A meta-analysis regarding fluvoxamine and hospitalization risk of COVID-19 patients: TOGETHER making a difference

Marcec et al., Journal of Infection, doi:10.1016/j.jinf.2022.11.011

Nov 2022

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Meta analysis of 7 fluvoxamine outpatient studies showing significantly lower hospitalization with treatment.

5 meta analyses show significant improvements with fluvoxamine for mortality Deng, hospitalization Deng, Lee, Lu, Marcec, and severity Nakhaee.

Currently there are 19 fluvoxamine for COVID-19 studies, showing 41% lower mortality [8‑62%], 22% lower ventilation [-28‑54%], 82% higher ICU admission [-86‑2278%], 26% lower hospitalization [4‑42%], and 25% fewer cases [11‑36%].

1. Deng et al., Efficacy and safety of selective serotonin reuptake inhibitors in COVID-19 management: A systematic review and meta-analysis, Clinical Microbiology and Infection, doi:10.1016/j.cmi.2023.01.010.clinicalmicrobiologyandinfection.com, doi.org.

2. Lee et al., Fluvoxamine for Outpatient Management of COVID-19 to Prevent Hospitalization: A Systematic Review and Meta-analysis, JAMA Network Open, doi:10.1001/jamanetworkopen.2022.6269.jamanetwork.com, doi.org.

3. Lu et al., Effect of fluvoxamine on outcomes of nonhospitalized patients with COVID-19: A systematic review and meta-analysis, Journal of Infection and Public Health, doi:10.1016/j.jiph.2022.10.010.sciencedirect.com, doi.org.

4. Marcec et al., A meta-analysis regarding fluvoxamine and hospitalization risk of COVID-19 patients: TOGETHER making a difference, Journal of Infection, doi:10.1016/j.jinf.2022.11.011.sciencedirect.com, doi.org.

5. Nakhaee et al., The effect of antidepressants on the severity of COVID-19 in hospitalized patients: A systematic review and meta-analysis, PLOS ONE, doi:10.1371/journal.pone.0267423.plos.org, doi.org.

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risk of hospitalization, 43.0% lower, RR 0.57, p = 0.03.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates

Marcec et al., 17 Nov 2022, peer-reviewed, 3 authors.

Contact: robert.likic@mef.hr, rlikic@kbc-zagreb.hr.

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A meta-analysis regarding fluvoxamine and hospitalization risk of COVID-19 patients: TOGETHER making a difference

Robert Marcec, Vinko Michael Dodig, MD Robert Likic

Journal of Infection, doi:10.1016/j.jinf.2022.11.011

This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

References

Cheema, Efficacy and safety of fluvoxamine for the treatment of COVID-19 patients: A systematic review and meta-analysis, J. Infect

Lee, Fluvoxamine for Outpatient Management of COVID-19 to Prevent Hospitalization: A Systematic Review and Meta-analysis, JAMA Netw. Open

Mccarthy, Fluvoxamine for Outpatient Treatment of COVID-19: A Decentralized, Placebo-controlled, Randomized, Platform Clinical Trial, doi:10.1101/2022.10.17.22281178

Reis, Effect of early treatment with fluvoxamine on risk of emergency care and hospitalisation among patients with COVID-19: the TOGETHER randomised, platform clinical trial, Lancet Glob. Heal

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