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All Studies   Meta Analysis    Recent:   

Melatonin for COVID-19: real-time meta analysis of 18 studies

Covid Analysis
Jun 2024  
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Melatonin for COVID-19
10th treatment shown to reduce risk in December 2020
 
*, now known with p = 0.0000002 from 18 studies.
Lower risk for mortality, ventilation, and recovery.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,200+ studies for 70+ treatments. c19early.org
Statistically significant lower risk is seen for mortality, ventilation, and recovery. 9 studies from 9 independent teams in 5 countries show significant improvements.
Meta analysis using the most serious outcome reported shows 43% [30‑54%] lower risk. Results are similar for higher quality studies and slightly worse for Randomized Controlled Trials and peer-reviewed studies. Early treatment is more effective than late treatment.
3 RCTs with 268 patients have not reported results (up to 3 years late).
No treatment or intervention is 100% effective. All practical, effective, and safe means should be used based on risk/benefit analysis. Multiple treatments are typically used in combination, and other treatments may be more effective. The quality of non-prescription supplements can vary widely1,2.
All data to reproduce this paper and sources are in the appendix. 5 other meta analyses show significant improvements with melatonin for mortality3,4, mechanical ventilation5, hospitalization5, clinical improvement5, and recovery6,7.
5 meta analyses show significant improvements with melatonin for mortality1,2, mechanical ventilation3, hospitalization3, improvement3, and recovery4,5.
Covid Analysis et al., Jun 2024, preprint, 1 author.
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Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
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