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Favipiravir pharmacokinetics in Thai adults with mild COVID‐19: A sub‐study of interpatient variability and ethnic differences in exposure

Prasanchaimontri et al., Pharmacology Research & Perspectives, doi:10.1002/prp2.1233
Nov 2024  
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Pharmacokinetic study of 8 Thai adults with mild COVID-19 showing higher favipiravir plasma concentrations compared to studies in other populations, suggesting regional/ethnic differences in pharmacokinetics. 7 of 8 adults achieved plasma concentrations above the EC90 in vitro target. Authors hypothesize that higher favipiravir doses may be needed in some populations to achieve therapeutic efficacy, and that suboptimal dosing may explain the failure of some clinical trials to demonstrate efficacy.
Potential risks of favipiravir include the creation of dangerous variants, and mutagenicity, carcinogenicity, teratogenicity, and embryotoxicity1-5.
Prasanchaimontri et al., 7 Nov 2024, Thailand, peer-reviewed, 11 authors. Contact: kulkanya.cho@mahidol.ac.th.
This PaperFavipiravirAll
Favipiravir pharmacokinetics in Thai adults with mild COVID‐19: A sub‐study of interpatient variability and ethnic differences in exposure
Ing‐orn Prasanchaimontri, Weerawat Manosuthi, Henry Pertinez, Andrew Owen, Suvimol Niyomnaitham, Rujipas Sirijatuphat, Lantharita Charoenpong, Tim R Cressey, Katherine Copeland, Phongpan Mokmued, Kulkanya Chokephaibulkit
Pharmacology Research & Perspectives, doi:10.1002/prp2.1233
This sub-study sought to characterize the pharmacokinetics (PK) of favipiravir (FPV) within Thai adults and quantitatively assess differences in exposure to those previously reported in other populations as a basis to understand putative differences in efficacy between studies conducted in different regions. It was nested within a prospective trial of adults with symptomatic COVID-19 infection without pneumonia receiving 1800 mg FPV twice-daily on day 1 and 800 mg twice-daily thereafter. Individual PK profiles were fitted with a one-compartment disposition model (firstorder absorption). Eight adults (seven female) with a median age of 39 years and BMI of 27.9 kg/m 2 were included. Seven adults achieved plasma concentrations above the EC 90 in vitro target (25 mg/L), with minimum-maximum concentrations decreasing with repeat dosing. The mean FPV apparent clearance observed in this study was
S U PP O RTI N G I N FO R M ATI O N Additional supporting information can be found online in the Supporting Information section at the end of this article.
References
Agrawal, Raju, Udwadia, Favipiravir: a new and emerging antiviral option in COVID-19, Med J Armed Forces India, doi:/10.1016/j.mjafi.2020.08.004
Anugulruengkitt, Teeraananchai, Chantasrisawad, Promsena, Jantarabenjakul et al., Clinical outcomes of pediatric COVID-19 in a tertiary care center in Bangkok, Thailand, IJID Reg
Arshad, Pertinez, Box, Prioritization of anti-SARS-Cov-2 drug repurposing opportunities based on plasma and target site concentrations derived from their established human pharmacokinetics, Clin Pharmacol Ther
Bergstrand, Hooker, Wallin, Mo, Predictioncorrected visual predictive checks for diagnosing nonlinear mixedeffects models, AAPS J
Chen, Chao, Lai, Clinical efficacy and safety of favipiravir in the treatment of COVID-19 patients, J Infect
Chiba, Kiso, Nakajima, Co-administration of favipiravir and the remdesivir metabolite GS-441524 effectively reduces SARS-CoV-2 replication in the lungs of the Syrian hamster model, MBio, doi:/10.1128/mbio.03044-21
Choy, Wong, Kaewpreedee, Remdesivir, lopinavir, emetine, and homoharringtonine inhibit SARS-CoV-2 replication in vitro, Antivir Res, doi:/10.1016/j.antiviral.2020.104786
Core, R: A Language and Environment for Statistical Computing
Doi, Hibino, Hase, A prospective, randomized, open-label trial of early versus late favipiravir therapy in hospitalized patients with COVID-19, Antimicrob Agents Chemother, doi:/10.1128/aac.01897-20
Driouich, Cochin, Lingas, Favipiravir antiviral efficacy against SARS-CoV-2 in a hamster model, Nat Commun
Du, Chen, Favipiravir: pharmacokinetics and concerns about clinical trials for 2019-nCoV infection, Clin Pharmacol Ther, doi:/10.1002/cpt.1844
Eroglu, Toprak, Overview of favipiravir and remdesivir treatment for COVID-19, Int J Pharm Sci Res, doi:/10.13040/ijpsr.0975-8232.12(4).1950-57
Ette, Williams, Population pharmacokinetics II: estimation methods, Ann Pharmacother
Furuta, Komeno, Nakamura, Favipiravir (T-705), a broad spectrum inhibitor of viral RNA polymerase, Proc Jpn Acad Ser B Phys Biol Sci, doi:/10.2183/pjab.93.027
Ghasemnejad-Berenji, Pashapour, Favipiravir and COVID-19: a simplified summary, Drug Res
Gowen, Sefing, Westover, Alterations in favipiravir (T-705) pharmacokinetics and biodistribution in a hamster model of viral hemorrhagic fever, Antivir Res, doi:/10.1016/j.antiviral.2015.07.003
