Exploring autophagy in treating SARS-CoV-2 spike protein-related pathology
Matthew T J Halma, Paul E Marik, Yusuf M Saleeby
Endocrine and Metabolic Science, doi:10.1016/j.endmts.2024.100163
Fasting, a practice with historical roots in various cultures, has recently garnered significant interest in the field of medicine. In this article, we delve into the mechanisms underlying fasting-induced autophagy and its therapeutic applications for spike protein associated pathology. We explore the therapeutic potential of fasting on spike protein-related pathology and the role of interventions to upregulate autophagy, including compounds like spermidine, resveratrol, rapamycin, and metformin. In conclusion, fasting, coupled with an understanding of its nuances, holds promise as a therapeutic intervention for SARS-CoV-2 spike protein related diseases; with broad implications for human health. This review presents the therapeutic possibility of using autophagy to treat spike protein related diseases, and details the interventions to deploy this therapeutic modality.
Institutional review board statement Not applicable.
CRediT authorship contribution
Declaration of competing interest M.T.J.H. is a member of the World Council for Health, a non-profit health advocacy organization. P.E.M. is the founder of the Frontline Covid-19 Critical Care Alliance (FLCCC). Y.M.S. is the medical director for Carolina Holistic Medicine and a member of the FLCCC.
References
Abramczyk, Brozek-Pluska, Beton, Decoding COVID-19 mRNA Vaccine Immunometabolism in Central Nervous System: Human Brain Normal Glial and Glioma Cells by Raman Imaging
Adzigbli, Sokolov, Wimmers, Sokolova, Ponsuksili, Effects of hypoxia and reoxygenation on mitochondrial functions and transcriptional profiles of isolated brain and muscle porcine cells, Sci. Rep,
doi:10.1038/s41598-022-24386-0Ajaz, Mcphail, Singh, Mujib, Trovato et al., Mitochondrial metabolic manipulation by SARS-CoV-2 in peripheral blood mononuclear cells of patients with COVID-19, Am. J. Phys. Cell Phys,
doi:10.1152/ajpcell.00426.2020Alamdari, Moghaddam, Amini, Keramati, Zarmehri et al., Application of methylene blue -vitamin C-N-acetyl cysteine for treatment of critically ill COVID-19 patients, report of a phase-I clinical trial, Eur. J. Pharmacol,
doi:10.1016/j.ejphar.2020.173494Albosta, Bakke, Intermittent fasting: is there a role in the treatment of diabetes? A review of the literature and guide for primary care physicians, Clinical Diabetes and Endocrinology,
doi:10.1186/s40842-020-00116-1Alirezaei, Kemball, Flynn, Wood, Whitton et al., Shortterm fasting induces profound neuronal autophagy, Autophagy,
doi:10.4161/auto.6.6.12376Altay, Arif, Li, Yang, Aydın et al., Combined metabolic activators accelerates recovery in mild-to-moderate COVID-19, Adv. Sci,
doi:10.1002/advs.202101222Alturaiki, Alkadi, Alamri, Awadalla, Alfaez et al., Association between the expression of toll-like receptors, cytokines, and homeostatic chemokines in SARS-CoV-2 infection and COVID-19 severity, Heliyon,
doi:10.1016/j.heliyon.2022.e12653Anand, Kunnumakkara, Newman, Aggarwal, Bioavailability of curcumin: problems and promises, Mol. Pharm,
doi:10.1021/mp700113rAncona, Alagna, Alteri, Palomba, Tonizzo et al., Gut and airway microbiota dysbiosis and their role in COVID-19 and long-COVID, Front. Immunol
Anton, Moehl, Donahoo, Marosi, Lee et al., Flipping the metabolic switch: understanding and applying the health benefits of fasting, Obesity (Silver Spring),
doi:10.1002/oby.22065Aparicio-Trejo, Reyes-Fermín, Briones-Herrera, Tapia, León-Contreras et al., Protective effects of N-acetyl-cysteine in mitochondria bioenergetics, oxidative stress, dynamics and S-glutathionylation alterations in acute kidney damage induced by folic acid, Free Radic. Biol. Med,
doi:10.1016/j.freeradbiomed.2018.11.005Assimakopoulos, Aretha, Komninos, Dimitropoulou, Lagadinou et al., N-acetyl-cysteine reduces the risk for mechanical ventilation and mortality in patients with COVID-19 pneumonia: a two-center retrospective cohort study, Infect. Dis. Ther,
doi:10.1080/23744235.2021.1945675Atkuri, Mantovani, Herzenberg, Herzenberg, Nacetylcysteine-a safe antidote for cysteine/glutathione deficiency, Curr. Opin. Pharmacol,
doi:10.1016/j.coph.2007.04.005Avolio, Carrabba, Milligan, Kavanagh Williamson, Beltrami et al., The SARS-CoV-2 spike protein disrupts human cardiac pericytes function through CD147 receptor-mediated signalling: a potential non-infective mechanism of COVID-19 microvascular disease, Clin. Sci,
doi:10.1042/CS20210735Banerjee, Baidya, Adhikari, Ghosh, Jha, Glycyrrhizin as a promising kryptonite against SARS-CoV-2: clinical, experimental, and theoretical evidences, J. Mol. Struct,
doi:10.1016/j.molstruc.2022.134642Barbara, Clavario, De Marzo, Lotti, Guglielmi et al., Effects of exercise rehabilitation in patients with long coronavirus disease 2019, Eur. J. Prev. Cardiol,
doi:10.1093/eurjpc/zwac019Bauer, Laksono, Vrij, De, Kushner et al., The neuroinvasiveness, neurotropism, and neurovirulence of SARS-CoV-2, Trends Neurosci,
doi:10.1016/j.tins.2022.02.006Begum, Calaza, Kam, Salt, Hogg et al., Near-infrared light increases ATP, extends lifespan and improves mobility in aged drosophila melanogaster, Biol. Lett,
doi:10.1098/rsbl.2015.0073Bellavite, Ferraresi, Isidoro, Immune response and molecular mechanisms of cardiovascular adverse effects of spike proteins from SARS-CoV-2 and mRNA vaccines, Biomedicines,
doi:10.3390/biomedicines11020451Bertholet, Delerue, Millet, Moulis, David et al., Mitochondrial fusion/ fission dynamics in neurodegeneration and neuronal plasticity, Neurobiol. Dis,
doi:10.1016/j.nbd.2015.10.011Bettuzzi, Gabba, Cataldo, Efficacy of a polyphenolic, standardized green tea extract for the treatment of COVID-19 syndrome: a proof-of-principle study, COVID,
doi:10.3390/covid1010002Bhargavan, Kanmogne, SARS-CoV-2 spike proteins and cell-cell communication inhibits TFPI and induces thrombogenic factors in human lung microvascular endothelial cells and neutrophils: implications for COVID-19 coagulopathy pathogenesis, Int. J. Mol. Sci,
doi:10.3390/ijms231810436Block, Kuo, Rationale for nicotinamide adenine dinucleotide (NAD+) metabolome disruption as a pathogenic mechanism of post-acute COVID-19 syndrome, Clin Med Insights Pathol,
doi:10.1177/2632010X221106986Booth, Ruegsegger, Toedebusch, Yan, Chapter six -endurance exercise and the regulation of skeletal muscle metabolism, Progress in Molecular Biology and Translational Science, Molecular and Cellular Regulation of Adaptation to Exercise
Brasche, Bischof, Daily time spent indoors in German homesbaseline data for the assessment of indoor exposure of German occupants, Int. J. Hyg. Environ. Health,
doi:10.1016/j.ijheh.2005.03.003Buzhdygan, Deore, Baldwin-Leclair, Bullock, Mcgary et al., The SARS-CoV-2 spike protein alters barrier function in 2D static and 3D microfluidic in-vitro models of the human blood-brain barrier, Neurobiol. Dis,
doi:10.1016/j.nbd.2020.105131Camell, Yousefzadeh, Zhu, Prata, Huggins et al., Senolytics reduce coronavirus-related mortality in old mice, Science,
doi:10.1126/science.abe4832Cardinali, Brown, Pandi-Perumal, Possible application of melatonin in long COVID, Biomolecules,
doi:10.3390/biom12111646Carrubba, Veronese, Di Bella, Cusumano, Di Prazza et al., Prognostic value of magnesium in COVID-19: findings from the COMEPA study, Nutrients,
doi:10.3390/nu15040830Catenacci, Pan, Ostendorf, Brannon, Gozansky et al., A randomized pilot study comparing zero-calorie alternate-day fasting to daily caloric restriction in adults with obesity, Obesity
Cattadori, Di Marco, Baravelli, Picozzi, Ambrosio, Exercise training in post-COVID-19 patients: the need for a multifactorial protocol for a multifactorial pathophysiology, J. Clin. Med,
doi:10.3390/jcm11082228Changeux, Amoura, Rey, Miyara, A nicotinic hypothesis for Covid-19 with preventive and therapeutic implications, C. R. Biol,
doi:10.5802/crbiol.8Chatam, Chapnik, Froy, Resveratrol induces the fasting state and alters circadian metabolism in hepatocytes, Plant Foods Hum. Nutr,
doi:10.1007/s11130-022-00954-7Cheema, Sohail, Fatima, Shahid, Shahzil et al., Quercetin for the treatment of COVID-19 patients: a systematic review and meta-analysis, Rev. Med. Virol,
doi:10.1002/rmv.2427Chen, Mcgowan, Ren, Lal, Nassif et al., Nattokinase: a promising alternative in prevention and treatment of cardiovascular diseases, Biomark. Insights,
doi:10.1177/1177271918785130Chen, Yang, Wang, Huang, Yu et al., Melatonin ameliorates cognitive deficits through improving mitophagy in a mouse model of Alzheimer's disease, J. Pineal Res,
doi:10.1111/jpi.12774Chen, Zhao, Shu, Xing, Wang et al., Effect of resveratrol on intestinal tight junction proteins and the gut microbiome in high-fat diet-fed insulin resistant mice, Int. J. Food Sci. Nutr,
doi:10.1080/09637486.2020.1754351Cheng, Adams, Perin, Wei, Zhou et al., Prolonged fasting reduces IGF-1/ PKA to promote hematopoietic-stem-cell-based regeneration and reverse immunosuppression, Cell Stem Cell,
doi:10.1016/j.stem.2014.04.014Cheng, Chen, Sun, Ahmadian, Ardalan et al., Natural phytochemicals that affect autophagy in the treatment of oral diseases and infections: a review, Oxidative Med. Cell. Longev,
doi:10.1155/2021/4946711Cheng, Luo, Wang, Zhang, Wang et al., Kidney disease is associated with in-hospital death of patients with COVID-19, Kidney Int,
doi:10.1016/j.kint.2020.03.005Choi, Lee, Seo, Kim, Jeon et al., Myocarditis-induced sudden death after BNT162b2 mRNA COVID-19 vaccination in Korea: case report focusing on histopathological findings, J. Korean Med. Sci,
doi:10.3346/jkms.2021.36.e286Choi, Park, Jo, Kim, Koh, SARS-CoV-2 spike S1 subunit protein-mediated increase of beta-secretase 1 (BACE1) impairs human brain vessel cells, Biochem. Biophys. Res. Commun,
doi:10.1016/j.bbrc.2022.07.113Chowdhury, Richardson, Tsintzas, Thompson, Betts, Effect of extended morning fasting upon ad libitum lunch intake and associated metabolic and hormonal responses in obese adults, Int. J. Obes,
doi:10.1038/ijo.2015.154Chuang, Papp, Kuczmog, Eells, Condor Capcha et al., Methylene blue is a nonspecific protein-protein interaction inhibitor with potential for repurposing as an antiviral for COVID-19, Pharmaceuticals,
doi:10.3390/ph15050621Chung, Park, Lim, The effects of exercise and cold exposure on mitochondrial biogenesis in skeletal muscle and white adipose tissue, J. Exerc. Nutr. Biochem,
doi:10.20463/jenb.2017.0020Clifton, Ma, Fontana, Peterson, Intermittent fasting in the prevention and treatment of cancer, CA Cancer J. Clin,
doi:10.3322/caac.21694Clough, Inigo, Chandra, Chaves, Reynolds et al., Mitochondrial dynamics in SARS-COV2 spike protein treated human microglia: implications for neuro-COVID, J. NeuroImmune Pharmacol,
doi:10.1007/s11481-021-10015-6Cnubben, Rietjens, Wortelboer, Van Zanden, Van Bladeren, The interplay of glutathione-related processes in antioxidant defense, Environ. Toxicol. Pharmacol,
doi:10.1016/S1382-6689(01)00077-1Cohen, Native American medicine, Altern. Ther. Health Med
Cosentino, Marino, Understanding the pharmacology of COVID-19 mRNA vaccines: playing dice with the spike?, Int. J. Mol. Sci,
doi:10.3390/ijms231810881Coto-Montes, Boga, Rosales-Corral, Fuentes-Broto, Tan et al., Role of melatonin in the regulation of autophagy and mitophagy: a review, Mol. Cell. Endocrinol,
doi:10.1016/j.mce.2012.04.009Cuervo, Knecht, Terlecky, Dice, Activation of a selective pathway of lysosomal proteolysis in rat liver by prolonged starvation, Am. J. Phys. Cell Phys,
doi:10.1152/ajpcell.1995.269.5.C1200Dabholkar, Gorantla, Dubey, Alexander, Taliyan et al., Repurposing methylene blue in the management of COVID-19: mechanistic aspects and clinical investigations, Biomed. Pharmacother,
doi:10.1016/j.biopha.2021.112023Davidovich, Kearney, Martin, Inflammatory outcomes of apoptosis. necrosis and necroptosis, Biol Chem,
doi:10.1515/hsz-2014-0164Denaro, Haloush, Hsiao, Orgera, Osorio et al., COVID-19 and neurodegeneration: the mitochondrial connection, Aging Cell,
doi:10.1111/acel.13727Deore, Tran, Andrews, Ramirez, Galie, SARS-CoV-2 spike protein disrupts blood-brain barrier integrity via RhoA activation, J. NeuroImmune Pharmacol,
doi:10.1007/s11481-021-10029-0Devaux, Camoin-Jau, Molecular mimicry of the viral spike in the SARS-CoV-2 vaccine possibly triggers transient dysregulation of ACE2, leading to vascular and coagulation dysfunction similar to SARS-CoV-2 infection, Viruses,
doi:10.3390/v15051045Di, He, Zhao, Huang, Wu et al., Methylene blue reduces acute cerebral ischemic injury via the induction of mitophagy, Mol. Med,
doi:10.2119/molmed.2015.00038Domi, Hoxha, Kolovani, Tricarico, Zappacosta, The importance of nutraceuticals in COVID-19: what's the role of resveratrol?, Molecules,
doi:10.3390/molecules27082376Dusabimana, Kim, Kim, Park, Kim, Nobiletin ameliorates hepatic ischemia and reperfusion injury through the activation of SIRT-1/FOXO3amediated autophagy and mitochondrial biogenesis, Exp. Mol. Med,
doi:10.1038/s12276-019-0245-zDíaz-Resendiz, Benitez-Trinidad, Covantes-Rosales, Toledo-Ibarra, Ortiz-Lazareno et al., Loss of mitochondrial membrane potential (ΔΨm) in leucocytes as post-COVID-19 sequelae, J. Leukoc. Biol,
doi:10.1002/JLB.3MA0322-279RRRDíaz-Resendiz, Covantes-Rosales, Benítez-Trinidad, Navidad-Murrieta, Razura-Carmona et al., Effect of fucoidan on the mitochondrial membrane potential (ΔΨm) of leukocytes from patients with active COVID-19 and subjects that recovered from SARS-CoV-2 infection, Mar. Drugs,
doi:10.3390/md20020099Díez, Iglesias, García, Martín-Casasempere, Bernabéu-Andréu, Serum calcium, magnesium, and phosphorus levels in patients with COVID-19: relationships with poor outcome and mortality, Horm. Metab. Res,
doi:10.1055/a-1899-8862Dörre, Time-activity-patterns of some selected small groups as a basis for exposure estimation: a methodological study, J. Expo. Anal. Environ. Epidemiol
Falconer, Skouras, Carter, Greenway, Paisley, Preoperative fasting: current practice and areas for improvement, Updat. Surg,
doi:10.1007/s13304-013-0242-zFazel, Medical implications of controlled fasting, J. R. Soc. Med
Fernandes, Demetriades, The multifaceted role of nutrient sensing and mTORC1 signaling in physiology and aging, Frontiers in Aging
Fernández-Galilea, Pérez-Matute, Prieto-Hontoria, Houssier, Burrell et al., α-Lipoic acid treatment increases mitochondrial biogenesis and promotes beige adipose features in subcutaneous adipocytes from overweight/obese subjects, Biochim. Biophys. Acta,
doi:10.1016/j.bbalip.2014.12.013Ferraresi, Titone, Follo, Castiglioni, Chiorino et al., The protein restriction mimetic resveratrol is an autophagy inducer stronger than amino acid starvation in ovarian cancer cells, Mol. Carcinog,
doi:10.1002/mc.22711Ferrari, Bettuzzi, Naponelli, The potential of epigallocatechin Gallate (EGCG) in targeting autophagy for cancer treatment: a narrative review, Int. J. Mol. Sci,
doi:10.3390/ijms23116075Forbes-Hernández, Giampieri, Gasparrini, Mazzoni, Quiles et al., The effects of bioactive compounds from plant foods on mitochondrial function: a focus on apoptotic mechanisms, Food Chem. Toxicol,
doi:10.1016/j.fct.2014.03.017Forsyth, Zhang, Bhushan, Swanson, Zhang et al., The SARS-CoV-2 S1 spike protein promotes MAPK and NF-kB activation in human lung cells and inflammatory cytokine production in human lung and intestinal epithelial cells, Microorganisms,
doi:10.3390/microorganisms10101996Fuhrman, Sarter, Glaser, Acocella, Changing perceptions of hunger on a high nutrient density diet, Nutr. J,
doi:10.1186/1475-2891-9-51Fujita, Nomura, Hong, Ito, Asada et al., Purification and characterization of a strong fibrinolytic enzyme (nattokinase) in the vegetable cheese natto, a popular soybean fermented food in Japan, Biochem. Biophys. Res. Commun,
doi:10.1006/bbrc.1993.2624Furmli, Elmasry, Ramos, Fung, Therapeutic use of intermittent fasting for people with type 2 diabetes as an alternative to insulin, Case Reports,
doi:10.1136/bcr-2017-221854Galan-Acosta, Xia, Yuan, Vakifahmetoglu-Norberg, Activation of chaperone-mediated autophagy as a potential anticancer therapy, Autophagy,
doi:10.1080/15548627.2015.1106666Georgakopoulos, Wells, Campanella, The pharmacological regulation of cellular mitophagy, Nat. Chem. Biol,
doi:10.1038/nchembio.2287Giannos, Prokopidis, Gut dysbiosis and long COVID-19: feeling gutted, J. Med. Virol,
doi:10.1002/jmv.27684Gill, Tashjian, Duncanson, Autopsy histopathologic cardiac findings in 2 adolescents following the second COVID-19 vaccine dose, Arch. Pathol. Lab. Med,
doi:10.5858/arpa.2021-0435-SAGillman, CNS toxicity involving methylene blue: the exemplar for understanding and predicting drug interactions that precipitate serotonin toxicity, J. Psychopharmacol,
doi:10.1177/0269881109359098Godar, Ma, Liu, Murphy, Weinheimer et al., Repetitive stimulation of autophagy-lysosome machinery by intermittent fasting preconditions the myocardium to ischemia-reperfusion injury, Autophagy,
doi:10.1080/15548627.2015.1063768Gomaa, Abdel-Wadood, Gomaa, Glycyrrhizin and boswellic acids, the golden nutraceuticals: multitargeting for treatment of mild-moderate COVID-19 and prevention of post-COVID cognitive impairment, Inflammopharmacol,
doi:10.1007/s10787-022-01062-3Gomaa, Mohamed, Abd-Ellatief, Gomaa, Hammam, Advancing combination treatment with glycyrrhizin and boswellic acids for hospitalized patients with moderate COVID-19 infection: a randomized clinical trial, Inflammopharmacol,
doi:10.1007/s10787-022-00939-7Gomes, Rigolon, Souza, Da, Alvarez-Leite et al., Antiobesity effects of anthocyanins on mitochondrial biogenesis, inflammation, and oxidative stress: a systematic review, Nutrition,
doi:10.1016/j.nut.2019.05.005Grobbelaar, Venter, Vlok, Ngoepe, Laubscher et al., SARS-CoV-2 spike protein S1 induces fibrin(ogen) resistant to fibrinolysis: implications for microclot formation in COVID-19, Biosci. Rep,
doi:10.1042/BSR20210611Grundler, Mesnage, Cerrada, Wilhelmi De Toledo, Improvements during long-term fasting in patients with long COVIDa case series and literature review, Front. Nutr,
doi:10.3389/fnut.2023.1195270Grune, Jung, Merker, Davies, Decreased proteolysis caused by protein aggregates, inclusion bodies, plaques, lipofuscin, ceroid, and 'aggresomes' during oxidative stress, aging, and disease, Int. J. Biochem. Cell Biol,
doi:10.1016/j.biocel.2004.04.020Guerrero-Romero, Mercado, Rodriguez-Moran, Ramírez-Renteria, Martínez-Aguilar et al., Magnesium-tocalcium ratio and mortality from COVID-19, Nutrients,
doi:10.3390/nu14091686Guntur, Nemkov, De Boer, Mohning, Baraghoshi et al., Signatures of mitochondrial dysfunction and impaired fatty acid metabolism in plasma of patients with postacute sequelae of COVID-19 (PASC), Metabolites,
doi:10.3390/metabo12111026Guo, Luo, Ye, Yin, Fan et al., Intermittent fasting improves cardiometabolic risk factors and alters gut microbiota in metabolic syndrome patients, J. Clin. Endocrinol. Metab,
doi:10.1210/clinem/dgaa644Ha, Kim, Park, Jung, Choo et al., Structural modification of (-)-epigallocatechin gallate (EGCG) shows significant enhancement in mitochondrial biogenesis, J. Agric. Food Chem,
doi:10.1021/acs.jafc.8b00364Halajian, Leblanc, Gee, Colpitts, Activation of TLR4 by viral glycoproteins: a double-edged sword? Front, Microbiol
Halma, Rose, Lawrie, The novelty of mRNA viral vaccines and potential harms: a scoping review, J 2023a,
doi:10.3390/j6020017Hamidi-Alamdari, Hafizi-Lotfabadi, Bagheri-Moghaddam, Safari, Mozdourian et al., Methylene blue for treatment of hospitalized COVID-19 patients: a randomized, controlled, open-label clinical trial, phase 2, Rev. Investig. Clin,
doi:10.24875/ric.21000028Hamidie, Yamada, Ishizawa, Saito, Masuda, Curcumin treatment enhances the effect of exercise on mitochondrial biogenesis in skeletal muscle by increasing cAMP levels, Metab. Clin. Exp,
doi:10.1016/j.metabol.2015.07.010Hao, Shen, Yu, Jia, Li et al., Hydroxytyrosol promotes mitochondrial biogenesis and mitochondrial function in 3T3-L1 adipocytes, J. Nutr. Biochem,
doi:10.1016/j.jnutbio.2009.03.012Hartl, Bracher, Hayer-Hartl, Molecular chaperones in protein folding and proteostasis, Nature,
doi:10.1038/nature10317Harvie, Pegington, Mattson, Frystyk, Dillon et al., The effects of intermittent or continuous energy restriction on weight loss and metabolic disease risk markers: a randomized trial in young overweight women, Int. J. Obes
Harvie, Wright, Pegington, Mcmullan, Mitchell et al., The effect of intermittent energy and carbohydrate restriction v. daily energy restriction on weight loss and metabolic disease risk markers in overweight women, Br. J. Nutr
Hazell, Khazova, Cohen, Felton, Raj, Post-exposure persistence of nitric oxide upregulation in skin cells irradiated by UV-A, Sci. Rep,
doi:10.1038/s41598-022-13399-4He, Bassik, Moresi, Sun, Wei et al., Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis, Nature,
doi:10.1038/nature10758He, Xu, Li, Yang, Mao, Intermittent fasting and immunomodulatory effects: a systematic review, Frontiers in Nutrition
He-Ling, Hong-Yuan, Zhen-Xiang, Zhi, Yi-Fen et al., Electrical stimulation induces mitochondrial autophagy via activating oxidative stress and Sirt3 signaling pathway, Chin. Med. J,
doi:10.1097/CM9.0000000000001165Hemilä, De Man, Vitamin C and COVID-19, Front. Med
Henagan, Cefalu, Ribnicky, Noland, Dunville et al., In vivo effects of dietary quercetin and quercetin-rich red onion extract on skeletal muscle mitochondria, metabolism, and insulin sensitivity, Genes Nutr,
doi:10.1007/s12263-014-0451-1Henry, Summa, Patrick, Schwartz, A cohort of cancer patients with no reported cases of SARS-CoV-2 infection: the possible preventive role of methylene blue, Substantia,
doi:10.13128/Substantia-888Heo, Ordureau, Paulo, Rinehart, Harper, The PINK1-PARKIN mitochondrial ubiquitylation pathway drives a program of OPTN/NDP52 recruitment and TBK1 activation to promote mitophagy, Mol. Cell,
doi:10.1016/j.molcel.2015.08.016Hiramitsu, Shimada, Kuroyanagi, Inoue, Katagiri et al., Eriocitrin ameliorates diet-induced hepatic steatosis with activation of mitochondrial biogenesis, Sci. Rep,
doi:10.1038/srep03708Ho, Veldhuis, Johnson, Furlanetto, Evans et al., Fasting enhances growth hormone secretion and amplifies the complex rhythms of growth hormone secretion in man, J. Clin. Invest
Hoffman, Eating and fasting for god in Sufi tradition, J. Am. Acad. Relig
Holick, Chapter 4 -photobiology of vitamin D
Horne, May, Muhlestein, Le, Bair et al., Association of periodic fasting with lower severity of COVID-19 outcomes in the SARS-CoV-2 prevaccine era: an observational cohort from the INSPIRE Registry, BMJ Nutr Prev Health,
doi:10.1136/bmjnph-2022-000462Hsu, Lee, Wang, Lee, Chen, Amyloid-degrading ability of nattokinase from Bacillus subtilis natto, J. Agric. Food Chem,
doi:10.1021/jf803072rHsu, Wang, Reid, Veerati, Pathinayake et al., SARS-CoV-2 Spike Protein Promotes Hyper-inflammatory Response That Can Be Ameliorated by Spikeantagonistic Peptide and FDA-approved ER Stress and MAP Kinase Inhibitors in, Vitro
Hu, Li, Wang, Luo, Zhang et al., Tau accumulation impairs mitophagy via increasing mitochondrial membrane potential and reducing mitochondrial Parkin, Oncotarget,
