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All Studies   Meta Analysis       

A Phase 2 Randomized, Double Blinded, Placebo Controlled Study of Oral Camostat Mesilate Compared to Standard of Care in Subjects With Mild-Moderate COVID-19

Parsonnet et al., NCT04524663, COPS-2003, NCT04524663
May 2021  
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Progression -392% Improvement Relative Risk Recovery 35% Serious adverse events 86% Viral clearance 41% Camostat  COPS-2003  EARLY TREATMENT  DB RCT Is early treatment with camostat beneficial for COVID-19? Double-blind RCT 49 patients in the USA Higher progression (p=0.49) and improved recovery (p=0.24), not sig. c19early.org Parsonnet et al., NCT04524663, May 2021 Favorscamostat Favorscontrol 0 0.5 1 1.5 2+
RCT 49 outpatients in the USA, showing no significant differences with camostat treatment.
risk of progression, 392.0% higher, RR 4.92, p = 0.49, treatment 2 of 25 (8.0%), control 0 of 24 (0.0%), continuity correction due to zero event (with reciprocal of the contrasting arm).
risk of no recovery, 35.0% lower, HR 0.65, p = 0.24, treatment 25, control 24, Cox proportional hazards.
serious adverse events, 86.0% lower, RR 0.14, p = 0.11, treatment 0 of 25 (0.0%), control 3 of 24 (12.5%), NNT 8.0, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).
risk of no viral clearance, 40.8% lower, HR 0.59, p = 0.24, treatment 25, control 24, inverted to make HR<1 favor treatment, Cox proportional hazards.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Parsonnet et al., 15 May 2021, Double Blind Randomized Controlled Trial, placebo-controlled, USA, preprint, 1 author, trial NCT04524663 (history) (COPS-2003). Contact: parsonnt@stanford.edu.
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