Combating pan-coronavirus infection by indomethacin through simultaneously inhibiting viral replication and inflammatory response
Yining Wang, Pengfei Li, Lei Xu, Annemarie C De Vries, Robbert J Rottier, Wenshi Wang, Marie-Rose B. S. Crombag, Maikel P Peppelenbosch, Denis E Kainov, PhD Qiuwei Pan
iScience, doi:10.1016/j.isci.2023.107631
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Author contributions Conceptualization, Y.W., and Q.P.; Methodology, Y.W., P.L., L.X., and W.W.; Resources, R.J.R., P.L., and D.E.K; Formal analysis, P.L., and Y.W.; Project discussion, M.B.C., R.J.R., DE.K., M.P.P., and A.C.V.; Writing-Original Draft, Y.W., and Q.P.; Funding acquisition, Q.P., and R.J.R.; Writing-Review & Editing, R.J.R., M.B.C., D.E.K., M.P.P., A.C.V., and Q.P.
Declaration of interest The authors disclose no conflicts.
Highlights • Indomethacin exerts pan-coronavirus antiviral activity • Indomethacin promotes interferon response through enhancing STAT1 phosphorylation • Indomethacin inhibits coronavirus-triggered inflammatory response
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