tsushima, Tanaka, Efficacy and safety of favipiravir in moderate COVID-19 pneumonia patients without oxygen therapy: a randomized, phase III clinical trial, Infect Dis Ther
Shiraki, Sato, Sakai, Antiviral therapy for COVID-19: derivation of optimal strategy based on past antiviral and favipiravir experiences, Pharmacol Therap
Udwadia, Singh, Barkate, Efficacy and safety of favipiravir, an oral RNA-dependent RNA polymerase inhibitor, in mild-to-moderate COVID-19: A randomized, comparative, open-label, multicenter, phase 3 clinical trial, Int J Infect Dis
Yu, Rohli, Yang, Impact of obesity on COVID-19 patients, J Diabetes Complications
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop