The close association of micronutrients with COVID-19
Aimin Zhang, Yue Yin, Jiashu Tian, Xialin Wang, Zhihong Yue, Lin Pei, Li Liu, Li Qin, Mei Jia, Hui Wang, Qingwei Ma, Wei-Bo Gao, Lin-Lin Cao
Heliyon, doi:10.1016/j.heliyon.2024.e28629
Objectives: The present study was conducted to explore the performance of micronutrients in the prediction and prevention of coronavirus disease 2019 . Methods: This is an observational case-control study. 149 normal controls (NCs) and 214 COVID-19 patients were included in this study. Fat-soluble and water-soluble vitamins were determined by liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis, and inorganic elements were detected by inductively coupled plasma-mass spectrometry (ICP-MS) analysis. A logistic regression model based on six micronutrients were constructed using DxAI platform. Results: Many micronutrients were dysregulated in COVID-19 compared to normal control (NC). 25-Hydroxyvitamin D3 [25(OH)D3], magnesium (Mg), copper (Cu), calcium (Ca) and vitamin B6 (pyridoxic acid, PA) were significantly independent risk factors for COVID-19. The logistic regression model consisted of 25(OH)D3, Mg, Cu, Ca, vitamin B5 (VB5) and PA was developed, and displayed a strong discriminative capability to differentiate COVID-19 patients from NC individuals [area under the receiver operating characteristic curve (AUROC) = 0.901]. In addition, the model had great predictive ability in discriminating mild/normal COVID-19 patients from NC individuals (AUROC = 0.883). Conclusions: Our study showed that micronutrients were associated with COVID-19, and our logistic regression model based on six micronutrients has potential in clinical management of COVID-19, and will be useful for prediction of COVID-19 and screening of high-risk population.
Ethics declarations This study was reviewed and approved by the Ethical Review Committee of Peking University People's Hospital, with the approval number: 2023PHB218-001 and 2023PHB156-001. Informed consent was obtained from all subjects involved in the study.
CRediT authorship contribution statement
Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests:Hui Wang reports financial support was provided by Beijing Major Epidemic Prevention and Control Key Specialty Project-Medical Laboratory Excellence Project (2022). Wei-bo Gao reports financial support was provided by Beijing Natural Science Foundation (L222118). Lin-Lin Cao reports financial support was provided by Peking University People's Hospital Scientific Research Development Funds (RDJP2022-57). If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. Supplementary data to this article can be found online at https://doi.org/10.1016/j.heliyon.2024.e28629.
References
Akiyama, Hayashi, Hanaoka, Shibata, Akiyama et al., Pyridoxal 5'-phosphate, pyridoxal, and 4-pyridoxic acid in the paired serum and cerebrospinal fluid of children, Clin. Chim. Acta,
doi:10.1016/j.cca.2017.07.032Bailey, West, Black, The epidemiology of global micronutrient deficiencies, Ann. Nutr. Metab,
doi:10.1159/000371618Campi, Gennari, Merlotti, Mingiano, Frosali et al., Vitamin D and COVID-19 severity and related mortality: a prospective study in Italy, BMC Infect. Dis,
doi:10.1186/s12879-021-06281-7Domingo, Marques, The effects of some essential and toxic metals/metalloids in COVID-19: a review, Food Chem. Toxicol,
doi:10.1016/j.fct.2021.112161Fatemi, Ardehali, Eslamian, Noormohammadi, Malek, Association of vitamin D deficiency with COVID-19 severity and mortality in Iranian people: a prospective observational study, Acute Crit Care,
doi:10.4266/acc.2021.00605Goldblatt, Alter, Crotty, Plotkin, Correlates of protection against SARS-CoV-2 infection and COVID-19 disease, Immunol. Rev,
doi:10.1111/imr.13091Gombart, Pierre, Maggini, A review of micronutrients and the immune system-working in harmony to reduce the risk of infection, Nutrients,
doi:10.3390/nu12010236Gorji, Ghadiri, Potential roles of micronutrient deficiency and immune system dysfunction in the coronavirus disease 2019 (COVID-19) pandemic, Nutrition,
