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All Studies   Meta Analysis   Recent:  
0 0.5 1 1.5 2+ Mortality 65% Improvement Relative Risk Mortality (b) -40% ICU admission 58% ICU time 68% Discharge, day 36 80% Discharge, day 28 85% Discharge, day 21 85% Discharge, day 14 65% Discharge, day 7 65% Recovery time, fever 45% Hospitalization time 50% De Niet et al. NCT04636086 Vitamin D RCT LATE TREATMENT Is late treatment with vitamin D beneficial for COVID-19? Double-blind RCT 43 patients in Belgium (August 2020 - August 2021) Shorter hospitalization with vitamin D (p=0.003) De Niet et al., Nutrients, doi:10.3390/nu14153048 Favors vitamin D Favors control

Positive Effects of Vitamin D Supplementation in Patients Hospitalized for COVID-19: A Randomized, Double-Blind, Placebo-Controlled Trial

De Niet et al., Nutrients, doi:10.3390/nu14153048, NCT04636086 (history)
De Niet et al., Positive Effects of Vitamin D Supplementation in Patients Hospitalized for COVID-19: A Randomized,.., Nutrients, doi:10.3390/nu14153048, NCT04636086
Jul 2022   Source   PDF  
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RCT with 21 vitamin D and 22 placebo hospitalized patients in Belgium with vitamin D deficiency, showing significantly shorter hospitalization and improved clinical recovery with treatment.
This is the 20th of 27 COVID-19 RCTs for vitamin D, which collectively show efficacy with p=0.00002.
This is the 90th of 111 COVID-19 controlled studies for vitamin D, which collectively show efficacy with p<0.0000000001 (1 in 49 sextillion).
risk of death, 65.1% lower, RR 0.35, p = 0.61, treatment 1 of 21 (4.8%), control 3 of 22 (13.6%), NNT 11, COVID-19 mortality.
risk of death, 39.7% higher, RR 1.40, p = 0.70, treatment 4 of 21 (19.0%), control 3 of 22 (13.6%), all cause including after discharge and non-COVID-19.
risk of ICU admission, 58.1% lower, RR 0.42, p = 0.41, treatment 2 of 21 (9.5%), control 5 of 22 (22.7%), NNT 7.6.
ICU time, 67.7% lower, relative time 0.32, p = 0.47, treatment 21, control 22.
risk of no hospital discharge, 79.6% lower, RR 0.20, p = 0.49, treatment 0 of 21 (0.0%), control 2 of 22 (9.1%), NNT 11, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm), day 36.
risk of no hospital discharge, 85.4% lower, RR 0.15, p = 0.23, treatment 0 of 21 (0.0%), control 3 of 22 (13.6%), NNT 7.3, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm), day 28.
risk of no hospital discharge, 85.4% lower, RR 0.15, p = 0.23, treatment 0 of 21 (0.0%), control 3 of 22 (13.6%), NNT 7.3, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm), day 21.
risk of no hospital discharge, 65.1% lower, RR 0.35, p = 0.61, treatment 1 of 21 (4.8%), control 3 of 22 (13.6%), NNT 11, day 14.
risk of no hospital discharge, 65.1% lower, RR 0.35, p = 0.03, treatment 4 of 21 (19.0%), control 12 of 22 (54.5%), NNT 2.8, day 7.
recovery time, 45.4% lower, relative time 0.55, p = 0.06, treatment 21, control 22, fever.
hospitalization time, 50.0% lower, relative time 0.50, p = 0.003, treatment 21, control 22.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
De Niet et al., 26 Jul 2022, Double Blind Randomized Controlled Trial, placebo-controlled, Belgium, peer-reviewed, 16 authors, study period August 2020 - August 2021, dosage 25,000IU days 1-4, 11, 18, 25, trial NCT04636086 (history).
