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Vitamin D on admission and disease severity in patients with COVID-19 in the Intensive Care Unit

Gonzalez et al., Revista de Nutrición Clínica y Metabolismo, doi:10.35454/rncm.v6n2.485
Mar 2023  
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Mortality 66% Improvement Relative Risk Vitamin D for COVID-19  Gonzalez et al.  Sufficiency Are vitamin D levels associated with COVID-19 outcomes? Retrospective 164 patients in Argentina Lower mortality with higher vitamin D levels (p=0.046) c19early.org Gonzalez et al., Revista de Nutrición .., Mar 2023 Favorsvitamin D Favorscontrol 0 0.5 1 1.5 2+
Vitamin D for COVID-19
8th treatment shown to reduce risk in October 2020
 
*, now with p < 0.00000000001 from 122 studies, recognized in 9 countries.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,800+ studies for 102 treatments. c19early.org
Retrospective 164 ICU patients in Argentina, showing significantly higher mortality with severe vitamin D deficiency.
This is the 164th of 204 COVID-19 sufficiency studies for vitamin D, which collectively show higher levels reduce risk with p<0.0000000001 (1 in 107,767,362 vigintillion).
risk of death, 66.1% lower, OR 0.34, p = 0.046, high D levels (≥12ng/ml) 129, low D levels (<12ng/ml) 35, adjusted per study, inverted to make OR<1 favor high D levels (≥12ng/ml), multivariable, RR approximated with OR.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Gonzalez et al., 13 Mar 2023, retrospective, Argentina, peer-reviewed, 10 authors.
This PaperVitamin DAll
Victoria Carolina González, Cayetano Galletti, Romina Álvarez Vizzoni, Yanina Saldivar, Nicolás Kessler, Francisco Irades, Estefanía Minoldo, Pablo Calcagno, Antonella Aliscioni, Ursula Zaya, Victoria Carolina González, Correo
doi:10.35454/rncm.v6n2.485
Vitamina D a la admisión y severidad de la enfermedad en pacientes con COVID-19 en la Unidad de Cuidados Intensivos Vitamin D on admission and disease severity in patients with COVID-19 in the Intensive Care Unit Vitamina D na admissão e gravidade da doença em pacientes com COVID-19 na Unidade de Cuidados Intensivos
Variables
References
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Los pacientes con deficiencia grave de 25(OH)D ' 'tuvieron significativamente mayor probabilidad de COVID-19 grave (odds ratio [OR]: 2,2; ' 'intervalo de confianza [IC] 95 %: 1,02 a 5,06; p = 0,049) y presentaron mayor probabilidad de ' 'requerir ventilación mecánica invasiva (OR: 2,4; IC 95 %: 1,09 a 5,58; p = 0 ,036). La ' 'mortalidad fue significativamente mayor en el grupo con deficiencia grave de 25(OH)D (40 % ' 'frente a 22 %; p = 0 ,03), con un OR de 2,4; IC 95 %: 1,07 a 5,32; p = 0 ,031. En el modelo ' 'multivariado, el antecedente de enfermedad cardiovascular, deficiencia grave de 25(OH)D, ' 'presión arterial de oxígeno/fracción inspirada de oxígeno (PaO2/FiO2) y ventilación mecánica ' 'invasiva permanecieron significativos.\xa0\n' 'Conclusión: este estudio confirma que la deficiencia grave de vitamina D se asocia con una ' 'afectación pulmonar más grave, una mayor gravedad de la enfermedad y riesgo de muerte en ' 'pacientes con COVID-19.\xa0</jats:p>', 'DOI': '10.35454/rncm.v6n2.485', 'type': 'journal-article', 'created': {'date-parts': [[2023, 8, 22]], 'date-time': '2023-08-22T12:43:12Z', 'timestamp': 1692708192000}, 'source': 'Crossref', 'is-referenced-by-count': 0, 'title': 'Vitamina D a la admisión y gravedad de la enfermedad en pacientes con COVID-19 en la unidad de ' 'cuidados intensivos', 'prefix': '10.35454', 'volume': '6', 'author': [ {'given': 'Victoria', 'family': 'Gonzalez', 'sequence': 'first', 'affiliation': []}, {'given': 'Cayetano', 'family': 'Galletti', 'sequence': 'additional', 'affiliation': []}, {'given': 'Romina', 'family': 'Alvarez Vizzoni', 'sequence': 'additional', 'affiliation': []}, {'given': 'Yanina', 'family': 'Saldivar', 'sequence': 'additional', 'affiliation': []}, {'given': 'Nicolás', 'family': 'Kessler', 'sequence': 'additional', 'affiliation': []}, {'given': 'Francisco', 'family': 'Irades', 'sequence': 'additional', 'affiliation': []}, {'given': 'Estefanía', 'family': 'Minoldo', 'sequence': 'additional', 'affiliation': []}, {'given': 'Pablo', 'family': 'Calcagno', 'sequence': 'additional', 'affiliation': []}, {'given': 'Antonella', 'family': 'Aliscioni', 'sequence': 'additional', 'affiliation': []}, {'given': 'Ursula', 'family': 'Zaya', 'sequence': 'additional', 'affiliation': []}], 'member': '20092', 'published-online': {'date-parts': [[2023, 5, 24]]}, 'container-title': 'Revista de Nutrición Clínica y Metabolismo', 'original-title': [], 'link': [ { 'URL': 'https://revistanutricionclinicametabolismo.org/index.php/nutricionclinicametabolismo/article/download/485/729', 'content-type': 'application/pdf', 'content-version': 'vor', 'intended-application': 'text-mining'}, { 'URL': 'https://revistanutricionclinicametabolismo.org/index.php/nutricionclinicametabolismo/article/download/485/788', 'content-type': 'text/html', 'content-version': 'vor', 'intended-application': 'text-mining'}, { 'URL': 'https://revistanutricionclinicametabolismo.org/index.php/nutricionclinicametabolismo/article/download/485/729', 'content-type': 'unspecified', 'content-version': 'vor', 'intended-application': 'similarity-checking'}], 'deposited': { 'date-parts': [[2023, 8, 22]], 'date-time': '2023-08-22T12:43:12Z', 'timestamp': 1692708192000}, 'score': 1, 'resource': { 'primary': { 'URL': 'https://revistanutricionclinicametabolismo.org/index.php/nutricionclinicametabolismo/article/view/485'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2023, 5, 24]]}, 'references-count': 0, 'journal-issue': {'issue': '2', 'published-online': {'date-parts': [[2023, 5, 24]]}}, 'URL': 'http://dx.doi.org/10.35454/rncm.v6n2.485', 'relation': {}, 'ISSN': ['2619-3906'], 'subject': ['General Medicine'], 'container-title-short': 'Rev. 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