doi:10.1016/j.nut.2020.111047Grandjean, Nielsen, Jorgensen, Horder, Reference intervals for trace elements in blood: significance of risk factors, Scand. J. Clin. Lab. Invest,
doi:10.1080/00365519209088366Grober, Holzhauer, Kisters, Holick, Adamietz, Micronutrients in oncological intervention, Nutrients,
doi:10.3390/nu8030163Han, Ding, Lu, Li, Global, regional, and national burdens of common micronutrient deficiencies from 1990 to 2019: a secondary trend analysis based on the Global Burden of Disease 2019 study, EClinicalMedicine,
doi:10.1016/j.eclinm.2022.101299Lai, Chang, Yang, Lin, Lai et al., The role of micronutrient and immunomodulation effect in the vaccine era of COVID-19, J. Chin. Med. Assoc,
doi:10.1097/JCMA.0000000000000587Maggini, Pierre, Calder, Immune function and micronutrient requirements change over the life course, Nutrients,
doi:10.3390/nu10101531Mercola, Grant, Wagner, Evidence regarding vitamin D and risk of COVID-19 and its severity, Nutrients,
doi:10.3390/nu12113361Msemburi, Karlinsky, Knutson, Aleshin-Guendel, Chatterji et al., The WHO estimates of excess mortality associated with the COVID-19 pandemic, Nature,
doi:10.1038/s41586-022-05522-2Munshi, Hussein, Toraih, Elshazli, Jardak et al., Vitamin D insufficiency as a potential culprit in critical COVID-19 patients, J. Med. Virol,
doi:10.1002/jmv.26360Radujkovic, Hippchen, Tiwari-Heckler, Dreher, Boxberger et al., Vitamin D deficiency and outcome of COVID-19 patients, Nutrients,
doi:10.3390/nu12092757Shakeri, Azimian, Ghasemzadeh-Moghaddam, Safdari, Haresabadi et al., Evaluation of the relationship between serum levels of zinc, vitamin B12, vitamin D, and clinical outcomes in patients with COVID-19, J. Med. Virol,
doi:10.1002/jmv.27277Spencer, Wilhelm, Yang, Hall, Bouladoux et al., Adaptation of innate lymphoid cells to a micronutrient deficiency promotes type 2 barrier immunity, Science,
doi:10.1126/science.1247606Su, Zhao, Zeng, Liu, Zheng et al., Epidemiology, clinical presentation, pathophysiology, and management of long COVID: an update, Mol. Psychiatr,
doi:10.1038/s41380-023-02171-3Tan, Ho, Kalimuddin, Cherng, Teh et al., Cohort study to evaluate the effect of vitamin D, magnesium, and vitamin B(12) in combination on progression to severe outcomes in older patients with coronavirus (COVID-19), Nutrition,
doi:10.1016/j.nut.2020.111017Wang, Joshi, Leopold, Jackson, Christensen et al., Association of vitamin D deficiency with COVID-19 infection severity: systematic review and meta-analysis, Clin. Endocrinol,
doi:10.1111/cen.14540Wang, Trace Elements in Life Science
Wiersinga, Rhodes, Cheng, Peacock, Prescott, Pathophysiology, transmission, diagnosis, and treatment of coronavirus disease 2019 (COVID-19): a review, JAMA,
doi:10.1001/jama.2020.12839Zhang, Rao, Li, Zhu, Liu et al., Pilot trial of high-dose vitamin C in critically ill COVID-19 patients, Ann. Intensive Care,
doi:10.1186/s13613-020-00792-3Zhu, Zhang, Wang, Li, Yang et al., A novel coronavirus from patients with Pneumonia in China, N. Engl. J. Med,
doi:10.1056/NEJMoa2001017{ 'indexed': {'date-parts': [[2024, 3, 29]], 'date-time': '2024-03-29T01:07:10Z', 'timestamp': 1711674430143},
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'volume': '324',
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'DOI': '10.1038/s41586-022-05522-2',
'article-title': 'The WHO estimates of excess mortality associated with the COVID-19 '
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'volume': '613',
'author': 'Msemburi',
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'article-title': 'Micronutrients in oncological intervention',
'volume': '8',
'author': 'Grober',
'year': '2016',
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'doi-asserted-by': 'crossref',
'DOI': '10.3390/nu12010236',
'article-title': 'A review of micronutrients and the immune system-working in harmony to '
'reduce the risk of infection',
'volume': '12',
'author': 'Gombart',
'year': '2020',
'journal-title': 'Nutrients'},
{ 'key': '10.1016/j.heliyon.2024.e28629_bib9',
'doi-asserted-by': 'crossref',
'first-page': '432',
'DOI': '10.1126/science.1247606',
