The association between vitamin D3 deficiency and acute kidney injury in COVID-19 patients
Mohsen Arabi, Hamid Reza Samimagham, Azadeh Moradkhani, Fatemeh Khajavi Mayvan, Sara Binaei, Ali Salimi Asl, Mitra Kazemi Jahromi
Journal of Renal Injury Prevention, doi:10.34172/jrip.2022.32126
In a cross-sectional study on 69 hospitalized patients in the ward with COVID-19, we found significant association between vitamin D deficiency and acute kidney injury. Moreover, there was relationship between vitamin D deficiency and mortality, ICU (intensive care unit) admission and hospital length of stay. These results suggest the correction of vitamin D deficiency may be beneficial to reduce acute kidney injury in patient with COVID-19.
Authors' contribution
Conflicts of interest The authors declare that they have no competing interests.
Ethical issues At each research stage, we followed the principlesof the Declaration of Helsinki and the Ethics Committee of the Ministry of Health. Each participant signed the informed written consent form. This project was also confirmed by the Ethics Committee of the Hormozgan University of Medical Sciences (ethical code #IR.HUMS. REC.1398.394). All participants signed the written informed consent. Besides, ethical issues (including plagiarism, data fabrication and double publication) have been completely observed by the authors.
References
Ala-Kokko, Mutt, Nisula, Koskenkari, Liisanantti et al., Vitamin D deficiency at admission is not associated with 90-day mortality in patients with severe sepsis or septic shock: Observational FINNAKI cohort study, Ann Med,
doi:10.3109/07853890.2015.1134807Ankova, Luini, Pedrazzoni, Riganti, Sironi et al., Impairment of cytokine production in mice fed a vitamin D3-deficient diet, Immunology
Arnson, Amital, Shoenfeld, Vitamin D and autoimmunity: new aetiological and therapeutic considerations, Ann Rheum Dis,
doi:10.1136/ard.2007.069831Braun, Litonjua, Moromizato, Gibbons, Giovannucci et al., Association of low serum 25-hydroxyvitamin D levels and acute kidney injury in the critically ill, Crit Care Med,
doi:10.1097/CCM.0b013e318260c928Cereda, Bogliolo, Klersy, Lobascio, Masi et al., Vitamin D 25OH deficiency in COVID-19 patients admitted to a tertiary referral hospital, Clin Nutr,
doi:10.1016/j.clnu.2020.10.055Giovannucci, Liu, Hollis, Rimm, 25-hydroxyvitamin D and risk of myocardial infarction in men: a prospective study, Arch Intern Med,
doi:10.1001/archinte.168.11.1174Gregori, Casorati, Amuchastegui, Smiroldo, Davalli et al., Regulatory T cells induced by 1 alpha,25-dihydroxyvitamin D3 and mycophenolate mofetil treatment mediate transplantation tolerance, J Immunol,
doi:10.4049/jimmunol.167.4.1945Hernández, Nan, Fernandez-Ayala, García-Unzueta, Hernández-Hernández et al., Vitamin D Status in Hospitalized Patients with SARS-CoV-2
Hoste, Bagshaw, Bellomo, Cely, Colman et al., Epidemiology of acute kidney injury in critically ill patients: the multinational AKI-EPI study, Intensive Care Med,
doi:10.1007/s00134-015-3934-7Hsieh, Hsiao, Liao, Hou, Chang et al., The Role of Vitamin D in SARS-CoV-2 Infection and Acute Kidney Injury, Int J Mol Sci,
doi:10.3390/ijms23137368Khwaja, KDIGO clinical practice guidelines for acute kidney injury, Nephron Clin Pract,
doi:10.1159/000339789Luo, Liao, Shen, Li, Cheng, Vitamin D Deficiency Is Associated with COVID-19 Incidence and Disease Severity in Chinese People
Macaya, Paeres, Valls, Fernández-Ortiz, Del Castillo et al., Interaction between age and vitamin D deficiency in severe COVID-19 infection, Nutr Hosp,
doi:10.20960/nh.03193Moraes, Friedman, Wawrzeniak, Marques, Nagel et al., Vitamin D deficiency is independently associated with mortality among critically ill patients, Clinics,
doi:10.6061/clinics/2015(05)04Orchard, Baldry, Nasim-Mohi, Monck, Saeed et al., Vitamin-D levels and intensive care unit outcomes of a cohort of critically ill COVID-19 patients, Clin Chem Lab Med,
doi:10.1515/cclm-2020-1567Panagiotou, Tee, Ihsan, Athar, Marchitelli et al., Low serum 25-hydroxyvitamin D (25[OH] D) levels in patients hospitalized with are associated with greater disease severity, Clin Endocrinol (Oxf),
doi:10.1111/cen.14276Pizzini, Aichner, Sahanic, Böhm, Egger et al., Impact of Vitamin D Deficiency on COVID-19-A Prospective Analysis from the CovILD Registry, Nutrients,
doi:10.3390/nu12092775Radujkovic, Hippchen, Tiwari-Heckler, Dreher, Boxberger, Vitamin D Deficiency and Outcome of COVID-19 Patients, Nutrients,
doi:10.3390/nu12092757Shah, Sharma, Mavalankar, Does vitamin D supplementation reduce COVID-19 severity? -a systematic review, QJM,
doi:10.1093/qjmed/hcac040Suzuki, Ichiyama, Ohsaki, Hasegawa, Shiraishi et al., Anti-inflammatory effect of 1alpha,25-Arabi M et al dihydroxyvitamin D(3) in human coronary arterial endothelial cells: Implication for the treatment of Kawasaki disease, J Steroid Biochem Mol Biol,
doi:10.1016/j.jsbmb.2008.12.004Zapatero, Dot, Diaz, Gracia, Pérez-Terán et al., Severe vitamin D deficiency upon admission in critically ill patients is related to acute kidney injury and a poor prognosis, Med Intensiva (Engl Ed),
doi:10.1016/j.medin.2017.07.004