Contact: (corresponding author),,,,,,,,,,,,,,,
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This PaperVitamin DAll
Positive Effects of Vitamin D Supplementation in Patients Hospitalized for COVID-19: A Randomized, Double-Blind, Placebo-Controlled Trial
Sophie De Niet, Mickaël Trémège, Monte Coffiner, Anne-Francoise Rousseau, Doriane Calmes, Anne-Noelle Frix, Fanny Gester, Muriel Delvaux, Anne-Francoise Dive, Elora Guglielmi, Monique Henket, Alicia Staderoli, Didier Maesen, Renaud Louis, Julien Guiot, Etienne Cavalier
Nutrients, doi:10.3390/nu14153048
Retrospective studies showed a relationship between vitamin D status and COVID-19 severity and mortality, with an inverse relation between SARS-CoV-2 positivity and circulating calcifediol levels. The objective of this pilot study was to investigate the effect of vitamin D supplementation on the length of hospital stay and clinical improvement in patients with vitamin D deficiency hospitalized with COVID-19. The study was randomized, double blind and placebo controlled. A total of 50 subjects were enrolled and received, in addition to the best available COVID therapy, either vitamin D (25,000 IU per day over 4 consecutive days, followed by 25,000 IU per week up to 6 weeks) or placebo. The length of hospital stay decreased significantly in the vitamin D group compared to the placebo group (4 days vs. 8 days; p = 0.003). At Day 7, a significantly lower percentage of patients were still hospitalized in the vitamin D group compared to the placebo group (19% vs. 54%; p = 0.0161), and none of the patients treated with vitamin D were hospitalized after 21 days compared to 14% of the patients treated with placebo. Vitamin D significantly reduced the duration of supplemental oxygen among the patients who needed it (4 days vs. 7 days in the placebo group; p = 0.012) and significantly improved the clinical recovery of the patients, as assessed by the WHO scale (p = 0.0048). In conclusion, this study demonstrated that the clinical outcome of COVID-19 patients requiring hospitalization was improved by administration of vitamin D.
Amrein, Schnedl, Holl, Riedl, Christopher et al., Effect of high-dose vitamin D 3 on hospital length of stay in critically ill patients with vitamin D deficiency: The VITdAL-ICU randomized clinical trial, JAMA, doi:10.1001/jama.2014.13204
Angelidi, Belanger, Lorinsky, Karamanis, Chamorro-Pareja et al., Vitamin D Status Is Associated With In-Hospital Mortality and Mechanical Ventilation: A Cohort of COVID-19 Hospitalized Patients, Mayo Clin. Proc, doi:10.1016/j.mayocp.2021.01.001
Barnett, Zhao, Koyama, Janz, Wang et al., Vitamin D deficiency and risk of acute lung injury in severe sepsis and severe trauma: A case-control study, Ann. Intensive Care, doi:10.1186/2110-5820-4-5
Beard, Bearden, Striker, Vitamin D and the anti-viral state, J. Clin. Virol, doi:10.1016/j.jcv.2010.12.006
Braun, Gibbons, Litonjua, Giovannucci, Christopher, Low serum 25-hydroxyvitamin D at critical care initiation is associated with increased mortality, Crit. Care Med, doi:10.1097/CCM.0b013e31822d74f3
Cannata-Andía, Díaz-Sottolano, Fernández, Palomo-Antequera, Herrero-Puente et al., A single-oral bolus of 100,000 IU of cholecalciferol at hospital admission did not improve outcomes in the COVID-19 disease: The COVID-VIT-D-a randomised multicentre international clinical trial, BMC Med, doi:10.1186/s12916-022-02290-8
Castillo, Costa, Barrios, Díaz, Miranda et al., Effect of calcifediol treatment and best available therapy versus best available therapy on intensive care unit admission and mortality among patients hospitalized for COVID-19: A pilot randomized clinical study, J. Steroid Biochem. Mol. Biol, doi:10.1016/j.jsbmb.2020.105751
Cavalier, Faché, Souberbielle, Randomised, Double-Blinded, Placebo-Controlled, Parallel Study of Vitamin D 3 Supplementation with Different Schemes Based on Multiples of 25,000 IU Doses, Int. J. Endocrinol, doi:10.1155/2013/327265
