Abstract: Journal Pre-proofs Original article Assessing the therapeutic potential of angomelatine, ramelteon, and melatonin against SARS-Cov-2 Pradeep Kumar Yadalam, Thodur Madapusi Balaji, Saranya Varadarajan, Khalid J Alzahrani, Mohammad S. Al-Ghamdi, Hosam Ali Baeshen, Mohammed Farhan A Alfarhan, Zohaib Khurshid, Shilpa Bhandi, Raghunathan Jagannathan, Vikrant R. Patil, A. Thirumal Raj, Jithendra Ratnayake, Shankargouda Patil PII: DOI: Reference: S1319-562X(22)00049-3 https://doi.org/10.1016/j.sjbs.2022.01.049 SJBS 3177 To appear in: Saudi Journal of Biological Sciences Received Date: Revised Date: Accepted Date: 19 December 2021 12 January 2022 20 January 2022 Please cite this article as: P. Kumar Yadalam, T. Madapusi Balaji, S. Varadarajan, K.J. Alzahrani, M.S. AlGhamdi, H. Ali Baeshen, M. Farhan A Alfarhan, Z. Khurshid, S. Bhandi, R. Jagannathan, V.R. Patil, A. Thirumal Raj, J. Ratnayake, S. Patil, Assessing the therapeutic potential of angomelatine, ramelteon, and melatonin against SARS-Cov-2, Saudi Journal of Biological Sciences (2022), doi: https://doi.org/10.1016/j.sjbs.2022.01.049 This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. © 2022 The Author(s). Published by Elsevier B.V. on behalf of King Saud University. Title page Title: Assessing the therapeutic potential of angomelatine, ramelteon, and melatonin against SARS-Cov-2 Running title: Angomelatine, ramelteon, and melatonin against SARS-Cov-2 Authors and affiliation: 1) Pradeep Kumar Yadalam Department of Periodontics, Saveetha Dental College and Hospital, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India. Mail id: pradeepkumar.sdc@saveetha.com 2) Thodur Madapusi Balaji Department of Periodontology, Tagore Dental College and Hospital, Chennai, India. Mail id: tmbala81@gmail.com 3) Saranya Varadarajan Department of Oral Pathology and Microbiology, Sri Venkateswara Dental College and Hospital, Chennai, India. Mail id: vsaranya87@gmail.com 4) Khalid J Alzahrani Department of Clinical Laboratories Sciences,College of Applied Medical Sciences, Taif University, Taif, Saudi Arabia. Mail id: ak.jamaan@tu.edu.sa 5) Mohammad S. Al-Ghamdi Department of Clinical Laboratories Sciences, College of Applied Medical Sciences, Taif University, Taif, Saudi Arabia. Mail id: abo_fares_@hotmail.com 6) Hosam Ali Baeshen Department of Orthodontics, Faculty of Dentistry, King Abdulaziz University, Jeddah, Saudi Arabia. Mail id: drbaeshen@me.com 7) Mohammed Farhan A Alfarhan Department of Surgery, College of Medicine, King Faisal University, Al-Ahsa, KSA. Mail id :malfarhan002@yahoo.com 8) Zohaib Khurshid Department of Prosthodontics and Dental Implantology, College of Dentistry, King Faisal University, Al- Ahsa, Saudi Arabia. Mail id: zsultan@kfu.edu.sa 9) Shilpa Bhandi Department of Restorative Dental Science, College of Dentistry, Jazan, University, Saudi Arabia. Mail id: shilpa.bhandi@gmail.com 10) Raghunathan Jagannathan Department of..