Victoria Carolina González, Cayetano Galletti, Romina Álvarez Vizzoni, Yanina Saldivar, Nicolás Kessler, Francisco Irades, Estefanía Minoldo, Pablo Calcagno, Antonella Aliscioni, Ursula Zaya, Victoria Carolina González, Correo
doi:10.35454/rncm.v6n2.485
Vitamina D a la admisión y severidad de la enfermedad en pacientes con COVID-19 en la Unidad de Cuidados Intensivos Vitamin D on admission and disease severity in patients with COVID-19 in the Intensive Care Unit Vitamina D na admissão e gravidade da doença em pacientes com COVID-19 na Unidade de Cuidados Intensivos
Variables
References
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doi:10.3389/fimmu.2020.01523Carpagnano, Lecce, Quaranta, Zito, Buonamico et al., Vitamin D deficiency as a predictor of poor prognosis in patients with acute respiratory failure due to COVID-19, Journal of Endocrinological Investigation,
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doi:10.1016/S0140-6736{ 'indexed': {'date-parts': [[2023, 8, 23]], 'date-time': '2023-08-23T04:29:45Z', 'timestamp': 1692764985066},
'reference-count': 0,
'publisher': 'Grupo Distribuna',
'issue': '2',
'license': [ { 'start': { 'date-parts': [[2023, 5, 24]],
'date-time': '2023-05-24T00:00:00Z',
'timestamp': 1684886400000},
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'URL': 'https://creativecommons.org/licenses/by-nc-sa/4.0'}],
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'abstract': '<jats:p>Introducción: la 25-hidroxivitamina D (25(OH)D) disminuiría la incidencia de '
'infecciones respiratorias virales por su efecto pleiotrópico en la inmunomodulación.\xa0\n'
'Objetivos: investigar la posible asociación entre deficiencia grave de 25(OH)D a la admisión '
'en la unidad de cuidados intensivos (UCI) y gravedad de la enfermedad en pacientes '
'diagnosticados con enfermedad por coronavirus de 2019 (COVID-19); determinar si existe una '
'asociación entre la deficiencia grave de 25(OH)D a la admisión, el requerimiento de '
'ventilación mecánica invasiva, las comorbilidades y la mortalidad.\xa0\n'
'Métodos: estudio retrospectivo observacional, que incluyó a 164 pacientes con diagnóstico de '
'COVID-19 ingresados a la UCI que tuvieran valores plasmáticos de 25(OH)D las primeras 72 '
'horas de internación.\xa0\n'
'Resultados: exhibieron deficiencia de 25(OH)D (< 30 ng/ mL) 136 (83 %) pacientes y 35 (21 '
'%) presentaron valores de 25(OH)D ≤ 12 ng/ml. Los pacientes con deficiencia grave de 25(OH)D '
'tuvieron significativamente mayor probabilidad de COVID-19 grave (odds ratio [OR]: 2,2; '
'intervalo de confianza [IC] 95 %: 1,02 a 5,06; p = 0,049) y presentaron mayor probabilidad de '
'requerir ventilación mecánica invasiva (OR: 2,4; IC 95 %: 1,09 a 5,58; p = 0 ,036). La '
'mortalidad fue significativamente mayor en el grupo con deficiencia grave de 25(OH)D (40 % '
'frente a 22 %; p = 0 ,03), con un OR de 2,4; IC 95 %: 1,07 a 5,32; p = 0 ,031. En el modelo '
'multivariado, el antecedente de enfermedad cardiovascular, deficiencia grave de 25(OH)D, '
'presión arterial de oxígeno/fracción inspirada de oxígeno (PaO2/FiO2) y ventilación mecánica '
'invasiva permanecieron significativos.\xa0\n'
'Conclusión: este estudio confirma que la deficiencia grave de vitamina D se asocia con una '
'afectación pulmonar más grave, una mayor gravedad de la enfermedad y riesgo de muerte en '
'pacientes con COVID-19.\xa0</jats:p>',
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