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All Studies   Meta Analysis    Recent:   

Vitamin D for COVID-19: real-time meta analysis of 310 studies (118 treatment studies and 192 sufficiency studies)

Covid Analysis
Feb 2024  
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Vitamin D for COVID-19
8th treatment shown to reduce risk in October 2020
 
*, now known with p < 0.00000000001 from 118 studies, recognized in 7 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
3,800+ studies for 60+ treatments. c19early.org
118 treatment studies show statistically significant lower risk for mortality, ICU admission, hospitalization, and cases.
60 studies from 56 independent teams in 21 countries show statistically significant lower risk.
Random effects meta-analysis with pooled effects using the most serious outcome reported shows 60% [40‑74%] and 36% [30‑41%] lower risk for early treatment and for all studies. Results are similar for higher quality studies, peer-reviewed studies, and mortality: early treatment - 68% [45‑82%], 57% [36‑71%], 68% [39‑84%]; all - 37% [31‑42%], 40% [34‑45%], 36% [28‑43%].
Late stage treatment with calcitriol/calcifediol and analogs is more effective than cholecalciferol: 65% [41‑79%] vs. 39% [26‑49%].
192 sufficiency studies show a strong association between vitamin D sufficiency and outcomes, with 52% [48‑56%] lower risk for higher levels.
No treatment or intervention is 100% effective. All practical, effective, and safe means should be used based on risk/benefit analysis. Multiple treatments are typically used in combination, and other treatments may be more effective. The quality of non-prescription supplements can vary widely Crawford, Crighton.
All data and sources to reproduce this paper are in the appendix. Other meta analyses show significant improvements with vitamin D treatment for mortality Argano, D’Ecclesiis, Hariyanto, Hosseini, Nikniaz, Shah, Xie, mechanical ventilation Hariyanto, Meng, Shah, Xie, ICU admission Hariyanto, Hosseini, Meng, Shah, Tentolouris, Xie, hospitalization Argano, severity D’Ecclesiis, Nikniaz, Varikasuvu, Xie, and cases Varikasuvu.
10 meta analyses show significant improvements with vitamin D treatment for mortality Argano, D’Ecclesiis, Hariyanto, Hosseini, Nikniaz, Shah, Xie, mechanical ventilation Hariyanto, Meng, Shah, Xie, ICU admission Hariyanto, Hosseini, Meng, Shah, Tentolouris, Xie, hospitalization Argano, severity D’Ecclesiis, Nikniaz, Varikasuvu, Xie, and cases Varikasuvu.
This PaperVitamin DAll
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Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Vaccines and treatments are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment, vaccine, or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
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