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All Studies   Meta Analysis    Recent:   

Screening Large Population Health Databases for Potential COVID-19 Therapeutics: A Pharmacopeia-Wide Association Study (PWAS) of Commonly Prescribed Medications

MacFadden et al., Open Forum Infectious Diseases, doi:10.1093/ofid/ofac156
Mar 2022  
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Case 14% Improvement Relative Risk Fluoxetine for COVID-19  MacFadden et al.  Prophylaxis Does fluoxetine reduce COVID-19 infections? Retrospective study in Canada (January - December 2020) Fewer cases with fluoxetine (p=0.015) c19early.org MacFadden et al., Open Forum Infectiou.., Mar 2022 Favorsfluoxetine Favorscontrol 0 0.5 1 1.5 2+
26th treatment shown to reduce risk in November 2021
 
*, now with p = 0.00014 from 21 studies, recognized in 3 countries.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,300+ studies for 77 treatments. c19early.org
Retrospective 26,121 cases and 2,369,020 controls ≥65yo in Canada, showing lower cases with chronic use of fluoxetine.
Study covers HCQ, metformin, famotidine, spironolactone, vitamin B9, acetaminophen, and fluvoxamine.
risk of case, 14.0% lower, OR 0.86, p = 0.02, RR approximated with OR.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
MacFadden et al., 29 Mar 2022, retrospective, Canada, peer-reviewed, 9 authors, study period 15 January, 2020 - 31 December, 2020. Contact: dmacfadden@toh.ca.
This PaperFluvoxamineAll
Screening Large Population Health Databases for Potential Coronavirus Disease 2019 Therapeutics: A Pharmacopeia-Wide Association Study of Commonly Prescribed Medications
MD, ScD Derek R Macfadden, Kevin Brown, Sarah A Buchan, Hannah Chung, Rob Kozak, Jeffrey C Kwong, Doug Manuel, Samira Mubareka, Nick Daneman
Open Forum Infectious Diseases, doi:10.1093/ofid/ofac156
Background. For both the current and future pandemics, there is a need for high-throughput drug screening methods to identify existing drugs with potential preventive and/or therapeutic activity. Epidemiologic studies could complement laboratory-focused efforts to identify possible therapeutic agents. Methods. We performed a pharmacopeia-wide association study (PWAS) to identify commonly prescribed medications and medication classes that are associated with the detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in older individuals (≥65 years) in long-term care homes (LTCHs) and the community, between 15 January 2020 and 31 December 2020, across the province of Ontario, Canada. Results. A total of 26 121 cases and 2 369 020 controls from LTCHs and the community were included in this analysis. Many of the drugs and drug classes evaluated did not yield significant associations with SARS-CoV-2 detection. However, some drugs and drug classes appeared to be significantly associated with reduced SARS-CoV-2 detection, including cardioprotective drug classes such as statins (weighted odds ratio [OR], 0.91; standard P < .01, adjusted P < .01) and β-blockers (weighted OR, 0.87; standard P < .01, adjusted P = .01), along with individual agents ranging from levetiracetam (weighted OR, 0.70; standard P < .01, adjusted P < .01) to fluoxetine (weighted OR, 0.86; standard P = .013, adjusted P = .198) to digoxin (weighted OR, 0.89; standard P < .01, adjusted P = .02). Conclusions. Using this epidemiologic approach, which can be applied to current and future pandemics, we have identified a variety of target drugs and drug classes that could offer therapeutic benefit in coronavirus disease 2019 (COVID-19) and may warrant further validation. Some of these agents (eg, fluoxetine) have already been identified for their therapeutic potential.
Supplementary Data Supplementary materials are available at Open Forum Infectious Diseases online. Consisting of data provided by the authors to benefit the reader, the posted materials are not copyedited and are the sole responsibility of the authors, so questions or comments should be addressed to the corresponding author. Disclaimer. The opinions, results, and conclusions reported in this article are those of the authors and are independent from the funding sources. No endorsement by ICES, the Ontario Ministry of Health (MOH), or the Ontario Ministry of Long-Term Care (MLTC) is intended or should be inferred. Notes Financial support. This work was supported by the COVID-19 Emergency Response Fund from The Ottawa Hospital. This study was also supported by ICES, which is funded by an annual grant from the MOH and MLTC. We thank IQVIA Solutions Canada Inc for use of their Drug Information Database. Potential conflicts of interest. All authors: No reported conflicts of interest. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed.
References
Absalon, Koury, Gruber, Safety and efficacy of the BNT162b2 mRNA Covid-19 vaccine. Reply, N Engl J Med