doi:10.18632/oncotarget.7861Hu, Zhang, Peng, Ma, Han, Efficiency of nicotinamidebased supportive therapy in lymphopenia for patients with ordinary or severe COVID-19: a randomized controlled trial, Medicine,
doi:10.1097/MD.0000000000031138Huang, Chen, Xie, Yang, Shen, Nebivolol stimulates mitochondrial biogenesis in 3T3-L1 adipocytes, Biochem. Biophys. Res. Commun,
doi:10.1016/j.bbrc.2013.07.055Hubert, Weiss, Rees, Kain, Modulating chaperone-mediated autophagy and its clinical applications in cancer, Cells,
doi:10.3390/cells11162562Huynh, Rethi, Lee, Higa, Kao et al., Spike protein impairs mitochondrial function in human cardiomyocytes: mechanisms underlying cardiac injury in COVID-19, Cells,
doi:10.3390/cells12060877Hwang, Machek, Cardaci, Wilburn, Kim et al., Effects of pyrroloquinoline quinone (PQQ) supplementation on aerobic exercise performance and indices of mitochondrial biogenesis in untrained men, J. Am. Coll. Nutr,
doi:10.1080/07315724.2019.1705203Islam, Yamamoto, Mizoue, Tanaka, Oshiro et al., Association of impaired fasting glucose and diabetes with SARS-CoV-2 spike antibody titers after the BNT162b2 vaccine among health care workers in a tertiary hospital in Japan, Vaccines,
doi:10.3390/vaccines10050776Izzo, Trimarco, Mone, Aloè, Capra Marzani et al., Combining L-arginine with vitamin C improves long-COVID symptoms: the LINCOLN Survey, Pharmacol. Res,
doi:10.1016/j.phrs.2022.106360Jaimes-Gualdrón, Flórez-Álvarez, Zapata-Cardona, Rojano, Rugeles et al., Corozo (Bactris guineensis) fruit extract has antiviral activity in vitro against SARS-CoV-2, Functional Foods in Health and Disease
Jamshed, Beyl, Della Manna, Yang, Ravussin et al., Early time-restricted feeding improves 24-hour glucose levels and affects markers of the circadian clock, aging, and autophagy in humans, Nutrients,
doi:10.3390/nu11061234Jang, Kang, Hwang, Nicotinamide-induced mitophagy: event mediated by high NAD+/NADH ratio and SIRT1 protein activation, J. Biol. Chem,
doi:10.1074/jbc.M112.363747Jang, Kim, Cai, Kim, Kim et al., Nattokinase improves blood flow by inhibiting platelet aggregation and thrombus formation, Lab Anim Res,
doi:10.5625/lar.2013.29.4.221Jin, Lazarou, Wang, Kane, Narendra et al., Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL, J. Cell Biol,
doi:10.1083/jcb.201008084Josifovska, Albert, Nagymihály, Lytvynchuk, Moe et al., Resveratrol as inducer of autophagy, pro-survival, and anti-inflammatory stimuli in cultured human RPE cells, Int. J. Mol. Sci,
doi:10.3390/ijms21030813Kane, Lazarou, Fogel, Li, Yamano et al., PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity, J. Cell Biol,
doi:10.1083/jcb.201402104Kang, Hong, Lee, Melatonin enhances mitophagy and mitochondrial biogenesis in rats with carbon tetrachloride-induced liver fibrosis, J. Pineal Res,
doi:10.1111/jpi.12319Kato, Tanaka, Masuda, Ogasawara, Sakurai et al., Melatonin promotes adipogenesis and mitochondrial biogenesis in 3T3-L1 preadipocytes, J. Pineal Res,
doi:10.1111/jpi.12259Kauser, Rubanyi, Potential cellular signaling mechanisms mediating upregulation of endothelial nitric oxide production by estrogen, J. Vasc. Res,
doi:10.1159/000159227Kazlauskaite, Kondapalli, Gourlay, Campbell, Ritorto et al., Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65, Biochem. J,
doi:10.1042/BJ20140334Kc, Càrcamo, Golde, Vitamin C enters mitochondria via facilitative glucose transporter 1 (Gluti) and confers mitochondrial protection against oxidative injury, FASEB J,
doi:10.1096/fj.05-4107comKepp, Chen, Carmona-Gutierrez, Madeo, Kroemer, A discovery platform for the identification of caloric restriction mimetics with broad healthimproving effects, Autophagy,
doi:10.1080/15548627.2019.1688984Khalaji, Behnoush, Alilou, Rezaee, Peiman et al., Adjunctive therapy with lipid-lowering agents in COVID-19: a systematic review and meta-analysis of randomized controlled trials, Lipids Health Dis,
doi:10.1186/s12944-023-01828-wKhan, Shafiei, Longoria, Schoggins, Savani et al., SARS-CoV-2 spike protein induces inflammation via TLR2-dependent activation of the NF-κB pathway, Elife,
doi:10.7554/eLife.68563Kidd, Lancaster, Anderson, Boogert, Fisher et al., Fetal death after exposure to methylene blue dye during midtrimester amniocentesis in twin pregnancy, Nat. Cell Biol,
doi:10.1038/s41556-018-0205-1Kim, Jeon, Kim, Lee, Kim et al., Spike proteins of SARS-CoV-2 induce pathological changes in molecular delivery and metabolic function in the brain endothelial cells, Viruses,
doi:10.3390/v13102021Kim, Park, Park, Jung, Youn et al., De Candolle ethanolic extract inhibits adipogenic regulators in 3T3-L1 cells and induces mitochondrial biogenesis in primary brown preadipocytes, J. Agric. Food Chem,
doi:10.1021/acs.jafc.5b01908Kou, Li, Wu, Liu, Hu et al., Citrus tangeretin improves skeletal muscle mitochondrial biogenesis via activating the AMPK-PGC1-α pathway in vitro and in vivo: a possible mechanism for its beneficial effect on physical performance, J. Agric. Food Chem,
doi:10.1021/acs.jafc.8b04124Koyano, Okatsu, Kosako, Tamura, Go et al., Ubiquitin is phosphorylated by PINK1 to activate Parkin, Nature,
doi:10.1038/nature13392Kumar, Liu, Hsu, Chacko, Minard et al., Glycine and N-acetylcysteine (GlyNAC) supplementation in older adults improves glutathione deficiency, oxidative stress, mitochondrial dysfunction, inflammation, insulin resistance, endothelial dysfunction, genotoxicity, muscle strength, and cognition: results of a pilot clinical trial, Clin. Transl. Med,
doi:10.1002/ctm2.372Kurosawa, Nirengi, Homma, Esaki, Ohta et al., A single-dose of oral nattokinase potentiates thrombolysis and anti-coagulation profiles, Sci. Rep,
doi:10.1038/srep11601Lan, Lee, Chao, Chang, Lu et al., Efficacy of melatonin in the treatment of patients with COVID-19: a systematic review and meta-analysis of randomized controlled trials, J. Med. Virol,
doi:10.1002/jmv.27595Larsson, Hellstrand, Hammarström, Nyström, SARS-CoV-2 Spike Amyloid Fibrils Specifically and Selectively Accelerates Amyloid Fibril Formation of Human Prion Protein and the Amyloid β Peptide
Laufs, La Fata, Plutzky, Liao, Upregulation of endothelial nitric oxide synthase by HMG CoA reductase inhibitors, Circulation,
doi:10.1161/01.CIR.97.12.1129Leary, Shoubridge, Mitochondrial biogenesis: which part of "NO" do we understand?, BioEssays,
doi:10.1002/bies.10298Lee, Shin, Jung, Kim, Effects of epigallocatechin-3-gallate on thermogenesis and mitochondrial biogenesis in brown adipose tissues of dietinduced obese mice, Food Nutr,
doi:10.1080/16546628.2017.1325307Lei, Zhang, Schiavon, He, Chen et al., SARS-CoV-2 spike protein impairs endothelial function via downregulation of ACE 2, Circ. Res,
doi:10.1161/CIRCRESAHA.121.318902Lescat, Véron, Mourot, Péron, Chenais et al., Chaperone-mediated autophagy in the light of evolution: insight from fish, Mol. Biol. Evol,
doi:10.1093/molbev/msaa127Lettieri-Barbato, Cannata, Casagrande, Ciriolo, Aquilano, Time-controlled fasting prevents aging-like mitochondrial changes induced by persistent dietary fat overload in skeletal muscle, PLoS One,
doi:10.1371/journal.pone.0195912Levine, Klionsky, Autophagy wins the 2016 Nobel prize in physiology or medicine: breakthroughs in baker's yeast fuel advances in biomedical research, Proc. Natl. Acad. Sci. U. S. A,
doi:10.1073/pnas.1619876114Lewis Luján, Mccarty, Di Nicolantonio, Gálvez Ruiz, Rosas-Burgos et al., Nutraceuticals/ drugs promoting mitophagy and mitochondrial biogenesis may combat the mitochondrial dysfunction driving progression of dry age-related macular degeneration, Nutrients,
doi:10.3390/nu14091985Li, Hou, Ma, Wang, Wang et al., SARS-CoV-2 ORF10 suppresses the antiviral innate immune response by degrading MAVS through mitophagy, Cell. Mol. Immunol,
doi:10.1038/s41423-021-00807-4Li, Li, Wang, Yang, Huang et al., SARS-CoV-2 spike promotes inflammation and apoptosis through autophagy by ROS-suppressed PI3K/AKT/mTOR signaling, Biochim. Biophys. Acta (BBA) -Mol. Basis Dis,
doi:10.1016/j.bbadis.2021.166260Li, Ou, Wei, Shang, Carnitine and COVID-19 susceptibility and severity: a Mendelian randomization study, Frontiers. Nutrition
Liang, Bao, Yang, Liu, Sun et al., SARS-CoV-2 spike protein induces IL-18-mediated cardiopulmonary inflammation via reduced mitophagy, Sig Transduct Target Ther,
doi:10.1038/s41392-023-01368-wLin, Fu, Tsai, Cheng, Weng, Natural compounds from herbs that can potentially execute as autophagy inducers for cancer therapy, Int. J. Mol. Sci,
doi:10.3390/ijms18071412Lin, More than a key-the pathological roles of SARS-CoV-2 spike protein in COVID-19 related cardiac injury, Sports Medicine and Health Science,
doi:10.1016/j.smhs.2023.03.004Lindqvist, Epstein, Nielsen, Landin-Olsson, Ingvar et al., Avoidance of Sun exposure as a risk factor for major causes of death: a competing risk analysis of the melanoma in southern Sweden cohort, J. Intern. Med,
doi:10.1111/joim.12496Lyamzaev, Tokarchuk, Panteleeva, Mulkidjanian, Skulachev et al., Induction of autophagy by depolarization of mitochondria, Autophagy,
doi:10.1080/15548627.2018.1436937Mahale, Godavarthy, Marreddy, Gokhale, Funde et al., Intravenous methylene blue as a rescue therapy in the management of refractory hypoxia in COVID-19 ARDS patients: a case series, Indian J Crit Care Med,
doi:10.5005/jp-journals-10071-23905Mao, Jin, Wang, Hu, Chen et al., Neurologic manifestations of hospitalized patients with coronavirus disease 2019 in Wuhan. China, JAMA Neurol,
doi:10.1001/jamaneurol.2020.1127Martin, Mattson, Maudsley, Caloric restriction and intermittent fasting: two potential diets for successful brain aging, Ageing Res. Rev,
doi:10.1016/j.arr.2006.04.002Martin-Rincon, Morales-Alamo, Calbet, Exercise-mediated modulation of autophagy in skeletal muscle, Scand. J. Med. Sci. Sports,
doi:10.1111/sms.12945Martinez-Lopez, Tarabra, Toledo, Garcia-Macia, Sahu et al., Systemwide benefits of intermeal fasting by autophagy, Cell Metab,
doi:10.1016/j.cmet.2017.09.020Mattson, Wan, Beneficial effects of intermittent fasting and caloric restriction on the cardiovascular and cerebrovascular systems, J. Nutr. Biochem,
doi:10.1016/j.jnutbio.2004.12.007Mccreary, Schnell, Rhoda, Randomized double-blind placebocontrolled proof-of-concept trial of resveratrol for outpatient treatment of mild coronavirus disease (COVID-19), Sci. Rep,
doi:10.1038/s41598-022-13920-9Mikirova, Casciari, Rogers, Taylor, Effect of high-dose intravenous vitamin C on inflammation in cancer patients, J. Transl. Med,
doi:10.1186/1479-5876-10-189Mittra, De Souza, Bhadade, Madke, Shankpal et al., Resveratrol and Copper for Treatment of Severe COVID-19: An Observational Study, RESCU
Mogalli, Matsukawa, Shimomura, Isoda, Ohkohchi, Cyanidin-3glucoside enhances mitochondrial function and biogenesis in a human hepatocyte cell line, Cytotechnology,
doi:10.1007/s10616-018-0242-4Montella-Manuel, Pujol-Carrion, Mechoud, De La Torre-Ruiz, Bulk autophagy induction and life extension is achieved when iron is the only limited nutrient in Saccharomyces cerevisiae, Biochem. J,
doi:10.1042/BCJ20200849Mörz, A case report: multifocal necrotizing encephalitis and myocarditis after BNT162b2 mRNA vaccination against COVID-19, Vaccines,
doi:10.3390/vaccines10101651Nair, Mohanty, Knowledge, Attitude and practice of therapeutic fasting among naturopathy physicians: across sectional national survey, Journal of Nutrition, Fasting and Health,
doi:10.22038/jfh.2015.6075Narendra, Tanaka, Suen, Youle, Parkin is recruited selectively to impaired mitochondria and promotes their autophagy, J. Cell Biol,
doi:10.1083/jcb.200809125Nazir, Asghar, Rathore, Shahzad, Shahid et al., Menstrual abnormalities after COVID-19 vaccines: a systematic review, Vacunas (English Edition),
doi:10.1016/j.vacune.2022.10.019Negro, Turco, Povero, Nebivolol: an effective option against longlasting dyspnoea following COVID-19 pneumonia -a pivotal double-blind, cross-over controlled study, Multidisciplinary Respiratory Medicine,
doi:10.4081/mrm.2022.886Nejatifard, Asefi, Jamali, Hamblin, Fekrazad, Probable positive effects of the photobiomodulation as an adjunctive treatment in COVID-19: a systematic review, Cytokine,
doi:10.1016/j.cyto.2020.155312Nguyen, Malamo, Larkin-Kaiser, Borsa, Adhihetty, Effect of near-infrared light exposure on mitochondrial signaling in C2C12 muscle cells, Mitochondrion,
doi:10.1016/j.mito.2013.11.001Nguyen, Zhang, Gao, Cao, Tian et al., The spike protein of SARS-CoV-2 impairs lipid metabolism and increases susceptibility to lipotoxicity: implication for a role of Nrf2, Cells,
doi:10.3390/cells11121916Nicassio, Fracasso, Sirago, Musicco, Picca et al., Dietary supplementation with acetyll-carnitine counteracts age-related alterations of mitochondrial biogenesis, dynamics and antioxidant defenses in brain of old rats, Exp. Gerontol,
doi:10.1016/j.exger.2017.08.017Nisoli, Clementi, Paolucci, Cozzi, Tonello et al., Mitochondrial biogenesis in mammals: the role of endogenous nitric oxide, Science,
doi:10.1126/science.1079368Niu, Zhou, Nie, Shin, Cui, Melatonin enhances mitochondrial biogenesis and protects against rotenone-induced mitochondrial deficiency in early porcine embryos, J. Pineal Res,
doi:10.1111/jpi.12627Nopp, Moik, Klok, Gattinger, Petrovic et al., Outpatient pulmonary rehabilitation in patients with long COVID improves exercise capacity, functional status, dyspnea, fatigue, and quality of life, Respiration,
doi:10.1159/000522118Nouri-Majd, Ebrahimzadeh, Mousavi, Zargarzadeh, Eslami et al., Higher intake of dietary magnesium is inversely associated with COVID-19 severity and symptoms in hospitalized patients: a cross-sectional study, Frontiers. Nutrition
Nunez-Castilla, Stebliankin, Baral, Balbin, Sobhan et al., Potential autoimmunity resulting from molecular mimicry between SARS-CoV-2 spike and human proteins, Viruses,
doi:10.3390/v14071415Nunn, Guy, Brysch, Bell, Understanding long COVID; mitochondrial health and adaptation-old pathways. new problems, Biomedicines,
doi:10.3390/biomedicines10123113Oba, Rongduo, Saito, Okabayashi, Yokota et al., Natto extract, a Japanese fermented soybean food, directly inhibits viral infections including SARS-CoV-2 in vitro, Biochem. Biophys. Res. Commun,
doi:10.1016/j.bbrc.2021.07.034Oliveira, Boulé, Berg, Sharma, Elliott et al., Consumption of a high-protein meal replacement leads to higher fat oxidation, suppression of hunger, and improved metabolic profile after an exercise session, Nutrients,
doi:10.3390/nu13010155Otten, Bourgonje, Peters, Alizadeh, Dijkstra et al., Vitamin C supplementation in healthy individuals leads to shifts of bacterial populations in the gut-a pilot study, Antioxidants (Basel),
doi:10.3390/antiox10081278Ozono, Zhang, Ode, Sano, Tan et al., SARS-CoV-2 D614G spike mutation increases entry efficiency with enhanced ACE2-binding affinity, Nat. Commun,
doi:10.1038/s41467-021-21118-2Pais, Alexy, Holsworth, Meiselman, Effects of nattokinase, a profibrinolytic enzyme, on red blood cell aggregation and whole blood viscosity, Clin. Hemorheol. Microcirc
Paraskevas, Kantanis, Karalis, Michailides, Karamouzos et al., N-acetylcysteine efficacy in patients hospitalized with COVID-19 pneumonia: a systematic review and meta-analysis, Rom. J. Intern. Med,
doi:10.2478/rjim-2023-0001Park, Jeong, Lee, Koh, Kwon et al., Resveratrol induces autophagy by directly inhibiting mTOR through ATP competition, Sci. Rep
Park, Kang, Lee, Autophagy in neurodegenerative diseases: a hunter for aggregates, Int. J. Mol. Sci,
doi:10.3390/ijms21093369Parry, Lefringhausen, Turni, Neil, Cosford et al., Spikeopathy': COVID-19 spike protein is pathogenic, from both virus and vaccine mRNA, Biomedicines,
doi:10.3390/biomedicines11082287Pasquereau, Nehme, Haidar Ahmad, Daouad, Van Assche et al., Resveratrol inhibits HCoV-229E and SARS-CoV-2 coronavirus replication in vitro, Viruses,
doi:10.3390/v13020354Patidar, Sharma, Bhoraskar, Tripathi, Dhaneriya, The role of nebulized methylene blue [NMB] in the management of COVID-19 cases: an observational study, International Journal of Medical Arts,
doi:10.21608/ijma.2022.112347.1416Patikorn, Roubal, Veettil, Chandran, Pham et al., Intermittent fasting and obesity-related health outcomes: an umbrella review of meta-analyses of randomized clinical trials, JAMA Netw. Open,
doi:10.1001/jamanetworkopen.2021.39558Patterson, Laughlin, Sears, Lacroix, Marinac et al., Intermittent fasting and human metabolic health, J. Acad. Nutr. Diet,
doi:10.1016/j.jand.2015.02.018Pattnaik, Bhatraju, Kashyap, Verma, Madan et al., Effect of a nutraceutical drug in COPD condition: a pilot study of in vitro, in vivo and clinical trial, Eur. Respir. J,
doi:10.1183/13993003.congress-2022.1661Pawar, Mastud, Pawar, Pawar, Bhoite et al., Oral curcumin with piperine as adjuvant therapy for the treatment of COVID-19: a randomized clinical trial, Front. Pharmacol
Pesce, Fracasso, Cassano, Lezza, Cantatore et al., Acetyl-L-carnitine supplementation to old rats partially reverts the age-related mitochondrial decay of soleus muscle by activating peroxisome proliferatoractivated receptor gamma coactivator-1alpha-dependent mitochondrial biogenesis, Rejuvenation Res,
doi:10.1089/rej.2009.0955Pesce, Nicassio, Fracasso, Musicco, Cantatore et al., Acetyl-L-carnitine activates the peroxisome proliferator-activated receptor-γ coactivators PGC-1α/PGC-1β-dependent signaling cascade of mitochondrial biogenesis and decreases the oxidized peroxiredoxins content in old rat liver, Rejuvenation Res,
doi:10.1089/rej.2011.1255Petrlova, Samsudin, Bond, Schmidtchen, SARS-CoV-2 spike protein aggregation is triggered by bacterial lipopolysaccharide, FEBS Lett,
doi:10.1002/1873-3468.14490Petrovszki, Walter, Vigh, Kocsis, Valkai et al., Penetration of the SARS-CoV-2 spike protein across the blood-brain barrier, as revealed by a combination of a human cell culture model system and optical biosensing, Biomedicines,
doi:10.3390/biomedicines10010188Pietrocola, Lachkar, Enot, Niso-Santano, Pedro et al., Spermidine induces autophagy by inhibiting the acetyltransferase EP300, Cell Death Differ,
doi:10.1038/cdd.2014.215Pietrocola, Malik, Mariño, Vacchelli, Senovilla et al., Coffee induces autophagy in vivo, Cell Cycle,
doi:10.4161/cc.28929Pilchova, Klacanova, Tatarkova, Kaplan, Racay, The involvement of Mg 2+ in regulation of cellular and mitochondrial functions, Oxidative Med. Cell. Longev,
doi:10.1155/2017/6797460Prasada Kabekkodu, Chakrabarty, Jayaram, Mallya, Thangaraj et al., Severe acute respiratory syndrome coronaviruses contributing to mitochondrial dysfunction: implications for post-COVID complications, Mitochondrion,
doi:10.1016/j.mito.2023.01.005Pujhari, Paul, Ahluwalia, Rasgon, Clotting disorder in severe acute respiratory syndrome coronavirus 2, Rev. Med. Virol,
doi:10.1002/rmv.2177Pulido Perez, Póndigo De Los Angeles, Perez Peralta, Ramirez Mojica, Torres Rasgado et al., Reduction in serum magnesium levels and renal function are associated with increased mortality in obese COVID-19 patients, Nutrients,
doi:10.3390/nu14194054Puyaubert, Baudouin, New clues for a cold case: nitric oxide response to low temperature, Plant Cell Environ,
doi:10.1111/pce.12329Rai, Russell, Lightowlers, Turnbull, Potential compounds for the treatment of mitochondrial disease, Br. Med. Bull,
doi:10.1093/bmb/ldv046Rajpal, Ismail-Beigi, Intermittent fasting and 'metabolic switch': effects on metabolic syndrome, prediabetes and type 2 diabetes, Diabetes Obes. Metab,
doi:10.1111/dom.14080Rangaraju, Verrier, Madorsky, Nicks, Dunn et al., Rapamycin activates autophagy and improves myelination in explant cultures from neuropathic mice, J. Neurosci,
doi:10.1523/JNEUROSCI.1356-10.2010Rashedinia, Saberzadeh, Khosravi Bakhtiari, Hozhabri, Arabsolghar, Glycyrrhizic acid ameliorates mitochondrial function and biogenesis against aluminum toxicity in PC12 cells, Neurotox. Res,
doi:10.1007/s12640-018-9967-2Rawat, Roy, Maitra, Gulati, Khanna et al., Vitamin C and COVID-19 treatment: a systematic review and meta-analysis of randomized controlled trials, Diabetes Metab. Syndr. Clin. Res. Rev,
doi:10.1016/j.dsx.2021.102324Ray, Caffeine is a potent stimulator of autophagy to reduce hepatic lipid content-a coffee for NAFLD?, Nat. Rev. Gastroenterol. Hepatol,
doi:10.1038/nrgastro.2013.170Real-Hohn, Navegantes, Ramos, Ramos-Filho, Cahuê et al., The synergism of high-intensity intermittent exercise and everyother-day intermittent fasting regimen on energy metabolism adaptations includes hexokinase activity and mitochondrial efficiency, PLoS One,
doi:10.1371/journal.pone.0202784Rehman, Krishnasamy, Haque, Thurman, Lemasters et al., Green tea polyphenols stimulate mitochondrial biogenesis and improve renal function after chronic cyclosporin A treatment in rats, PLoS One,
doi:10.1371/journal.pone.0065029Rhea, Logsdon, Hansen, Williams, Reed et al., The S1 protein of SARS-CoV-2 crosses the blood-brain barrier in mice, Nat. Neurosci,
doi:10.1038/s41593-020-00771-8Roberts, Barnard, Jasman, Balon, Acute exercise increases nitric oxide synthase activity in skeletal muscle, American Journal of Physiology-Endocrinology and Metabolism,
doi:10.1152/ajpendo.1999.277.2.E390Rojas-Morales, León-Contreras, Granados-Pineda, Hernández-Pando, Gonzaga et al., Protection against renal ischemia and reperfusion injury by shortterm time-restricted feeding involves the mitochondrial unfolded protein response, Free Radic. Biol. Med,
doi:10.1016/j.freeradbiomed.2020.04.025Romanet, Wormser, Fels, Lucas, Prudat et al., Effectiveness of exercise training on the dyspnoea of individuals with long COVID: a randomised controlled multicentre trial, Ann. Phys. Rehabil. Med,
doi:10.1016/j.rehab.2023.101765Rushworth, Megson, Existing and potential therapeutic uses for Nacetylcysteine: the need for conversion to intracellular glutathione for antioxidant benefits, Pharmacol. Ther,
doi:10.1016/j.pharmthera.2013.09.006Sanchetee, Sanchetee, Garg, Effect of Jain fasting on anthropometric, clinical and biochemical parameters, Indian J Endocrinol Metab,
doi:10.4103/ijem.IJEM_601_19Sanz-Biset, Cañigueral, Plant use in the medicinal practices known as "strict diets" in Chazuta Valley (Peruvian Amazon), J. Ethnopharmacol,
doi:10.1016/j.jep.2011.05.021Sarkar, Ravikumar, Floto, Rubinsztein, Rapamycin and mTORindependent autophagy inducers ameliorate toxicity of polyglutamine-expanded huntingtin and related proteinopathies, Cell Death Differ,
doi:10.1038/cdd.2008.110Schiavi, Maglioni, Palikaras, Shaik, Strappazzon et al., Ironstarvation-induced mitophagy mediates lifespan extension upon mitochondrial stress in C. elegans, Curr. Biol,
doi:10.1016/j.cub.2015.05.059Schwab, Domke, Hartmann, Stenzinger, Longerich et al., Autopsy-based histopathological characterization of myocarditis after anti-SARS-CoV-2-vaccination, Clin. Res. Cardiol,
doi:10.1007/s00392-022-02129-5Schwarz, Benson, Horn, Wurdack, Grittner et al., Effects of spermidine supplementation on cognition and biomarkers in older adults with subjective cognitive decline: a randomized clinical trial, JAMA Netw. Open,
doi:10.1001/jamanetworkopen.2022.13875Schwarz, Stekovic, Wirth, Benson, Royer et al., Safety and tolerability of spermidine supplementation in mice and older adults with subjective cognitive decline, Aging,
