Wang: Relationship between antidepressants and severity of SARS-CoV-2 Omicron infection: a retrospective cohort study using real-world data [Fluvoxamine]

Relationship between antidepressants and severity of SARS-CoV-2 Omicron infection: a retrospective cohort study using real-world data

Wang et al., The Lancet Regional Health - Western Pacific, doi:10.1016/j.lanwpc.2023.100716 (meta analysis)

Wang et al., Relationship between antidepressants and severity of SARS-CoV-2 Omicron infection: a retrospective cohort.., The Lancet Regional Health - Western Pacific, doi:10.1016/j.lanwpc.2023.100716 (meta analysis)

Feb 2023 Source PDF

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PSM retrospective 60,903 hospitalized COVID-19 patients in Hong Kong, showing antidepressants associated with lower mortality, including for SSRIs, and for FIASMA antidepressants.

Currently there are 14 fluvoxamine studies and meta analysis shows:

Outcome	Improvement
Mortality	47% lower [16‑67%]
Ventilation	22% lower [-28‑53%]
Hospitalization	28% lower [-3‑49%]
Cases	28% fewer [18‑37%]

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Wang et al., 27 Feb 2023, retrospective, China, peer-reviewed, 15 authors.

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