Gulhan, Eryuksel, Idriz Oglu, Pharmacokinetic characterization of favipiravir in patients with COVID-19, Br J Clin Pharmacol, doi:/10.1111/bcp.15227
Hung, Ghula, Aziz, The efficacy and adverse effects of favipiravir on patients with COVID-19: a systematic review and meta-analysis of published clinical trials and observational studies, Int J Infect Dis
Irie, Nakagawa, Fujita, Pharmacokinetics of favipiravir in critically ill patients with COVID-19, Clin Transl Sci, doi:/10.1111/cts.12827
Irie, Nakagawa, Fujita, Population pharmacokinetics of favipiravir in patients with COVID-19, CPT Pharmacometrics Syst Pharmacol, doi:/10.1002/psp4.12685
Ison, Scheetz, Understanding the pharmacokinetics of favipiravir: implications for treatment of influenza and COVID-19, EBioMedicine, doi:/10.1016/j.ebiom.2020.103204
Jeon, Ko, Lee, Identification of antiviral drug candidates against SARS-CoV-2 from FDA-approved drugs, Antimicrob Agents Chemother
Joshi, Parkar, Ansari, Role of favipiravir in the treatment of COVID-19, Int J Infect Dis, doi:/10.1016/j.ijid.2020.10.069
Kaptein, Jacobs, Langendries, Favipiravir at high doses has potent antiviral activity in SARS-CoV-2-infected hamsters, whereas hydroxychloroquine lacks activity, Proc Natl Acad Sci, doi:/10.1073/pnas.2014441117
Kumari, Rawat, Saha, Pipeline pharmacological therapies in clinical trial for COVID-19 pandemic: a recent update, Curr Pharmacol Rep
Lou, Liu, Yao, Clinical outcomes and plasma concentrations of baloxavir marboxil and favipiravir in COVID-19 patients: an exploratory randomized, controlled trial, Eur J Pharm Sci, doi:/10.1016/j.ejps.2020.105631
Lowe, Brown, Chowdhury, Favipiravir, lopinavirritonavir, or combination therapy (FLARE): a randomised, double-blind, 2 × 2 factorial placebo-controlled trial of early antiviral therapy in COVID-19, PLoS Med, doi:/10.1371/journal.pmed.1004120
Mould, Upton, Basic concepts in population modeling, simulation, and model-based drug development, CPT Pharmacometrics Syst Pharmacol
Mould, Upton, Basic concepts in population modeling, simulation, and model-based drug development-part 2: introduction to pharmacokinetic modeling methods, CPT Pharmacometrics Syst Pharmacol
Nguyen, Guedj, Anglaret, Favipiravir pharmacokinetics in Ebola-infected patients of the JIKI trial reveals concentrations lower than targeted, PLoS Negl Trop Dis
Ozsurekci, Oygar, Gürlevik, Favipiravir use in children with COVID-19 and acute kidney injury: is it safe?, Pediatr Nephrol
Pertinez, Rajoli, Khoo, Owen, Pharmacokinetic modelling to estimate intracellular favipiravir ribofuranosyl-5′triphosphate exposure to support posology for SARS-CoV-2, J Antimicrob Chemother, doi:/10.1093/jac/dkab135
Pilkington, Pepperrell, Hill, A review of the safety of favipiravir-a potential treatment in the COVID-19 pandemic?, J Virus Erad, doi:/10.1016/s2055-6640(20)30016-9
Rattanaumpawan, Jirajariyavej, Lerdlamyong, Palavutitotai, Saiyarin, Real-world effectiveness and optimal dosage of favipiravir for treatment of COVID-19: results from a multicenter observational study in Thailand, Antibiotics
Seneviratne, Abeysuriya, De Mel, De Zoysa, Niloofa, Favipiravir in COVID-19, IJPSAT
Shah, Orton, Grinsztejn, Favipiravir in patients hospitalised with COVID-19 (PIONEER trial): a multicentre, open-label, phase 3, randomised controlled trial of early intervention versus standard care, Lancet Respir Med, doi:/10.1016/s2213-2600(22)00412-x
Shannon, Selisko, Le, Rapid incorporation of Favipiravir by the fast and permissive viral RNA polymerase complex results in SARS-CoV-2 lethal mutagenesis, Nat Commun
Sirijatuphat, Manosuthi, Niyomnaitham, Early treatment of Favipiravir in COVID-19 patients without pneumonia: a multicentre, open-labelled, randomized Control Study
Solaymani-Dodaran, Ghanei, Bagheri, Safety and efficacy of favipiravir in moderate to severe SARS-CoV-2 pneumonia, Int Immunopharmacol
Takahashi, Luzum, Nicol, Jacobson, Pharmacogenomics of COVID-19 therapies, NPJ Genom Med, doi:/10.1038/s41525-020-00143-y
Tuesuwan, Mueannoom, Jamnongtanachot, Basis to aid crisis: favipiravir oral solution for hospital compounding during COVID-19 drug shortage, J Pharm Sci
Tırmıkçıoğlu, Favipiravir exposure and pregnancy outcome of COVID-19 patients, Eur J Obstet Gynecol Reprod Biol
Wang, Cao, Zhang, Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro, Cell Res, doi:/10.1038/s41422-020-0282-0
Wang, Zhong, Salam, Phase 2a, open-label, dosemulti-center pharmacokinetic study of favipiravir (T-705) in combination with oseltamivir in patients with severe influenza, EBioMedicine, doi:/10.1016/j.ebiom.2020.103125
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Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
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