doi:10.18632/aging.101354Segev, Sagir, Matetzky, Segev, Atar et al., Admission serum magnesium levels is associated with short and long-term clinical outcomes in COVID-19 patients, Nutrients,
doi:10.3390/nu15092016Semmarath, Mapoung, Umsumarng, Arjsri, Srisawad et al., Cyanidin-3-O-glucoside and peonidin-3-Oglucoside-rich fraction of black rice germ and bran suppresses inflammatory responses from SARS-CoV-2 spike glycoprotein S1-induction in vitro in A549 lung cells and THP-1 macrophages via inhibition of the NLRP3 inflammasome pathway, Nutrients,
doi:10.3390/nu14132738Senekowitsch, Wietkamp, Grimm, Schmelter, Schick et al., High-dose spermidine supplementation does not increase spermidine levels in blood plasma and saliva of healthy adults: a randomized placebo-controlled pharmacokinetic and metabolomic study, Nutrients,
doi:10.3390/nu15081852Sessa, Salerno, Esposito, Di Nunno, Zamboni et al., Autopsy findings and causality relationship between death and COVID-19 vaccination: a systematic review, J. Clin. Med,
doi:10.3390/jcm10245876Shakeri, Cicero, Panahi, Mohajeri, Sahebkar, Curcumin: a naturally occurring autophagy modulator, J. Cell. Physiol,
doi:10.1002/jcp.27404Shamloo, Defensor, Ciari, Ogawa, Vidano et al., The anti-inflammatory effects of photobiomodulation are mediated by cytokines: evidence from a mouse model of inflammation, Front. Neurosci
Shang, Liu, Zhu, Lu, Ge et al., SARS-CoV-2 causes mitochondrial dysfunction and mitophagy impairment, Front. Microbiol,
doi:10.3389/fmicb.2021.780768Shen, Hao, Feng, Tian, Chen et al., Lipoamide or lipoic acid stimulates mitochondrial biogenesis in 3T3-L1 adipocytes via the endothelial NO synthase-cGMP-protein kinase G signalling pathway: lipoamide, lipoic acid and mitochondrial biogenesis, Br. J. Pharmacol,
doi:10.1111/j.1476-5381.2010.01134.xShen, Liu, Tian, Yang, Li et al., R-alpha-lipoic acid and acetyl-L-carnitine complementarily promote mitochondrial biogenesis in murine 3T3-L1 adipocytes, Diabetologia,
doi:10.1007/s00125-007-0852-4Shen, Zhang, Zhao, Wolin, Sessa et al., Nitric oxide production and NO synthase gene expression contribute to vascular regulation during exercise, Med. Sci. Sports Exerc
Shiba-Fukushima, Arano, Matsumoto, Inoshita, Yoshida et al., Phosphorylation of mitochondrial polyubiquitin by PINK1 promotes Parkin mitochondrial tethering, PLoS Genet,
doi:10.1371/journal.pgen.1004861Shirato, Kizaki, SARS-CoV-2 spike protein S1 subunit induces proinflammatory responses via Toll-like receptor 4 signaling in murine and human macrophages, Heliyon,
doi:10.1016/j.heliyon.2021.e06187Shoba, Joy, Joseph, Majeed, Rajendran et al., Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers, Planta Med,
doi:10.1055/s-2006-957450Shripathi Adiga, Adiga, Concept and canons of fasting in Ayurveda, Journal of Nutrition, Fasting and Health,
doi:10.22038/jfh.2013.419Singh, Bharara Singh, S2 subunit of SARS-nCoV-2 interacts with tumor suppressor protein P53 and BRCA: an in silico study, Transl. Oncol,
doi:10.1016/j.tranon.2020.100814Singh, Mohapatra, Tripathi, Targeting mitochondrial biogenesis: a potential approach for preventing and controlling diabetes, Future Journal of Pharmaceutical Sciences,
doi:10.1186/s43094-021-00360-xSoda, Kano, Sakuragi, Takao, Lefor et al., Long-term oral polyamine intake increases blood polyamine concentrations, J. Nutr. Sci. Vitaminol,
doi:10.3177/jnsv.55.361Soda, Uemura, Sanayama, Igarashi, Fukui, Polyamine-rich diet elevates blood Spermine levels and inhibits pro-inflammatory status: an interventional study, Med Sci,
doi:10.3390/medsci9020022Solaini, Baracca, Lenaz, Sgarbi, Hypoxia and mitochondrial oxidative metabolism, Biochimica et Biophysica Acta (BBA) -Bioenergetics,
doi:10.1016/j.bbabio.2010.02.011Solis, Beccari, Iaconis, Talarico, Ruiz-Bedoya et al., The SARS-CoV-2 spike protein binds and modulates estrogen receptors, Sci. Adv,
doi:10.1126/sciadv.add4150Sotthibundhu, Mcdonagh, Von Kriegsheim, Garcia-Munoz, Klawiter et al., Rapamycin regulates autophagy and cell adhesion in induced pluripotent stem cells, Stem Cell Res Ther,
doi:10.1186/s13287-016-0425-xStein, Ramelli, Grazioli, Chung, Singh et al., SARS-CoV-2 infection and persistence in the human body and brain at autopsy, Nature,
doi:10.1038/s41586-022-05542-ySu, Yu, Chen, Huang, Chen et al., Rutin, a flavonoid and principal component of Saussurea involucrata, attenuates physical fatigue in a forced swimming mouse model, Int. J. Med. Sci,
doi:10.7150/ijms.8220Sumi, Hamada, Tsushima, Mihara, Muraki, A novel fibrinolytic enzyme (nattokinase) in the vegetable cheese natto; a typical and popular soybean food in the Japanese diet, Experientia,
doi:10.1007/BF01956052Sutton, Beyl, Early, Cefalu, Ravussin et al., Early time-restricted feeding improves insulin sensitivity, blood pressure, and oxidative stress even without weight loss in men with prediabetes, Cell Metab,
doi:10.1016/j.cmet.2018.04.010Suzuki, Onodera, Ohsumi, Starvation induced cell death in autophagydefective yeast mutants is caused by mitochondria dysfunction, PLoS One,
doi:10.1371/journal.pone.0017412Swank, Senussi, Manickas-Hill, Yu, Li et al., Persistent circulating severe acute respiratory syndrome coronavirus 2 spike is associated with post-acute coronavirus disease 2019 sequelae, Clin. Infect. Dis,
doi:10.1093/cid/ciac722Sánchez-Vicente, Lorenzo, Nitric oxide regulation of temperature acclimation: a molecular genetic perspective, J. Exp. Bot,
doi:10.1093/jxb/erab049Takeshige, Baba, Tsuboi, Noda, Ohsumi, Autophagy in yeast demonstrated with proteinase-deficient mutants and conditions for its induction, J. Cell Biol,
doi:10.1083/jcb.119.2.301Tan, Ho, Kalimuddin, Cherng, Teh et al., Cohort study to evaluate the effect of vitamin D, magnesium, and vitamin B12 in combination on progression to severe outcomes in older patients with coronavirus (COVID-19), Nutrition,
doi:10.1016/j.nut.2020.111017Temkin, The Falling Sickness: A History of Epilepsy From the Greeks to the Beginnings of Modern Neurology
Tenório, Graciliano, Moura, Oliveira, De et al., N-acetylcysteine (NAC): impacts on human health, Antioxidants,
doi:10.3390/antiox10060967Thissen, Ketelslegers, Underwood, Nutritional regulation of the insulin-like growth factors, Endocr. Rev
Tian, Tang, Liu, Li, Chen et al., Populations in lowmagnesium areas were associated with higher risk of infection in COVID-19's Early transmission: a nationwide retrospective cohort study in the United States, Nutrients,
doi:10.3390/nu14040909Tillman, Chen, Bondarenko, Coleman, Xu et al., SARS-CoV-2 spike protein downregulates cell surface α7nAChR through a helical motif in the spike neck, ACS Chem. Neurosci,
doi:10.1021/acschemneuro.2c00610Tosato, Calvani, Picca, Ciciarello, Galluzzo et al., Effects of L-arginine plus vitamin C supplementation on physical performance, endothelial function, and persistent fatigue in adults with long COVID: a single-blind randomized controlled trial, Nutrients,
doi:10.3390/nu14234984Tsutsumi, Yoshida, Nii, Okahisa, Iwata et al., Sudachitin, a polymethoxylated flavone, improves glucose and lipid metabolism by increasing mitochondrial biogenesis in skeletal muscle, Nutrition & Metabolism,
doi:10.1186/1743-7075-11-32Tucker, Lu, Zhang, From mitochondrial function to neuroprotection-an emerging role for methylene blue, Mol. Neurobiol,
doi:10.1007/s12035-017-0712-2Vahedian-Azimi, Abbasifard, Rahimi-Bashar, Guest, Majeed et al., Effectiveness of curcumin on outcomes of hospitalized COVID-19 patients: a systematic review of clinical trials, Nutrients,
doi:10.3390/nu14020256Valenti, De Rasmo, Signorile, Rossi, De Bari et al., Epigallocatechin-3-gallate prevents oxidative phosphorylation deficit and promotes mitochondrial biogenesis in human cells from subjects with Down's syndrome, Biochim. Biophys. Acta (BBA) -Mol. Basis Dis,
doi:10.1016/j.bbadis.2012.12.011Vargas, Hamasaki, Kawabata, Youle, Yoshimori, The mechanisms and roles of selective autophagy in mammals, Nat. Rev. Mol. Cell Biol,
doi:10.1038/s41580-022-00542-2Vetrici, Mokmeli, Bohm, Monici, Sigman, Evaluation of adjunctive photobiomodulation (PBMT) for COVID-19 pneumonia via clinical status and pulmonary severity indices in a preliminary trial, J. Inflamm. Res,
doi:10.2147/JIR.S301625Vineetha, Mathews, Nair, Chapter 28 -ascorbic acid and the mitochondria
Visioli, Mucignat-Caretta, Anile, Panaite, Traditional and medical applications of fasting, Nutrients,
doi:10.3390/nu14030433Vollbracht, Kraft, Feasibility of vitamin C in the treatment of post viral fatigue with focus on long COVID, based on a systematic review of IV vitamin C on fatigue, Nutrients,
doi:10.3390/nu13041154Vásquez-Reyes, Velázquez-Villegas, Vargas-Castillo, Noriega, Torres et al., Dietary bioactive compounds as modulators of mitochondrial function, J. Nutr. Biochem,
doi:10.1016/j.jnutbio.2021.108768Walski, Dąbrowska, Drohomirecka, Jędruchniewicz, Trochanowska-Pauk et al., The effect of red-to-near-infrared (R/NIR) irradiation on inflammatory processes, Int. J. Radiat. Biol,
doi:10.1080/09553002.2019.1625464Wang, Chen, The effects of sunlight exposure therapy on the improvement of depression and quality of life in post-stroke patients: a RCT study, Heliyon,
doi:10.1016/j.heliyon.2020.e04379Wang, Chen, Zhang, Deng, Lian et al., CD147-spike protein is a novel route for SARS-CoV-2 infection to host cells, Sig Transduct Target Ther,
doi:10.1038/s41392-020-00426-xWang, Ming, Wang, Cao, Wang et al., Long-term extreme fasting following a traditional Chinese "Bigu" regimen: a preliminary retrospective and prospective cohort study, SSRN Journal,
doi:10.2139/ssrn.3237012Winchester, John, Jabbar, John, Clinical efficacy of nitric oxide nasal spray (NONS) for the treatment of mild COVID-19 infection, Journal of Infection,
doi:10.1016/j.jinf.2021.05.009Wirth, Benson, Schwarz, Köbe, Grittner et al., The effect of spermidine on memory performance in older adults at risk for dementia: a randomized controlled trial, Cortex,
doi:10.1016/j.cortex.2018.09.014Wissler Gerdes, Vanichkachorn, Verdoorn, Hanson, Joshi et al., Role of senescence in the chronic health consequences of COVID-19, Transl. Res,
doi:10.1016/j.trsl.2021.10.003Yamamoto, Morino, Mengistu, Ishibashi, Kiriyama et al., Amla enhances mitochondrial spare respiratory capacity by increasing mitochondrial biogenesis and antioxidant systems in a murine skeletal muscle cell line, Oxidative Med. Cell. Longev,
doi:10.1155/2016/1735841Yanagisawa, Chatake, Chiba-Kamoshida, Naito, Ohsugi et al., Purification, crystallization and preliminary X-ray diffraction experiment of nattokinase from Bacillus subtilis natto, Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun,
doi:10.1107/S1744309110043137Yang, Petitjean, Koehler, Zhang, Dumitru et al., Molecular interaction and inhibition of SARS-CoV-2 binding to the ACE2 receptor, Nat. Commun,
doi:10.1038/s41467-020-18319-6You, Liang, Han, Guo, Ren et al., Mulberry anthocyanins, cyanidin 3-glucoside and cyanidin 3-rutinoside, increase the quantity of mitochondria during brown adipogenesis, J. Funct. Foods,
doi:10.1016/j.jff.2017.07.007You, Yuan, Lee, Huang, Jin et al., Mulberry and mulberry wine extract increase the number of mitochondria during brown adipogenesis, Food Funct,
doi:10.1039/C4FO00719KYu, Mcphee, Zheng, Mardones, Rong et al., Termination of autophagy and reformation of lysosomes regulated by mTOR, Nature,
doi:10.1038/nature09076Zauner, Schneeweiss, Kranz, Madl, Ratheiser et al., Resting energy expenditure in short-term starvation is increased as a result of an increase in serum norepinephrine, Am. J. Clin. Nutr
Zhang, Si, Lu, Zhang, Zheng et al., SARS-CoV-2 omicron variant clearance delayed in breakthrough cases with elevated fasting blood glucose, Virol. J,
doi:10.1186/s12985-022-01877-0Zhen, Lu, Wang, Vaziri, Zhou, Upregulation of endothelial and inducible nitric oxide synthase expression by reactive oxygen species, Am. J. Hypertens,
doi:10.1038/ajh.2007.14Zhong, Sun, Xiao, Yao, Sang et al., A randomized, single-blind, group sequential, activecontrolled study to evaluate the clinical efficacy and safety of α-lipoic acid for critically ill patients with coronavirus disease 2019,
doi:10.1038/ajh.2007.14Zhou, Farah, Sinha, Wu, Singh et al., Epigallocatechin-3-gallate (EGCG), a green tea polyphenol, stimulates hepatic autophagy and lipid clearance, PLoS One,
doi:10.1371/journal.pone.0087161Zong, Wei, Ren, Zhang, Zhou, The intersection of COVID-19 and cancer: signaling pathways and treatment implications, Mol. Cancer,
doi:10.1186/s12943-021-01363-1{ 'indexed': {'date-parts': [[2024, 2, 9]], 'date-time': '2024-02-09T00:32:04Z', 'timestamp': 1707438724960},
'reference-count': 362,
'publisher': 'Elsevier BV',
'license': [ { 'start': { 'date-parts': [[2024, 3, 1]],
'date-time': '2024-03-01T00:00:00Z',
'timestamp': 1709251200000},
'content-version': 'tdm',
'delay-in-days': 0,
'URL': 'https://www.elsevier.com/tdm/userlicense/1.0/'},
{ 'start': { 'date-parts': [[2024, 1, 25]],
'date-time': '2024-01-25T00:00:00Z',
'timestamp': 1706140800000},
'content-version': 'vor',
'delay-in-days': 0,
'URL': 'http://creativecommons.org/licenses/by/4.0/'}],
'content-domain': {'domain': ['elsevier.com', 'sciencedirect.com'], 'crossmark-restriction': True},
'published-print': {'date-parts': [[2024, 3]]},
'DOI': '10.1016/j.endmts.2024.100163',
'type': 'journal-article',
'created': {'date-parts': [[2024, 1, 30]], 'date-time': '2024-01-30T18:03:51Z', 'timestamp': 1706637831000},
'page': '100163',
'update-policy': 'http://dx.doi.org/10.1016/elsevier_cm_policy',
'source': 'Crossref',
'is-referenced-by-count': 0,
'title': 'Exploring autophagy in treating SARS-CoV-2 spike protein-related pathology',
'prefix': '10.1016',
'volume': '14',
'author': [ {'given': 'Matthew T.J.', 'family': 'Halma', 'sequence': 'first', 'affiliation': []},
{'given': 'Paul E.', 'family': 'Marik', 'sequence': 'additional', 'affiliation': []},
{'given': 'Yusuf M.', 'family': 'Saleeby', 'sequence': 'additional', 'affiliation': []}],
'member': '78',
'reference': [ { 'key': '10.1016/j.endmts.2024.100163_bb0005',
'series-title': 'Decoding COVID-19 mRNA Vaccine Immunometabolism in Central Nervous '
'System: Human Brain Normal Glial and Glioma Cells by Raman Imaging',
'author': 'Abramczyk',
'year': '2022'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0010',
'doi-asserted-by': 'crossref',
'DOI': '10.1038/s41598-022-24386-0',
'article-title': 'Effects of hypoxia and reoxygenation on mitochondrial functions and '
'transcriptional profiles of isolated brain and muscle porcine cells',
'volume': '12',
'author': 'Adzigbli',
'year': '2022',
'journal-title': 'Sci. Rep.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0015',
'first-page': 'C57',
'article-title': 'Mitochondrial metabolic manipulation by SARS-CoV-2 in peripheral blood '
'mononuclear cells of patients with COVID-19',
'volume': '320',
'author': 'Ajaz',
'year': '2021',
'journal-title': 'Am. J. Phys. Cell Phys.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0020',
'doi-asserted-by': 'crossref',
'DOI': '10.1016/j.ejphar.2020.173494',
'article-title': 'Application of methylene blue -vitamin C–N-acetyl cysteine for '
'treatment of critically ill COVID-19 patients, report of a phase-I '
'clinical trial',
'volume': '885',
'author': 'Alamdari',
'year': '2020',
'journal-title': 'Eur. J. Pharmacol.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0025',
'doi-asserted-by': 'crossref',
'first-page': '3',
'DOI': '10.1186/s40842-020-00116-1',
'article-title': 'Intermittent fasting: is there a role in the treatment of diabetes? A '
'review of the literature and guide for primary care physicians',
'volume': '7',
'author': 'Albosta',
'year': '2021',
'journal-title': 'Clinical Diabetes and Endocrinology'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0030',
'first-page': '5572',
'article-title': 'Polyamines in foods: development of a food database',
'volume': '55',
'author': 'Ali',
'year': '2011',
'journal-title': 'Food Nutr.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0035',
'doi-asserted-by': 'crossref',
'unstructured': 'Alirezaei, M.; Kemball, C.C.; Flynn, C.T.; Wood, M.R.; Whitton, J.L.; '
'Kiosses, W.B. Short-term fasting induces profound neuronal autophagy. '
'Autophagy 2010, 6, 702–710, doi:https://doi.org/10.4161/auto.6.6.12376.',
'DOI': '10.4161/auto.6.6.12376'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0040',
'doi-asserted-by': 'crossref',
'first-page': '1887',
'DOI': '10.1007/s00277-022-04907-7',
'article-title': 'Hemolytic anemia in COVID-19',
'volume': '101',
'author': 'Al-kuraishy',
'year': '2022',
'journal-title': 'Ann. Hematol.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0045',
'doi-asserted-by': 'crossref',
'DOI': '10.1002/advs.202101222',
'article-title': 'Combined metabolic activators accelerates recovery in mild-to-moderate '
'COVID-19',
'volume': '8',
'author': 'Altay',
'year': '2021',
'journal-title': 'Adv. Sci.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0050',
'article-title': 'Association between the expression of toll-like receptors, cytokines, '
'and homeostatic chemokines in SARS-CoV-2 infection and COVID-19 '
'severity',
'volume': '9',
'author': 'Alturaiki',
'year': '2022',
'journal-title': 'Heliyon'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0055',
'doi-asserted-by': 'crossref',
'first-page': '807',
'DOI': '10.1021/mp700113r',
'article-title': 'Bioavailability of curcumin: problems and promises',
'volume': '4',
'author': 'Anand',
'year': '2007',
'journal-title': 'Mol. Pharm.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0060',
'doi-asserted-by': 'crossref',
'DOI': '10.3389/fimmu.2023.1080043',
'article-title': 'Gut and airway microbiota dysbiosis and their role in COVID-19 and '
'long-COVID',
'volume': '14',
'author': 'Ancona',
'year': '2023',
'journal-title': 'Front. Immunol.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0065',
'doi-asserted-by': 'crossref',
'first-page': '254',
'DOI': '10.1002/oby.22065',
'article-title': 'Flipping the metabolic switch: understanding and applying the health '
'benefits of fasting',
'volume': '26',
'author': 'Anton',
'year': '2018',
'journal-title': 'Obesity (Silver Spring)'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0070',
'doi-asserted-by': 'crossref',
'first-page': '379',
'DOI': '10.1016/j.freeradbiomed.2018.11.005',
'article-title': 'Protective effects of N-acetyl-cysteine in mitochondria bioenergetics, '
'oxidative stress, dynamics and S-glutathionylation alterations in acute '
'kidney damage induced by folic acid',
'volume': '130',
'author': 'Aparicio-Trejo',
'year': '2019',
'journal-title': 'Free Radic. Biol. Med.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0075',
'doi-asserted-by': 'crossref',
'first-page': '2525',
'DOI': '10.1007/s00018-007-7188-6',
'article-title': 'To be, or not to be — molecular chaperones in protein degradation',
'volume': '64',
'author': 'Arndt',
'year': '2007',
'journal-title': 'Cell. Mol. Life Sci.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0080',
'doi-asserted-by': 'crossref',
'first-page': '847',
'DOI': '10.1080/23744235.2021.1945675',
'article-title': 'N-acetyl-cysteine reduces the risk for mechanical ventilation and '
'mortality in patients with COVID-19 pneumonia: a two-center '
'retrospective cohort study',
'volume': '53',
'author': 'Assimakopoulos',
'year': '2021',
'journal-title': 'Infect. Dis. Ther.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0085',
'doi-asserted-by': 'crossref',
'first-page': '355',
'DOI': '10.1016/j.coph.2007.04.005',
'article-title': 'N-acetylcysteine—a safe antidote for cysteine/glutathione deficiency',
'volume': '7',
'author': 'Atkuri',
'year': '2007',
'journal-title': 'Curr. Opin. Pharmacol.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0090',
'doi-asserted-by': 'crossref',
'first-page': '1570',
'DOI': '10.3390/nu13051570',
'article-title': 'Fasting: how to guide',
'volume': '13',
'author': 'Attinà',
'year': '2021',
'journal-title': 'Nutrients'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0095',
'doi-asserted-by': 'crossref',
'first-page': '2667',
'DOI': '10.1042/CS20210735',
'article-title': 'The SARS-CoV-2 spike protein disrupts human cardiac pericytes function '
'through CD147 receptor-mediated signalling: a potential non-infective '
'mechanism of COVID-19 microvascular disease',
'volume': '135',
'author': 'Avolio',
'year': '2021',
'journal-title': 'Clin. Sci.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0100',
'doi-asserted-by': 'crossref',
'DOI': '10.1016/j.molstruc.2022.134642',
'article-title': 'Glycyrrhizin as a promising kryptonite against SARS-CoV-2: clinical, '
'experimental, and theoretical evidences',
'volume': '1275',
'author': 'Banerjee',
'year': '2023',
'journal-title': 'J. Mol. Struct.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0105',
'doi-asserted-by': 'crossref',
'first-page': '463',
'DOI': '10.3390/nu13020463',
'article-title': 'Magnesium in aging, health and diseases',
'volume': '13',
'author': 'Barbagallo',
'year': '2021',
'journal-title': 'Nutrients'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0110',
'doi-asserted-by': 'crossref',
'first-page': 'e258',
'DOI': '10.1093/eurjpc/zwac019',
'article-title': 'Effects of exercise rehabilitation in patients with long coronavirus '
'disease 2019',
'volume': '29',
'author': 'Barbara',
'year': '2022',
'journal-title': 'Eur. J. Prev. Cardiol.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0115',
'doi-asserted-by': 'crossref',
'first-page': '358',
'DOI': '10.1016/j.tins.2022.02.006',
'article-title': 'The neuroinvasiveness, neurotropism, and neurovirulence of SARS-CoV-2',
'volume': '45',
'author': 'Bauer',
'year': '2022',
'journal-title': 'Trends Neurosci.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0120',
'doi-asserted-by': 'crossref',
'DOI': '10.1098/rsbl.2015.0073',
'article-title': 'Near-infrared light increases ATP, extends lifespan and improves '
'mobility in aged drosophila melanogaster',
'volume': '11',
'author': 'Begum',
'year': '2015',
'journal-title': 'Biol. Lett.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0125',
'doi-asserted-by': 'crossref',
'first-page': '451',
'DOI': '10.3390/biomedicines11020451',
'article-title': 'Immune response and molecular mechanisms of cardiovascular adverse '
'effects of spike proteins from SARS-CoV-2 and mRNA vaccines',
'volume': '11',
'author': 'Bellavite',
'year': '2023',
'journal-title': 'Biomedicines'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0130',
'doi-asserted-by': 'crossref',
'first-page': '685',
'DOI': '10.1146/annurev-biochem-060815-014556',
'article-title': 'Mammalian autophagy: how does it work?',
'volume': '85',
'author': 'Bento',
'year': '2016',
'journal-title': 'Annu. Rev. Biochem.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0135',
'doi-asserted-by': 'crossref',
'first-page': '3',
'DOI': '10.1016/j.nbd.2015.10.011',
'article-title': 'Mitochondrial fusion/fission dynamics in neurodegeneration and neuronal '
'plasticity',
'volume': '90',
'author': 'Bertholet',
'year': '2016',
'journal-title': 'Neurobiol. Dis.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0140',
'doi-asserted-by': 'crossref',
'first-page': '2',
'DOI': '10.3390/covid1010002',
