Statistically significant lower risk is seen for mortality, ventilation, and recovery. 9 studies from 9 independent teams in 5 countries show significant improvements.
Meta analysis using the most serious outcome reported shows 43% [30‑54%] lower risk. Results are similar for higher quality studies and slightly worse for Randomized Controlled Trials and peer-reviewed studies. Early treatment is more effective than late treatment.
3 RCTs with 268 patients have not reported results (up to 3 years late).
No treatment or intervention is 100% effective. All practical, effective, and safe means should be used based on risk/benefit analysis. Multiple treatments are typically used in combination, and other treatments may be more effective. The quality of non-prescription supplements can vary widely1,2.
All data to reproduce this paper and sources are in the appendix. 6 other meta analyses show significant improvements with melatonin for mortality3-5, mechanical ventilation6, hospitalization5,6, clinical improvement6, and recovery7,8.
6 meta analyses show significant improvements with melatonin for mortality
1-3,
mechanical ventilation
4,
hospitalization
3,4,
improvement
4, and
recovery
5,6.
Covid Analysis et al., Jul 2024, preprint, 1 author.