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All Studies   Meta Analysis   Recent:  

Melatonin for COVID-19: real-time meta analysis of 18 studies

Covid Analysis (Preprint) (meta analysis)
Covid Analysis, Melatonin for COVID-19: real-time meta analysis of 18 studies, (Preprint) (meta analysis)
Jun 2023   Source   PDF  
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• Statistically significant improvements are seen for mortality, ventilation, and recovery. 9 studies from 9 independent teams in 5 different countries show statistically significant improvements in isolation (7 for the most serious outcome).
• Meta analysis using the most serious outcome reported shows 43% [30‑54%] improvement. Results are slightly worse for Randomized Controlled Trials, similar after exclusions, and slightly worse for peer-reviewed studies. Early treatment is more effective than late treatment.
• No treatment, vaccine, or intervention is 100% effective and available. All practical, effective, and safe means should be used based on risk/benefit analysis. Multiple treatments are typically used in combination, and other treatments may be more effective. Only 11% of melatonin studies show zero events with treatment. The quality of non-prescription supplements can vary widely [Crawford, Crighton].
• All data to reproduce this paper and sources are in the appendix. Other meta analyses for melatonin can be found in [Lan, Pilia, Tan, Wang], showing significant improvements for mortality and recovery.
Percentage improvement with melatonin (more)
Early treatmentLate treatmentAll studiesStudies Patients Authors
All studies78% [25‑94%]*45% [27‑58%]****43% [30‑54%]**** 1814,301 159
Randomized Controlled TrialsRCTs73% [-5‑93%]23% [0‑41%]*26% [4‑43%]* 91,022 88
Mortality-48% [27‑63%]***48% [27‑63%]*** 92,054 52
Cases--38% [-6‑64%] 311,986 51
RCT mortality-25% [-7‑48%]25% [-7‑48%] 4547 30
Covid Analysis et al., Jun 2023, preprint, 1 author.
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Please send us corrections, updates, or comments. Vaccines and treatments are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment, vaccine, or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
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