'article-title': 'Efficacy of a polyphenolic, standardized green tea extract for the '
'treatment of COVID-19 syndrome: a proof-of-principle study',
'volume': '1',
'author': 'Bettuzzi',
'year': '2021',
'journal-title': 'COVID'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0145',
'doi-asserted-by': 'crossref',
'DOI': '10.3390/ijms231810436',
'article-title': 'SARS-CoV-2 spike proteins and cell-cell communication inhibits TFPI and '
'induces thrombogenic factors in human lung microvascular endothelial '
'cells and neutrophils: implications for COVID-19 coagulopathy '
'pathogenesis',
'volume': '23',
'author': 'Bhargavan',
'year': '2022',
'journal-title': 'Int. J. Mol. Sci.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0150',
'article-title': 'Rationale for nicotinamide adenine dinucleotide (NAD+) metabolome '
'disruption as a pathogenic mechanism of post-acute COVID-19 syndrome',
'volume': '15',
'author': 'Block',
'year': '2022',
'journal-title': 'Clin Med Insights Pathol'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0155',
'series-title': 'Progress in Molecular Biology and Translational Science',
'doi-asserted-by': 'crossref',
'first-page': '129',
'DOI': '10.1016/bs.pmbts.2015.07.016',
'article-title': 'Chapter six - endurance exercise and the regulation of skeletal muscle '
'metabolism',
'volume': 'vol. 135',
'author': 'Booth',
'year': '2015'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0160',
'doi-asserted-by': 'crossref',
'first-page': '247',
'DOI': '10.1016/j.ijheh.2005.03.003',
'article-title': 'Daily time spent indoors in German homes – baseline data for the '
'assessment of indoor exposure of German occupants',
'volume': '208',
'author': 'Brasche',
'year': '2005',
'journal-title': 'Int. J. Hyg. Environ. Health'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0165',
'doi-asserted-by': 'crossref',
'first-page': '81',
'DOI': '10.1038/s41581-020-00381-4',
'article-title': 'The COVID-19 pandemic: consequences for nephrology',
'volume': '17',
'author': 'Bruchfeld',
'year': '2021',
'journal-title': 'Nat. Rev. Nephrol.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0170',
'doi-asserted-by': 'crossref',
'DOI': '10.1016/j.nbd.2020.105131',
'article-title': 'The SARS-CoV-2 spike protein alters barrier function in 2D static and '
'3D microfluidic in-vitro models of the human blood-brain barrier',
'volume': '146',
'author': 'Buzhdygan',
'year': '2020',
'journal-title': 'Neurobiol. Dis.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0175',
'doi-asserted-by': 'crossref',
'DOI': '10.1126/science.abe4832',
'article-title': 'Senolytics reduce coronavirus-related mortality in old mice',
'volume': '373',
'author': 'Camell',
'year': '2021',
'journal-title': 'Science'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0180',
'doi-asserted-by': 'crossref',
'first-page': '1646',
'DOI': '10.3390/biom12111646',
'article-title': 'Possible application of melatonin in long COVID',
'volume': '12',
'author': 'Cardinali',
'year': '2022',
'journal-title': 'Biomolecules'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0185',
'doi-asserted-by': 'crossref',
'first-page': '1211',
'DOI': '10.3390/nu9111211',
'article-title': 'Vitamin C and immune function',
'volume': '9',
'author': 'Carr',
'year': '2017',
'journal-title': 'Nutrients'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0190',
'doi-asserted-by': 'crossref',
'unstructured': 'Catenacci, V.A.; Pan, Z.; Ostendorf, D.; Brannon, S.; Gozansky, W.S.; '
'Mattson, M.P.; Martin, B.; MacLean, P.S.; Melanson, E.L.; Troy Donahoo, '
'W. A randomized pilot study comparing zero-calorie alternate-day fasting '
'to daily caloric restriction in adults with obesity. Obesity 2016, 24, '
'1874–1883.',
'DOI': '10.1002/oby.21581'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0195',
'doi-asserted-by': 'crossref',
'first-page': '2228',
'DOI': '10.3390/jcm11082228',
'article-title': 'Exercise training in post-COVID-19 patients: the need for a '
'multifactorial protocol for a multifactorial pathophysiology',
'volume': '11',
'author': 'Cattadori',
'year': '2022',
'journal-title': 'J. Clin. Med.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0200',
'first-page': '33',
'article-title': 'A nicotinic hypothesis for Covid-19 with preventive and therapeutic '
'implications',
'volume': '343',
'author': 'Changeux',
'year': '2020',
'journal-title': 'C. R. Biol.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0205',
'doi-asserted-by': 'crossref',
'first-page': '128',
'DOI': '10.1007/s11130-022-00954-7',
'article-title': 'Resveratrol induces the fasting state and alters circadian metabolism '
'in hepatocytes',
'volume': '77',
'author': 'Chatam',
'year': '2022',
'journal-title': 'Plant Foods Hum. Nutr.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0210',
'doi-asserted-by': 'crossref',
'DOI': '10.1002/rmv.2427',
'article-title': 'Quercetin for the treatment of COVID-19 patients: a systematic review '
'and meta-analysis',
'volume': '33',
'author': 'Cheema',
'year': '2023',
'journal-title': 'Rev. Med. Virol.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0215',
'doi-asserted-by': 'crossref',
'DOI': '10.1177/1177271918785130',
'article-title': 'Nattokinase: a promising alternative in prevention and treatment of '
'cardiovascular diseases',
'volume': '13',
'author': 'Chen',
'year': '2018',
'journal-title': 'Biomark. Insights'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0220',
'doi-asserted-by': 'crossref',
'first-page': '965',
'DOI': '10.1080/09637486.2020.1754351',
'article-title': 'Effect of resveratrol on intestinal tight junction proteins and the gut '
'microbiome in high-fat diet-fed insulin resistant mice',
'volume': '71',
'author': 'Chen',
'year': '2020',
'journal-title': 'Int. J. Food Sci. Nutr.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0225',
'doi-asserted-by': 'crossref',
'DOI': '10.1111/jpi.12774',
'article-title': 'Melatonin ameliorates cognitive deficits through improving mitophagy in '
'a mouse model of Alzheimer’s disease',
'volume': '71',
'author': 'Chen',
'year': '2021',
'journal-title': 'J. Pineal Res.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0230',
'doi-asserted-by': 'crossref',
'first-page': '810',
'DOI': '10.1016/j.stem.2014.04.014',
'article-title': 'Prolonged fasting reduces IGF-1/PKA to promote '
'hematopoietic-stem-cell-based regeneration and reverse '
'immunosuppression',
'volume': '14',
'author': 'Cheng',
'year': '2014',
'journal-title': 'Cell Stem Cell'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0235',
'doi-asserted-by': 'crossref',
'first-page': '829',
'DOI': '10.1016/j.kint.2020.03.005',
'article-title': 'Kidney disease is associated with in-hospital death of patients with '
'COVID-19',
'volume': '97',
'author': 'Cheng',
'year': '2020',
'journal-title': 'Kidney Int.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0240',
'first-page': '13',
'article-title': 'Natural phytochemicals that affect autophagy in the treatment of oral '
'diseases and infections: a review',
'author': 'Cheng',
'year': '2022',
'journal-title': 'Front. Pharmacol.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0245',
'doi-asserted-by': 'crossref',
'unstructured': 'Chodari, L.; Dilsiz Aytemir, M.; Vahedi, P.; Alipour, M.; Vahed, S.Z.; '
'Khatibi, S.M.H.; Ahmadian, E.; Ardalan, M.; Eftekhari, A. Targeting '
'mitochondrial biogenesis with polyphenol compounds. Oxidative Med. Cell. '
'Longev. 2021, 2021, e4946711, doi:https://doi.org/10.1155/2021/4946711.',
'DOI': '10.1155/2021/4946711'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0250',
'doi-asserted-by': 'crossref',
'DOI': '10.3346/jkms.2021.36.e286',
'article-title': 'Myocarditis-induced sudden death after BNT162b2 mRNA COVID-19 '
'vaccination in Korea: case report focusing on histopathological '
'findings',
'volume': '36',
'author': 'Choi',
'year': '2021',
'journal-title': 'J. Korean Med. Sci.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0255',
'doi-asserted-by': 'crossref',
'first-page': '66',
'DOI': '10.1016/j.bbrc.2022.07.113',
'article-title': 'SARS-CoV-2 spike S1 subunit protein-mediated increase of beta-secretase '
'1 (BACE1) impairs human brain vessel cells',
'volume': '626',
'author': 'Choi',
'year': '2022',
'journal-title': 'Biochem. Biophys. Res. Commun.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0260',
'doi-asserted-by': 'crossref',
'first-page': '4',
'DOI': '10.1186/s40170-015-0130-8',
'volume': '3',
'author': 'Chourasia',
'year': '2015',
'journal-title': 'Mitophagy and cancer. Cancer & Metabolism'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0265',
'doi-asserted-by': 'crossref',
'first-page': '305',
'DOI': '10.1038/ijo.2015.154',
'article-title': 'Effect of extended morning fasting upon ad libitum lunch intake and '
'associated metabolic and hormonal responses in obese adults',
'volume': '40',
'author': 'Chowdhury',
'year': '2016',
'journal-title': 'Int. J. Obes.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0270',
'doi-asserted-by': 'crossref',
'unstructured': 'Chuang, S.-T.; Papp, H.; Kuczmog, A.; Eells, R.; Condor Capcha, J.M.; '
'Shehadeh, L.A.; Jakab, F.; Buchwald, P. Methylene blue is a nonspecific '
'protein–protein interaction inhibitor with potential for repurposing as '
'an antiviral for COVID-19. Pharmaceuticals 2022, 15, 621, '
'doi:https://doi.org/10.3390/ph15050621.',
'DOI': '10.3390/ph15050621'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0275',
'doi-asserted-by': 'crossref',
'first-page': '39',
'DOI': '10.20463/jenb.2017.0020',
'article-title': 'The effects of exercise and cold exposure on mitochondrial biogenesis '
'in skeletal muscle and white adipose tissue',
'volume': '21',
'author': 'Chung',
'year': '2017',
'journal-title': 'J. Exerc. Nutr. Biochem.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0280',
'doi-asserted-by': 'crossref',
'first-page': '527',
'DOI': '10.3322/caac.21694',
'article-title': 'Intermittent fasting in the prevention and treatment of cancer',
'volume': '71',
'author': 'Clifton',
'year': '2021',
'journal-title': 'CA Cancer J. Clin.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0285',
'doi-asserted-by': 'crossref',
'first-page': '770',
'DOI': '10.1007/s11481-021-10015-6',
'article-title': 'Mitochondrial dynamics in SARS-COV2 spike protein treated human '
'microglia: implications for neuro-COVID',
'volume': '16',
'author': 'Clough',
'year': '2021',
'journal-title': 'J. NeuroImmune Pharmacol.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0290',
'doi-asserted-by': 'crossref',
'first-page': '141',
'DOI': '10.1016/S1382-6689(01)00077-1',
'article-title': 'The interplay of glutathione-related processes in antioxidant defense',
'volume': '10',
'author': 'Cnubben',
'year': '2001',
'journal-title': 'Environ. Toxicol. Pharmacol.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0295',
'first-page': '45',
'article-title': 'Native American medicine',
'volume': '4',
'author': 'Cohen',
'year': '1998',
'journal-title': 'Altern. Ther. Health Med.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0300',
'doi-asserted-by': 'crossref',
'DOI': '10.3390/ijms231810881',
'article-title': 'Understanding the pharmacology of COVID-19 mRNA vaccines: playing dice '
'with the spike?',
'volume': '23',
'author': 'Cosentino',
'year': '2022',
'journal-title': 'Int. J. Mol. Sci.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0305',
'doi-asserted-by': 'crossref',
'first-page': '12',
'DOI': '10.1016/j.mce.2012.04.009',
'article-title': 'Role of melatonin in the regulation of autophagy and mitophagy: a '
'review',
'volume': '361',
'author': 'Coto-Montes',
'year': '2012',
'journal-title': 'Mol. Cell. Endocrinol.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0310',
'doi-asserted-by': 'crossref',
'unstructured': "Couzin-Frankel, J. The mystery of the pandemic's ‘happy hypoxia.’ "
'Science 2020, 368, 455–456, '
'doi:https://doi.org/10.1126/science.368.6490.455.',
'DOI': '10.1126/science.368.6490.455'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0315',
'doi-asserted-by': 'crossref',
'first-page': '181',
'DOI': '10.1016/S1440-2440(99)80172-8',
'article-title': 'Physiological determinants of endurance exercise performance',
'volume': '2',
'author': 'Coyle',
'year': '1999',
'journal-title': 'J. Sci. Med. Sport'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0320',
'first-page': 'C1200',
'article-title': 'Activation of a selective pathway of lysosomal proteolysis in rat liver '
'by prolonged starvation',
'volume': '269',
'author': 'Cuervo',
'year': '1995',
'journal-title': 'Am. J. Phys. Cell Phys.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0325',
'doi-asserted-by': 'crossref',
'DOI': '10.1016/j.biopha.2021.112023',
'article-title': 'Repurposing methylene blue in the management of COVID-19: mechanistic '
'aspects and clinical investigations',
'volume': '142',
'author': 'Dabholkar',
'year': '2021',
'journal-title': 'Biomed. Pharmacother.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0330',
'doi-asserted-by': 'crossref',
'first-page': '1163',
'DOI': '10.1515/hsz-2014-0164',
'article-title': 'Inflammatory outcomes of apoptosis',
'volume': '395',
'author': 'Davidovich',
'year': '2014',
'journal-title': 'necrosis and necroptosis. Biol Chem'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0335',
'doi-asserted-by': 'crossref',
'DOI': '10.1111/acel.13727',
'article-title': 'COVID-19 and neurodegeneration: the mitochondrial connection',
'volume': '21',
'author': 'Denaro',
'year': '2022',
'journal-title': 'Aging Cell'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0340',
'doi-asserted-by': 'crossref',
'first-page': '722',
'DOI': '10.1007/s11481-021-10029-0',
'article-title': 'SARS-CoV-2 spike protein disrupts blood–brain barrier integrity via '
'RhoA activation',
'volume': '16',
'author': 'DeOre',
'year': '2021',
'journal-title': 'J. NeuroImmune Pharmacol.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0345',
'doi-asserted-by': 'crossref',
'first-page': '1045',
'DOI': '10.3390/v15051045',
'article-title': 'Molecular mimicry of the viral spike in the SARS-CoV-2 vaccine possibly '
'triggers transient dysregulation of ACE2, leading to vascular and '
'coagulation dysfunction similar to SARS-CoV-2 infection',
'volume': '15',
'author': 'Devaux',
'year': '2023',
'journal-title': 'Viruses'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0350',
'doi-asserted-by': 'crossref',
'first-page': '420',
'DOI': '10.2119/molmed.2015.00038',
'article-title': 'Methylene blue reduces acute cerebral ischemic injury via the induction '
'of mitophagy',
'volume': '21',
'author': 'Di',
'year': '2015',
'journal-title': 'Mol. Med.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0355',
'doi-asserted-by': 'crossref',
'first-page': '23',
'DOI': '10.1002/JLB.3MA0322-279RRR',
'article-title': 'Loss of mitochondrial membrane potential (ΔΨm) in leucocytes as '
'post-COVID-19 sequelae',
'volume': '112',
'author': 'Díaz-Resendiz',
'year': '2022',
'journal-title': 'J. Leukoc. Biol.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0360',
'doi-asserted-by': 'crossref',
'first-page': '99',
'DOI': '10.3390/md20020099',
'article-title': 'Effect of fucoidan on the mitochondrial membrane potential (ΔΨm) of '
'leukocytes from patients with active COVID-19 and subjects that '
'recovered from SARS-CoV-2 infection',
'volume': '20',
'author': 'Díaz-Resendiz',
'year': '2022',
'journal-title': 'Mar. Drugs'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0365',
'doi-asserted-by': 'crossref',
'unstructured': 'Dice, J.F. Chaperone-mediated autophagy. Autophagy 2007, 3, 295–299, '
'doi:https://doi.org/10.4161/auto.4144.',
'DOI': '10.4161/auto.4144'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0370',
'doi-asserted-by': 'crossref',
'first-page': '31',
'DOI': '10.1055/a-1899-8862',
'article-title': 'Serum calcium, magnesium, and phosphorus levels in patients with '
'COVID-19: relationships with poor outcome and mortality',
'volume': '55',
'author': 'Díez',
'year': '2023',
'journal-title': 'Horm. Metab. Res.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0375',
'doi-asserted-by': 'crossref',
'first-page': '2376',
'DOI': '10.3390/molecules27082376',
'article-title': 'The importance of nutraceuticals in COVID-19: what’s the role of '
'resveratrol?',
'volume': '27',
'author': 'Domi',
'year': '2022',
'journal-title': 'Molecules'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0380',
'first-page': '471',
'article-title': 'Time-activity-patterns of some selected small groups as a basis for '
'exposure estimation: a methodological study',
'volume': '7',
'author': 'Dörre',
'year': '1997',
'journal-title': 'J. Expo. Anal. Environ. Epidemiol.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0385',
'doi-asserted-by': 'crossref',
'first-page': '1',
'DOI': '10.1038/s12276-019-0245-z',
'article-title': 'Nobiletin ameliorates hepatic ischemia and reperfusion injury through '
'the activation of SIRT-1/FOXO3a-mediated autophagy and mitochondrial '
'biogenesis',
'volume': '51',
'author': 'Dusabimana',
'year': '2019',
'journal-title': 'Exp. Mol. Med.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0390',
'doi-asserted-by': 'crossref',
'first-page': '31',
'DOI': '10.1007/s13304-013-0242-z',
'article-title': 'Preoperative fasting: current practice and areas for improvement',
'volume': '66',
'author': 'Falconer',
'year': '2014',
'journal-title': 'Updat. Surg.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0395',
'doi-asserted-by': 'crossref',
'first-page': '260',
'DOI': '10.1177/014107689809100505',
'article-title': 'Medical implications of controlled fasting',
'volume': '91',
'author': 'Fazel',
'year': '1998',
'journal-title': 'J. R. Soc. Med.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0400',
'first-page': '2',
'article-title': 'The multifaceted role of nutrient sensing and mTORC1 signaling in '
'physiology and aging',
'author': 'Fernandes',
'year': '2021',
'journal-title': 'Frontiers in Aging'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0405',
'doi-asserted-by': 'crossref',
'first-page': '273',
'DOI': '10.1016/j.bbalip.2014.12.013',
'article-title': 'α-Lipoic acid treatment increases mitochondrial biogenesis and promotes '
'beige adipose features in subcutaneous adipocytes from overweight/obese '
'subjects',
'volume': '1851',
'author': 'Fernández-Galilea',
'year': '2015',
'journal-title': 'Biochim. Biophys. Acta'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0410',
'doi-asserted-by': 'crossref',
'first-page': '2681',
'DOI': '10.1002/mc.22711',
'article-title': 'The protein restriction mimetic resveratrol is an autophagy inducer '
'stronger than amino acid starvation in ovarian cancer cells',
'volume': '56',
'author': 'Ferraresi',
'year': '2017',
'journal-title': 'Mol. Carcinog.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0415',
'doi-asserted-by': 'crossref',
'first-page': '6075',
'DOI': '10.3390/ijms23116075',
'article-title': 'The potential of epigallocatechin Gallate (EGCG) in targeting autophagy '
'for cancer treatment: a narrative review',
'volume': '23',
'author': 'Ferrari',
'year': '2022',
'journal-title': 'Int. J. Mol. Sci.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0420',
'doi-asserted-by': 'crossref',
'first-page': '25864',
'DOI': '10.1074/jbc.M502456200',
'article-title': 'Ketone bodies stimulate chaperone-mediated autophagy',
'volume': '280',
'author': 'Finn',
'year': '2005',
'journal-title': 'J. Biol. Chem.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0425',
'doi-asserted-by': 'crossref',
'first-page': '154',
'DOI': '10.1016/j.fct.2014.03.017',
'article-title': 'The effects of bioactive compounds from plant foods on mitochondrial '
'function: a focus on apoptotic mechanisms',
'volume': '68',
'author': 'Forbes-Hernández',
'year': '2014',
'journal-title': 'Food Chem. Toxicol.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0430',
'first-page': '10',
'article-title': 'The SARS-CoV-2 S1 spike protein promotes MAPK and NF-kB activation in '
'human lung cells and inflammatory cytokine production in human lung and '
'intestinal epithelial cells',
'volume': '2022',
'author': 'Forsyth',
'year': '1996',
'journal-title': 'Microorganisms'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0435',
'doi-asserted-by': 'crossref',
'first-page': '2620',
'DOI': '10.1038/s41596-022-00734-2',
'article-title': 'Determining small-molecule permeation through lipid membranes',
'volume': '17',
'author': 'Frallicciardi',
'year': '2022',
'journal-title': 'Nat. Protoc.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0440',
'doi-asserted-by': 'crossref',
'first-page': '51',
'DOI': '10.1186/1475-2891-9-51',
'article-title': 'Changing perceptions of hunger on a high nutrient density diet',
'volume': '9',
'author': 'Fuhrman',
'year': '2010',
'journal-title': 'Nutr. J.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0445',
'doi-asserted-by': 'crossref',
'first-page': '1340',
'DOI': '10.1006/bbrc.1993.2624',
'article-title': 'Purification and characterization of a strong fibrinolytic enzyme '
'(nattokinase) in the vegetable cheese natto, a popular soybean '
'fermented food in Japan',
'volume': '197',
'author': 'Fujita',
'year': '1993',
'journal-title': 'Biochem. Biophys. Res. Commun.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0450',
'article-title': 'Therapeutic use of intermittent fasting for people with type 2 diabetes '
'as an alternative to insulin',
'volume': '2018',
'author': 'Furmli',
'year': '2018',
'journal-title': 'Case Reports'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0455',
'doi-asserted-by': 'crossref',
'first-page': '2370',
'DOI': '10.1080/15548627.2015.1106666',
'article-title': 'Activation of chaperone-mediated autophagy as a potential anticancer '
'therapy',
'volume': '11',
'author': 'Galan-Acosta',
'year': '2015',
'journal-title': 'Autophagy'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0460',
'doi-asserted-by': 'crossref',
'first-page': '136',
'DOI': '10.1038/nchembio.2287',
'article-title': 'The pharmacological regulation of cellular mitophagy',
'volume': '13',
'author': 'Georgakopoulos',
'year': '2017',
'journal-title': 'Nat. Chem. Biol.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0465',
'doi-asserted-by': 'crossref',
'first-page': '2917',
'DOI': '10.1002/jmv.27684',
'article-title': 'Gut dysbiosis and long COVID-19: feeling gutted',
'volume': '94',
'author': 'Giannos',
'year': '2022',
'journal-title': 'J. Med. Virol.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0470',
'doi-asserted-by': 'crossref',
'first-page': '925',
'DOI': '10.5858/arpa.2021-0435-SA',
'article-title': 'Autopsy histopathologic cardiac findings in 2 adolescents following the '
'second COVID-19 vaccine dose',
'volume': '146',
'author': 'Gill',
'year': '2022',
'journal-title': 'Arch. Pathol. Lab. Med.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0475',
'doi-asserted-by': 'crossref',
'first-page': '429',
'DOI': '10.1177/0269881109359098',
'article-title': 'CNS toxicity involving methylene blue: the exemplar for understanding '
'and predicting drug interactions that precipitate serotonin toxicity',
'volume': '25',
'author': 'Gillman',
'year': '2011',
'journal-title': 'J. Psychopharmacol.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0480',
