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All Studies   Meta Analysis    Recent:   

Assessing the therapeutic potential of angomelatine, ramelteon, and melatonin against SARS-Cov-2

Kumar Yadalam et al., Saudi Journal of Biological Sciences, doi:10.1016/j.sjbs.2022.01.049
Jan 2022  
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Melatonin for COVID-19
10th treatment shown to reduce risk in December 2020
 
*, now known with p = 0.0000002 from 18 studies.
Lower risk for mortality, ventilation, and recovery.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,200+ studies for 70+ treatments. c19early.org
In Silico study of melatonin, angomelatine, and ramelteon for SARS-CoV-2, predicting significant SARS-CoV-2 RBD and ACE2 binding with all three.
3 preclinical studies support the efficacy of melatonin for COVID-19:
Kumar Yadalam et al., 25 Jan 2022, peer-reviewed, 14 authors.
In Silico studies are an important part of preclinical research, however results may be very different in vivo.
This PaperMelatoninAll
Assessing the therapeutic potential of agomelatine, ramelteon, and melatonin against SARS-CoV-2
Thodur Pradeep Kumar Yadalam, Thodur Madapusi Balaji, Saranya Varadarajan, M.S Khalid J Alzahrani, Mohammad S Al-Ghamdi, Hosam Ali Baeshen, Mohammed Farhan A Alfarhan, Zohaib Khurshid, Shilpa Bhandi, Raghunathan Jagannathan, Vikrant R Patil, A Thirumal Raj, Jithendra Ratnayake, Shankargouda Patil
Saudi Journal of Biological Sciences, doi:10.1016/j.sjbs.2022.01.049
This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
Conflicts of Interest: The authors declare no conflict of interest.
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Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
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