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0 0.5 1 1.5 2+ Mortality 99% Improvement Relative Risk Vitamin D  Parra-Ortega et al.  Sufficiency Are vitamin D levels associated with COVID-19 outcomes? Prospective study of 94 patients in Mexico Lower mortality with higher vitamin D levels (p<0.000001) Parra-Ortega et al., Nutrition Researc.., Aug 2021 Favors vitamin D Favors control

25-Hydroxyvitamin D level is associated with mortality in patients with critical COVID-19: a prospective observational study in Mexico City

Parra-Ortega et al., Nutrition Research and Practice, doi:10.4162/nrp.2021.15.S1.S32
Aug 2021  
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Vitamin D for COVID-19
8th treatment shown to reduce risk in October 2020
*, now known with p < 0.00000000001 from 120 studies, recognized in 8 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,000+ studies for 60+ treatments.
Prospective study of 94 COVID-19 patients in Mexico, showing lower vitamin D levels associated with mortality in multivariate analysis. 84% of patients were vitamin D deficient, and the remaining 16% had insufficient vitamin D levels.
This is the 92nd of 196 COVID-19 sufficiency studies for vitamin D, which collectively show higher levels reduce risk with p<0.0000000001 (1 in 11,637 vigintillion).
This study is excluded in the after exclusion results of meta analysis: unadjusted results with no group details.
risk of death, 98.7% lower, RR 0.01, p < 0.001, high D levels (≥20ng/dL) 0 of 15 (0.0%), low D levels (<20ng/dL) 63 of 79 (79.7%), NNT 1.3, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm), unadjusted.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Parra-Ortega et al., 24 Aug 2021, prospective, Mexico, peer-reviewed, 9 authors.
This PaperVitamin DAll
25-Hydroxyvitamin D level is associated with mortality in patients with critical COVID-19: a prospective observational study in Mexico City
Israel Parra-Ortega, Diana Guadalupe Alcara-Ramírez, Alma Angélica Ronzon-Ronzon, Fermín Elías-García, José Agustín Mata-Chapol, Alejandro Daniel Cervantes-Cote, Briceida López-Martínez, Miguel Angel Villasis-Keever, Jessie Nallely Zurita-Cruz
Nutrition Research and Practice, doi:10.4162/nrp.2021.15.s1.s32
BACKGROUND/OBJECTIVES: Considering the high number of deaths from coronavirus disease 2019 in Latin American countries, together with multiple factors that increase the prevalence of vitamin D deficiency, we aimed to determine 25-hydroxyvitamin D (25[OH]D) levels and its association with mortality in patients with critical COVID-19. SUBJECTS/METHODS: This was a prospective observational study including adult patients with critical COVID-19. Data, including clinical characteristics and 25(OH)D levels measured at the time of intensive care unit admission, were collected. All patients were followed until hospital discharge or in-hospital death. The patients were divided into those surviving and deceased patient groups, and univariate and multivariate logistic regression analyses were performed to determine independent predictors of in hospital mortality. RESULTS: The entire cohort comprised 94 patients with critical COVID-19 (males, 59.6%; median age, 61.5 years). The median 25(OH)D level was 12.7 ng/mL, and 15 (16%) and 79 (84%) patients had vitamin D insufficiency and vitamin D deficiency, respectively. The median serum 25(OH)D level was significantly lower in deceased patients compared with surviving (12.1 vs. 18.7 ng/mL, P < 0.001). Vitamin D deficiency was present in 100% of the deceased patients. Multivariate logistic regression analysis revealed that age, body mass index, other risk factors, and 25(OH)D level were independent predictors of mortality. CONCLUSIONS: Vitamin D deficiency was present in 84% of critical COVID-19 patients. Serum 25(OH)D was independently associated with mortality in critical patients with COVID-19.
Conflict of Interest The authors declare no potential conflicts of interests. SUPPLEMENTARY MATERIAL Supplementary Material 1 Diagnosis of coronavirus disease 2019 (COVID-19) Click here to view
Acharya, Poudel, Bowers, Patel, Schultz et al., Low serum albumin predicts severe outcomes in COVID-19 infection: a single-center retrospective case-control study, J Clin Med Res, doi:10.14740/jocmr4507
Alguwaihes, Al-Sofiani, Megdad, Albader, Alsari et al., Diabetes and COVID-19 among hospitalized patients in Saudi Arabia: a single-centre retrospective study, Cardiovasc Diabetol, doi:10.1186/s12933-020-01184-4
Allegra, Tonacci, Pioggia, Musolino, Gangemi, Vitamin deficiency as risk factor for SARS-CoV-2 infection: correlation with susceptibility and prognosis, Eur Rev Med Pharmacol Sci, doi:10.26355/eurrev_202009_23064
Amrein, Scherkl, Hoffmann, Neuwersch-Sommeregger, Köstenberger et al., Vitamin D deficiency 2.0: an update on the current status worldwide, Eur J Clin Nutr, doi:10.1038/s41430-020-0558-y
Barlow, Svoboda, Mackellar, Nash, York et al., Antiviral activity and increased host defense against influenza infection elicited by the human cathelicidin LL-37, PLoS One, doi:10.1371/journal.pone.0025333
Brenner, Hearing, The protective role of melanin against UV damage in human skin, Photochem Photobiol