'doi-asserted-by': 'crossref',
'first-page': '1537',
'DOI': '10.1080/15548627.2015.1063768',
'article-title': 'Repetitive stimulation of autophagy-lysosome machinery by intermittent '
'fasting preconditions the myocardium to ischemia-reperfusion injury',
'volume': '11',
'author': 'Godar',
'year': '2015',
'journal-title': 'Autophagy'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0485',
'doi-asserted-by': 'crossref',
'first-page': '477',
'DOI': '10.1007/s10787-022-00939-7',
'article-title': 'Advancing combination treatment with glycyrrhizin and boswellic acids '
'for hospitalized patients with moderate COVID-19 infection: a '
'randomized clinical trial',
'volume': '30',
'author': 'Gomaa',
'year': '2022',
'journal-title': 'Inflammopharmacol'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0490',
'doi-asserted-by': 'crossref',
'unstructured': 'Gomaa, A.A.; Abdel-Wadood, Y.A.; Gomaa, M.A. Glycyrrhizin and boswellic '
'acids, the golden nutraceuticals: multitargeting for treatment of '
'mild–moderate COVID-19 and prevention of post-COVID cognitive '
'impairment. Inflammopharmacol 2022b, 30, 1977–1992, '
'doi:https://doi.org/10.1007/s10787-022-01062-3.',
'DOI': '10.1007/s10787-022-01062-3'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0495',
'doi-asserted-by': 'crossref',
'first-page': '192',
'DOI': '10.1016/j.nut.2019.05.005',
'article-title': 'Antiobesity effects of anthocyanins on mitochondrial biogenesis, '
'inflammation, and oxidative stress: a systematic review',
'volume': '66',
'author': 'Gomes',
'year': '2019',
'journal-title': 'Nutrition'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0500',
'doi-asserted-by': 'crossref',
'DOI': '10.1042/BSR20210611',
'article-title': 'SARS-CoV-2 spike protein S1 induces fibrin(ogen) resistant to '
'fibrinolysis: implications for microclot formation in COVID-19',
'volume': '41',
'author': 'Grobbelaar',
'year': '2021',
'journal-title': 'Biosci. Rep.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0505',
'doi-asserted-by': 'crossref',
'DOI': '10.3389/fnut.2023.1195270',
'article-title': 'Improvements during long-term fasting in patients with long COVID – a '
'case series and literature review',
'volume': '10',
'author': 'Grundler',
'year': '2023',
'journal-title': 'Front. Nutr.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0510',
'doi-asserted-by': 'crossref',
'first-page': '2519',
'DOI': '10.1016/j.biocel.2004.04.020',
'article-title': 'Decreased proteolysis caused by protein aggregates, inclusion bodies, '
'plaques, lipofuscin, ceroid, and ‘aggresomes’ during oxidative stress, '
'aging, and disease',
'volume': '36',
'author': 'Grune',
'year': '2004',
'journal-title': 'Int. J. Biochem. Cell Biol.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0515',
'doi-asserted-by': 'crossref',
'first-page': '1686',
'DOI': '10.3390/nu14091686',
'article-title': 'Magnesium-to-calcium ratio and mortality from COVID-19',
'volume': '14',
'author': 'Guerrero-Romero',
'year': '2022',
'journal-title': 'Nutrients'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0520',
'doi-asserted-by': 'crossref',
'first-page': '1026',
'DOI': '10.3390/metabo12111026',
'article-title': 'Signatures of mitochondrial dysfunction and impaired fatty acid '
'metabolism in plasma of patients with post-acute sequelae of COVID-19 '
'(PASC)',
'volume': '12',
'author': 'Guntur',
'year': '2022',
'journal-title': 'Metabolites'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0525',
'doi-asserted-by': 'crossref',
'first-page': '64',
'DOI': '10.1210/clinem/dgaa644',
'article-title': 'Intermittent fasting improves cardiometabolic risk factors and alters '
'gut microbiota in metabolic syndrome patients',
'volume': '106',
'author': 'Guo',
'year': '2021',
'journal-title': 'J. Clin. Endocrinol. Metab.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0530',
'doi-asserted-by': 'crossref',
'first-page': '3850',
'DOI': '10.1021/acs.jafc.8b00364',
'article-title': 'Structural modification of (−)-epigallocatechin gallate (EGCG) shows '
'significant enhancement in mitochondrial biogenesis',
'volume': '66',
'author': 'Ha',
'year': '2018',
'journal-title': 'J. Agric. Food Chem.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0535',
'doi-asserted-by': 'crossref',
'DOI': '10.3389/fmicb.2022.1007081',
'article-title': 'Activation of TLR4 by viral glycoproteins: a double-edged sword?',
'volume': '13',
'author': 'Halajian',
'year': '2022',
'journal-title': 'Front. Microbiol.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0540',
'doi-asserted-by': 'crossref',
'unstructured': 'Halma, M.T.J.; Rose, J.; Lawrie, T. The novelty of mRNA viral vaccines '
'and potential harms: a scoping review. J 2023a, 6, 220–235, '
'doi:https://doi.org/10.3390/j6020017.',
'DOI': '10.3390/j6020017'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0545',
'doi-asserted-by': 'crossref',
'first-page': '1308',
'DOI': '10.3390/microorganisms11051308',
'article-title': 'Strategies for the management of spike protein-related pathology',
'volume': '11',
'author': 'Halma',
'year': '2023',
'journal-title': 'Microorganisms'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0550',
'first-page': '190',
'article-title': 'Methylene blue for treatment of hospitalized COVID-19 patients: a '
'randomized, controlled, open-label clinical trial, phase 2',
'volume': '73',
'author': 'Hamidi-Alamdari',
'year': '2021',
'journal-title': 'Rev. Investig. Clin.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0555',
'doi-asserted-by': 'crossref',
'first-page': '1334',
'DOI': '10.1016/j.metabol.2015.07.010',
'article-title': 'Curcumin treatment enhances the effect of exercise on mitochondrial '
'biogenesis in skeletal muscle by increasing cAMP levels',
'volume': '64',
'author': 'Hamidie',
'year': '2015',
'journal-title': 'Metab. Clin. Exp.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0560',
'doi-asserted-by': 'crossref',
'first-page': '634',
'DOI': '10.1016/j.jnutbio.2009.03.012',
'article-title': 'Hydroxytyrosol promotes mitochondrial biogenesis and mitochondrial '
'function in 3T3-L1 adipocytes',
'volume': '21',
'author': 'Hao',
'year': '2010',
'journal-title': 'J. Nutr. Biochem.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0565',
'doi-asserted-by': 'crossref',
'first-page': '324',
'DOI': '10.1038/nature10317',
'article-title': 'Molecular chaperones in protein folding and proteostasis',
'volume': '475',
'author': 'Hartl',
'year': '2011',
'journal-title': 'Nature'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0570',
'doi-asserted-by': 'crossref',
'first-page': '714',
'DOI': '10.1038/ijo.2010.171',
'article-title': 'The effects of intermittent or continuous energy restriction on weight '
'loss and metabolic disease risk markers: a randomized trial in young '
'overweight women',
'volume': '35',
'author': 'Harvie',
'year': '2011',
'journal-title': 'Int. J. Obes.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0575',
'doi-asserted-by': 'crossref',
'first-page': '1534',
'DOI': '10.1017/S0007114513000792',
'article-title': 'The effect of intermittent energy and carbohydrate restriction v. daily '
'energy restriction on weight loss and metabolic disease risk markers in '
'overweight women',
'volume': '110',
'author': 'Harvie',
'year': '2013',
'journal-title': 'Br. J. Nutr.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0580',
'doi-asserted-by': 'crossref',
'first-page': '147',
'DOI': '10.1016/j.biocel.2014.05.012',
'article-title': 'Regulation by mitophagy',
'volume': '53',
'author': 'Hattori',
'year': '2014',
'journal-title': 'Int. J. Biochem. Cell Biol.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0585',
'doi-asserted-by': 'crossref',
'first-page': '9465',
'DOI': '10.1038/s41598-022-13399-4',
'article-title': 'Post-exposure persistence of nitric oxide upregulation in skin cells '
'irradiated by UV-A',
'volume': '12',
'author': 'Hazell',
'year': '2022',
'journal-title': 'Sci. Rep.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0590',
'doi-asserted-by': 'crossref',
'first-page': '511',
'DOI': '10.1038/nature10758',
'article-title': 'Exercise-induced BCL2-regulated autophagy is required for muscle '
'glucose homeostasis',
'volume': '481',
'author': 'He',
'year': '2012',
'journal-title': 'Nature'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0595',
'doi-asserted-by': 'crossref',
'DOI': '10.3389/fnut.2023.1048230',
'article-title': 'Intermittent fasting and immunomodulatory effects: a systematic review',
'volume': '10',
'author': 'He',
'year': '2023',
'journal-title': 'Frontiers in Nutrition'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0600',
'doi-asserted-by': 'crossref',
'first-page': '628',
'DOI': '10.1097/CM9.0000000000001165',
'article-title': 'Electrical stimulation induces mitochondrial autophagy via activating '
'oxidative stress and Sirt3 signaling pathway',
'volume': '134',
'author': 'He-Ling',
'year': '2021',
'journal-title': 'Chin. Med. J.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0605',
'first-page': '7',
'article-title': 'Vitamin C and COVID-19',
'author': 'Hemilä',
'year': '2021',
'journal-title': 'Front. Med.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0610',
'doi-asserted-by': 'crossref',
'first-page': '2',
'DOI': '10.1007/s12263-014-0451-1',
'article-title': 'In vivo effects of dietary quercetin and quercetin-rich red onion '
'extract on skeletal muscle mitochondria, metabolism, and insulin '
'sensitivity',
'volume': '10',
'author': 'Henagan',
'year': '2014',
'journal-title': 'Genes Nutr.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0615',
'first-page': '888',
'article-title': 'A cohort of cancer patients with no reported cases of SARS-CoV-2 '
'infection: the possible preventive role of methylene blue',
'author': 'Henry',
'year': '2020',
'journal-title': 'Substantia'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0620',
'doi-asserted-by': 'crossref',
'first-page': '7',
'DOI': '10.1016/j.molcel.2015.08.016',
'article-title': 'The PINK1-PARKIN mitochondrial ubiquitylation pathway drives a program '
'of OPTN/NDP52 recruitment and TBK1 activation to promote mitophagy',
'volume': '60',
'author': 'Heo',
'year': '2015',
'journal-title': 'Mol. Cell'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0625',
'doi-asserted-by': 'crossref',
'first-page': '92',
'DOI': '10.3390/foods6100092',
'article-title': 'Curcumin: a review of its effects on human health',
'volume': '6',
'author': 'Hewlings',
'year': '2017',
'journal-title': 'Foods'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0630',
'doi-asserted-by': 'crossref',
'first-page': '3708',
'DOI': '10.1038/srep03708',
'article-title': 'Eriocitrin ameliorates diet-induced hepatic steatosis with activation '
'of mitochondrial biogenesis',
'volume': '4',
'author': 'Hiramitsu',
'year': '2014',
'journal-title': 'Sci. Rep.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0635',
'doi-asserted-by': 'crossref',
'first-page': '968',
'DOI': '10.1172/JCI113450',
'article-title': 'Fasting enhances growth hormone secretion and amplifies the complex '
'rhythms of growth hormone secretion in man',
'volume': '81',
'author': 'Ho',
'year': '1988',
'journal-title': 'J. Clin. Invest.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0640',
'doi-asserted-by': 'crossref',
'first-page': 'S236',
'DOI': '10.2105/AJPH.2008.134627',
'article-title': 'The open-air treatment of pandemic influenza',
'volume': '99',
'author': 'Hobday',
'year': '2009',
'journal-title': 'Am. J. Public Health'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0645',
'doi-asserted-by': 'crossref',
'first-page': '465',
'DOI': '10.1093/jaarel/LXIII.3.465',
'article-title': 'Eating and fasting for god in Sufi tradition',
'volume': '63',
'author': 'Hoffman',
'year': '1995',
'journal-title': 'J. Am. Acad. Relig.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0650',
'series-title': 'Vitamin D',
'isbn-type': 'print',
'doi-asserted-by': 'crossref',
'first-page': '45',
'DOI': '10.1016/B978-0-12-809965-0.00004-5',
'article-title': 'Chapter 4 - photobiology of vitamin D',
'author': 'Holick',
'year': '2018',
'ISBN': 'http://id.crossref.org/isbn/9780128099650'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0655',
'doi-asserted-by': 'crossref',
'first-page': '145',
'DOI': '10.1136/bmjnph-2022-000462',
'article-title': 'Association of periodic fasting with lower severity of COVID-19 '
'outcomes in the SARS-CoV-2 prevaccine era: an observational cohort from '
'the INSPIRE Registry',
'volume': '5',
'author': 'Horne',
'year': '2022',
'journal-title': 'BMJ Nutr Prev Health'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0660',
'doi-asserted-by': 'crossref',
'first-page': '503',
'DOI': '10.1021/jf803072r',
'article-title': 'Amyloid-degrading ability of nattokinase from Bacillus subtilis natto',
'volume': '57',
'author': 'Hsu',
'year': '2009',
'journal-title': 'J. Agric. Food Chem.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0665',
'series-title': 'SARS-CoV-2 Spike Protein Promotes Hyper-inflammatory Response That Can '
'Be Ameliorated by Spike-antagonistic Peptide and FDA-approved ER Stress '
'and MAP Kinase Inhibitors in Vitro',
'author': 'Hsu',
'year': '2020'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0670',
'doi-asserted-by': 'crossref',
'first-page': '17356',
'DOI': '10.18632/oncotarget.7861',
'article-title': 'Tau accumulation impairs mitophagy via increasing mitochondrial '
'membrane potential and reducing mitochondrial Parkin',
'volume': '7',
'author': 'Hu',
'year': '2016',
'journal-title': 'Oncotarget'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0675',
'doi-asserted-by': 'crossref',
'DOI': '10.1097/MD.0000000000031138',
'article-title': 'Efficiency of nicotinamide-based supportive therapy in lymphopenia for '
'patients with ordinary or severe COVID-19: a randomized controlled '
'trial',
'volume': '101',
'author': 'Hu',
'year': '2022',
'journal-title': 'Medicine (Baltimore)'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0680',
'doi-asserted-by': 'crossref',
'first-page': '211',
'DOI': '10.1016/j.bbrc.2013.07.055',
'article-title': 'Nebivolol stimulates mitochondrial biogenesis in 3T3-L1 adipocytes',
'volume': '438',
'author': 'Huang',
'year': '2013',
'journal-title': 'Biochem. Biophys. Res. Commun.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0685',
'doi-asserted-by': 'crossref',
'first-page': '456',
'DOI': '10.1016/j.molcel.2014.12.013',
'article-title': 'Deacetylation of nuclear LC3 drives autophagy initiation under '
'starvation',
'volume': '57',
'author': 'Huang',
'year': '2015',
'journal-title': 'Mol. Cell'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0690',
'doi-asserted-by': 'crossref',
'first-page': '2562',
'DOI': '10.3390/cells11162562',
'article-title': 'Modulating chaperone-mediated autophagy and its clinical applications '
'in cancer',
'volume': '11',
'author': 'Hubert',
'year': '2022',
'journal-title': 'Cells'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0695',
'doi-asserted-by': 'crossref',
'first-page': '225',
'DOI': '10.1146/annurev-biochem-061516-044820',
'article-title': 'Mechanisms of autophagy initiation',
'volume': '86',
'author': 'Hurley',
'year': '2017',
'journal-title': 'Annu. Rev. Biochem.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0700',
'doi-asserted-by': 'crossref',
'first-page': '877',
'DOI': '10.3390/cells12060877',
'article-title': 'Spike protein impairs mitochondrial function in human cardiomyocytes: '
'mechanisms underlying cardiac injury in COVID-19',
'volume': '12',
'author': 'Huynh',
'year': '2023',
'journal-title': 'Cells'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0705',
'doi-asserted-by': 'crossref',
'first-page': '547',
'DOI': '10.1080/07315724.2019.1705203',
'article-title': 'Effects of pyrroloquinoline quinone (PQQ) supplementation on aerobic '
'exercise performance and indices of mitochondrial biogenesis in '
'untrained men',
'volume': '39',
'author': 'Hwang',
'year': '2020',
'journal-title': 'J. Am. Coll. Nutr.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0710',
'doi-asserted-by': 'crossref',
'first-page': '776',
'DOI': '10.3390/vaccines10050776',
'article-title': 'Association of impaired fasting glucose and diabetes with SARS-CoV-2 '
'spike antibody titers after the BNT162b2 vaccine among health care '
'workers in a tertiary hospital in Japan',
'volume': '10',
'author': 'Islam',
'year': '2022',
'journal-title': 'Vaccines'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0715',
'doi-asserted-by': 'crossref',
'DOI': '10.1016/j.phrs.2022.106360',
'article-title': 'Combining L-arginine with vitamin C improves long-COVID symptoms: the '
'LINCOLN Survey',
'volume': '183',
'author': 'Izzo',
'year': '2022',
'journal-title': 'Pharmacol. Res.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0720',
'doi-asserted-by': 'crossref',
'first-page': '3',
'DOI': '10.1038/s41580-021-00418-x',
'article-title': 'Mechanisms of SARS-CoV-2 entry into cells',
'volume': '23',
'author': 'Jackson',
'year': '2022',
'journal-title': 'Nat. Rev. Mol. Cell Biol.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0725',
'doi-asserted-by': 'crossref',
'first-page': '534',
'DOI': '10.31989/ffhd.v12i9.918',
'article-title': 'Corozo (Bactris guineensis) fruit extract has antiviral activity in '
'vitro against SARS-CoV-2',
'volume': '12',
'author': 'Jaimes-Gualdrón',
'year': '2022',
'journal-title': 'Functional Foods in Health and Disease'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0730',
'doi-asserted-by': 'crossref',
'first-page': '1234',
'DOI': '10.3390/nu11061234',
'article-title': 'Early time-restricted feeding improves 24-hour glucose levels and '
'affects markers of the circadian clock, aging, and autophagy in humans',
'volume': '11',
'author': 'Jamshed',
'year': '2019',
'journal-title': 'Nutrients'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0735',
'doi-asserted-by': 'crossref',
'first-page': '19304',
'DOI': '10.1074/jbc.M112.363747',
'article-title': 'Nicotinamide-induced mitophagy: event mediated by high NAD+/NADH ratio '
'and SIRT1 protein activation',
'volume': '287',
'author': 'Jang',
'year': '2012',
'journal-title': 'J. Biol. Chem.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0740',
'doi-asserted-by': 'crossref',
'first-page': '221',
'DOI': '10.5625/lar.2013.29.4.221',
'article-title': 'Nattokinase improves blood flow by inhibiting platelet aggregation and '
'thrombus formation',
'volume': '29',
'author': 'Jang',
'year': '2013',
'journal-title': 'Lab Anim Res'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0745',
'doi-asserted-by': 'crossref',
'first-page': '933',
'DOI': '10.1083/jcb.201008084',
'article-title': 'Mitochondrial membrane potential regulates PINK1 import and proteolytic '
'destabilization by PARL',
'volume': '191',
'author': 'Jin',
'year': '2010',
'journal-title': 'J. Cell Biol.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0750',
'doi-asserted-by': 'crossref',
'first-page': '69',
'DOI': '10.1042/bse0470069',
'article-title': 'Regulation of mitochondrial biogenesis',
'volume': '47',
'author': 'Jornayvaz',
'year': '2010',
'journal-title': 'Essays Biochem.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0755',
'doi-asserted-by': 'crossref',
'first-page': '813',
'DOI': '10.3390/ijms21030813',
'article-title': 'Resveratrol as inducer of autophagy, pro-survival, and '
'anti-inflammatory stimuli in cultured human RPE cells',
'volume': '21',
'author': 'Josifovska',
'year': '2020',
'journal-title': 'Int. J. Mol. Sci.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0760',
'doi-asserted-by': 'crossref',
'first-page': '143',
'DOI': '10.1083/jcb.201402104',
'article-title': 'PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase '
'activity',
'volume': '205',
'author': 'Kane',
'year': '2014',
'journal-title': 'J. Cell Biol.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0765',
'doi-asserted-by': 'crossref',
'first-page': '383',
'DOI': '10.1111/jpi.12319',
'article-title': 'Melatonin enhances mitophagy and mitochondrial biogenesis in rats with '
'carbon tetrachloride-induced liver fibrosis',
'volume': '60',
'author': 'Kang',
'year': '2016',
'journal-title': 'J. Pineal Res.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0770',
'doi-asserted-by': 'crossref',
'first-page': '267',
'DOI': '10.1111/jpi.12259',
'article-title': 'Melatonin promotes adipogenesis and mitochondrial biogenesis in 3T3-L1 '
'preadipocytes',
'volume': '59',
'author': 'Kato',
'year': '2015',
'journal-title': 'J. Pineal Res.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0775',
'doi-asserted-by': 'crossref',
'first-page': '229',
'DOI': '10.1159/000159227',
'article-title': 'Potential cellular signaling mechanisms mediating upregulation of '
'endothelial nitric oxide production by estrogen',
'volume': '34',
'author': 'Kauser',
'year': '2008',
'journal-title': 'J. Vasc. Res.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0780',
'doi-asserted-by': 'crossref',
'first-page': '365',
'DOI': '10.1038/s41580-018-0001-6',
'article-title': 'The coming of age of chaperone-mediated autophagy',
'volume': '19',
'author': 'Kaushik',
'year': '2018',
'journal-title': 'Nat. Rev. Mol. Cell Biol.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0785',
'doi-asserted-by': 'crossref',
'first-page': '127',
'DOI': '10.1042/BJ20140334',
'article-title': 'Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at '
'Ser65',
'volume': '460',
'author': 'Kazlauskaite',
'year': '2014',
'journal-title': 'Biochem. J.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0790',
'doi-asserted-by': 'crossref',
'first-page': '1657',
'DOI': '10.1096/fj.05-4107com',
'article-title': 'Vitamin C enters mitochondria via facilitative glucose transporter 1 '
'(Gluti) and confers mitochondrial protection against oxidative injury',
'volume': '19',
'author': 'Kc',
'year': '2005',
'journal-title': 'FASEB J.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0795',
'doi-asserted-by': 'crossref',
'first-page': '188',
'DOI': '10.1080/15548627.2019.1688984',
'article-title': 'A discovery platform for the identification of caloric restriction '
'mimetics with broad health-improving effects',
'volume': '16',
'author': 'Kepp',
'year': '2020',
'journal-title': 'Autophagy'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0800',
'doi-asserted-by': 'crossref',
'first-page': '61',
'DOI': '10.1186/s12944-023-01828-w',
'article-title': 'Adjunctive therapy with lipid-lowering agents in COVID-19: a systematic '
'review and meta-analysis of randomized controlled trials',
'volume': '22',
'author': 'Khalaji',
'year': '2023',
'journal-title': 'Lipids Health Dis.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0805',
'doi-asserted-by': 'crossref',
'DOI': '10.7554/eLife.68563',
'article-title': 'SARS-CoV-2 spike protein induces inflammation via TLR2-dependent '
'activation of the NF-κB pathway',
'volume': '10',
'author': 'Khan',
'year': '2021',
'journal-title': 'Elife'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0810',
'doi-asserted-by': 'crossref',
'first-page': '39',
'DOI': '10.1002/(SICI)1097-0223(199601)16:1<39::AID-PD789>3.0.CO;2-P',
'article-title': 'Fetal death after exposure to methylene blue dye during mid-trimester '
'amniocentesis in twin pregnancy',
'volume': '16',
'author': 'Kidd',
'year': '1996',
