Analysis of the effects of indomethacin on SARS-CoV-2 infection and the inflammatory response associated with the purinergic system

Souza et al., Master's Dissertation

Mar 2023

Source PDF All Studies Meta AnalysisMeta

Vero E6 and Calu-3 In Vitro study showing that indomethacin protects against SARS-CoV-2-induced cytopathic effects and suppresses ATP-associated inflammatory responses.

7 preclinical studies support the efficacy of indomethacin for COVID-19:

3 In Silico studies1-3

4 In Vitro studies1,4-6

Important missing comments or errors? Let us know.

1. Metwaly et al., Discovery of potential FDA-approved SARS-CoV-2 Papain-like protease inhibitors: A multi-phase in silico approach, Journal of Chemical Research, doi:10.1177/17475198241298547.sagepub.com, doi.org.

2. Agamah et al., Network-based multi-omics-disease-drug associations reveal drug repurposing candidates for COVID-19 disease phases, ScienceOpen, doi:10.58647/DRUGARXIV.PR000010.v1.scienceopen.com, doi.org.

3. Chakraborty et al., In-silico screening and in-vitro assay show the antiviral effect of Indomethacin against SARS-CoV-2, Computers in Biology and Medicine, doi:10.1016/j.compbiomed.2022.105788.sciencedirect.com, doi.org.

4. Tramontozzi et al., Indomethacin inhibits human seasonal coronaviruses at late stages of viral replication in lung cells: Impact on virus-induced COX-2 expression, Journal of Virus Eradication, doi:10.1016/j.jve.2024.100387.sciencedirect.com, doi.org.

5. Wang et al., Combating pan-coronavirus infection by indomethacin through simultaneously inhibiting viral replication and inflammatory response, iScience, doi:10.1016/j.isci.2023.107631.sciencedirect.com, doi.org.

6. Souza et al., Analysis of the effects of indomethacin on SARS-CoV-2 infection and the inflammatory response associated with the purinergic system, Master's Dissertation, repositorio.ufsm.br/handle/1/29252.ufsm.br.

Souza et al., 31 Mar 2023, peer-reviewed, 1 author.

In Vitro studies are an important part of preclinical research, however results may be very different in vivo.

This Paper Indomethacin All

Download Image

Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.

Submit

Post

@CovidAnalysis

FAQ

Public domain CC0 1.0