Cavalier, Fraser, Bhattoa, Heijboer, Makris et al., Analytical Performance Specifications for 25-Hydroxyvitamin D Examinations, Nutrients, doi:10.3390/nu13020431
Cavalier, Lukas, Bekaert, Peeters, Le Goff et al., Analytical and clinical evaluation of the new Fujirebio Lumipulse ® G non-competitive assay for 25(OH)-vitamin D and three immunoassays for 25(OH)D in healthy subjects, osteoporotic patients, third trimester pregnant women, healthy African subjects, hemodialyzed and intensive care patients, Clin. Chem. Lab. Med, doi:10.1515/cclm-2015-0923
Cavalier, Lukas, Crine, Peeters, Carlisi et al., Evaluation of automated immunoassays for 25(OH)-vitamin D determination in different critical populations before and after standardization of the assays, Clin. Chim. Acta Int. J. Clin. Chem, doi:10.1016/j.cca.2014.01.026
Coussens, The role of UV radiation and vitamin D in the seasonality and outcomes of infectious disease, Photochem. Photobiol. Sci, doi:10.1039/c6pp00355a
De Niet, Coffiner, Da Silva, Jandrain, Souberbielle et al., A Randomized Study to Compare a Monthly to a Daily Administration of Vitamin D 3 Supplementation, Nutrients, doi:10.3390/nu10060659
Dijkman, Jebbink, Deijs, Milewska, Pyrc et al., Replication-dependent downregulation of cellular angiotensin-converting enzyme 2 protein expression by human coronavirus NL63, J. Gen. Virol, doi:10.1099/vir.0.043919-0
Dopico, Evangelou, Ferreira, Guo, Pekalski et al., Widespread seasonal gene expression reveals annual differences in human immunity and physiology, Nat. Commun, doi:10.1038/ncomms8000
Fabbri, Infante, Ricordi, Editorial-Vitamin D status: A key modulator of innate immunity and natural defense from acute viral respiratory infections, Eur. Rev. Med. Pharmacol. Sci, doi:10.26355/eurrev_202004_20876
Golpour, Bereswill, Heimesaat, Antimicrobial and Immune-Modulatory Effects of Vitamin D Provide Promising Antibiotics-Independent Approaches to Tackle Bacterial Infections-Lessons Learnt from a Literature Survey, Eur. J. Microbiol. Immunol, doi:10.1556/1886.2019.00014
Gombart, Pierre, Maggini, A Review of Micronutrients and the Immune System-Working in Harmony to Reduce the Risk of Infection, Nutrients, doi:10.3390/nu12010236
Grant, Lahore, Mcdonnell, Baggerly, French et al., Evidence that Vitamin D Supplementation Could Reduce Risk of Influenza and COVID-19 Infections and Deaths, Nutrients, doi:10.3390/nu12040988
Greiller, Martineau, Modulation of the immune response to respiratory viruses by vitamin D, Nutrients, doi:10.3390/nu7064240
Gruber-Bzura, Vitamin D and Influenza-Prevention or Therapy?, Int. J. Mol. Sci, doi:10.3390/ijms19082419
Han, Jones, Tangpricha, Brown, Hao et al., High Dose Vitamin D Administration in Ventilated Intensive Care Unit Patients: A Pilot Double Blind Randomized Controlled Trial, J. Clin. Transl. Endocrinol, doi:10.1016/j.jcte.2016.04.004
Hansdottir, Monick, Hinde, Lovan, Look et al., Respiratory epithelial cells convert inactive vitamin D to its active form: Potential effects on host defense, J. Immunol. Baltim. Md, doi:10.4049/jimmunol.181.10.7090
Hewison, Vitamin D and immune function: An overview, Proc. Nutr. Soc, doi:10.1017/S0029665111001650
Higgins, Wischmeyer, Queensland, Sillau, Sufit et al., Relationship of vitamin D deficiency to clinical outcomes in critically ill patients, JPEN J. Parenter. Enter. Nutr, doi:10.1177/0148607112444449
Holick, Vitamin, Deficiency, None, N. Engl. J. Med, doi:10.1056/NEJMra070553
Jolliffe, Camargo, Sluyter, Aglipay, Aloia et al., Vitamin D supplementation to prevent acute respiratory infections: A systematic review and meta-analysis of aggregate data from randomised controlled trials, Lancet Diabetes Endocrinol, doi:10.1016/S2213-8587(21)00051-6
Jolliffe, Griffiths, Martineau, Vitamin D in the prevention of acute respiratory infection: Systematic review of clinical studies, J. Steroid Biochem. Mol. Biol, doi:10.1016/j.jsbmb.2012.11.017
