Efficacy and safety of azvudine in patients with COVID-19: A systematic review and meta-analysis
et al., Heliyon, doi:10.1016/j.heliyon.2023.e20153, Sep 2023
Azvudine for COVID-19
48th treatment shown to reduce risk in
January 2023, now with p = 0.000000017 from 39 studies.
No treatment is 100% effective. Protocols
combine treatments.
6,400+ studies for
210+ treatments. c19early.org
|
Systematic review and meta analysis of 5 RCTs showing improved clinical recovery and faster viral clearance with azvudine treatment.
5 meta-analyses show significant improvements with azvudine for mortality3-7,
mechanical ventilation3,
improvement3,
progression7, and
viral clearance3,5,6 .
Currently there are 39 azvudine for COVID-19 studies, showing 30% lower mortality [20‑39%], 18% lower ventilation [-10‑39%], 21% lower ICU admission [5‑34%], and 10% lower hospitalization [0‑19%].
1.
Xiong et al., Real-world data of Azvudine-induced hepatotoxicity among hospitalized COVID-19 patients in China: a retrospective case-control study, Frontiers in Pharmacology, doi:10.3389/fphar.2025.1558054.
2.
Wang et al., Development and validation of a nomogram to assess the occurrence of liver dysfunction in patients with COVID-19 pneumonia in the ICU, BMC Infectious Diseases, doi:10.1186/s12879-025-10684-1.
3.
Zheng et al., Small-molecule antivirals treatment for COVID-19: A systematic review and network meta-analysis, International Journal of Antimicrobial Agents, doi:10.1016/j.ijantimicag.2024.107096.
4.
Wang (B) et al., Effectiveness of azvudine in reducing mortality of COVID-19 patients: a systematic review and meta-analysis, Virology Journal, doi:10.1186/s12985-024-02316-y.
5.
Amani et al., Effectiveness and safety of azvudine in COVID-19: A systematic review and meta-analysis, PLOS ONE, doi:10.1371/journal.pone.0298772.
Chen et al., 30 Sep 2023, peer-reviewed, 2 authors.
Contact: tianfangyuan0608@163.com.
Efficacy and safety of azvudine in patients with COVID-19: A systematic review and meta-analysis
Heliyon, doi:10.1016/j.heliyon.2023.e20153
Introduction: Azivudine has undergone a few randomized controlled trials (RCTs) as of late. This study aimed to assess the COVID-19 treatment with azvudine's efficacy and safety. Methods: Through January 20, 2023, systematic searches of PubMed, Embase, ClinicalTrials.gov, International Clinical Trials Registry Platform (ICTRP), Cochrane Central Register of Controlled Trials (CENTRAL), and MedRxiv were conducted to find the RCTs. The included studies' bias risk was evaluated using the Cochrane Handbook for Systematic Reviews of Interventions. Metaanalysis was performed using Revman 5.4 (PROSPERO Code: CRD42023395022). Results: A total of five RCTs with 1142 COVID-19 patients, 575 of whom received azvudine, were included. Additionally, seven RCTs are currently being conducted. In terms of clinical improvement and PT-PCR (reverse transcription polymerase chain reaction) negativity, the azvudine group had a greater patient percentage than the usual treatment or placebo group. It also took less time for the PT-PCR to become negative. In comparison to the placebo or standard treatment groups, the frequency of adverse events was reduced in the azvudine group (risk ratio [RR] = 0.89, 95% confidence interval [CI]: 0.80 to 0.99) and major adverse events (RR = 0.63, 95% CI: 0.22 to 1.79) groups. Conclusions: Without the burden of side effects, azvudine can hasten the clinical symptoms of COVID-19 patients and PT-PCR negative. It will take more extensive research to confirm these conclusions.
Author contribution statement All authors listed have significantly contributed to the development and the writing of this article.
Ethics statement Not required.
Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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