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0 0.5 1 1.5 2+ Case, supplementation 69% treatment Improvement Relative Risk Case, levels 76% levels Vitamin D for COVID-19  Şengül et al.  Prophylaxis Does vitamin D reduce COVID-19 infections? Retrospective 318 patients in Turkey (March 2020 - December 2021) Fewer cases with vitamin D (p=0.0042) Şengül et al., Cukurova Anestezi ve Ce.., Dec 2022 Favors vitamin D Favors control

Serum Vitamin D Concentrations and Covid-19 In Pregnant Women, Does Vitamin D Supplementation Impact Results? A Comprehensive Study

Şengül et al., Cukurova Anestezi ve Cerrahi Bilimler Dergisi, doi:10.36516/jocass.1185181
Dec 2022  
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Retrospective 318 pregnant women, 54 COVID+ and 264 healthy controls, showing lower risk of COVID-19 with vitamin D supplementation, and with higher vitamin D levels.
This is the 105th of 115 COVID-19 controlled studies for vitamin D, which collectively show efficacy with p<0.0000000001 (1 in 30 sextillion). 27 studies are RCTs, which show efficacy with p=0.00002.
risk of case, 68.5% lower, OR 0.31, p = 0.004, treatment 8 of 54 (14.8%) cases, 94 of 264 (35.6%) controls, NNT 7.4, case control OR.
risk of case, 75.6% lower, OR 0.24, p < 0.001, high D levels (≥20ng/mL) 7 of 54 (13.0%) cases, 100 of 264 (37.9%) controls, NNT 6.4, case control OR, outcome based on serum levels.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Şengül et al., 31 Dec 2022, retrospective, Turkey, peer-reviewed, 4 authors, study period March 2020 - December 2021, dosage not specified.
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Serum Vitamin D Concentrations and Covid-19 In Pregnant Women, Does Vitamin D Supplementation Impact Results? A Comprehensive Study
Mustafa Şengül, Halime Şen Selim, Serhat Şen, Huriye Erbak Yilmaz
Cukurova Anestezi ve Cerrahi Bilimler Dergisi, doi:10.36516/jocass.1185181
Aim: Low vitamin D levels were related to an increased risk of upper respiratory tract infection and pneumonia. Vitamin D might therefore protect against symptoms of the Covid 19. The present study aims to evaluate the relationship between the acquisition and course of Covid 19 and serum vitamin D levels and investigate the prophylactic efficacy of vitamin D supplementation in pregnant women. Methods: This case-control study was conducted on 318 pregnant women admitted to our tertiary clinic to give birth between March 2020 and December 2021. All cases were tested for Covid 19 via nasopharyngeal swab. Fifty-four patients with positive PCR for SARS-CoV-2 (Group 1) were matched with 264 consecutive healthy controls (Group 2). 25 OH D Vitamin levels were measured and compared between the two groups, along with the frequency of vitamin D supplementation. Results: Group 1 showed significantly low mean 25 OH D levels, compared to Group 2 (10,22 ± 7,10 (3-37) ng/ml vs. 16,63 ± 10,80 (3,40-48,90) ng/ml, p = 0,000). Sixteen point seven % of controls and 3,7% of cases had normal Vitamin D levels (>30 ng/mL); the difference was also statistically significant (p=0,005). The frequency of vitamin D supplementation was also detected higher in controls than those with positive SARS-CoV-2 (35,6% vs. 14,8%, p=0,003). Conclusions: Sustaining adequate levels of Vitamin D may positively impact protection against Covid 19 during pregnancy. In this context, Vitamin D supplementation should be considered for the pregnant population, particularly in settings where profound vitamin D deficiency is common.
Author contributions All authors read and approved the final manuscript. M. Sengül: Project development, Data Collection, data analyzing Manuscript writing H. Sen Selim: Data collection, data analyzing, manuscript writing S. Sen: Data analyzing, manuscript writing H.Erbak Yılmaz: Data Collection K.Kurt: Project development Conflict of interest The authors declare that they have no conflict of interest. Ethical approval Informed consent was obtained from pregnant women both for herself and the newborn. This study was approved by the ethical committee with date 21.09.2021 and number 408 of Izmir Katip Celebi Univesity, Faculty of Medicine and the Turkish Ministry of Health.
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