Analysis of the effects of indomethacin on SARS-CoV-2 infection and the inflammatory response associated with the purinergic system

Souza et al., Master's Dissertation

Mar 2023

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Vero E6 and Calu-3 In Vitro study showing that indomethacin protects against SARS-CoV-2-induced cytopathic effects and suppresses ATP-associated inflammatory responses.

3 preclinical studies support the efficacy of indomethacin for COVID-19:

1 In Silico study Chakraborty

2 In Vitro studies Souza, Wang

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1. Chakraborty et al., In-silico screening and in-vitro assay show the antiviral effect of Indomethacin against SARS-CoV-2, Computers in Biology and Medicine, doi:10.1016/j.compbiomed.2022.105788.sciencedirect.com, doi.org.

2. Souza et al., Analysis of the effects of indomethacin on SARS-CoV-2 infection and the inflammatory response associated with the purinergic system, Master's Dissertation, repositorio.ufsm.br/handle/1/29252.ufsm.br.

3. Wang et al., Combating pan-coronavirus infection by indomethacin through simultaneously inhibiting viral replication and inflammatory response, iScience, doi:10.1016/j.isci.2023.107631.sciencedirect.com, doi.org.

Souza et al., 31 Mar 2023, peer-reviewed, 1 author.

In Vitro studies are an important part of preclinical research, however results may be very different in vivo.

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