N-acetyl-cysteine reduces the risk for mechanical ventilation and mortality in patients with COVID-19 pneumonia: a two-center retrospective cohort study
et al., Infectious Diseases,
Retrospective 42 hospitalized PCR+ COVID-19 pneumonia patients treated with NAC, and a matched control group of 40 patients, showing significantly lower severe respiratory failure and significantly lower mortality with treatment. NAC 600 mg bid orally for 14 days.
risk of death, 97.1% lower, RR 0.03, p = 0.006, treatment 2 of 42 (4.8%), control 12 of 40 (30.0%), NNT 4.0, inverted to make RR<1 favor treatment, odds ratio converted to relative risk.
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Assimakopoulos et al., 29 Jun 2021, retrospective, Greece, peer-reviewed, 9 authors, study period 1 February, 2021 - 30 April, 2021.