'journal-title': 'Prenat. Diagn.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0815',
'doi-asserted-by': 'crossref',
'first-page': '63',
'DOI': '10.1038/s41556-018-0205-1',
'article-title': 'mTOR as a central hub of nutrient signalling and cell growth',
'volume': '21',
'author': 'Kim',
'year': '2019',
'journal-title': 'Nat. Cell Biol.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0820',
'doi-asserted-by': 'crossref',
'first-page': '7721',
'DOI': '10.1021/acs.jafc.5b01908',
'article-title': 'De Candolle ethanolic extract inhibits adipogenic regulators in 3T3-L1 '
'cells and induces mitochondrial biogenesis in primary brown '
'preadipocytes',
'volume': '63',
'author': 'Kim',
'year': '2015',
'journal-title': 'J. Agric. Food Chem.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0825',
'first-page': '13',
'article-title': 'Spike proteins of SARS-CoV-2 induce pathological changes in molecular '
'delivery and metabolic function in the brain endothelial cells',
'volume': '2021',
'author': 'Kim',
'year': '2021',
'journal-title': 'Viruses'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0830',
'doi-asserted-by': 'crossref',
'first-page': '11917',
'DOI': '10.1021/acs.jafc.8b04124',
'article-title': 'Citrus tangeretin improves skeletal muscle mitochondrial biogenesis via '
'activating the AMPK-PGC1-α pathway in vitro and in vivo: a possible '
'mechanism for its beneficial effect on physical performance',
'volume': '66',
'author': 'Kou',
'year': '2018',
'journal-title': 'J. Agric. Food Chem.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0835',
'doi-asserted-by': 'crossref',
'first-page': '162',
'DOI': '10.1038/nature13392',
'article-title': 'Ubiquitin is phosphorylated by PINK1 to activate Parkin',
'volume': '510',
'author': 'Koyano',
'year': '2014',
'journal-title': 'Nature'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0840',
'doi-asserted-by': 'crossref',
'first-page': '258',
'DOI': '10.1097/MBP.0000000000000271',
'article-title': 'Fasting and ambulatory blood pressure monitoring',
'volume': '22',
'author': 'Krakoff',
'year': '2017',
'journal-title': 'Blood Pressure Monitoring'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0845',
'doi-asserted-by': 'crossref',
'first-page': '532',
'DOI': '10.1111/j.1742-4658.2011.08456.x',
'article-title': 'Molecular chaperones in targeting misfolded proteins for '
'ubiquitin-dependent degradation',
'volume': '279',
'author': 'Kriegenburg',
'year': '2012',
'journal-title': 'FEBS J.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0850',
'doi-asserted-by': 'crossref',
'volume': '11',
'author': 'Kumar',
'year': '2021',
'journal-title': 'Clin. Transl. Med.',
'DOI': '10.1002/ctm2.372'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0855',
'doi-asserted-by': 'crossref',
'DOI': '10.1038/srep11601',
'article-title': 'A single-dose of oral nattokinase potentiates thrombolysis and '
'anti-coagulation profiles',
'volume': '5',
'author': 'Kurosawa',
'year': '2015',
'journal-title': 'Sci. Rep.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0860',
'doi-asserted-by': 'crossref',
'first-page': '830',
'DOI': '10.3390/nu15040830',
'article-title': 'Prognostic value of magnesium in COVID-19: findings from the COMEPA '
'study',
'volume': '15',
'author': 'La Carrubba',
'year': '2023',
'journal-title': 'Nutrients'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0865',
'doi-asserted-by': 'crossref',
'first-page': '2102',
'DOI': '10.1002/jmv.27595',
'article-title': 'Efficacy of melatonin in the treatment of patients with COVID-19: a '
'systematic review and meta-analysis of randomized controlled trials',
'volume': '94',
'author': 'Lan',
'year': '2022',
'journal-title': 'J. Med. Virol.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0870',
'series-title': 'SARS-CoV-2 Spike Amyloid Fibrils Specifically and Selectively '
'Accelerates Amyloid Fibril Formation of Human Prion Protein and the '
'Amyloid β Peptide',
'author': 'Larsson',
'year': '2023'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0875',
'doi-asserted-by': 'crossref',
'first-page': '1129',
'DOI': '10.1161/01.CIR.97.12.1129',
'article-title': 'Upregulation of endothelial nitric oxide synthase by HMG CoA reductase '
'inhibitors',
'volume': '97',
'author': 'Laufs',
'year': '1998',
'journal-title': 'Circulation'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0880',
'doi-asserted-by': 'crossref',
'first-page': '538',
'DOI': '10.1002/bies.10298',
'article-title': 'Mitochondrial biogenesis: which part of “NO” do we understand?',
'volume': '25',
'author': 'Leary',
'year': '2003',
'journal-title': 'BioEssays'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0885',
'first-page': '23',
'article-title': 'Effects of isorhamnetin on adipocyte mitochondrial biogenesis and AMPK '
'activation',
'volume': '2018',
'author': 'Lee',
'year': '1853',
'journal-title': 'Molecules'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0890',
'doi-asserted-by': 'crossref',
'first-page': '1',
'DOI': '10.4196/kjpp.2011.15.1.1',
'article-title': 'Involvement of ROS in curcumin-induced autophagic cell death',
'volume': '15',
'author': 'Lee',
'year': '2011',
'journal-title': 'Korean J Physiol Pharmacol'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0895',
'article-title': 'Effects of epigallocatechin-3-gallate on thermogenesis and '
'mitochondrial biogenesis in brown adipose tissues of diet-induced obese '
'mice',
'volume': '61',
'author': 'Lee',
'year': '2017',
'journal-title': 'Food Nutr'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0900',
'first-page': '1',
'article-title': 'Transcriptional regulation of autophagy and its implications in human '
'disease',
'author': 'Lei',
'year': '2023',
'journal-title': 'Cell Death Differ.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0905',
'doi-asserted-by': 'crossref',
'first-page': '1323',
'DOI': '10.1161/CIRCRESAHA.121.318902',
'article-title': 'SARS-CoV-2 spike protein impairs endothelial function via '
'downregulation of ACE 2',
'volume': '128',
'author': 'Lei',
'year': '2021',
'journal-title': 'Circ. Res.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0910',
'doi-asserted-by': 'crossref',
'first-page': '2887',
'DOI': '10.1093/molbev/msaa127',
'article-title': 'Chaperone-mediated autophagy in the light of evolution: insight from '
'fish',
'volume': '37',
'author': 'Lescat',
'year': '2020',
'journal-title': 'Mol. Biol. Evol.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0915',
'doi-asserted-by': 'crossref',
'DOI': '10.1371/journal.pone.0195912',
'article-title': 'Time-controlled fasting prevents aging-like mitochondrial changes '
'induced by persistent dietary fat overload in skeletal muscle',
'volume': '13',
'author': 'Lettieri-Barbato',
'year': '2018',
'journal-title': 'PLoS One'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0920',
'doi-asserted-by': 'crossref',
'first-page': '201',
'DOI': '10.1073/pnas.1619876114',
'article-title': 'Autophagy wins the 2016 Nobel prize in physiology or medicine: '
'breakthroughs in baker’s yeast fuel advances in biomedical research',
'volume': '114',
'author': 'Levine',
'year': '2017',
'journal-title': 'Proc. Natl. Acad. Sci. U. S. A.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0925',
'first-page': '14',
'article-title': 'Nutraceuticals/drugs promoting mitophagy and mitochondrial biogenesis '
'may combat the mitochondrial dysfunction driving progression of dry '
'age-related macular degeneration',
'volume': '2022',
'author': 'Lewis Luján',
'year': '1985',
'journal-title': 'Nutrients'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0930',
'article-title': 'SARS-CoV-2 spike promotes inflammation and apoptosis through autophagy '
'by ROS-suppressed PI3K/AKT/mTOR signaling',
'volume': '2021',
'author': 'Li',
'year': '1867',
'journal-title': 'Biochim. Biophys. Acta (BBA) - Mol. Basis Dis.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0935',
'first-page': '8',
'article-title': 'Carnitine and COVID-19 susceptibility and severity: a Mendelian '
'randomization study. Frontiers',
'author': 'Li',
'year': '2021',
'journal-title': 'Nutrition'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0940',
'doi-asserted-by': 'crossref',
'first-page': '67',
'DOI': '10.1038/s41423-021-00807-4',
'article-title': 'SARS-CoV-2 ORF10 suppresses the antiviral innate immune response by '
'degrading MAVS through mitophagy',
'volume': '19',
'author': 'Li',
'year': '2022',
'journal-title': 'Cell. Mol. Immunol.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0945',
'doi-asserted-by': 'crossref',
'first-page': '1',
'DOI': '10.1038/s41392-023-01368-w',
'article-title': 'SARS-CoV-2 spike protein induces IL-18-mediated cardiopulmonary '
'inflammation via reduced mitophagy',
'volume': '8',
'author': 'Liang',
'year': '2023',
'journal-title': 'Sig Transduct Target Ther'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0950',
'doi-asserted-by': 'crossref',
'first-page': '1439',
'DOI': '10.1007/s11010-020-04006-z',
'article-title': 'Dysfunction of chaperone-mediated autophagy in human diseases',
'volume': '476',
'author': 'Liao',
'year': '2021',
'journal-title': 'Mol. Cell. Biochem.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0955',
'doi-asserted-by': 'crossref',
'article-title': 'More than a key—the pathological roles of SARS-CoV-2 spike protein in '
'COVID-19 related cardiac injury',
'author': 'Lin',
'year': '2023',
'journal-title': 'Sports Medicine and Health Science',
'DOI': '10.1016/j.smhs.2023.03.004'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0960',
'doi-asserted-by': 'crossref',
'first-page': '1412',
'DOI': '10.3390/ijms18071412',
'article-title': 'Natural compounds from herbs that can potentially execute as autophagy '
'inducers for cancer therapy',
'volume': '18',
'author': 'Lin',
'year': '2017',
'journal-title': 'Int. J. Mol. Sci.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0965',
'doi-asserted-by': 'crossref',
'first-page': '375',
'DOI': '10.1111/joim.12496',
'article-title': 'Avoidance of Sun exposure as a risk factor for major causes of death: a '
'competing risk analysis of the melanoma in southern Sweden cohort',
'volume': '280',
'author': 'Lindqvist',
'year': '2016',
'journal-title': 'J. Intern. Med.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0970',
'doi-asserted-by': 'crossref',
'first-page': '181',
'DOI': '10.1016/j.cmet.2013.12.008',
'article-title': 'Fasting: molecular mechanisms and clinical applications',
'volume': '19',
'author': 'Longo',
'year': '2014',
'journal-title': 'Cell Metab.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0975',
'doi-asserted-by': 'crossref',
'first-page': '921',
'DOI': '10.1080/15548627.2018.1436937',
'article-title': 'Induction of autophagy by depolarization of mitochondria',
'volume': '14',
'author': 'Lyamzaev',
'year': '2018',
'journal-title': 'Autophagy'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0980',
'doi-asserted-by': 'crossref',
'DOI': '10.1126/science.aan2788',
'article-title': 'Spermidine in health and disease',
'volume': '359',
'author': 'Madeo',
'year': '2018',
'journal-title': 'Science'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0985',
'doi-asserted-by': 'crossref',
'first-page': '135',
'DOI': '10.1146/annurev-nutr-120419-015419',
'article-title': 'Nutritional aspects of spermidine',
'volume': '40',
'author': 'Madeo',
'year': '2020',
'journal-title': 'Annu. Rev. Nutr.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0990',
'doi-asserted-by': 'crossref',
'first-page': '934',
'DOI': '10.5005/jp-journals-10071-23905',
'article-title': 'Intravenous methylene blue as a rescue therapy in the management of '
'refractory hypoxia in COVID-19 ARDS patients: a case series',
'volume': '25',
'author': 'Mahale',
'year': '2021',
'journal-title': 'Indian J Crit Care Med'},
{ 'key': '10.1016/j.endmts.2024.100163_bb0995',
'first-page': '1',
'article-title': 'Neurologic manifestations of hospitalized patients with coronavirus '
'disease 2019 in Wuhan',
'volume': '77',
'author': 'Mao',
'year': '2020',
'journal-title': 'China. JAMA Neurol'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1000',
'doi-asserted-by': 'crossref',
'first-page': '332',
'DOI': '10.1016/j.arr.2006.04.002',
'article-title': 'Caloric restriction and intermittent fasting: two potential diets for '
'successful brain aging',
'volume': '5',
'author': 'Martin',
'year': '2006',
'journal-title': 'Ageing Res. Rev.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1005',
'doi-asserted-by': 'crossref',
'first-page': '856',
'DOI': '10.1016/j.cmet.2017.09.020',
'article-title': 'System-wide benefits of intermeal fasting by autophagy',
'volume': '26',
'author': 'Martinez-Lopez',
'year': '2017',
'journal-title': 'Cell Metab.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1010',
'doi-asserted-by': 'crossref',
'first-page': '772',
'DOI': '10.1111/sms.12945',
'article-title': 'Exercise-mediated modulation of autophagy in skeletal muscle',
'volume': '28',
'author': 'Martin-Rincon',
'year': '2018',
'journal-title': 'Scand. J. Med. Sci. Sports'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1015',
'doi-asserted-by': 'crossref',
'first-page': '129',
'DOI': '10.1016/j.jnutbio.2004.12.007',
'article-title': 'Beneficial effects of intermittent fasting and caloric restriction on '
'the cardiovascular and cerebrovascular systems',
'volume': '16',
'author': 'Mattson',
'year': '2005',
'journal-title': 'J. Nutr. Biochem.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1020',
'doi-asserted-by': 'crossref',
'first-page': '46',
'DOI': '10.1016/j.arr.2016.10.005',
'article-title': 'Impact of intermittent fasting on health and disease processes',
'volume': '39',
'author': 'Mattson',
'year': '2017',
'journal-title': 'Ageing Res. Rev.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1025',
'doi-asserted-by': 'crossref',
'DOI': '10.1038/s41598-022-13920-9',
'article-title': 'Randomized double-blind placebo-controlled proof-of-concept trial of '
'resveratrol for outpatient treatment of mild coronavirus disease '
'(COVID-19)',
'volume': '12',
'author': 'McCreary',
'year': '2022',
'journal-title': 'Sci. Rep.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1030',
'doi-asserted-by': 'crossref',
'first-page': '229',
'DOI': '10.3390/molecules26010229',
'article-title': 'Anti-inflammatory action and mechanisms of resveratrol',
'volume': '26',
'author': 'Meng',
'year': '2021',
'journal-title': 'Molecules'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1035',
'doi-asserted-by': 'crossref',
'first-page': '189',
'DOI': '10.1186/1479-5876-10-189',
'article-title': 'Effect of high-dose intravenous vitamin C on inflammation in cancer '
'patients',
'volume': '10',
'author': 'Mikirova',
'year': '2012',
'journal-title': 'J. Transl. Med.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1040',
'series-title': 'Resveratrol and Copper for Treatment of Severe COVID-19: An '
'Observational Study (RESCU 002)',
'author': 'Mittra',
'year': '2020'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1045',
'doi-asserted-by': 'crossref',
'first-page': '1519',
'DOI': '10.1007/s10616-018-0242-4',
'article-title': 'Cyanidin-3-glucoside enhances mitochondrial function and biogenesis in '
'a human hepatocyte cell line',
'volume': '70',
'author': 'Mogalli',
'year': '2018',
'journal-title': 'Cytotechnology'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1050',
'doi-asserted-by': 'crossref',
'first-page': '811',
'DOI': '10.1042/BCJ20200849',
'article-title': 'Bulk autophagy induction and life extension is achieved when iron is '
'the only limited nutrient in Saccharomyces cerevisiae',
'volume': '478',
'author': 'Montella-Manuel',
'year': '2021',
'journal-title': 'Biochem. J.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1055',
'doi-asserted-by': 'crossref',
'first-page': '1651',
'DOI': '10.3390/vaccines10101651',
'article-title': 'A case report: multifocal necrotizing encephalitis and myocarditis '
'after BNT162b2 mRNA vaccination against COVID-19',
'volume': '10',
'author': 'Mörz',
'year': '2022',
'journal-title': 'Vaccines'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1060',
'doi-asserted-by': 'crossref',
'first-page': '3650',
'DOI': '10.1158/0008-5472.CAN-22-0887',
'article-title': 'The mechanisms of action of tumor treating fields',
'volume': '82',
'author': 'Moser',
'year': '2022',
'journal-title': 'Cancer Res.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1065',
'first-page': '177',
'article-title': 'Attitude and practice of therapeutic fasting among naturopathy '
'physicians: across sectional national survey',
'volume': '3',
'author': 'Nair',
'year': '2015',
'journal-title': 'Journal of Nutrition, Fasting and Health'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1070',
'doi-asserted-by': 'crossref',
'first-page': '795',
'DOI': '10.1083/jcb.200809125',
'article-title': 'Parkin is recruited selectively to impaired mitochondria and promotes '
'their autophagy',
'volume': '183',
'author': 'Narendra',
'year': '2008',
'journal-title': 'J. Cell Biol.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1075',
'doi-asserted-by': 'crossref',
'first-page': 'S77',
'DOI': '10.1016/j.vacune.2022.10.019',
'article-title': 'Menstrual abnormalities after COVID-19 vaccines: a systematic review',
'volume': '23',
'author': 'Nazir',
'year': '2022',
'journal-title': 'Vacunas (English Edition)'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1080',
'article-title': 'Nebivolol: an effective option against long-lasting dyspnoea following '
'COVID-19 pneumonia - a pivotal double-blind, cross-over controlled '
'study',
'volume': '17',
'author': 'Negro',
'year': '2022',
'journal-title': 'Multidisciplinary Respiratory Medicine'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1085',
'doi-asserted-by': 'crossref',
'DOI': '10.1016/j.cyto.2020.155312',
'article-title': 'Probable positive effects of the photobiomodulation as an adjunctive '
'treatment in COVID-19: a systematic review',
'volume': '137',
'author': 'Nejatifard',
'year': '2021',
'journal-title': 'Cytokine'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1090',
'first-page': '11',
'article-title': 'The spike protein of SARS-CoV-2 impairs lipid metabolism and increases '
'susceptibility to lipotoxicity: implication for a role of Nrf2',
'volume': '2022',
'author': 'Nguyen',
'year': '1916',
'journal-title': 'Cells'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1095',
'doi-asserted-by': 'crossref',
'first-page': '42',
'DOI': '10.1016/j.mito.2013.11.001',
'article-title': 'Effect of near-infrared light exposure on mitochondrial signaling in '
'C2C12 muscle cells',
'volume': '14',
'author': 'Nguyen',
'year': '2014',
'journal-title': 'Mitochondrion'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1100',
'doi-asserted-by': 'crossref',
'first-page': '99',
'DOI': '10.1016/j.exger.2017.08.017',
'article-title': 'Dietary supplementation with acetyl-l-carnitine counteracts age-related '
'alterations of mitochondrial biogenesis, dynamics and antioxidant '
'defenses in brain of old rats',
'volume': '98',
'author': 'Nicassio',
'year': '2017',
'journal-title': 'Exp. Gerontol.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1105',
'doi-asserted-by': 'crossref',
'first-page': '896',
'DOI': '10.1126/science.1079368',
'article-title': 'Mitochondrial biogenesis in mammals: the role of endogenous nitric '
'oxide',
'volume': '299',
'author': 'Nisoli',
'year': '2003',
'journal-title': 'Science'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1110',
'doi-asserted-by': 'crossref',
'DOI': '10.1111/jpi.12627',
'article-title': 'Melatonin enhances mitochondrial biogenesis and protects against '
'rotenone-induced mitochondrial deficiency in early porcine embryos',
'volume': '68',
'author': 'Niu',
'year': '2020',
'journal-title': 'J. Pineal Res.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1115',
'doi-asserted-by': 'crossref',
'first-page': '593',
'DOI': '10.1159/000522118',
'article-title': 'Outpatient pulmonary rehabilitation in patients with long COVID '
'improves exercise capacity, functional status, dyspnea, fatigue, and '
'quality of life',
'volume': '101',
'author': 'Nopp',
'year': '2022',
'journal-title': 'Respiration'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1120',
'first-page': '9',
'article-title': 'Higher intake of dietary magnesium is inversely associated with '
'COVID-19 severity and symptoms in hospitalized patients: a '
'cross-sectional study. Frontiers',
'author': 'Nouri-Majd',
'year': '2022',
'journal-title': 'Nutrition'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1125',
'doi-asserted-by': 'crossref',
'first-page': '1415',
'DOI': '10.3390/v14071415',
'article-title': 'Potential autoimmunity resulting from molecular mimicry between '
'SARS-CoV-2 spike and human proteins',
'volume': '14',
'author': 'Nunez-Castilla',
'year': '2022',
'journal-title': 'Viruses'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1130',
'doi-asserted-by': 'crossref',
'first-page': '3113',
'DOI': '10.3390/biomedicines10123113',
'article-title': 'Understanding long COVID; mitochondrial health and adaptation—old '
'pathways',
'volume': '10',
'author': 'Nunn',
'year': '2022',
'journal-title': 'new problems. Biomedicines'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1135',
'doi-asserted-by': 'crossref',
'first-page': '8945',
'DOI': '10.1021/jacs.2c03925',
'article-title': 'Amyloidogenesis of SARS-CoV-2 spike protein',
'volume': '144',
'author': 'Nyström',
'year': '2022',
'journal-title': 'J. Am. Chem. Soc.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1140',
'doi-asserted-by': 'crossref',
'first-page': '21',
'DOI': '10.1016/j.bbrc.2021.07.034',
'article-title': 'Natto extract, a Japanese fermented soybean food, directly inhibits '
'viral infections including SARS-CoV-2 in vitro',
'volume': '570',
'author': 'Oba',
'year': '2021',
'journal-title': 'Biochem. Biophys. Res. Commun.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1145',
'doi-asserted-by': 'crossref',
'first-page': '155',
'DOI': '10.3390/nu13010155',
'article-title': 'Consumption of a high-protein meal replacement leads to higher fat '
'oxidation, suppression of hunger, and improved metabolic profile after '
'an exercise session',
'volume': '13',
'author': 'Oliveira',
'year': '2021',
'journal-title': 'Nutrients'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1150',
'doi-asserted-by': 'crossref',
'first-page': '1278',
'DOI': '10.3390/antiox10081278',
'article-title': 'Vitamin C supplementation in healthy individuals leads to shifts of '
'bacterial populations in the gut-a pilot study',
'volume': '10',
'author': 'Otten',
'year': '2021',
'journal-title': 'Antioxidants (Basel)'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1155',
'doi-asserted-by': 'crossref',
'first-page': '848',
'DOI': '10.1038/s41467-021-21118-2',
'article-title': 'SARS-CoV-2 D614G spike mutation increases entry efficiency with '
'enhanced ACE2-binding affinity',
'volume': '12',
'author': 'Ozono',
'year': '2021',
'journal-title': 'Nat. Commun.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1160',
'first-page': '139',
'article-title': 'Effects of nattokinase, a pro-fibrinolytic enzyme, on red blood cell '
'aggregation and whole blood viscosity',
'volume': '35',