Kaufman, Niles, Kroll, Bi, Holick, SARS-CoV-2 positivity rates associated with circulating 25-hydroxyvitamin D levels, PLoS ONE, doi:10.1371/journal.pone.0239252
Kempker, West, Kempker, Siwamogsatham, Alvarez et al., Vitamin D status and the risk for hospital-acquired infections in critically ill adults: A prospective cohort study, PLoS ONE, doi:10.1371/journal.pone.0122136
Lang, Aspinall, Vitamin D Status and the Host Resistance to Infections: What It Is Currently (Not) Understood, Clin. Ther, doi:10.1016/j.clinthera.2017.04.004
Mcnally, Menon, Chakraborty, Fisher, Williams et al., The association of vitamin D status with pediatric critical illness, Pediatrics, doi:10.1542/peds.2011-3059
Meltzer, Best, Zhang, Vokes, Arora et al., Association of Vitamin D Status and Other Clinical Characteristics With COVID-19 Test Results, JAMA Netw. Open, doi:10.1001/jamanetworkopen.2020.19722
Milani, Simonetti, Edefonti, Lava, Agostoni et al., Seasonal variability of the vitamin D effect on physical fitness in adolescents, Sci. Rep, doi:10.1038/s41598-020-80511-x
Moromizato, Litonjua, Braun, Gibbons, Giovannucci et al., Association of low serum 25-hydroxyvitamin D levels and sepsis in the critically ill, Crit. Care Med, doi:10.1097/CCM.0b013e31829eb7af
Murai, Fernandes, Sales, Pinto, Goessler et al., Effect of a Single High Dose of Vitamin D 3 on Hospital Length of Stay in Patients With Moderate to Severe COVID-19: A Randomized Clinical Trial, JAMA, doi:10.1001/jama.2020.26848
Nair, Lee, Reynolds, Nguyen, Myburgh et al., Significant perturbation of vitamin Dparathyroid-calcium axis and adverse clinical outcomes in critically ill patients, Intensive Care Med, doi:10.1007/s00134-012-2713-y
Olliver, Spelmink, Hiew, Meyer-Hoffert, Henriques-Normark et al., Immunomodulatory effects of vitamin D on innate and adaptive immune responses to Streptococcus pneumoniae, J. Infect Dis, doi:10.1093/infdis/jit355
Quraishi, Litonjua, Moromizato, Gibbons, Camargo et al., Association between prehospital vitamin D status and hospital-acquired Clostridium difficile infections, JPEN J. Parenter. Enter. Nutr, doi:10.1177/0148607113511991
Rondanelli, Miccono, Lamburghini, Avanzato, Riva et al., Self-Care for Common Colds: The Pivotal Role of Vitamin D, Vitamin C, Zinc, and Echinacea in Three Main Immune Interactive Clusters (Physical Barriers, Innate and Adaptive Immunity) Involved during an Episode of Common Colds-Practical Advice on Dosages and on the Time to Take These Nutrients/Botanicals in order to Prevent or Treat Common Colds, Evid.-Based Complement. Altern. Med. ECAM, doi:10.1155/2018/5813095
Schleck, Souberbielle, Jandrain, Da Silva, De Niet et al., Double-Blind, Parallel Study to Evaluate the Dose-Response of Three Different Vitamin D Treatment Schemes on the 25-Hydroxyvitamin D Serum Concentration in Patients with Vitamin D Deficiency, Nutrients, doi:10.3390/nu7075227
Teymoori-Rad, Marashi, Vitamin D and COVID-19: From potential therapeutic effects to unanswered questions, Rev. Med. Virol, doi:10.1002/rmv.2159
Thickett, Moromizato, Litonjua, Amrein, Quraishi et al., Association between prehospital vitamin D status and incident acute respiratory failure in critically ill patients: A retrospective cohort study, BMJ Open Respir. Res, doi:10.1136/bmjresp-2014-000074
Wei, Christakos, Mechanisms Underlying the Regulation of Innate and Adaptive Immunity by Vitamin D, Nutrients, doi:10.3390/nu7105392
Who, Working Group on the Clinical Characterisation and Management of COVID-19 infection. A minimal common outcome measure set for COVID-19 clinical research, Lancet Infect Dis, doi:10.1016/S1473-3099(20)30483-7
Wise, Camara, Sempos, Lukas, Le Goff et al., Vitamin D Standardization Program (VDSP) intralaboratory study for the assessment of 25-hydroxyvitamin D assay variability and bias, J. Steroid Biochem. Mol. Biol, doi:10.1016/j.jsbmb.2021.105917
Late treatment
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