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0 0.5 1 1.5 2+ Case, supplementation 69% Improvement Relative Risk Case, levels 76% levels Şengül et al. Vitamin D for COVID-19 Prophylaxis Does vitamin D reduce COVID-19 infections? Retrospective 318 patients in Turkey (March 2020 - December 2021) Fewer cases with vitamin D (p=0.0042) Şengül et al., Cukurova Anestezi ve Cerrahi Bili.., doi:10.36516/jocass.1185181 Favors vitamin D Favors control
Serum Vitamin D Concentrations and Covid-19 In Pregnant Women, Does Vitamin D Supplementation Impact Results? A Comprehensive Study
Şengül et al., Cukurova Anestezi ve Cerrahi Bilimler Dergisi, doi:10.36516/jocass.1185181
Şengül et al., Serum Vitamin D Concentrations and Covid-19 In Pregnant Women, Does Vitamin D Supplementation Impact Results?.., Cukurova Anestezi ve Cerrahi Bilimler Dergisi, doi:10.36516/jocass.1185181
Dec 2022   Source   PDF  
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Retrospective 318 pregnant women, 54 COVID+ and 264 healthy controls, showing lower risk of COVID-19 with vitamin D supplementation, and with higher vitamin D levels.
risk of case, 68.5% lower, OR 0.31, p = 0.004, treatment 8 of 54 (14.8%) cases, 94 of 264 (35.6%) controls, NNT 7.4, case control OR.
risk of case, 75.6% lower, OR 0.24, p < 0.001, high D levels (≥20ng/mL) 7 of 54 (13.0%) cases, 100 of 264 (37.9%) controls, NNT 6.4, cutoff ≥20ng/mL, case control OR, outcome based on serum levels.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Şengül et al., 31 Dec 2022, retrospective, Turkey, peer-reviewed, 4 authors, study period March 2020 - December 2021, dosage not specified.
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This PaperVitamin DAll
Abstract: SERUM VITAMIN D CONCENTRATIONS AND COVID-19 IN PREGNANT WOMEN, DOES VITAMIN D SUPPLEMENTATION IMPACT RESULTS? A COMPREHENSIVE STUDY Mustafa Sengul1, Halime Sen Selim2, Serhat Sen2, Huriye Erbak Yılmaz2, Kutlu Kurt2 1 Katip Çelebi University, Department of Obstetrics and Gynecology, İzmir, Türkiye 2 Katip Çelebi University, Atatürk Training and Research Hospital, Department of Obstetrics and Gynecology, İzmir, Türkiye Abstract Aim: Low vitamin D levels were related to an increased risk of upper respiratory tract infection and pneumonia. Vitamin D might therefore protect against symptoms of the Covid 19. The present study aims to evaluate the relationship between the acquisition and course of Covid 19 and serum vitamin D levels and investigate the prophylactic efficacy of vitamin D supplementation in pregnant women. Methods: This case-control study was conducted on 318 pregnant women admitted to our tertiary clinic to give birth between March 2020 and December 2021. All cases were tested for Covid 19 via nasopharyngeal swab. Fifty-four patients with positive PCR for SARS-CoV-2 (Group 1) were matched with 264 consecutive healthy controls (Group 2). 25 OH D Vitamin levels were measured and compared between the two groups, along with the frequency of vitamin D supplementation. Results: Group 1 showed significantly low mean 25 OH D levels, compared to Group 2 (10,22 ± 7,10 (3-37) ng/ml vs. 16,63 ± 10,80 (3,40-48,90) ng/ml, p = 0,000). Sixteen point seven % of controls and 3,7% of cases had normal Vitamin D levels (>30 ng/mL); the difference was also statistically significant (p=0,005). The frequency of vitamin D supplementation was also detected higher in controls than those with positive SARS-CoV-2 (35,6% vs. 14,8%, p=0,003). Conclusions: Sustaining adequate levels of Vitamin D may positively impact protection against Covid 19 during pregnancy. In this context, Vitamin D supplementation should be considered for the pregnant population, particularly in settings where profound vitamin D deficiency is common. Keywords: Vitamin D deficiency; COVID-19; pregnancy; vitamin D supplementation Corresponding Author: Mustafa Sengul, e-mail: Received: 07.10.2022, Accepted: 05.12.2022, Available Online Date: 31.12.2022 Cite this article as: Sengul M, Selim HS, Sen S, et al. Serum Vitamin D Concentrations and Covid-19 In Pregnant Women, Does Vitamin D Supplementation Impact Results? A Comprehensive Study. J Cukurova Anesth Surg. 2022;5(3):368-74. doi: 10.36516/jocass.1185181 ©Copyright 2022 by Çukurova Anestezi ve Cerrahi Bilimler Dergisi - Available online at This work is licensed under a Creative Commons Attribution 4.0 International License.
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