'author': 'Pais',
'year': '2006',
'journal-title': 'Clin. Hemorheol. Microcirc.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1165',
'first-page': '41',
'article-title': 'N-acetylcysteine efficacy in patients hospitalized with COVID-19 '
'pneumonia: a systematic review and meta-analysis',
'volume': '61',
'author': 'Paraskevas',
'year': '2023',
'journal-title': 'Rom. J. Intern. Med.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1170',
'first-page': '1',
'article-title': 'Resveratrol induces autophagy by directly inhibiting mTOR through ATP '
'competition',
'volume': '6',
'author': 'Park',
'year': '2016',
'journal-title': 'Sci. Rep.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1175',
'doi-asserted-by': 'crossref',
'first-page': '3369',
'DOI': '10.3390/ijms21093369',
'article-title': 'Autophagy in neurodegenerative diseases: a hunter for aggregates',
'volume': '21',
'author': 'Park',
'year': '2020',
'journal-title': 'Int. J. Mol. Sci.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1180',
'doi-asserted-by': 'crossref',
'first-page': '2287',
'DOI': '10.3390/biomedicines11082287',
'article-title': '‘Spikeopathy’: COVID-19 spike protein is pathogenic, from both virus '
'and vaccine mRNA',
'volume': '11',
'author': 'Parry',
'year': '2023',
'journal-title': 'Biomedicines'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1185',
'doi-asserted-by': 'crossref',
'first-page': '354',
'DOI': '10.3390/v13020354',
'article-title': 'Resveratrol inhibits HCoV-229E and SARS-CoV-2 coronavirus replication '
'in vitro',
'volume': '13',
'author': 'Pasquereau',
'year': '2021',
'journal-title': 'Viruses'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1190',
'first-page': '2129',
'article-title': 'The role of nebulized methylene blue [NMB] in the management of '
'COVID-19 cases: an observational study',
'volume': '4',
'author': 'Patidar',
'year': '2022',
'journal-title': 'International Journal of Medical Arts'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1195',
'doi-asserted-by': 'crossref',
'DOI': '10.1001/jamanetworkopen.2021.39558',
'article-title': 'Intermittent fasting and obesity-related health outcomes: an umbrella '
'review of meta-analyses of randomized clinical trials',
'volume': '4',
'author': 'Patikorn',
'year': '2021',
'journal-title': 'JAMA Netw. Open'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1200',
'doi-asserted-by': 'crossref',
'first-page': '371',
'DOI': '10.1146/annurev-nutr-071816-064634',
'article-title': 'Metabolic effects of intermittent fasting',
'volume': '37',
'author': 'Patterson',
'year': '2017',
'journal-title': 'Annu. Rev. Nutr.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1205',
'doi-asserted-by': 'crossref',
'first-page': '1203',
'DOI': '10.1016/j.jand.2015.02.018',
'article-title': 'Intermittent fasting and human metabolic health',
'volume': '115',
'author': 'Patterson',
'year': '2015',
'journal-title': 'J. Acad. Nutr. Diet.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1210',
'article-title': 'Effect of a nutraceutical drug in COPD condition: a pilot study of in '
'vitro, in vivo and clinical trial',
'volume': '60',
'author': 'Pattnaik',
'year': '2022',
'journal-title': 'Eur. Respir. J.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1215',
'doi-asserted-by': 'crossref',
'DOI': '10.3389/fphar.2021.669362',
'article-title': 'Oral curcumin with piperine as adjuvant therapy for the treatment of '
'COVID-19: a randomized clinical trial',
'volume': '12',
'author': 'Pawar',
'year': '2021',
'journal-title': 'Front. Pharmacol.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1220',
'doi-asserted-by': 'crossref',
'first-page': '148',
'DOI': '10.1089/rej.2009.0955',
'article-title': 'Acetyl-L-carnitine supplementation to old rats partially reverts the '
'age-related mitochondrial decay of soleus muscle by activating '
'peroxisome proliferator-activated receptor gamma '
'coactivator-1alpha-dependent mitochondrial biogenesis',
'volume': '13',
'author': 'Pesce',
'year': '2010',
'journal-title': 'Rejuvenation Res.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1225',
'doi-asserted-by': 'crossref',
'first-page': '136',
'DOI': '10.1089/rej.2011.1255',
'article-title': 'Acetyl-L-carnitine activates the peroxisome proliferator-activated '
'receptor-γ coactivators PGC-1α/PGC-1β-dependent signaling cascade of '
'mitochondrial biogenesis and decreases the oxidized peroxiredoxins '
'content in old rat liver',
'volume': '15',
'author': 'Pesce',
'year': '2012',
'journal-title': 'Rejuvenation Res.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1230',
'doi-asserted-by': 'crossref',
'first-page': '2566',
'DOI': '10.1002/1873-3468.14490',
'article-title': 'SARS-CoV-2 spike protein aggregation is triggered by bacterial '
'lipopolysaccharide',
'volume': '596',
'author': 'Petrlova',
'year': '2022',
'journal-title': 'FEBS Lett.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1235',
'doi-asserted-by': 'crossref',
'first-page': '188',
'DOI': '10.3390/biomedicines10010188',
'article-title': 'Penetration of the SARS-CoV-2 spike protein across the blood-brain '
'barrier, as revealed by a combination of a human cell culture model '
'system and optical biosensing',
'volume': '10',
'author': 'Petrovszki',
'year': '2022',
'journal-title': 'Biomedicines'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1240',
'doi-asserted-by': 'crossref',
'first-page': '257',
'DOI': '10.1016/j.neuron.2014.12.007',
'article-title': 'The roles of PINK1, Parkin, and mitochondrial fidelity in Parkinson’s '
'disease',
'volume': '85',
'author': 'Pickrell',
'year': '2015',
'journal-title': 'Neuron'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1245',
'doi-asserted-by': 'crossref',
'first-page': '1987',
'DOI': '10.4161/cc.28929',
'article-title': 'Coffee induces autophagy in vivo',
'volume': '13',
'author': 'Pietrocola',
'year': '2014',
'journal-title': 'Cell Cycle'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1250',
'doi-asserted-by': 'crossref',
'first-page': '509',
'DOI': '10.1038/cdd.2014.215',
'article-title': 'Spermidine induces autophagy by inhibiting the acetyltransferase EP300',
'volume': '22',
'author': 'Pietrocola',
'year': '2015',
'journal-title': 'Cell Death Differ.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1255',
'doi-asserted-by': 'crossref',
'DOI': '10.1155/2017/6797460',
'article-title': 'The involvement of Mg2+ in regulation of cellular and mitochondrial '
'functions',
'volume': '2017',
'author': 'Pilchova',
'year': '2017',
'journal-title': 'Oxidative Med. Cell. Longev.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1260',
'doi-asserted-by': 'crossref',
'DOI': '10.1371/journal.pone.0048279',
'article-title': 'Neuroprotective actions of methylene blue and its derivatives',
'volume': '7',
'author': 'Poteet',
'year': '2012',
'journal-title': 'PLoS One'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1265',
'doi-asserted-by': 'crossref',
'first-page': '43',
'DOI': '10.1016/j.mito.2023.01.005',
'article-title': 'Severe acute respiratory syndrome coronaviruses contributing to '
'mitochondrial dysfunction: implications for post-COVID complications',
'volume': '69',
'author': 'Prasada Kabekkodu',
'year': '2023',
'journal-title': 'Mitochondrion'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1270',
'doi-asserted-by': 'crossref',
'DOI': '10.1002/rmv.2177',
'article-title': 'Clotting disorder in severe acute respiratory syndrome coronavirus 2',
'volume': '31',
'author': 'Pujhari',
'year': '2021',
'journal-title': 'Rev. Med. Virol.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1275',
'doi-asserted-by': 'crossref',
'first-page': '4054',
'DOI': '10.3390/nu14194054',
'article-title': 'Reduction in serum magnesium levels and renal function are associated '
'with increased mortality in obese COVID-19 patients',
'volume': '14',
'author': 'Pulido Perez',
'year': '2022',
'journal-title': 'Nutrients'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1280',
'doi-asserted-by': 'crossref',
'first-page': '2623',
'DOI': '10.1111/pce.12329',
'article-title': 'New clues for a cold case: nitric oxide response to low temperature',
'volume': '37',
'author': 'Puyaubert',
'year': '2014',
'journal-title': 'Plant Cell Environ.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1285',
'doi-asserted-by': 'crossref',
'first-page': '136',
'DOI': '10.1016/j.cellbi.2007.08.024',
'article-title': 'Effect of magnesium on calcium-induced depolarisation of mitochondrial '
'transmembrane potential',
'volume': '32',
'author': 'Racay',
'year': '2008',
'journal-title': 'Cell Biol. Int.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1290',
'first-page': '5',
'article-title': 'Potential compounds for the treatment of mitochondrial disease',
'volume': '116',
'author': 'Rai',
'year': '2015',
'journal-title': 'Br. Med. Bull.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1295',
'doi-asserted-by': 'crossref',
'first-page': '1496',
'DOI': '10.1111/dom.14080',
'article-title': 'Intermittent fasting and ‘metabolic switch’: effects on metabolic '
'syndrome, prediabetes and type 2 diabetes',
'volume': '22',
'author': 'Rajpal',
'year': '2020',
'journal-title': 'Diabetes Obes. Metab.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1300',
'doi-asserted-by': 'crossref',
'first-page': '11388',
'DOI': '10.1523/JNEUROSCI.1356-10.2010',
'article-title': 'Rapamycin activates autophagy and improves myelination in explant '
'cultures from neuropathic mice',
'volume': '30',
'author': 'Rangaraju',
'year': '2010',
'journal-title': 'J. Neurosci.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1305',
'doi-asserted-by': 'crossref',
'first-page': '536',
'DOI': '10.1124/jpet.107.134882',
'article-title': 'Isoflavones promote mitochondrial biogenesis',
'volume': '325',
'author': 'Rasbach',
'year': '2008',
'journal-title': 'J. Pharmacol. Exp. Ther.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1310',
'doi-asserted-by': 'crossref',
'first-page': '584',
'DOI': '10.1007/s12640-018-9967-2',
'article-title': 'Glycyrrhizic acid ameliorates mitochondrial function and biogenesis '
'against aluminum toxicity in PC12 cells',
'volume': '35',
'author': 'Rashedinia',
'year': '2019',
'journal-title': 'Neurotox. Res.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1315',
'article-title': 'Vitamin C and COVID-19 treatment: a systematic review and meta-analysis '
'of randomized controlled trials',
'volume': '15',
'author': 'Rawat',
'year': '2021',
'journal-title': 'Diabetes Metab. Syndr. Clin. Res. Rev.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1320',
'doi-asserted-by': 'crossref',
'first-page': '563',
'DOI': '10.1038/nrgastro.2013.170',
'article-title': 'Caffeine is a potent stimulator of autophagy to reduce hepatic lipid '
'content—a coffee for NAFLD?',
'volume': '10',
'author': 'Ray',
'year': '2013',
'journal-title': 'Nat. Rev. Gastroenterol. Hepatol.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1325',
'doi-asserted-by': 'crossref',
'DOI': '10.1371/journal.pone.0202784',
'article-title': 'The synergism of high-intensity intermittent exercise and '
'every-other-day intermittent fasting regimen on energy metabolism '
'adaptations includes hexokinase activity and mitochondrial efficiency',
'volume': '13',
'author': 'Real-Hohn',
'year': '2018',
'journal-title': 'PLoS One'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1330',
'doi-asserted-by': 'crossref',
'DOI': '10.1016/j.isci.2020.101161',
'article-title': 'Time-restricted eating: benefits, mechanisms, and challenges in '
'translation',
'volume': '23',
'author': 'Regmi',
'year': '2020',
'journal-title': 'iScience'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1335',
'doi-asserted-by': 'crossref',
'DOI': '10.1371/journal.pone.0065029',
'article-title': 'Green tea polyphenols stimulate mitochondrial biogenesis and improve '
'renal function after chronic cyclosporin A treatment in rats',
'volume': '8',
'author': 'Rehman',
'year': '2013',
'journal-title': 'PLoS One'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1340',
'doi-asserted-by': 'crossref',
'unstructured': 'Rhea, E.M.; Logsdon, A.F.; Hansen, K.M.; Williams, L.M.; Reed, M.J.; '
'Baumann, K.K.; Holden, S.J.; Raber, J.; Banks, W.A.; Erickson, M.A. The '
'S1 protein of SARS-CoV-2 crosses the blood–brain barrier in mice. Nat. '
'Neurosci. 2021, 24, 368–378, '
'doi:https://doi.org/10.1038/s41593-020-00771-8.',
'DOI': '10.1038/s41593-020-00771-8'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1345',
'doi-asserted-by': 'crossref',
'first-page': 'E390',
'DOI': '10.1152/ajpendo.1999.277.2.E390',
'article-title': 'Acute exercise increases nitric oxide synthase activity in skeletal '
'muscle',
'volume': '277',
'author': 'Roberts',
'year': '1999',
'journal-title': 'American Journal of Physiology-Endocrinology and Metabolism'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1350',
'doi-asserted-by': 'crossref',
'first-page': '75',
'DOI': '10.1016/j.freeradbiomed.2020.04.025',
'article-title': 'Protection against renal ischemia and reperfusion injury by short-term '
'time-restricted feeding involves the mitochondrial unfolded protein '
'response',
'volume': '154',
'author': 'Rojas-Morales',
'year': '2020',
'journal-title': 'Free Radic. Biol. Med.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1355',
'doi-asserted-by': 'crossref',
'DOI': '10.1016/j.rehab.2023.101765',
'article-title': 'Effectiveness of exercise training on the dyspnoea of individuals with '
'long COVID: a randomised controlled multicentre trial',
'volume': '66',
'author': 'Romanet',
'year': '2023',
'journal-title': 'Ann. Phys. Rehabil. Med.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1360',
'doi-asserted-by': 'crossref',
'first-page': 'E181',
'DOI': '10.1073/pnas.1014633107',
'article-title': 'Rapamycin induces autophagic flux in neurons',
'volume': '107',
'author': 'Rubinsztein',
'year': '2010',
'journal-title': 'Proc. Natl. Acad. Sci.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1365',
'doi-asserted-by': 'crossref',
'first-page': '150',
'DOI': '10.1016/j.pharmthera.2013.09.006',
'article-title': 'Existing and potential therapeutic uses for N-acetylcysteine: the need '
'for conversion to intracellular glutathione for antioxidant benefits',
'volume': '141',
'author': 'Rushworth',
'year': '2014',
'journal-title': 'Pharmacol. Ther.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1370',
'doi-asserted-by': 'crossref',
'first-page': '187',
'DOI': '10.4103/ijem.IJEM_601_19',
'article-title': 'Effect of Jain fasting on anthropometric, clinical and biochemical '
'parameters',
'volume': '24',
'author': 'Sanchetee',
'year': '2020',
'journal-title': 'Indian J Endocrinol Metab'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1375',
'doi-asserted-by': 'crossref',
'first-page': '5789',
'DOI': '10.1093/jxb/erab049',
'article-title': 'Nitric oxide regulation of temperature acclimation: a molecular genetic '
'perspective',
'volume': '72',
'author': 'Sánchez-Vicente',
'year': '2021',
'journal-title': 'J. Exp. Bot.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1380',
'doi-asserted-by': 'crossref',
'first-page': '271',
'DOI': '10.1016/j.jep.2011.05.021',
'article-title': 'Plant use in the medicinal practices known as “strict diets” in Chazuta '
'Valley (Peruvian Amazon)',
'volume': '137',
'author': 'Sanz-Biset',
'year': '2011',
'journal-title': 'J. Ethnopharmacol.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1385',
'doi-asserted-by': 'crossref',
'first-page': '46',
'DOI': '10.1038/cdd.2008.110',
'article-title': 'Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity '
'of polyglutamine-expanded huntingtin and related proteinopathies',
'volume': '16',
'author': 'Sarkar',
'year': '2009',
'journal-title': 'Cell Death Differ.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1390',
'doi-asserted-by': 'crossref',
'first-page': '1810',
'DOI': '10.1016/j.cub.2015.05.059',
'article-title': 'Iron-starvation-induced mitophagy mediates lifespan extension upon '
'mitochondrial stress in C. elegans',
'volume': '25',
'author': 'Schiavi',
'year': '2015',
'journal-title': 'Curr. Biol.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1395',
'doi-asserted-by': 'crossref',
'first-page': '417',
'DOI': '10.1016/j.cmet.2014.06.009',
'article-title': 'Deficient chaperone-mediated autophagy in liver leads to metabolic '
'dysregulation',
'volume': '20',
'author': 'Schneider',
'year': '2014',
'journal-title': 'Cell Metab.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1400',
'doi-asserted-by': 'crossref',
'first-page': '431',
'DOI': '10.1007/s00392-022-02129-5',
'article-title': 'Autopsy-based histopathological characterization of myocarditis after '
'anti-SARS-CoV-2-vaccination',
'volume': '112',
'author': 'Schwab',
'year': '2023',
'journal-title': 'Clin. Res. Cardiol.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1405',
'doi-asserted-by': 'crossref',
'first-page': '19',
'DOI': '10.18632/aging.101354',
'article-title': 'Safety and tolerability of spermidine supplementation in mice and older '
'adults with subjective cognitive decline',
'volume': '10',
'author': 'Schwarz',
'year': '2018',
'journal-title': 'Aging'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1410',
'doi-asserted-by': 'crossref',
'DOI': '10.1001/jamanetworkopen.2022.13875',
'article-title': 'Effects of spermidine supplementation on cognition and biomarkers in '
'older adults with subjective cognitive decline: a randomized clinical '
'trial',
'volume': '5',
'author': 'Schwarz',
'year': '2022',
'journal-title': 'JAMA Netw. Open'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1415',
'first-page': '15',
'article-title': 'Admission serum magnesium levels is associated with short and long-term '
'clinical outcomes in COVID-19 patients',
'volume': '2023',
'author': 'Segev',
'year': '2016',
'journal-title': 'Nutrients'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1420',
'doi-asserted-by': 'crossref',
'first-page': '2738',
'DOI': '10.3390/nu14132738',
'volume': '14',
'author': 'Semmarath',
'year': '2022',
'journal-title': 'Nutrients'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1425',
'first-page': '15',
'article-title': 'High-dose spermidine supplementation does not increase spermidine '
'levels in blood plasma and saliva of healthy adults: a randomized '
'placebo-controlled pharmacokinetic and metabolomic study',
'volume': '2023',
'author': 'Senekowitsch',
'year': '1852',
'journal-title': 'Nutrients'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1430',
'doi-asserted-by': 'crossref',
'first-page': '5876',
'DOI': '10.3390/jcm10245876',
'article-title': 'Autopsy findings and causality relationship between death and COVID-19 '
'vaccination: a systematic review',
'volume': '10',
'author': 'Sessa',
'year': '2021',
'journal-title': 'J. Clin. Med.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1435',
'doi-asserted-by': 'crossref',
'first-page': '5643',
'DOI': '10.1002/jcp.27404',
'article-title': 'Curcumin: a naturally occurring autophagy modulator',
'volume': '234',
'author': 'Shakeri',
'year': '2019',
'journal-title': 'J. Cell. Physiol.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1440',
'doi-asserted-by': 'crossref',
'DOI': '10.3389/fnins.2023.1150156',
'article-title': 'The anti-inflammatory effects of photobiomodulation are mediated by '
'cytokines: evidence from a mouse model of inflammation',
'volume': '17',
'author': 'Shamloo',
'year': '2023',
'journal-title': 'Front. Neurosci.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1445',
'article-title': 'SARS-CoV-2 causes mitochondrial dysfunction and mitophagy impairment',
'volume': '12',
'author': 'Shang',
'year': '2021',
'journal-title': 'Front. Microbiol.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1450',
'doi-asserted-by': 'crossref',
'first-page': '1125',
'DOI': '10.1249/00005768-199508000-00005',
'article-title': 'Nitric oxide production and NO synthase gene expression contribute to '
'vascular regulation during exercise',
'volume': '27',
'author': 'Shen',
'year': '1995',
'journal-title': 'Med. Sci. Sports Exerc.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1455',
'doi-asserted-by': 'crossref',
'first-page': '165',
'DOI': '10.1007/s00125-007-0852-4',
'article-title': 'R-alpha-lipoic acid and acetyl-L-carnitine complementarily promote '
'mitochondrial biogenesis in murine 3T3-L1 adipocytes',
'volume': '51',
'author': 'Shen',
'year': '2008',
'journal-title': 'Diabetologia'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1460',
'doi-asserted-by': 'crossref',
'first-page': '1213',
'DOI': '10.1111/j.1476-5381.2010.01134.x',
'article-title': 'Lipoamide or lipoic acid stimulates mitochondrial biogenesis in 3T3-L1 '
'adipocytes via the endothelial NO synthase-cGMP-protein kinase G '
'signalling pathway: lipoamide, lipoic acid and mitochondrial biogenesis',
'volume': '162',
'author': 'Shen',
'year': '2011',
'journal-title': 'Br. J. Pharmacol.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1465',
'doi-asserted-by': 'crossref',
'DOI': '10.1371/journal.pgen.1004861',
'article-title': 'Phosphorylation of mitochondrial polyubiquitin by PINK1 promotes Parkin '
'mitochondrial tethering',
'volume': '10',
'author': 'Shiba-Fukushima',
'year': '2014',
'journal-title': 'PLoS Genet.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1470',
'doi-asserted-by': 'crossref',
'DOI': '10.1016/j.heliyon.2021.e06187',
'article-title': 'SARS-CoV-2 spike protein S1 subunit induces pro-inflammatory responses '
'via Toll-like receptor 4 signaling in murine and human macrophages',
'volume': '7',
'author': 'Shirato',
'year': '2021',
'journal-title': 'Heliyon'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1475',
'doi-asserted-by': 'crossref',
'first-page': '353',
'DOI': '10.1055/s-2006-957450',
'article-title': 'Influence of piperine on the pharmacokinetics of curcumin in animals '
'and human volunteers',
'volume': '64',
'author': 'Shoba',
'year': '1998',
'journal-title': 'Planta Med.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1480',
'first-page': '37',
'article-title': 'Concept and canons of fasting in Ayurveda',
'volume': '1',
'author': 'Shripathi Adiga',
'year': '2013',
'journal-title': 'Journal of Nutrition, Fasting and Health'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1485',
'doi-asserted-by': 'crossref',
'DOI': '10.1016/j.tranon.2020.100814',
'article-title': 'S2 subunit of SARS-nCoV-2 interacts with tumor suppressor protein P53 '
'and BRCA: an in silico study',
'volume': '13',
'author': 'Singh',
'year': '2020',
'journal-title': 'Transl. Oncol.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1490',
'doi-asserted-by': 'crossref',
'first-page': '212',
'DOI': '10.1186/s43094-021-00360-x',
'article-title': 'Targeting mitochondrial biogenesis: a potential approach for preventing '
'and controlling diabetes',
'volume': '7',
'author': 'Singh',
'year': '2021',
'journal-title': 'Future Journal of Pharmaceutical Sciences'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1495',
'doi-asserted-by': 'crossref',
'first-page': '361',
'DOI': '10.3177/jnsv.55.361',
'article-title': 'Long-term oral polyamine intake increases blood polyamine '
'concentrations',
'volume': '55',
'author': 'Soda',
'year': '2009',