Austin, Daly, Tu, A multicenter study of the coding accuracy of hospital discharge administrative data for patients admitted to cardiac care units in Ontario, Am Heart J
Baden, Sahly, Essink, Efficacy and safety of the mRNA-1273 SARS-CoV-2 vaccine, N Engl J Med
Benjamini, Yekutieli, The control of the false discovery rate in multiple testing under dependency, Ann Stat
Berkowitz, Cené, Chatterjee, Covid-19 and health equity-time to think big, N Engl J Med
Charpiat, Bleyzac, Tod, Proton pump inhibitors are risk factors for viral infections: even for COVID-19?, Clin Drug Investig
Cho, Lee, Kim, Antiviral activity of digoxin and ouabain against SARS-CoV-2 infection and its implication for COVID-19, Sci Rep
Dibner, Direct COVID-19 infection of enterocytes: the role of hypochlorhydria, Am J Infect Control
Fauci, Lane, Redfield, Covid-19-navigating the uncharted, N Engl J Med
Fisman, Bogoch, Lapointe-Shaw, Mccready, Tuite, Risk factors associated with mortality among residents with coronavirus disease 2019 (COVID-19) in long-term care facilities in Ontario, Canada, JAMA Netw Open
Griffith, Morris, Tudball, Collider bias undermines our understanding of COVID-19 disease risk and severity, Nat Commun
Haas, Angulo, Mclaughlin, Impact and effectiveness of mRNA BNT162b2 vaccine against SARS-CoV-2 infections and COVID-19 cases, hospitalisations, and deaths following a nationwide vaccination campaign in Israel: an observational study using national surveillance data, Lancet
Hansen, Michlmayr, Gubbels, Mølbak, Ethelberg, Assessment of protection against reinfection with SARS-CoV-2 among 4 million PCR-tested individuals in Denmark in 2020: a population-level observational study, Lancet
Hippisley-Cox, Young, Coupland, Risk of severe COVID-19 disease with ACE inhibitors and angiotensin receptor blockers: cohort study including 8.3 million people, Heart
Horby, Lim, Group. Dexamethasone in hospitalized patients with Covid-19, N Engl J Med
Huang, Huang, Wang, 6-month consequences of COVID-19 in patients discharged from hospital: a cohort study, Lancet
Hux, Ivis, Flintoft, Bica, Diabetes in Ontario: determination of prevalence and incidence using a validated administrative data algorithm, Diabetes Care
Israel, Schäffer, Cicurel, Identification of drugs associated with reduced severity of COVID-19: a case-control study in a large population, Elife
Lenze, Mattar, Zorumski, Fluvoxamine vs placebo and clinical deterioration in outpatients with symptomatic COVID-19, JAMA
Lopes, Macedo, De Barros, Effect of discontinuing vs continuing angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers on days alive and out of the hospital in patients admitted with COVID-19: a randomized clinical trial, JAMA
Pan, Peto, Henao-Restrepo, WHO Solidarity Trial Consortium. Repurposed antiviral drugs for Covid-19-interim WHO Solidarity trial results, N Engl J Med
Pefoyo, Bronskill, Gruneir, The increasing burden and complexity of multimorbidity, BMC Public Health
Salama, Han, Yau, Tocilizumab in patients hospitalized with Covid-19 pneumonia, N Engl J Med
Schmidt, Wing, Mckeating, Maini, Cholesterol-modifying drugs in COVID-19, Oxf Open Immunol
Schultz, Rothwell, Chen, Tu, Identifying cases of congestive heart failure from administrative data: a validation study using primary care patient records, Chronic Dis Inj Can
Sen, Vardaxis, Lindqvist, Systematic assessment of prescribed medications and short-term risk of myocardial infarction-a pharmacopeia-wide association study from Norway and Sweden, Sci Rep
Sonnweber, Boehm, Sahanic, Persisting alterations of iron homeostasis in COVID-19 are associated with non-resolving lung pathologies and poor patients' performance: a prospective observational cohort study, Respir Res
Sundaram, Calzavara, Mishra, Individual and social determinants of SARS-CoV-2 testing and positivity in Ontario, Canada: a population-wide study, CMAJ
Tillett, Sevinsky, Hartley, Genomic evidence for reinfection with SARS-CoV-2: a case study, Lancet Infect Dis
Torjesen, Covid-19: Delta variant is now UK's most dominant strain and spreading through schools, BMJ
Tu, Campbell, Chen, Cauch-Dudek, Mcalister, Accuracy of administrative databases in identifying patients with hypertension, Open Med
Von Delft, Calmiano, Chodera, A white-knuckle ride of open COVID drug discovery, Nature
Widdifield, Bernatsky, Paterson, Accuracy of Canadian health administrative databases in identifying patients with rheumatoid arthritis: a validation study using the medical records of rheumatologists, Arthritis Care Res
Zhang, Kossmeier, Tran, Voracek, Zhang, Rainforest plots for the presentation of patient-subgroup analysis in clinical trials, Ann Transl Med
Zhao, Du, Duan, High-throughput screening identifies established drugs as SARS-CoV-2 PLpro inhibitors, Protein Cell
Zhao, Huang, Dai, Feng, Liu et al., Serum iron level as a potential predictor of coronavirus disease 2019 severity and mortality: a retrospective study, Open Forum Infect Dis
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