Analysis of the effects of indomethacin on SARS-CoV-2 infection and the inflammatory response associated with the purinergic system

Souza et al., Master's Dissertation, Mar 2023

Vero E6 and Calu-3 in vitro study showing that indomethacin protects against SARS-CoV-2-induced cytopathic effects and suppresses ATP-associated inflammatory responses.

7 preclinical studies support the efficacy of indomethacin for COVID-19:

3 in silico studies1-3

4 in vitro studies1,4-6

Important missing comments or errors? Let us know.

1. Metwaly et al., Discovery of potential FDA-approved SARS-CoV-2 Papain-like protease inhibitors: A multi-phase in silico approach, Journal of Chemical Research, doi:10.1177/17475198241298547.sagepub.com, doi.org.

2. Agamah et al., Network-based multi-omics-disease-drug associations reveal drug repurposing candidates for COVID-19 disease phases, ScienceOpen, doi:10.58647/DRUGARXIV.PR000010.v1.scienceopen.com, doi.org.

3. Chakraborty et al., In-silico screening and in-vitro assay show the antiviral effect of Indomethacin against SARS-CoV-2, Computers in Biology and Medicine, doi:10.1016/j.compbiomed.2022.105788.sciencedirect.com, doi.org.

4. Tramontozzi et al., Indomethacin inhibits human seasonal coronaviruses at late stages of viral replication in lung cells: Impact on virus-induced COX-2 expression, Journal of Virus Eradication, doi:10.1016/j.jve.2024.100387.sciencedirect.com, doi.org.

5. Wang et al., Combating pan-coronavirus infection by indomethacin through simultaneously inhibiting viral replication and inflammatory response, iScience, doi:10.1016/j.isci.2023.107631.sciencedirect.com, doi.org.

6. Souza et al., Analysis of the effects of indomethacin on SARS-CoV-2 infection and the inflammatory response associated with the purinergic system, Master's Dissertation, repositorio.ufsm.br/handle/1/29252ufsm.br.

Souza et al., 31 Mar 2023, peer-reviewed, 1 author.

In vitro studies are an important part of preclinical research, however results may be very different in vivo.