Vitamin D status and its association with the severity of COVID-19 among hospitalized patients
et al., International Journal of Advances in Medicine, doi:10.18203/2349-3933.ijam20241623, Jun 2024
Vitamin D for COVID-19
8th treatment shown to reduce risk in
October 2020, now with p < 0.00000000001 from 136 studies, recognized in 18 countries.
No treatment is 100% effective. Protocols
combine treatments.
6,400+ studies for
210+ treatments. c19early.org
|
Cross-sectional study of 103 hospitalized COVID-19 patients in Bangladesh showing that vitamin D deficiency was independently associated with greater disease severity.
This is the 201st of 229 COVID-19 sufficiency studies for vitamin D, which collectively show higher levels reduce risk with p<0.0000000001.
|
risk of severe case, 88.4% lower, OR 0.12, p = 0.003, high D levels (≥20 ng/ml) 46, low D levels (<20 ng/ml) 57, adjusted per study, inverted to make OR<1 favor high D levels (≥20 ng/ml), multivariable, RR approximated with OR.
|
| Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates |
Dip et al., 25 Jun 2024, retrospective, Bangladesh, peer-reviewed, 9 authors, study period January 2021 - December 2021.
Contact: abir.ayan.1984@gmail.com.
Vitamin D status and its association with the severity of COVID-19 among hospitalized patients
International Journal of Advances in Medicine, doi:10.18203/2349-3933.ijam20241623
Coronavirus disease (COVID-19) is a respiratory and systemic disorder caused by SARS-CoV-2 with a range of severity from mild respiratory symptoms to severe lung injury, multi-organ failure, and death. WHO declared COVID-19 outbreak as a pandemic, On March 11, 2020. 1 The outbreak of (COVID-19) is ongoing globally and ABSTRACT Background: Severe acute respiratory syndrome corona virus 2 (SARS-CoV-2), causing COVID-19, manifests with outcomes ranging from mild to severe, even fatal. The reason for severe symptoms remains unclear. Vitamin D is implicated in the pathogenesis of severe COVID-19, including ARDS, cytokine storms, and thrombotic complications. The aim of this study was evaluation of vitamin D status and its association with the severity of COVID-19 patients attending Bangabandhu Sheikh Mujib medical University (BSMMU). Methods: This cross-sectional study, conducted at BSMMU, Dhaka from January to December 2021, included 103 adult COVID-19-positive patients from both genders. Disease severity was assessed using WHO guidelines, and vitamin D levels recorded. Data were collected using a pre-designed datasheet after obtaining written informed consent. Results: Among 103 COVID-19 patients, 55.3% were vitamin D deficient, 26.2% insufficient, and 18.4% sufficient. Most were male (65%) in their sixth and seventh decades. The mean vitamin D level was 20.97±10.96 ng/ml with a median of 18.10 ng/ml. Vitamin D deficiency was highest among critical patients (84.6%), followed by severe (71.1%), moderate (41.9%), and mild (28.6%) cases (p<0.001). Severe patients had a significantly higher deficiency rate (74.5%) compared to non-severe (36.5%) cases (p<0.001). Symptoms such as cough (96.5%), fever (89.5%), and shortness of breath (78.9%) were prevalent in the vitamin D deficiency group. Conclusions: This study reveals a 55% prevalence of vitamin D deficiency in COVID-19 patients, correlating independently with disease severity. Hypertension and diabetes are notable comorbidities. It underscores the importance of assessing vitamin D levels in clinical practice.
