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All Studies   Meta Analysis    Recent:   
0 0.5 1 1.5 2+ Case 7% Improvement Relative Risk Spironolactone  MacFadden et al.  Prophylaxis Does spironolactone reduce COVID-19 infections? Retrospective study in Canada (January - December 2020) Fewer cases with spironolactone (p=0.0082) c19early.org MacFadden et al., Open Forum Infectiou.., Mar 2022 Favors spironolactone Favors control

Screening Large Population Health Databases for Potential COVID-19 Therapeutics: A Pharmacopeia-Wide Association Study (PWAS) of Commonly Prescribed Medications

MacFadden et al., Open Forum Infectious Diseases, doi:10.1093/ofid/ofac156
Mar 2022  
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33rd treatment shown to reduce risk in February 2022
 
*, now known with p = 0.00046 from 12 studies.
Lower risk for mortality, progression, and recovery.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
3,800+ studies for 60+ treatments. c19early.org
Retrospective 26,121 cases and 2,369,020 controls ≥65yo in Canada, showing lower cases with chronic use of spironolactone.
Study covers HCQ, metformin, famotidine, spironolactone, vitamin B9, acetaminophen, and fluvoxamine.
risk of case, 7.0% lower, OR 0.93, p = 0.008, RR approximated with OR.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
MacFadden et al., 29 Mar 2022, retrospective, Canada, peer-reviewed, 9 authors, study period 15 January, 2020 - 31 December, 2020. Contact: dmacfadden@toh.ca.
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