Efficacy of melatonin in non-intensive care unit patients with COVID-19 pneumonia and sleep dysregulation

{ 'indexed': {'date-parts': [[2023, 4, 19]], 'date-time': '2023-04-19T08:19:23Z', 'timestamp': 1681892363197}, 'reference-count': 0, 'publisher': 'ST Bio-life', 'issue': '1', 'license': [ { 'start': { 'date-parts': [[2021, 1, 1]], 'date-time': '2021-01-01T00:00:00Z', 'timestamp': 1609459200000}, 'content-version': 'unspecified', 'delay-in-days': 0, 'URL': 'http://creativecommons.org/licenses/by/4.0'}], 'content-domain': {'domain': [], 'crossmark-restriction': False}, 'abstract': '<jats:p>The association of sleep disruption with a higher vulnerability to&#x0D;\n' 'COVID-19 infection is a subject of major clinical importance. In patients with&#x0D;\n' 'pneumonia associated with COVID-19 admitted to non-intensive care unit (NICU) several&#x0D;\n' 'factors, like the disrupting influence of respiratory distress, medication, greater&#x0D;\n' 'stress due to social isolation, and lack of appropriate exposure to environmental&#x0D;\n' 'light can be instrumental to disrupt sleep/wake cycle. The&#x0D;\n' 'therapeutic potential of melatonin to counteract the consequences of COVID-19&#x0D;\n' 'infection has been advocated. Because of its wide-ranging effects as an&#x0D;\n' 'antioxidant, anti-inflammatory, and immunomodulatory compound, melatonin could&#x0D;\n' 'be unique in impairing the consequences of SARS-CoV-2 infection. Melatonin is&#x0D;\n' 'also an effective chronobiotic agent to reverse the circadian disruption of social&#x0D;\n' 'isolation and to control delirium in severely affected patients. Properly&#x0D;\n' 'administered, melatonin may restore the optimal circadian pattern of the&#x0D;\n' 'sleep-wake cycle and improve clinical condition in pneumonia associated with COVID-19&#x0D;\n' 'patients. The present review article discusses the importance of maintaining&#x0D;\n' 'normal sleep and circadian rhythmicity in NICU patients and provides&#x0D;\n' 'preliminary data suggesting the efficacy of melatonin (9 mg/day) to reduce&#x0D;\n' 'length of stay of pneumonia patients associated with COVID-19 in NICU. </jats:p>', 'DOI': '10.32794/mr11250089', 'type': 'journal-article', 'created': {'date-parts': [[2021, 1, 4]], 'date-time': '2021-01-04T02:01:11Z', 'timestamp': 1609725671000}, 'page': '173-188', 'source': 'Crossref', 'is-referenced-by-count': 5, 'title': 'Efficacy of melatonin in non-intensive care unit patients with COVID-19 pneumonia and sleep ' 'dysregulation', 'prefix': '10.32794', 'volume': '4', 'author': [ {'given': 'Luis I.', 'family': 'Brusco', 'sequence': 'first', 'affiliation': []}, {'given': 'Pablo', 'family': 'Cruz', 'sequence': 'first', 'affiliation': []}, {'given': 'Alicia V', 'family': 'Cangas', 'sequence': 'first', 'affiliation': []}, {'given': 'Carmen González', 'family': 'Rojas', 'sequence': 'first', 'affiliation': []}, {'given': 'Daniel E', 'family': 'Vigo', 'sequence': 'first', 'affiliation': []}, {'given': 'Daniel Pedro', 'family': 'Cardinali', 'sequence': 'first', 'affiliation': []}], 'member': '18079', 'published-online': {'date-parts': [[2021, 1, 1]]}, 'container-title': 'Melatonin Research', 'original-title': [], 'deposited': { 'date-parts': [[2021, 1, 4]], 'date-time': '2021-01-04T02:01:34Z', 'timestamp': 1609725694000}, 'score': 1, 'resource': {'primary': {'URL': 'https://www.melatonin-research.net/index.php/MR/article/view/125'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2021, 1, 1]]}, 'references-count': 0, 'journal-issue': {'issue': '1', 'published-online': {'date-parts': [[2021, 1, 3]]}}, 'URL': 'http://dx.doi.org/10.32794/mr11250089', 'relation': {}, 'ISSN': ['2641-0281'], 'subject': [], 'container-title-short': 'Melatonin Res.', 'published': {'date-parts': [[2021, 1, 1]]}}