Effect of Androgen Suppression on Clinical Outcomes in Hospitalized Men With COVID-19
MD Nicholas G Nickols, PhD Zhibao Mi, PhD Ellen Dematt, Kousick Biswas, PharmD; Christina E Clise, MD John T Huggins, MD Spyridoula Maraka, MD Elena Ambrogini, PhD Mehdi S Mirsaeidi, MD, MPH Ellis R Levin, MD Daniel J Becker, MD, MPH Danil V Makarov, Victor Adorno Febles, MD Pooja M Belligund, MD Mohammad Al-Ajam, MD Muthiah P Muthiah, MD Robert B Montgomery, MD Kyle W Robinson, MD; Yu-Ning Wong, MSCE Roger J Bedimo, MD Reina C Villareal, MD; Samuel M Aguayo, MD Martin W Schoen, MD, MPH Matthew B Goetz, MD Christopher J Graber, MD Debika Bhattacharya, Guy Soo Hoo, MD Greg Orshansky, MSW Leslie E Norman, BS Samantha Tran, BA Leila Ghayouri, AA Sonny Tsai, MPAS Michelle Geelhoed, MD Mathew B Rettig
JAMA Network Open, doi:10.1001/jamanetworkopen.2022.7852
IMPORTANCE SARS-CoV-2 entry requires the TMPRSS2 cell surface protease. Antiandrogen therapies reduce expression of TMPRSS2. OBJECTIVE To determine if temporary androgen suppression induced by degarelix improves clinical outcomes of inpatients hospitalized with COVID-19. DESIGN, SETTING, AND PARTICIPANTS The Hormonal Intervention for the Treatment in Veterans With COVID-19 Requiring Hospitalization (HITCH) phase 2, placebo-controlled, double-blind, randomized clinical trial compared efficacy of degarelix plus standard care vs placebo plus standard care on clinical outcomes in men hospitalized with COVID-19 but not requiring invasive mechanical ventilation. Inpatients were enrolled at 14 Department of Veterans Affairs hospitals from July 22,
Conflict of Interest Disclosures: Dr Nickols reported receiving grants from Lantheus, Bayer, and Janssen and personal fees from Oncolinea outside the submitted work. Dr Wong reported receiving grants from the Prostate Cancer Foundation during the conduct of the study. Dr Bedimo reported receiving grants from Merck and ViiV Healthcare and personal fees from Merck, ViiV Healthcare, Janssen, Gilead Sciences, and Theratechnologies outside the submitted work. Dr Rettig reported receiving grants from Johnson & Johnson, Bayer, and Pfizer and
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