Brito, Cori, Olivares, Mujica, Cediel et al., Less than adequate vitamin D status and intake in Latin America and the Caribbean: a problem of unknown magnitude, Food Nutr Bull
Cano, Gajardo, Freundlich, Renin angiotensin axis, angiotensin converting enzyme 2 and coronavirus, Rev Chil Pediatr, doi:10.32641/rchped.v91i3.2548
Carrillo, Vega, Mf, García-Peña, Gutiérrez-Robledo et al., Vitamin D deficiency in older adults and its associated factors: a cross-sectional analysis of the Mexican Health and Aging Study, doi:10.1007/s11657-016-0297-9
Catanzaro, Fagiani, Racchi, Corsini, Govoni et al., Immune response in COVID-19: addressing a pharmacological challenge by targeting pathways triggered by SARS-CoV-2, Signal Transduct Target Ther, doi:10.1038/s41392-020-0191-1
Chang, Lee, Vitamin D and health -The missing vitamin in humans, Pediatr Neonatol, doi:10.1016/j.pedneo.2019.04.007
Contreras-Manzano, Villalpando, Robledo-Pérez, Vitamin D status by sociodemographic factors and body mass index in Mexican women at reproductive age, Salud Publica Mex, doi:10.21149/8080
Docherty, Harrison, Green, Hardwick, Pius et al., Features of 20 133 UK patients in hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: prospective observational cohort study, BMJ, doi:10.1136/bmj.m1985
Flores, Sánchez-Romero, Macías, Lozada, Díaz et al., Concentraciones séricas de vitamina D en niños, adolescentes y adultos mexicanos, Resultados de la ENSANUT
Grant, Lahore, Mcdonnell, Baggerly, French et al., Evidence that vitamin D supplementation could reduce risk of influenza and COVID-19 infections and deaths, Nutrients, doi:10.3390/nu12040988
Greiller, Martineau, Modulation of the immune response to respiratory viruses by vitamin D, Nutrients
Hansdottir, Monick, Hinde, Lovan, Look et al., Respiratory epithelial cells convert inactive vitamin D to its active form: potential effects on host defense, J Immunol, doi:10.4049/jimmunol.181.10.7090
Hewison, Antibacterial effects of vitamin D, Nat Rev Endocrinol, doi:10.1038/nrendo.2010.226
Hewison, Vitamin D and the immune system: new perspectives on an old theme, Endocrinol Metab Clin North Am, doi:10.1016/j.ecl.2010.02.010
Karahan, Katkat, Impact of serum 25(OH) vitamin D level on mortality in patients with COVID-19 in Turkey, J Nutr Health Aging, doi:10.1007/s12603-020-1479-0
Laird, Rhodes, Kenny, Vitamin D and inflammation: potential implications for severity of COVID-19, Ir Med
López-Feldman, Heres, Marquez-Padilla, Air pollution exposure and COVID-19: a look at mortality in Mexico City using individual-level data, Sci Total Environ, doi:10.1016/j.scitotenv.2020.143929
Martineau, Jolliffe, Hooper, Greenberg, Aloia et al., Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data, BMJ, doi:10.1136/bmj.i6583
Martínez-Zavala, López-Sánchez, Vergara-Lopez, Chávez-Tapia, Uribe et al., Vitamin D deficiency in Mexicans have a high prevalence: a cross-sectional analysis of the patients from the Centro Médico Nacional 20 de Noviembre, Arch Osteoporos, doi:10.1007/s11657-020-00765-w
Mendes, Hart, Botelho, Lanham-New, Sa, Vitamin D status in the tropics: is sunlight exposure the main determinant?, Nutr Bull, doi:10.1111/nbu.12349
Munshi, Hussein, Toraih, Elshazli, Jardak et al., Vitamin D insufficiency as a potential culprit in critical COVID-19 patients, J Med Virol, doi:10.1002/jmv.26360
Norval, Wulf, Does chronic sunscreen use reduce vitamin D production to insufficient levels?, Br J Dermatol
Palacios, Gonzalez, Is vitamin D deficiency a major global public health problem?, J Steroid Biochem Mol Biol, doi:10.1016/j.jsbmb.2013.11.003
Pubmed | Crossref, None, doi:10.1111/j.1365-2133.2009.09332.x
Pubmed | Crossref, None, doi:10.1111/j.1751-1097.2007.00226.x
Pubmed | Crossref, None, doi:10.3390/nu7064240
Rezende, Thome, Schveitzer, Souza-Júnior, Szwarcwald, Adults at high-risk of severe coronavirus disease-2019 (Covid-19) in Brazil, Rev Saude Publica, doi:10.11606/s1518-8787.2020054002596
Sassi, Tamone, Amelio, Vitamin D: Nutrient, Hormone, and Immunomodulator, Nutrients, doi:10.3390/nu10111656
Smet, Smet, Herroelen, Gryspeerdt, Martens, Serum 25(OH)D level on hospital admission associated with COVID-19 stage and mortality, Am J Clin Pathol, doi:10.1093/ajcp/aqaa252
Sørensen, Follin, Johnsen, Calafat, Tjabringa et al., Human cathelicidin, hCAP-18, is processed to the antimicrobial peptide LL-37 by extracellular cleavage with proteinase 3, Blood, doi:10.1182/blood.V97.12.3951
Vanherwegen, Gysemans, Mathieu, Regulation of immune function by vitamin D and its use in diseases of immunity, Endocrinol Metab Clin North Am, doi:10.1016/j.ecl.2017.07.010
Vassiliou, Jahaj, Pratikaki, Orfanos, Dimopoulou et al., Low 25-hydroxyvitamin D levels on admission to the intensive care unit may predispose COVID-19 pneumonia patients to a higher 28-day mortality risk: a pilot study on a Greek ICU cohort, Nutrients, doi:10.3390/nu12123773
Vranić, Mikolašević, Milić, Vitamin D deficiency: consequence or cause of obesity?, Medicina, doi:10.3390/medicina55090541
Wang, Li, Yin, Zhang, Olsen et al., Vitamin D and chronic diseases, Aging Dis, doi:10.14336/AD.2016.1021
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