'journal-title': 'J. Nutr. Sci. Vitaminol. (Tokyo)'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1500',
'first-page': '22',
'article-title': 'Polyamine-rich diet elevates blood Spermine levels and inhibits '
'pro-inflammatory status: an interventional study',
'volume': '9',
'author': 'Soda',
'year': '2021',
'journal-title': 'Med Sci (Basel)'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1505',
'doi-asserted-by': 'crossref',
'first-page': '1171',
'DOI': '10.1016/j.bbabio.2010.02.011',
'article-title': 'Hypoxia and mitochondrial oxidative metabolism',
'volume': '1797',
'author': 'Solaini',
'year': '2010',
'journal-title': 'Biochimica et Biophysica Acta (BBA) - Bioenergetics'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1510',
'doi-asserted-by': 'crossref',
'DOI': '10.1126/sciadv.add4150',
'article-title': 'The SARS-CoV-2 spike protein binds and modulates estrogen receptors',
'volume': '8',
'author': 'Solis',
'year': '2022',
'journal-title': 'Sci. Adv.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1515',
'doi-asserted-by': 'crossref',
'first-page': '166',
'DOI': '10.1186/s13287-016-0425-x',
'article-title': 'Rapamycin regulates autophagy and cell adhesion in induced pluripotent '
'stem cells',
'volume': '7',
'author': 'Sotthibundhu',
'year': '2016',
'journal-title': 'Stem Cell Res Ther'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1520',
'doi-asserted-by': 'crossref',
'first-page': '758',
'DOI': '10.1038/s41586-022-05542-y',
'article-title': 'SARS-CoV-2 infection and persistence in the human body and brain at '
'autopsy',
'volume': '612',
'author': 'Stein',
'year': '2022',
'journal-title': 'Nature'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1525',
'doi-asserted-by': 'crossref',
'first-page': '528',
'DOI': '10.7150/ijms.8220',
'article-title': 'Rutin, a flavonoid and principal component of Saussurea involucrata, '
'attenuates physical fatigue in a forced swimming mouse model',
'volume': '11',
'author': 'Su',
'year': '2014',
'journal-title': 'Int. J. Med. Sci.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1530',
'doi-asserted-by': 'crossref',
'first-page': '401',
'DOI': '10.1080/15548627.2022.2084862',
'article-title': 'Mitochondria ROS and mitophagy in acute kidney injury',
'volume': '19',
'author': 'Su',
'year': '2023',
'journal-title': 'Autophagy'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1535',
'doi-asserted-by': 'crossref',
'first-page': '1110',
'DOI': '10.1007/BF01956052',
'article-title': 'A novel fibrinolytic enzyme (nattokinase) in the vegetable cheese '
'natto; a typical and popular soybean food in the Japanese diet',
'volume': '43',
'author': 'Sumi',
'year': '1987',
'journal-title': 'Experientia'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1540',
'doi-asserted-by': 'crossref',
'DOI': '10.3389/fphys.2019.01521',
'article-title': 'Acute heat exposure alters autophagy signaling in C2C12 myotubes',
'volume': '10',
'author': 'Summers',
'year': '2020',
'journal-title': 'Front. Physiol.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1545',
'doi-asserted-by': 'crossref',
'first-page': '2246',
'DOI': '10.1080/15548627.2021.2021496',
'article-title': 'SARS-CoV-2 targets the lysosome to mediate airway inflammatory cell '
'death',
'volume': '18',
'author': 'Sun',
'year': '2022',
'journal-title': 'Autophagy'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1550',
'doi-asserted-by': 'crossref',
'first-page': '1212',
'DOI': '10.1016/j.cmet.2018.04.010',
'article-title': 'Early time-restricted feeding improves insulin sensitivity, blood '
'pressure, and oxidative stress even without weight loss in men with '
'prediabetes',
'volume': '27',
'author': 'Sutton',
'year': '2018',
'journal-title': 'Cell Metab.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1555',
'doi-asserted-by': 'crossref',
'DOI': '10.1371/journal.pone.0017412',
'article-title': 'Starvation induced cell death in autophagy-defective yeast mutants is '
'caused by mitochondria dysfunction',
'volume': '6',
'author': 'Suzuki',
'year': '2011',
'journal-title': 'PLoS One'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1560',
'doi-asserted-by': 'crossref',
'first-page': 'e487',
'DOI': '10.1093/cid/ciac722',
'article-title': 'Persistent circulating severe acute respiratory syndrome coronavirus 2 '
'spike is associated with post-acute coronavirus disease 2019 sequelae',
'volume': '76',
'author': 'Swank',
'year': '2023',
'journal-title': 'Clin. Infect. Dis.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1565',
'doi-asserted-by': 'crossref',
'first-page': '301',
'DOI': '10.1083/jcb.119.2.301',
'article-title': 'Autophagy in yeast demonstrated with proteinase-deficient mutants and '
'conditions for its induction',
'volume': '119',
'author': 'Takeshige',
'year': '1992',
'journal-title': 'J. Cell Biol.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1570',
'article-title': 'Cohort study to evaluate the effect of vitamin D, magnesium, and '
'vitamin B12 in combination on progression to severe outcomes in older '
'patients with coronavirus (COVID-19)',
'volume': '79–80',
'author': 'Tan',
'year': '2020',
'journal-title': 'Nutrition'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1575',
'doi-asserted-by': 'crossref',
'first-page': '9',
'DOI': '10.1016/j.neures.2020.01.006',
'article-title': 'The PINK1–Parkin axis: an overview',
'volume': '159',
'author': 'Tanaka',
'year': '2020',
'journal-title': 'Neurosci. Res.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1580',
'doi-asserted-by': 'crossref',
'first-page': '5405',
'DOI': '10.3390/molecules27175405',
'article-title': 'Degradative effect of nattokinase on spike protein of SARS-CoV-2',
'volume': '27',
'author': 'Tanikawa',
'year': '2022',
'journal-title': 'Molecules'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1585',
'series-title': 'The Falling Sickness: A History of Epilepsy From the Greeks to the '
'Beginnings of Modern Neurology',
'isbn-type': 'print',
'volume': 'vol. 4',
'author': 'Temkin',
'year': '1994',
'ISBN': 'http://id.crossref.org/isbn/0801848490'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1590',
'doi-asserted-by': 'crossref',
'first-page': '967',
'DOI': '10.3390/antiox10060967',
'article-title': 'N-acetylcysteine (NAC): impacts on human health',
'volume': '10',
'author': 'Tenório',
'year': '2021',
'journal-title': 'Antioxidants'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1595',
'doi-asserted-by': 'crossref',
'first-page': '1850',
'DOI': '10.1007/s12035-021-02696-0',
'article-title': 'Could SARS-CoV-2 spike protein be responsible for long-COVID syndrome?',
'volume': '59',
'author': 'Theoharides',
'year': '2022',
'journal-title': 'Mol. Neurobiol.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1600',
'first-page': '80',
'article-title': 'Nutritional regulation of the insulin-like growth factors',
'volume': '15',
'author': 'Thissen',
'year': '1994',
'journal-title': 'Endocr. Rev.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1605',
'doi-asserted-by': 'crossref',
'first-page': '909',
'DOI': '10.3390/nu14040909',
'article-title': 'Populations in low-magnesium areas were associated with higher risk of '
'infection in COVID-19’s Early transmission: a nationwide retrospective '
'cohort study in the United States',
'volume': '14',
'author': 'Tian',
'year': '2022',
'journal-title': 'Nutrients'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1610',
'doi-asserted-by': 'crossref',
'first-page': '689',
'DOI': '10.1021/acschemneuro.2c00610',
'article-title': 'SARS-CoV-2 spike protein downregulates cell surface α7nAChR through a '
'helical motif in the spike neck',
'volume': '14',
'author': 'Tillman',
'year': '2023',
'journal-title': 'ACS Chem. Neurosci.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1615',
'doi-asserted-by': 'crossref',
'first-page': '4984',
'DOI': '10.3390/nu14234984',
'article-title': 'Effects of L-arginine plus vitamin C supplementation on physical '
'performance, endothelial function, and persistent fatigue in adults '
'with long COVID: a single-blind randomized controlled trial',
'volume': '14',
'author': 'Tosato',
'year': '2022',
'journal-title': 'Nutrients'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1620',
'doi-asserted-by': 'crossref',
'first-page': '197',
'DOI': '10.1016/j.jphotobiol.2017.04.014',
'article-title': 'Biological effects and medical applications of infrared radiation',
'volume': '170',
'author': 'Tsai',
'year': '2017',
'journal-title': 'J. Photochem. Photobiol. B'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1625',
'doi-asserted-by': 'crossref',
'first-page': '169',
'DOI': '10.1016/0014-5793(93)80398-E',
'article-title': 'Isolation and characterization of autophagy-defective mutants of '
'Saccharomyces cerevisiae',
'volume': '333',
'author': 'Tsukada',
'year': '1993',
'journal-title': 'FEBS Lett.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1630',
'doi-asserted-by': 'crossref',
'first-page': '32',
'DOI': '10.1186/1743-7075-11-32',
'article-title': 'Sudachitin, a polymethoxylated flavone, improves glucose and lipid '
'metabolism by increasing mitochondrial biogenesis in skeletal muscle',
'volume': '11',
'author': 'Tsutsumi',
'year': '2014',
'journal-title': 'Nutrition & Metabolism'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1635',
'doi-asserted-by': 'crossref',
'first-page': '5137',
'DOI': '10.1007/s12035-017-0712-2',
'article-title': 'From mitochondrial function to neuroprotection—an emerging role for '
'methylene blue',
'volume': '55',
'author': 'Tucker',
'year': '2018',
'journal-title': 'Mol. Neurobiol.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1640',
'doi-asserted-by': 'crossref',
'first-page': '256',
'DOI': '10.3390/nu14020256',
'article-title': 'Effectiveness of curcumin on outcomes of hospitalized COVID-19 '
'patients: a systematic review of clinical trials',
'volume': '14',
'author': 'Vahedian-Azimi',
'year': '2022',
'journal-title': 'Nutrients'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1645',
'doi-asserted-by': 'crossref',
'first-page': '664',
'DOI': '10.1152/japplphysiol.00550.2015',
'article-title': 'The regulation of autophagy during exercise in skeletal muscle',
'volume': '120',
'author': 'Vainshtein',
'year': '2016',
'journal-title': 'J. Appl. Physiol.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1650',
'doi-asserted-by': 'crossref',
'first-page': '542',
'DOI': '10.1016/j.bbadis.2012.12.011',
'article-title': 'Epigallocatechin-3-gallate prevents oxidative phosphorylation deficit '
'and promotes mitochondrial biogenesis in human cells from subjects with '
'Down’s syndrome',
'volume': '1832',
'author': 'Valenti',
'year': '2013',
'journal-title': 'Biochim. Biophys. Acta (BBA) - Mol. Basis Dis.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1655',
'doi-asserted-by': 'crossref',
'first-page': '167',
'DOI': '10.1038/s41580-022-00542-2',
'article-title': 'The mechanisms and roles of selective autophagy in mammals',
'volume': '24',
'author': 'Vargas',
'year': '2023',
'journal-title': 'Nat. Rev. Mol. Cell Biol.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1660',
'doi-asserted-by': 'crossref',
'DOI': '10.1016/j.jnutbio.2021.108768',
'article-title': 'Dietary bioactive compounds as modulators of mitochondrial function',
'volume': '96',
'author': 'Vásquez-Reyes',
'year': '2021',
'journal-title': 'J. Nutr. Biochem.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1665',
'doi-asserted-by': 'crossref',
'first-page': '131',
'DOI': '10.1007/s13668-018-0233-2',
'article-title': 'From religion to secularism: the benefits of fasting',
'volume': '7',
'author': 'Venegas-Borsellino',
'year': '2018',
'journal-title': 'Curr Nutr Rep'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1670',
'doi-asserted-by': 'crossref',
'first-page': '965',
'DOI': '10.2147/JIR.S301625',
'article-title': 'Evaluation of adjunctive photobiomodulation (PBMT) for COVID-19 '
'pneumonia via clinical status and pulmonary severity indices in a '
'preliminary trial',
'volume': '14',
'author': 'Vetrici',
'year': '2021',
'journal-title': 'J. Inflamm. Res.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1675',
'series-title': 'Mitochondrial Physiology and Vegetal Molecules',
'isbn-type': 'print',
'doi-asserted-by': 'crossref',
'first-page': '613',
'DOI': '10.1016/B978-0-12-821562-3.00034-4',
'article-title': 'Chapter 28 - ascorbic acid and the mitochondria',
'author': 'Vineetha',
'year': '2021',
'ISBN': 'http://id.crossref.org/isbn/9780128215623'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1680',
'doi-asserted-by': 'crossref',
'first-page': '433',
'DOI': '10.3390/nu14030433',
'article-title': 'Traditional and medical applications of fasting',
'volume': '14',
'author': 'Visioli',
'year': '2022',
'journal-title': 'Nutrients'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1685',
'doi-asserted-by': 'crossref',
'first-page': '1154',
'DOI': '10.3390/nu13041154',
'article-title': 'Feasibility of vitamin C in the treatment of post viral fatigue with '
'focus on long COVID, based on a systematic review of IV vitamin C on '
'fatigue',
'volume': '13',
'author': 'Vollbracht',
'year': '2021',
'journal-title': 'Nutrients'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1690',
'doi-asserted-by': 'crossref',
'first-page': '1326',
'DOI': '10.1080/09553002.2019.1625464',
'article-title': 'The effect of red-to-near-infrared (R/NIR) irradiation on inflammatory '
'processes',
'volume': '95',
'author': 'Walski',
'year': '2019',
'journal-title': 'Int. J. Radiat. Biol.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1695',
'doi-asserted-by': 'crossref',
'DOI': '10.1016/j.heliyon.2020.e04379',
'article-title': 'The effects of sunlight exposure therapy on the improvement of '
'depression and quality of life in post-stroke patients: a RCT study',
'volume': '6',
'author': 'Wang',
'year': '2020',
'journal-title': 'Heliyon'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1700',
'article-title': 'Long-term extreme fasting following a traditional Chinese “Bigu” '
'regimen: a preliminary retrospective and prospective cohort study',
'author': 'Wang',
'year': '2018',
'journal-title': 'SSRN Journal'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1705',
'doi-asserted-by': 'crossref',
'first-page': '1',
'DOI': '10.1038/s41392-020-00426-x',
'article-title': 'CD147-spike protein is a novel route for SARS-CoV-2 infection to host '
'cells',
'volume': '5',
'author': 'Wang',
'year': '2020',
'journal-title': 'Sig Transduct Target Ther'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1710',
'doi-asserted-by': 'crossref',
'first-page': '237',
'DOI': '10.1016/j.jinf.2021.05.009',
'article-title': 'Clinical efficacy of nitric oxide nasal spray (NONS) for the treatment '
'of mild COVID-19 infection',
'volume': '83',
'author': 'Winchester',
'year': '2021',
'journal-title': 'Journal of Infection'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1715',
'doi-asserted-by': 'crossref',
'first-page': '181',
'DOI': '10.1016/j.cortex.2018.09.014',
'article-title': 'The effect of spermidine on memory performance in older adults at risk '
'for dementia: a randomized controlled trial',
'volume': '109',
'author': 'Wirth',
'year': '2018',
'journal-title': 'Cortex'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1720',
'doi-asserted-by': 'crossref',
'first-page': '96',
'DOI': '10.1016/j.trsl.2021.10.003',
'article-title': 'Role of senescence in the chronic health consequences of COVID-19',
'volume': '241',
'author': 'Wissler Gerdes',
'year': '2022',
'journal-title': 'Transl. Res.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1725',
'doi-asserted-by': 'crossref',
'DOI': '10.1155/2016/1735841',
'article-title': 'Amla enhances mitochondrial spare respiratory capacity by increasing '
'mitochondrial biogenesis and antioxidant systems in a murine skeletal '
'muscle cell line',
'volume': '2016',
'author': 'Yamamoto',
'year': '2016',
'journal-title': 'Oxidative Med. Cell. Longev.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1730',
'doi-asserted-by': 'crossref',
'first-page': '382',
'DOI': '10.1038/s41576-022-00562-w',
'article-title': 'Autophagy genes in biology and disease',
'volume': '24',
'author': 'Yamamoto',
'year': '2023',
'journal-title': 'Nat. Rev. Genet.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1735',
'doi-asserted-by': 'crossref',
'first-page': '1758',
'DOI': '10.4161/auto.24633',
'article-title': 'PINK1 is degraded through the N-end rule pathway',
'volume': '9',
'author': 'Yamano',
'year': '2013',
'journal-title': 'Autophagy'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1740',
'doi-asserted-by': 'crossref',
'first-page': '1670',
'DOI': '10.1107/S1744309110043137',
'article-title': 'Purification, crystallization and preliminary X-ray diffraction '
'experiment of nattokinase from Bacillus subtilis natto',
'volume': '66',
'author': 'Yanagisawa',
'year': '2010',
'journal-title': 'Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1745',
'doi-asserted-by': 'crossref',
'first-page': '201',
'DOI': '10.1146/annurev-nutr-082018-124643',
'article-title': 'Mitochondrial DNA mutation, diseases, and nutrient-regulated mitophagy',
'volume': '39',
'author': 'Yang',
'year': '2019',
'journal-title': 'Annu. Rev. Nutr.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1750',
'doi-asserted-by': 'crossref',
'first-page': '4541',
'DOI': '10.1038/s41467-020-18319-6',
'article-title': 'Molecular interaction and inhibition of SARS-CoV-2 binding to the ACE2 '
'receptor',
'volume': '11',
'author': 'Yang',
'year': '2020',
'journal-title': 'Nat. Commun.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1755',
'first-page': '62',
'article-title': 'Does methylene blue satisfy an option in COVID-19 ARDS',
'volume': '22',
'author': 'Yella',
'year': '2022',
'journal-title': 'Infectious Disorders - Drug TargetsDisorders'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1760',
'doi-asserted-by': 'crossref',
'first-page': '401',
'DOI': '10.1039/C4FO00719K',
'article-title': 'Mulberry and mulberry wine extract increase the number of mitochondria '
'during brown adipogenesis',
'volume': '6',
'author': 'You',
'year': '2015',
'journal-title': 'Food Funct.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1765',
'doi-asserted-by': 'crossref',
'first-page': '348',
'DOI': '10.1016/j.jff.2017.07.007',
'article-title': 'Mulberry anthocyanins, cyanidin 3-glucoside and cyanidin 3-rutinoside, '
'increase the quantity of mitochondria during brown adipogenesis',
'volume': '36',
'author': 'You',
'year': '2017',
'journal-title': 'J. Funct. Foods'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1770',
'doi-asserted-by': 'crossref',
'first-page': '942',
'DOI': '10.1038/nature09076',
'article-title': 'Termination of autophagy and reformation of lysosomes regulated by mTOR',
'volume': '465',
'author': 'Yu',
'year': '2010',
'journal-title': 'Nature'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1775',
'doi-asserted-by': 'crossref',
'first-page': '1511',
'DOI': '10.1093/ajcn/71.6.1511',
'article-title': 'Resting energy expenditure in short-term starvation is increased as a '
'result of an increase in serum norepinephrine',
'volume': '71',
'author': 'Zauner',
'year': '2000',
'journal-title': 'Am. J. Clin. Nutr.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1780',
'doi-asserted-by': 'crossref',
'first-page': '148',
'DOI': '10.1186/s12985-022-01877-0',
'article-title': 'SARS-CoV-2 omicron variant clearance delayed in breakthrough cases with '
'elevated fasting blood glucose',
'volume': '19',
'author': 'Zhang',
'year': '2022',
'journal-title': 'Virol. J.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1785',
'doi-asserted-by': 'crossref',
'first-page': '818',
'DOI': '10.1038/s41422-021-00495-9',
'article-title': 'SARS-CoV-2 spike protein interacts with and activates TLR41',
'volume': '31',
'author': 'Zhao',
'year': '2021',
'journal-title': 'Cell Res.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1790',
'article-title': 'SARS-CoV-2, long COVID',
'volume': '16',
'author': 'Zhao',
'year': '2022',
'journal-title': 'prion disease and neurodegeneration. Front Neurosci'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1795',
'doi-asserted-by': 'crossref',
'first-page': '28',
'DOI': '10.1038/ajh.2007.14',
'article-title': 'Upregulation of endothelial and inducible nitric oxide synthase '
'expression by reactive oxygen species',
'volume': '21',
'author': 'Zhen',
'year': '2008',
'journal-title': 'Am. J. Hypertens.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1800',
'doi-asserted-by': 'crossref',
'DOI': '10.3389/fmed.2021.566609',
'article-title': 'A randomized, single-blind, group sequential, active-controlled study '
'to evaluate the clinical efficacy and safety of α-lipoic acid for '
'critically ill patients with coronavirus disease 2019 (COVID-19)',
'volume': '8',
'author': 'Zhong',
'year': '2022',
'journal-title': 'Front. Med.'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1805',
'article-title': 'Epigallocatechin-3-gallate (EGCG), a green tea polyphenol, stimulates '
'hepatic autophagy and lipid clearance',
'volume': '9',
'author': 'Zhou',
'year': '2014',
'journal-title': 'PLoS One'},
{ 'key': '10.1016/j.endmts.2024.100163_bb1810',
'doi-asserted-by': 'crossref',
'first-page': '76',
'DOI': '10.1186/s12943-021-01363-1',
'article-title': 'The intersection of COVID-19 and cancer: signaling pathways and '
'treatment implications',
'volume': '20',
'author': 'Zong',
'year': '2021',
'journal-title': 'Mol. Cancer'}],
'container-title': 'Endocrine and Metabolic Science',
'original-title': [],
'language': 'en',
'link': [ { 'URL': 'https://api.elsevier.com/content/article/PII:S2666396124000074?httpAccept=text/xml',
'content-type': 'text/xml',
'content-version': 'vor',
'intended-application': 'text-mining'},
{ 'URL': 'https://api.elsevier.com/content/article/PII:S2666396124000074?httpAccept=text/plain',
'content-type': 'text/plain',
'content-version': 'vor',
'intended-application': 'text-mining'}],
'deposited': { 'date-parts': [[2024, 2, 8]],
'date-time': '2024-02-08T08:05:14Z',
'timestamp': 1707379514000},
'score': 1,
'resource': {'primary': {'URL': 'https://linkinghub.elsevier.com/retrieve/pii/S2666396124000074'}},
'subtitle': [],
'short-title': [],
'issued': {'date-parts': [[2024, 3]]},
'references-count': 362,
'alternative-id': ['S2666396124000074'],
'URL': 'http://dx.doi.org/10.1016/j.endmts.2024.100163',
'relation': {},
'ISSN': ['2666-3961'],
'subject': ['Endocrinology', 'Endocrinology, Diabetes and Metabolism'],
'container-title-short': 'Endocrine and Metabolic Science',
'published': {'date-parts': [[2024, 3]]},
'assertion': [ {'value': 'Elsevier', 'name': 'publisher', 'label': 'This article is maintained by'},
{ 'value': 'Exploring autophagy in treating SARS-CoV-2 spike protein-related pathology',
'name': 'articletitle',
'label': 'Article Title'},
{ 'value': 'Endocrine and Metabolic Science',
'name': 'journaltitle',
'label': 'Journal Title'},
{ 'value': 'https://doi.org/10.1016/j.endmts.2024.100163',
'name': 'articlelink',
'label': 'CrossRef DOI link to publisher maintained version'},
{'value': 'article', 'name': 'content_type', 'label': 'Content Type'},
{ 'value': '© 2024 The Authors. Published by Elsevier Ltd.',
'name': 'copyright',
'label': 'Copyright'}],
'article-number': '100163'}
