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All Studies   Meta Analysis    Recent:   

Serum Vitamin D Levels Are Associated With Increased COVID-19 Severity and Mortality Independent of Whole-Body and Visceral Adiposity

Vanegas-Cedillo et al., medRxiv, doi:10.1101/2021.03.12.21253490
Mar 2021  
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Mortality 53% Improvement Relative Risk Vitamin D  Vanegas-Cedillo et al.  Sufficiency Are vitamin D levels associated with COVID-19 outcomes? Retrospective 551 patients in Mexico Lower mortality with higher vitamin D levels (p=0.006) c19early.org Vanegas-Cedillo et al., medRxiv, March 2021 Favorsvitamin D Favorscontrol 0 0.5 1 1.5 2+
Vitamin D for COVID-19
8th treatment shown to reduce risk in October 2020
 
*, now with p < 0.00000000001 from 122 studies, recognized in 9 countries.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,400+ studies for 81 treatments. c19early.org
Retrospective 551 moderate to severe COVID-19 patients in Mexico showing vitamin D ≤12ng/mL independently associated with COVID-19 mortality. No association was found between vitamin D levels and the need for intubation. Vitamin D deficiency was more prevalent in women and patients with type 2 diabetes.
This is the 55th of 199 COVID-19 sufficiency studies for vitamin D, which collectively show higher levels reduce risk with p<0.0000000001 (1 in 835,162 vigintillion).
risk of death, 52.6% lower, RR 0.47, p = 0.006, high D levels (≥12ng/mL) 95 of 494 (19.2%), low D levels (<12ng/mL) 21 of 57 (36.8%), NNT 5.7, adjusted per study, inverted to make RR<1 favor high D levels (≥12ng/mL).
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Vanegas-Cedillo et al., 14 Mar 2021, retrospective, Mexico, peer-reviewed, 15 authors.
This PaperVitamin DAll
Serum Vitamin D Levels Are Associated With Increased COVID-19 Severity and Mortality Independent of Whole-Body and Visceral Adiposity
Pablo Esteban Vanegas-Cedillo, Omar Yaxmehen Bello-Chavolla, Natalia Ramírez-Pedraza, Bethsabel Rodríguez Encinas, Carolina Isabel Pérez Carrión, María Isabel Jasso-Ávila, Jorge Carlos Valladares-García, Diana Hernández-Juárez, Arsenio Vargas-Vázquez, Neftali Eduardo Antonio-Villa, Monica Chapa-Ibarguengoitia, Alfredo Ponce De Leon, José Sifuentes-Osornio, Carlos A Aguilar-Salinas, Roopa Mehta
Frontiers in Nutrition, doi:10.3389/fnut.2022.813485
Conclusion: Vitamin D deficiency (≤12 ng/ml or <30 nmol/L), is independently associated with COVID-19 mortality after adjustment for visceral fat (epicardial fat thickness). Low vitamin D may contribute to a pro-inflammatory and pro-thrombotic state, increasing the risk for adverse COVID-19 outcomes.
DATA AVAILABILITY STATEMENT The datasets presented in this study can be found in online repositories. The names of the repository/repositories and accession number(s) can be found at: https://github.com/ oyaxbell/covid_metabolism. ETHICS STATEMENT The studies involving human participants were reviewed and approved by Research and Ethics Committee of the INCMNZ (Ref 3383). Written informed consent for participation was not required for this study in accordance with the national legislation and the institutional requirements. AUTHOR CONTRIBUTIONS RM, OB-C, and CA-S: research idea and study design. RM, PV-C, NR-P, MJ-Á, CP, BR, JV-G, and CA-S: data acquisition. OB-C, RM, CA-S, NA-V, and AV-V: data analysis/interpretation. OB-C and NA-V: statistical analysis. RM, OB-C, NA-V, AV-V, and CA-S: manuscript drafting. RM, CA-S, AP, and JS-O: supervision or mentorship. All authors contributed important intellectual content during manuscript drafting or revision and accepts accountability for the overall work by ensuring that questions pertaining to the accuracy or integrity of any portion of the work are appropriately investigated and resolved. Conflict of Interest: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Publisher's Note: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated..
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All patients underwent clinical evaluation ' 'and follow-up, laboratory measurements and a thoracic computerized tomography, including the ' 'measurement of epicardial fat thickness. Low vitamin D was defined as levels &lt;20ng/mL ' '(&lt;50nmol/L) and deficient Vitamin D as a level ≤12ng/mL ' '(&lt;30nmol/L)</jats:p></jats:sec><jats:sec><jats:title>RESULTS</jats:title><jats:p>Of the ' '551 patients included, low vitamin D levels were present in 45.6% and deficient levels in ' '10.9%. Deficient Vitamin D levels were associated with mortality (HR 2.11, 95%CI 1.24-3.58, ' 'p=0.006) but not with critical COVID-19, adjusted for age, sex, body-mass index and ' 'epicardial fat. Using model-based causal mediation analyses the increased risk of COVID-19 ' 'mortality conferred by low vitamin D levels was partly mediated by its effect on D-dimer and ' 'cardiac ultrasensitive troponins. Notably, increased risk of COVID-19 mortality conferred by ' 'low vitamin D levels was independent of BMI and epicardial ' 'fat.</jats:p></jats:sec><jats:sec><jats:title>CONCLUSION</jats:title><jats:p>Vitamin D ' 'deficiency (≤12ng/mL or &lt;30nmol/L), is independently associated with COVID-19 mortality ' 'after adjustment for visceral fat (epicardial fat thickness). Low vitamin D may contribute to ' 'a pro-inflammatory and pro-thrombotic state, increasing the risk for adverse COVID-19 ' 'outcomes.</jats:p></jats:sec>', 'DOI': '10.1101/2021.03.12.21253490', 'type': 'posted-content', 'created': {'date-parts': [[2021, 3, 14]], 'date-time': '2021-03-14T04:20:15Z', 'timestamp': 1615695615000}, 'source': 'Crossref', 'is-referenced-by-count': 2, 'title': 'Serum Vitamin D levels are associated with increased COVID-19 severity and mortality independent ' 'of whole-body and visceral adiposity', 'prefix': '10.1101', 'author': [ { 'ORCID': 'http://orcid.org/0000-0003-1338-9724', 'authenticated-orcid': False, 'given': 'Pablo Esteban', 'family': 'Vanegas-Cedillo', 'sequence': 'first', 'affiliation': []}, { 'ORCID': 'http://orcid.org/0000-0003-3093-937X', 'authenticated-orcid': False, 'given': 'Omar Yaxmehen', 'family': 'Bello-Chavolla', 'sequence': 'additional', 'affiliation': []}, { 'ORCID': 'http://orcid.org/0000-0002-8268-4869', 'authenticated-orcid': False, 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