Efficacy of melatonin in non-intensive care unit patients with COVID-19 pneumonia and sleep dysregulation

DOI record: { "DOI": "10.32794/mr11250089", "ISSN": [ "2641-0281" ], "URL": "http://dx.doi.org/10.32794/mr11250089", "abstract": "<jats:p>The association of sleep disruption with a higher vulnerability to&#x0D;\nCOVID-19 infection is a subject of major clinical importance. In patients with&#x0D;\npneumonia associated with COVID-19 admitted to non-intensive care unit (NICU) several&#x0D;\nfactors, like the disrupting influence of respiratory distress, medication, greater&#x0D;\nstress due to social isolation, and lack of appropriate exposure to environmental&#x0D;\nlight can be instrumental to disrupt sleep/wake cycle. The&#x0D;\ntherapeutic potential of melatonin to counteract the consequences of COVID-19&#x0D;\ninfection has been advocated. Because of its wide-ranging effects as an&#x0D;\nantioxidant, anti-inflammatory, and immunomodulatory compound, melatonin could&#x0D;\nbe unique in impairing the consequences of SARS-CoV-2 infection. Melatonin is&#x0D;\nalso an effective chronobiotic agent to reverse the circadian disruption of social&#x0D;\nisolation and to control delirium in severely affected patients. Properly&#x0D;\nadministered, melatonin may restore the optimal circadian pattern of the&#x0D;\nsleep-wake cycle and improve clinical condition in pneumonia associated with COVID-19&#x0D;\npatients. The present review article discusses the importance of maintaining&#x0D;\nnormal sleep and circadian rhythmicity in NICU patients and provides&#x0D;\npreliminary data suggesting the efficacy of melatonin (9 mg/day) to reduce&#x0D;\nlength of stay of pneumonia patients associated with COVID-19 in NICU. </jats:p>", "author": [ { "affiliation": [], "family": "Brusco", "given": "Luis I.", "sequence": "first" }, { "affiliation": [], "family": "Cruz", "given": "Pablo", "sequence": "first" }, { "affiliation": [], "family": "Cangas", "given": "Alicia V", "sequence": "first" }, { "affiliation": [], "family": "Rojas", "given": "Carmen González", "sequence": "first" }, { "affiliation": [], "family": "Vigo", "given": "Daniel E", "sequence": "first" }, { "affiliation": [], "family": "Cardinali", "given": "Daniel Pedro", "sequence": "first" } ], "container-title": "Melatonin Research", "container-title-short": "Melatonin Res.", "content-domain": { "crossmark-restriction": false, "domain": [] }, "created": { "date-parts": [ [ 2021, 1, 4 ] ], "date-time": "2021-01-04T02:01:11Z", "timestamp": 1609725671000 }, "deposited": { "date-parts": [ [ 2021, 1, 4 ] ], "date-time": "2021-01-04T02:01:34Z", "timestamp": 1609725694000 }, "indexed": { "date-parts": [ [ 2023, 4, 19 ] ], "date-time": "2023-04-19T08:19:23Z", "timestamp": 1681892363197 }, "is-referenced-by-count": 5, "issue": "1", "issued": { "date-parts": [ [ 2021, 1, 1 ] ] }, "journal-issue": { "issue": "1", "published-online": { "date-parts": [ [ 2021, 1, 3 ] ] } }, "license": [ { "URL": "http://creativecommons.org/licenses/by/4.0", "content-version": "unspecified", "delay-in-days": 0, "start": { "date-parts": [ [ 2021, 1, 1 ] ], "date-time": "2021-01-01T00:00:00Z", "timestamp": 1609459200000 } } ], "member": "18079", "original-title": [], "page": "173-188", "prefix": "10.32794", "published": { "date-parts": [ [ 2021, 1, 1 ] ] }, "published-online": { "date-parts": [ [ 2021, 1, 1 ] ] }, "publisher": "ST Bio-life", "reference-count": 0, "references-count": 0, "relation": {}, "resource": { "primary": { "URL": "https://www.melatonin-research.net/index.php/MR/article/view/125" } }, "score": 1, "short-title": [], "source": "Crossref", "subject": [], "subtitle": [], "title": "Efficacy of melatonin in non-intensive care unit patients with COVID-19 pneumonia and sleep dysregulation", "type": "journal-article", "volume": "4" }