'article-title': 'Adaptation of innate lymphoid cells to a micronutrient deficiency '
'promotes type 2 barrier immunity',
'volume': '343',
'author': 'Spencer',
'year': '2014',
'journal-title': 'Science'},
{ 'key': '10.1016/j.heliyon.2024.e28629_bib10',
'doi-asserted-by': 'crossref',
'DOI': '10.3390/nu10101531',
'article-title': 'Immune function and micronutrient requirements change over the life '
'course',
'volume': '10',
'author': 'Maggini',
'year': '2018',
'journal-title': 'Nutrients'},
{ 'key': '10.1016/j.heliyon.2024.e28629_bib11',
'doi-asserted-by': 'crossref',
'first-page': 'e107',
'DOI': '10.7861/clinmed.2020-0301',
'article-title': 'Does vitamin D deficiency increase the severity of COVID-19?',
'volume': '20',
'author': 'Weir',
'year': '2020',
'journal-title': 'Clin. Med.'},
{ 'key': '10.1016/j.heliyon.2024.e28629_bib12',
'doi-asserted-by': 'crossref',
'first-page': '1373',
'DOI': '10.1016/j.jiph.2020.06.021',
'article-title': 'Role of vitamin D in preventing of COVID-19 infection, progression and '
'severity',
'volume': '13',
'author': 'Ali',
'year': '2020',
'journal-title': 'J Infect Public Health'},
{ 'key': '10.1016/j.heliyon.2024.e28629_bib13',
'doi-asserted-by': 'crossref',
'DOI': '10.3390/nu12113361',
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'volume': '12',
'author': 'Mercola',
'year': '2020',
'journal-title': 'Nutrients'},
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'doi-asserted-by': 'crossref',
'first-page': '566',
'DOI': '10.1186/s12879-021-06281-7',
'article-title': 'Vitamin D and COVID-19 severity and related mortality: a prospective '
'study in Italy',
'volume': '21',
'author': 'Campi',
'year': '2021',
'journal-title': 'BMC Infect. Dis.'},
{ 'key': '10.1016/j.heliyon.2024.e28629_bib15',
'doi-asserted-by': 'crossref',
'first-page': '300',
'DOI': '10.4266/acc.2021.00605',
'article-title': 'Association of vitamin D deficiency with COVID-19 severity and '
'mortality in Iranian people: a prospective observational study',
'volume': '36',
'author': 'Fatemi',
'year': '2021',
'journal-title': 'Acute Crit Care'},
{ 'key': '10.1016/j.heliyon.2024.e28629_bib16',
'doi-asserted-by': 'crossref',
'first-page': '281',
'DOI': '10.1111/cen.14540',
'article-title': 'Association of vitamin D deficiency with COVID-19 infection severity: '
'systematic review and meta-analysis',
'volume': '96',
'author': 'Wang',
'year': '2022',
'journal-title': 'Clin. Endocrinol.'},
{ 'key': '10.1016/j.heliyon.2024.e28629_bib17',
'series-title': 'Guidelines on the COVID-19 Diagnosis and Treatment',
'first-page': '1',
'year': '2022'},
{ 'key': '10.1016/j.heliyon.2024.e28629_bib18',
'doi-asserted-by': 'crossref',
'first-page': '321',
'DOI': '10.1080/00365519209088366',
'article-title': 'Reference intervals for trace elements in blood: significance of risk '
'factors',
'volume': '52',
'author': 'Grandjean',
'year': '1992',
'journal-title': 'Scand. J. Clin. Lab. Invest.'},
{ 'key': '10.1016/j.heliyon.2024.e28629_bib19',
'series-title': 'Trace Elements in Life Science',
'author': 'Wang',
'year': '1996'},
{ 'key': '10.1016/j.heliyon.2024.e28629_bib20',
'first-page': '677',
'article-title': 'Consensus on the application of mass spectrometry technology in the '
'detection of clinical trace element',
'volume': '34',
'year': '2019',
'journal-title': 'Lab. Med.'},
{ 'key': '10.1016/j.heliyon.2024.e28629_bib21',
'series-title': 'In Vitro Diagnostic Medical Devices-Measurement of Quantities in '
'Biological Samples-Metrological Traceability of Values Assigned to '
'Calibrators and Control Materials',
'first-page': '1',
'year': '2008'},
{ 'key': '10.1016/j.heliyon.2024.e28629_bib22',
'doi-asserted-by': 'crossref',
'first-page': '141',
'DOI': '10.1038/s41579-020-00459-7',
'article-title': 'Characteristics of SARS-CoV-2 and COVID-19',
'volume': '19',
'author': 'Hu',
'year': '2021',
'journal-title': 'Nat. Rev. Microbiol.'},
{ 'key': '10.1016/j.heliyon.2024.e28629_bib23',
'doi-asserted-by': 'crossref',
'first-page': '6',
'DOI': '10.1111/imr.13091',
'article-title': 'Correlates of protection against SARS-CoV-2 infection and COVID-19 '
'disease',
'volume': '310',