References
Almehmadi, Turjoman, El-Askary, Shafie, Rebh et al., Association of vitamin D deficiency with clinical presentation of COVID-19, Eur J Inflammation
Baktash, Hosack, Patel, Shah, Kandiah et al., Vitamin D status and outcomes for hospitalised older patients with COVID-19, Postgraduate Med J
Bassford, Vitamin D deficiency contributes directly to the acute respiratory distress syndrome (ARDS), Thorax
Carpagnano, Lecce, Quaranta, Zito, Buonamico et al., Vitamin D deficiency as a predictor of poor prognosis in patients with acute respiratory failure due to COVID-19, J Endocrinological Investigation
Dancer, Parekh, Lax, Souza, Zheng et al., None, International Journal of Advances in Medicine
Farsalinos, Bagos, Giannouchos, Niaura, Barbouni et al., Smoking prevalence among hospitalized COVID-19 patients and its association with disease severity and mortality: an expanded reanalysis of a recent publication, Harm Reduction J
Ghasemian, Shamshirian, Heydari, Malekan, Alizadeh-Navaei et al., The Role of Vitamin D in The Age of COVID-19: A Systematic Review and Meta-Analysis Along with an Ecological Approach, Int J Clin Pract
Green, How many subjects does it take to do a regressionanalysis, Multivariate Behavioral Res
Guan, Ni, Hu, Liang, Ou et al., Clinical characteristics of coronavirus disease 2019 in China, N Eng J Med
Islam, Hasan, Rahman, Asaduzzaman, Rahim et al., Vitamin D status in Bangladeshi subjects: a laboratory-based study, BIRDEM Med J
Karahan, Katkat, Impact of serum 25 (OH) vitamin D level on mortality in patients with COVID-19 in Turkey, J Nutrit Health Aging
Lau, Majumder, Torabi, Saeg, Hoffman et al., Vitamin D insufficiency is prevalent in severe COVID-19, MedRxiv
Maghbooli, Sahraian, Ebrahimi, Pazoki, Kafan et al., Vitamin D sufficiency, a serum 25-hydroxyvitamin D at least 30 ng/mL reduced risk for adverse clinical outcomes in patients with COVID-19 infection, PloS one
Mamani, Muceli, Basir, Vasheghani, Poorolajal, Association between serum concentration of 25-hydroxyvitamin D and community-acquired pneumonia: a case-control study, Int J General Med
Meltzer, Best, Zhang, Vokes, Arora et al., Association of vitamin D status and other clinical characteristics with COVID-19 test results, JAMA Network Open
Mohan, Cherian, Sharma, Exploring links between vitamin D deficiency and COVID-19, PLoS Pathogens
Mohsin, Tonmon, Nahrin, Tithy, Ara, Association Between Smoking and COVID-19 Severity: Evidence from Bangladesh, J Multidisciplinary Healthcare
Radujkovic, Hippchen, Tiwari-Heckler, Dreher, Boxberger et al., Vitamin D status and its association with the severity of COVID-19 among hospitalized patients, Int J Adv Med
Razdan, Singh, Singh, Vitamin D levels and COVID-19 susceptibility: is there any correlation?, Med Drug Discovery
Verdoia, Luca, Potential role of hypovitaminosis D and vitamin D supplementation during COVID-19 pandemic, Int J Med
Worldometer, Countries where COVID-19
Wu, Wu, Liu, Yang, The SARS-CoV-2 outbreak: what we know, Int J Infect Dis
Ye, Tang, Liao, Shaw, Deng et al., Does serum vitamin D level affect COVID-19 infection and its severity?-a case-control study, J Am College Nutr
Zwart, Smith, Vitamin d and covid-19: lessons from spaceflight analogs, J Nutr
DOI record:
{
"DOI": "10.18203/2349-3933.ijam20241623",
"ISSN": [
"2349-3933",
"2349-3925"
],
"URL": "http://dx.doi.org/10.18203/2349-3933.ijam20241623",
