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All Studies   Meta Analysis    Recent:   
0 0.5 1 1.5 2+ Mortality 99% Improvement Relative Risk Vitamin D  Parra-Ortega et al.  Sufficiency Are vitamin D levels associated with COVID-19 outcomes? Prospective study of 94 patients in Mexico Lower mortality with higher vitamin D levels (p<0.000001) c19early.org Parra-Ortega et al., Nutrition Researc.., Aug 2021 Favors vitamin D Favors control

25-Hydroxyvitamin D level is associated with mortality in patients with critical COVID-19: a prospective observational study in Mexico City

Parra-Ortega et al., Nutrition Research and Practice, doi:10.4162/nrp.2021.15.S1.S32
Aug 2021  
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Vitamin D for COVID-19
8th treatment shown to reduce risk in October 2020
 
*, now known with p < 0.00000000001 from 120 studies, recognized in 8 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,000+ studies for 60+ treatments. c19early.org
Prospective study of 94 COVID-19 patients in Mexico, showing lower vitamin D levels associated with mortality in multivariate analysis. 84% of patients were vitamin D deficient, and the remaining 16% had insufficient vitamin D levels.
This is the 92nd of 196 COVID-19 sufficiency studies for vitamin D, which collectively show higher levels reduce risk with p<0.0000000001 (1 in 11,637 vigintillion).
This study is excluded in the after exclusion results of meta analysis: unadjusted results with no group details.
risk of death, 98.7% lower, RR 0.01, p < 0.001, high D levels (≥20ng/dL) 0 of 15 (0.0%), low D levels (<20ng/dL) 63 of 79 (79.7%), NNT 1.3, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm), unadjusted.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Parra-Ortega et al., 24 Aug 2021, prospective, Mexico, peer-reviewed, 9 authors.
This PaperVitamin DAll
25-Hydroxyvitamin D level is associated with mortality in patients with critical COVID-19: a prospective observational study in Mexico City
Israel Parra-Ortega, Diana Guadalupe Alcara-Ramírez, Alma Angélica Ronzon-Ronzon, Fermín Elías-García, José Agustín Mata-Chapol, Alejandro Daniel Cervantes-Cote, Briceida López-Martínez, Miguel Angel Villasis-Keever, Jessie Nallely Zurita-Cruz
Nutrition Research and Practice, doi:10.4162/nrp.2021.15.s1.s32
BACKGROUND/OBJECTIVES: Considering the high number of deaths from coronavirus disease 2019 in Latin American countries, together with multiple factors that increase the prevalence of vitamin D deficiency, we aimed to determine 25-hydroxyvitamin D (25[OH]D) levels and its association with mortality in patients with critical COVID-19. SUBJECTS/METHODS: This was a prospective observational study including adult patients with critical COVID-19. Data, including clinical characteristics and 25(OH)D levels measured at the time of intensive care unit admission, were collected. All patients were followed until hospital discharge or in-hospital death. The patients were divided into those surviving and deceased patient groups, and univariate and multivariate logistic regression analyses were performed to determine independent predictors of in hospital mortality. RESULTS: The entire cohort comprised 94 patients with critical COVID-19 (males, 59.6%; median age, 61.5 years). The median 25(OH)D level was 12.7 ng/mL, and 15 (16%) and 79 (84%) patients had vitamin D insufficiency and vitamin D deficiency, respectively. The median serum 25(OH)D level was significantly lower in deceased patients compared with surviving (12.1 vs. 18.7 ng/mL, P < 0.001). Vitamin D deficiency was present in 100% of the deceased patients. Multivariate logistic regression analysis revealed that age, body mass index, other risk factors, and 25(OH)D level were independent predictors of mortality. CONCLUSIONS: Vitamin D deficiency was present in 84% of critical COVID-19 patients. Serum 25(OH)D was independently associated with mortality in critical patients with COVID-19.
Conflict of Interest The authors declare no potential conflicts of interests. SUPPLEMENTARY MATERIAL Supplementary Material 1 Diagnosis of coronavirus disease 2019 (COVID-19) Click here to view
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