'author': 'Goldblatt',
'year': '2022',
'journal-title': 'Immunol. Rev.'},
{ 'key': '10.1016/j.heliyon.2024.e28629_bib24',
'doi-asserted-by': 'crossref',
'DOI': '10.1038/s41598-022-21513-9',
'article-title': 'Vitamin D status and severity of COVID-19',
'volume': '12',
'author': 'Nielsen',
'year': '2022',
'journal-title': 'Sci. Rep.'},
{ 'key': '10.1016/j.heliyon.2024.e28629_bib25',
'doi-asserted-by': 'crossref',
'first-page': '733',
'DOI': '10.1002/jmv.26360',
'article-title': 'Vitamin D insufficiency as a potential culprit in critical COVID-19 '
'patients',
'volume': '93',
'author': 'Munshi',
'year': '2021',
'journal-title': 'J. Med. Virol.'},
{ 'key': '10.1016/j.heliyon.2024.e28629_bib26',
'doi-asserted-by': 'crossref',
'DOI': '10.3390/nu12092757',
'article-title': 'Vitamin D deficiency and outcome of COVID-19 patients',
'volume': '12',
'author': 'Radujkovic',
'year': '2020',
'journal-title': 'Nutrients'},
{ 'key': '10.1016/j.heliyon.2024.e28629_bib27',
'doi-asserted-by': 'crossref',
'first-page': '1517',
'DOI': '10.1007/s43440-020-00176-1',
'article-title': 'Overview of the possible role of vitamin C in management of COVID-19',
'volume': '72',
'author': 'Abobaker',
'year': '2020',
'journal-title': 'Pharmacol. Rep.'},
{ 'key': '10.1016/j.heliyon.2024.e28629_bib28',
'doi-asserted-by': 'crossref',
'first-page': '5',
'DOI': '10.1186/s13613-020-00792-3',
'article-title': 'Pilot trial of high-dose vitamin C in critically ill COVID-19 patients',
'volume': '11',
'author': 'Zhang',
'year': '2021',
'journal-title': 'Ann. Intensive Care'},
{ 'key': '10.1016/j.heliyon.2024.e28629_bib29',
'doi-asserted-by': 'crossref',
'DOI': '10.3390/nu13041172',
'article-title': 'Vitamin C in the treatment of COVID-19',
'volume': '13',
'author': 'Milani',
'year': '2021',
'journal-title': 'Nutrients'},
{ 'key': '10.1016/j.heliyon.2024.e28629_bib30',
'article-title': 'Cohort study to evaluate the effect of vitamin D, magnesium, and '
'vitamin B(12) in combination on progression to severe outcomes in older '
'patients with coronavirus (COVID-19)',
'volume': '79–80',
'author': 'Tan',
'year': '2020',
'journal-title': 'Nutrition'},
{ 'key': '10.1016/j.heliyon.2024.e28629_bib31',
'doi-asserted-by': 'crossref',
'first-page': '141',
'DOI': '10.1002/jmv.27277',
'article-title': 'Evaluation of the relationship between serum levels of zinc, vitamin '
'B12, vitamin D, and clinical outcomes in patients with COVID-19',
'volume': '94',
'author': 'Shakeri',
'year': '2022',
'journal-title': 'J. Med. Virol.'},
{ 'key': '10.1016/j.heliyon.2024.e28629_bib32',
'doi-asserted-by': 'crossref',
'DOI': '10.1016/j.nut.2020.111047',
'article-title': 'Potential roles of micronutrient deficiency and immune system '
'dysfunction in the coronavirus disease 2019 (COVID-19) pandemic',
'volume': '82',
'author': 'Gorji',
'year': '2021',
'journal-title': 'Nutrition'},
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'doi-asserted-by': 'crossref',
'first-page': '821',
'DOI': '10.1097/JCMA.0000000000000587',
'article-title': 'The role of micronutrient and immunomodulation effect in the vaccine '
'era of COVID-19',
'volume': '84',
'author': 'Lai',
'year': '2021',
'journal-title': 'J. Chin. Med. Assoc.'},
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'doi-asserted-by': 'crossref',
'DOI': '10.1016/j.fct.2021.112161',
'article-title': 'The effects of some essential and toxic metals/metalloids in COVID-19: '
'a review',
'volume': '152',
'author': 'Domingo',
'year': '2021',
'journal-title': 'Food Chem. Toxicol.'},
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'serum and cerebrospinal fluid of children',
'volume': '472',
'author': 'Akiyama',
'year': '2017',
'journal-title': 'Clin. Chim. Acta'}],
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{ 'value': 'https://doi.org/10.1016/j.heliyon.2024.e28629',
'name': 'articlelink',
'label': 'CrossRef DOI link to publisher maintained version'},
{'value': 'article', 'name': 'content_type', 'label': 'Content Type'},
{ 'value': '© 2024 The Authors. Published by Elsevier Ltd.',
'name': 'copyright',
'label': 'Copyright'}],
'article-number': 'e28629'}
