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0 0.5 1 1.5 2+ Mortality 40% Improvement Relative Risk ICU admission 39% AKI 42% Vitamin D for COVID-19  Arabi et al.  Sufficiency Are vitamin D levels associated with COVID-19 outcomes? Retrospective 69 patients in Iran Lower mortality (p=0.28) and ICU admission (p=0.2), not sig. Arabi et al., J. Renal Injury Prevention, Jan 2023 Favors vitamin D Favors control

The association between vitamin D3 deficiency and acute kidney injury in COVID-19 patients

Arabi et al., Journal of Renal Injury Prevention, doi:10.34172/jrip.2022.32126
Jan 2023  
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Retrospective 69 hospitalized COVID-19 patients in Iran, showing lower vitamin D associated with higher mortality, ICU admission, and AKI in unadjusted results. The mean age of deficient patients was lower. Statistical significance is not reached for the binary comparison between the groups with levels <20 ng/mL and ≥20 ng/mL.
This is the 155th of 184 COVID-19 sufficiency studies for vitamin D, which collectively show higher levels reduce risk with p<0.0000000001 (1 in 712 vigintillion).
risk of death, 40.0% lower, RR 0.60, p = 0.28, high D levels (≥20ng/mL) 6 of 30 (20.0%), low D levels (<20ng/mL) 13 of 39 (33.3%), NNT 7.5.
risk of ICU admission, 39.3% lower, RR 0.61, p = 0.20, high D levels (≥20ng/mL) 7 of 30 (23.3%), low D levels (<20ng/mL) 15 of 39 (38.5%), NNT 6.6.
risk of AKI, 42.2% lower, RR 0.58, p = 0.13, high D levels (≥20ng/mL) 8 of 30 (26.7%), low D levels (<20ng/mL) 18 of 39 (46.2%), NNT 5.1.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Arabi et al., 22 Jan 2023, retrospective, Iran, peer-reviewed, 7 authors.
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This PaperVitamin DAll
The association between vitamin D3 deficiency and acute kidney injury in COVID-19 patients
Mohsen Arabi, Hamid Reza Samimagham, Azadeh Moradkhani, Fatemeh Khajavi Mayvan, Sara Binaei, Ali Salimi Asl, Mitra Kazemi Jahromi
Journal of Renal Injury Prevention, doi:10.34172/jrip.2022.32126
In a cross-sectional study on 69 hospitalized patients in the ward with COVID-19, we found significant association between vitamin D deficiency and acute kidney injury. Moreover, there was relationship between vitamin D deficiency and mortality, ICU (intensive care unit) admission and hospital length of stay. These results suggest the correction of vitamin D deficiency may be beneficial to reduce acute kidney injury in patient with COVID-19.
Authors' contribution Conflicts of interest The authors declare that they have no competing interests. Ethical issues At each research stage, we followed the principlesof the Declaration of Helsinki and the Ethics Committee of the Ministry of Health. Each participant signed the informed written consent form. This project was also confirmed by the Ethics Committee of the Hormozgan University of Medical Sciences (ethical code #IR.HUMS. REC.1398.394). All participants signed the written informed consent. Besides, ethical issues (including plagiarism, data fabrication and double publication) have been completely observed by the authors.
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