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J Antimicrob Chemother 2021; 76: 827–829
doi:10.1093/jac/dkaa477
Advance Access publication 21 November 2020
Hydroxychloroquine pre-exposure
prophylaxis for COVID-19 in healthcare
workers
~ afiel2,
Boris Revollo1, Cristian Tebe2, Judith Pen
3
1,4
Ignacio Blanco , Nuria Perez-Alvarez , Ruth Lopez5,
Laura Rodriguez6, Josep Ferrer7, Pilar Ricart8,
Enrique Moret9, Cristina Tural7, Anna Carreres10,
Videla1,11,
Joan Matllo5, Sebastia
1,12,13
and Josep M. Llibre1*
Bonaventura Clotet
1
Division of Infectious Diseases and FLS Foundation for Fighting
AIDS, Infectious Diseases and Promoting Health and Science,
University Hospital Germans Trias, Badalona, Spain; 2Biostatistics
Unit, Bellvitge Biomedical Research Institute (IDIBELL)/University
of Barcelona, L’Hospitalet de Llobregat, Barcelona, Spain;
3
de la Salut,
Metropolitana Nord Laboratory, Institut Catala
Badalona, Spain; 4Statistics and Operations Research
Department, Universitat Politècnica de Catalunya-Barcelona
Tech, Barcelona, Spain; 5Occupational Risk Prevention Unit,
University Hospital Germans Trias, Badalona, Spain; 6Pulmonary
Medicine, University Hospital Germans Trias, Badalona, Spain;
7
Internal Medicine Department, University Hospital Germans
Trias, Badalona, Spain; 8Intensive Care Unit Division, University
Hospital Germans Trias, Badalona, Spain; 9Anaesthesiology
Department, University Hospital Germans Trias, Badalona, Spain;
10
Emergency Department, University Hospital Germans Trias,
Badalona, Spain; 11Clinical Research Support Unit, Clinical
Pharmacology Department, Bellvitge University Hospital/Bellvitge
Biomedical Research Institute (IDIBELL)/University of Barcelona,
*Corresponding author. E-mail: jmllibre@flsida.org
Sir,
Healthcare workers (HCWs) are a high-risk population for SARSCoV-2 infection and account for at least 11% of reported cases.1,2
We performed an observational cross-sectional case-control
study to evaluate the efficacy of hydroxychloroquine pre-exposure
prophylaxis (PrEP) among hospital HCWs.
All HCWs (of all categories) who worked in the COVID-19 frontline wards of University Hospital Germans Trias (Badalona, Spain)
were invited to participate. There was no protocol in the institution
recommending hydroxychloroquine PrEP. The dose used by HCWs
was 400 mg twice daily on the first day and 200 mg twice daily for
an additional 4 days, with a maintenance dosing of 200 mg weekly
thereafter.
HCWs were classified as having high-risk occupational exposure
if they worked in hospital-based COVID-19 wards, moderate-risk
occupational exposure if they had direct contact with admitted
patients, but not in COVID-19 wards, and low-risk occupational
exposure if they had occasional contact with hospitalized patients.
Reverse real-time PCR was performed for nasopharyngeal
swabs of all HCWs with symptoms or suspicion of COVID-19.
A screening of SARS-CoV-2 serology of all hospital HCWs was
performed when the epidemic reached its end (late May 2020).
The study..
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