Serum Vitamin D Concentrations and Covid-19 In Pregnant Women, Does Vitamin D Supplementation Impact Results? A Comprehensive Study
Şengül et al.
, Serum Vitamin D Concentrations and Covid-19 In Pregnant Women, Does Vitamin D Supplementation Impact Results?..
, Cukurova Anestezi ve Cerrahi Bilimler Dergisi, doi:10.36516/jocass.1185181
Retrospective 318 pregnant women, 54 COVID+ and 264 healthy controls, showing lower risk of COVID-19 with vitamin D supplementation, and with higher vitamin D levels.
risk of case, 68.5% lower, OR 0.31, p = 0.004, treatment 8 of 54 (14.8%) cases,
94 of 264 (35.6%) controls, NNT 7.4, case control OR.
risk of case, 75.6% lower, OR 0.24, p < 0.001, high D levels (≥20ng/mL) 7 of 54 (13.0%) cases,
100 of 264 (37.9%) controls, NNT 6.4, cutoff ≥20ng/mL, case control OR, outcome based on serum levels.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Şengül et al., 31 Dec 2022, retrospective, Turkey, peer-reviewed, 4 authors, study period March 2020 - December 2021, dosage not specified.
Abstract: SERUM VITAMIN D CONCENTRATIONS AND COVID-19 IN PREGNANT WOMEN,
DOES VITAMIN D SUPPLEMENTATION IMPACT RESULTS?
A COMPREHENSIVE STUDY
Halime Sen Selim2,
Huriye Erbak Yılmaz2,
Katip Çelebi University, Department of Obstetrics and Gynecology, İzmir, Türkiye
Katip Çelebi University, Atatürk Training and Research Hospital, Department of Obstetrics and Gynecology, İzmir, Türkiye
Aim: Low vitamin D levels were related to an increased risk of upper respiratory tract infection and
pneumonia. Vitamin D might therefore protect against symptoms of the Covid 19. The present study
aims to evaluate the relationship between the acquisition and course of Covid 19 and serum vitamin
D levels and investigate the prophylactic efficacy of vitamin D supplementation in pregnant women.
Methods: This case-control study was conducted on 318 pregnant women admitted to our tertiary
clinic to give birth between March 2020 and December 2021. All cases were tested for Covid 19 via
nasopharyngeal swab. Fifty-four patients with positive PCR for SARS-CoV-2 (Group 1) were
matched with 264 consecutive healthy controls (Group 2). 25 OH D Vitamin levels were measured
and compared between the two groups, along with the frequency of vitamin D supplementation.
Results: Group 1 showed significantly low mean 25 OH D levels, compared to Group 2 (10,22 ±
7,10 (3-37) ng/ml vs. 16,63 ± 10,80 (3,40-48,90) ng/ml, p = 0,000). Sixteen point seven % of controls
and 3,7% of cases had normal Vitamin D levels (>30 ng/mL); the difference was also statistically
significant (p=0,005). The frequency of vitamin D supplementation was also detected higher in
controls than those with positive SARS-CoV-2 (35,6% vs. 14,8%, p=0,003).
Conclusions: Sustaining adequate levels of Vitamin D may positively impact protection against
Covid 19 during pregnancy. In this context, Vitamin D supplementation should be considered for
the pregnant population, particularly in settings where profound vitamin D deficiency is common.
Keywords: Vitamin D deficiency; COVID-19; pregnancy; vitamin D supplementation
Corresponding Author: Mustafa Sengul, e-mail: email@example.com
Received: 07.10.2022, Accepted: 05.12.2022, Available Online Date: 31.12.2022
Cite this article as: Sengul M, Selim HS, Sen S, et al. Serum Vitamin D Concentrations and Covid-19 In Pregnant Women, Does Vitamin D Supplementation Impact
Results? A Comprehensive Study. J Cukurova Anesth Surg. 2022;5(3):368-74.
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