A meta-analysis regarding fluvoxamine and hospitalization risk of COVID-19 patients: TOGETHER making a difference

Marcec et al., Journal of Infection, doi:10.1016/j.jinf.2022.11.011, Nov 2022
Hospitalization 43% improvement lower risk ← → higher risk Fluvoxamine  Marcec et al.  META ANALYSIS c19early.org Marcec et al., J. Infection, November 2022 0 0.5 1 1.5 2+ RR
30th treatment shown to reduce risk in November 2021, now with p = 0.00014 from 21 studies, recognized in 2 countries.
Lower risk for mortality, hospitalization, progression, recovery, and cases.
No treatment is 100% effective. Protocols combine treatments.
6,300+ studies for 210+ treatments. c19early.org
Meta Analysis
Meta analysis of 7 fluvoxamine outpatient studies showing significantly lower hospitalization with treatment.
9 meta analyses show significant improvements with fluvoxamine for mortality1-3, hospitalization1,4-8, progression2,8, and severity9.
Currently there are 21 fluvoxamine for COVID-19 studies, showing 44% lower mortality [15‑63%], 42% lower ventilation [-151‑86%], 10% higher ICU admission [-72‑326%], 51% lower hospitalization [8‑73%], and 27% fewer cases [18‑35%].
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risk of hospitalization, 43.0% lower, RR 0.57, p = 0.03.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Marcec et al., 17 Nov 2022, peer-reviewed, 3 authors. Contact: robert.likic@mef.hr, rlikic@kbc-zagreb.hr.
A meta-analysis regarding fluvoxamine and hospitalization risk of COVID-19 patients: TOGETHER making a difference
Robert Marcec, Vinko Michael Dodig, MD Robert Likic
Journal of Infection, doi:10.1016/j.jinf.2022.11.011
This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
References
Cheema, Efficacy and safety of fluvoxamine for the treatment of COVID-19 patients: A systematic review and meta-analysis, J. Infect
Lee, Fluvoxamine for Outpatient Management of COVID-19 to Prevent Hospitalization: A Systematic Review and Meta-analysis, JAMA Netw. Open
Mccarthy, Fluvoxamine for Outpatient Treatment of COVID-19: A Decentralized, Placebo-controlled, Randomized, Platform Clinical Trial, doi:10.1101/2022.10.17.22281178
Reis, Effect of early treatment with fluvoxamine on risk of emergency care and hospitalisation among patients with COVID-19: the TOGETHER randomised, platform clinical trial, Lancet Glob. Heal
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