Association Between Serum Zinc Concentration Levels And Severity Of Coronavirus Disease 2019 (Covid-19) In Japanese Inpatients
Naomi Matsumoto, Hirohide Yokokawa, Hirotake Mori, Makoto Hiki, Yoko Tabe, Kazuhisa Takahashi, Toshio Naito
International Journal of General Medicine, doi:10.2147/ijgm.s476578
Background: It has been reported that zinc deficiency is related to severe inflammatory conditions especially those of respiratory diseases. However, studies that have examined the association between the serum zinc concentration and the severity of coronavirus disease 2019 (COVID-19) are still limited. The aim of this study was to assess that association in Japanese inpatients with COVID-19. Methods: This cross-sectional study, conducted from April 2020 to August 2021, included 467 eligible adult inpatients with COVID-19 whose serum zinc concentration was measured. Serum zinc concentration categories were defined as deficiency (< 60 μg/dL), marginal deficiency (≥ 60 to < 80 μg/dL), and normal (≥ 80 μg/dL). Multivariate logistic regression was used to assess the association between serum zinc deficiency and severe COVID-19. Serum zinc concentration levels were compared between mild and other severities of COVID-19 by Dunnett's method. The P for trend was estimated using the Jonckheere-Terpstra test.
Results: The proportions of subjects with serum zinc deficiency (< 60 μg/dL) and marginal zinc deficiency (≥ 60 to < 80 μg/dL) were 39.5% and 54.3% in women, and 36.4% and 57.0% in men, respectively. Serum zinc deficiency was significantly associated with severe COVID-19 compared to marginal deficiency and normal (odds ratio = 3.60, 95% confidence interval = 1.60-8.13, P < 0.01) after adjusting for confounders. An increase in severity of COVID-19 was inversely related to increases in serum zinc concentration levels (P < 0.01 for trend). Each serum zinc concentration of moderate and severe cases was also significantly lower compared with mild cases (P < 0.01).
Conclusion: The severity of COVID-19 was significantly related to serum zinc concentration levels. These results suggest the importance of considering the serum zinc concentration when treating patients with COVID-19.
Ethics Approval and Informed Consent The Ethics Committee of Juntendo University approved using retrospective data for research related with COVID-19 (No H20-0036). In addition, the Ethics Committee of Juntendo University reviewed and approved the research protocol of the study using retrospective data (No E21-0039). Informed consent was obtained in the form of opt-out on the website according to guidelines of the Ethics Committee of Juntendo University. This survey was conducted in compliance with the Ethical Guidelines for Epidemiological Studies established by the Japanese Government and in accordance with the Declaration of Helsinki of 1975 (revised in 2000).
Author Contributions All authors made a significant contribution to the work reported, whether that is in the conception, study design, execution, acquisition of data, analysis and interpretation, or in all these areas; took part in drafting, revising or critically reviewing the article; gave final approval of the version to be published; have agreed on the journal to which the article has been submitted; and agree to be accountable for all aspects of the work.
Disclosure HY and TN are supervisors of Nobelpharma Co., Ltd (Tokyo, Japan). The other authors have declared that no conflict of interest exists.
International Journal of General Medicine
Dovepress
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