"abstract": "<jats:p>Background: Severe acute respiratory syndrome corona virus 2 (SARS-CoV-2), causing COVID-19, manifests with outcomes ranging from mild to severe, even fatal. The reason for severe symptoms remains unclear. Vitamin D is implicated in the pathogenesis of severe COVID-19, including ARDS, cytokine storms, and thrombotic complications. The aim of this study was evaluation of vitamin D status and its association with the severity of COVID-19 patients attending Bangabandhu Sheikh Mujib medical University (BSMMU).\nMethods: This cross-sectional study, conducted at BSMMU, Dhaka from January to December 2021, included 103 adult COVID-19-positive patients from both genders. Disease severity was assessed using WHO guidelines, and vitamin D levels recorded. Data were collected using a pre-designed datasheet after obtaining written informed consent.\nResults: Among 103 COVID-19 patients, 55.3% were vitamin D deficient, 26.2% insufficient, and 18.4% sufficient. Most were male (65%) in their sixth and seventh decades. The mean vitamin D level was 20.97±10.96 ng/ml with a median of 18.10 ng/ml. Vitamin D deficiency was highest among critical patients (84.6%), followed by severe (71.1%), moderate (41.9%), and mild (28.6%) cases (p<0.001). Severe patients had a significantly higher deficiency rate (74.5%) compared to non-severe (36.5%) cases (p<0.001). Symptoms such as cough (96.5%), fever (89.5%), and shortness of breath (78.9%) were prevalent in the vitamin D deficiency group.\nConclusions: This study reveals a 55% prevalence of vitamin D deficiency in COVID-19 patients, correlating independently with disease severity. Hypertension and diabetes are notable comorbidities. It underscores the importance of assessing vitamin D levels in clinical practice.</jats:p>",
"author": [
{
"affiliation": [],
"family": "Dip",
"given": "Abir Hasan",
"sequence": "first"
},
{
"affiliation": [],
"family": "Quadry",
"given": "Shaiful Azam",
"sequence": "additional"
},
{
"affiliation": [],
"family": "Alam",
"given": "M. Shariful",
"sequence": "additional"
},
{
"affiliation": [],
"family": "Rijvy",
"given": "M. Tanimul Haque",
"sequence": "additional"
},
{
"affiliation": [],
"family": "Akter",
"given": "Shilpy",
"sequence": "additional"
},
{
"affiliation": [],
"family": "Parvin",
"given": "Hosneara",
"sequence": "additional"
},
{
"affiliation": [],
"family": "Sarker",
"given": "Mohammad Arbab",
"sequence": "additional"
},
{
"affiliation": [],
"family": "Ahmed",
"given": "Shamim",
"sequence": "additional"
},
{
"affiliation": [],
"family": "Chakrobortty",
"given": "Rajashish",
"sequence": "additional"
}
],
"container-title": "International Journal of Advances in Medicine",
"container-title-short": "Int J Adv Med",
"content-domain": {
"crossmark-restriction": false,
"domain": []
},
"created": {
"date-parts": [
[
2024,
6,
26
]
],
"date-time": "2024-06-26T00:15:40Z",
"timestamp": 1719360940000
},
"deposited": {
"date-parts": [
[
2024,
6,
26
]
],
"date-time": "2024-06-26T00:15:58Z",
"timestamp": 1719360958000
},
"indexed": {
"date-parts": [
[
2024,
6,
27
]
],
"date-time": "2024-06-27T00:29:01Z",
"timestamp": 1719448141035
},
"is-referenced-by-count": 0,
"issue": "4",
"issued": {
"date-parts": [
[
2024,
6,
25
]
]
},
"journal-issue": {
"issue": "4",
"published-online": {
"date-parts": [
[
2024,
6,
25
]
]
}
},
"link": [
{
"URL": "https://www.ijmedicine.com/index.php/ijam/article/download/4046/2707",
"content-type": "application/pdf",
"content-version": "vor",
"intended-application": "text-mining"
},
{
"URL": "https://www.ijmedicine.com/index.php/ijam/article/download/4046/2707",
"content-type": "unspecified",
"content-version": "vor",
"intended-application": "similarity-checking"
}
],
"member": "7570",
"original-title": [],
"page": "319-327",
"prefix": "10.18203",
"published": {
"date-parts": [
[
2024,
6,
25
]
]
},
"published-online": {
"date-parts": [
[
2024,
6,
25
]
]
},
"publisher": "Medip Academy",
"reference-count": 0,
"references-count": 0,
"relation": {},
"resource": {
"primary": {
"URL": "https://www.ijmedicine.com/index.php/ijam/article/view/4046"
}
},
"score": 1,
"short-title": [],
"source": "Crossref",
"subject": [],
"subtitle": [],
"title": "Vitamin D status and its association with the severity of COVID-19 among hospitalized patients",
"type": "journal-article",
"volume": "11"
}