The association between vitamin D3 deficiency and acute kidney injury in COVID-19 patients

Arabi et al., Journal of Renal Injury Prevention, doi:10.34172/jrip.2022.32126

Jan 2023

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Retrospective 69 hospitalized COVID-19 patients in Iran, showing lower vitamin D associated with higher mortality, ICU admission, and AKI in unadjusted results. The mean age of deficient patients was lower. Statistical significance is not reached for the binary comparison between the groups with levels <20 ng/mL and ≥20 ng/mL.

This is the 155th of 184 COVID-19 sufficiency studies for vitamin D, which collectively show higher levels reduce risk with p<0.0000000001 (1 in 712 vigintillion).

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risk of death, 40.0% lower, RR 0.60, p = 0.28, high D levels (≥20ng/mL) 6 of 30 (20.0%), low D levels (<20ng/mL) 13 of 39 (33.3%), NNT 7.5.

risk of ICU admission, 39.3% lower, RR 0.61, p = 0.20, high D levels (≥20ng/mL) 7 of 30 (23.3%), low D levels (<20ng/mL) 15 of 39 (38.5%), NNT 6.6.

risk of AKI, 42.2% lower, RR 0.58, p = 0.13, high D levels (≥20ng/mL) 8 of 30 (26.7%), low D levels (<20ng/mL) 18 of 39 (46.2%), NNT 5.1.

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Arabi et al., 22 Jan 2023, retrospective, Iran, peer-reviewed, 7 authors.

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The association between vitamin D3 deficiency and acute kidney injury in COVID-19 patients

Mohsen Arabi, Hamid Reza Samimagham, Azadeh Moradkhani, Fatemeh Khajavi Mayvan, Sara Binaei, Ali Salimi Asl, Mitra Kazemi Jahromi

Journal of Renal Injury Prevention, doi:10.34172/jrip.2022.32126

In a cross-sectional study on 69 hospitalized patients in the ward with COVID-19, we found significant association between vitamin D deficiency and acute kidney injury. Moreover, there was relationship between vitamin D deficiency and mortality, ICU (intensive care unit) admission and hospital length of stay. These results suggest the correction of vitamin D deficiency may be beneficial to reduce acute kidney injury in patient with COVID-19.

Authors' contribution Conflicts of interest The authors declare that they have no competing interests. Ethical issues At each research stage, we followed the principlesof the Declaration of Helsinki and the Ethics Committee of the Ministry of Health. Each participant signed the informed written consent form. This project was also confirmed by the Ethics Committee of the Hormozgan University of Medical Sciences (ethical code #IR.HUMS. REC.1398.394). All participants signed the written informed consent. Besides, ethical issues (including plagiarism, data fabrication and double publication) have been completely observed by the authors.

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