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0 0.5 1 1.5 2+ Case, above vs. below gui.. 31% Improvement Relative Risk Case, above vs. meeting.. 34% Case, any vs. none 23% Case, moderate/vigorou.. 22% Exercise for COVID-19  CoCo-Fakt  Prophylaxis Does physical activity reduce risk for COVID-19? Retrospective 5,338 patients in Germany Fewer cases with higher activity levels (p=0.02) Schmidt et al., Sports Medicine - Open, Jun 2023 Favors exercise Favors inactivity

Self-Reported Pre-Pandemic Physical Activity and Likelihood of COVID-19 Infection: Data from the First Wave of the CoCo-Fakt Survey

Schmidt et al., Sports Medicine - Open, doi:10.1186/s40798-023-00592-6, CoCo-Fakt
Jun 2023  
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Retrospective 5,338 individuals with confirmed contact with a COVID-19 patient, showing lower risk of COVID-19 with exercise.
risk of case, 31.1% lower, OR 0.69, p = 0.02, high activity levels 956, low activity levels 2,705, adjusted per study, inverted to make OR<1 favor high activity levels, above guidelines vs. below guidelines, multivariable, RR approximated with OR.
risk of case, 34.5% lower, OR 0.66, p = 0.02, high activity levels 956, low activity levels 1,113, adjusted per study, inverted to make OR<1 favor high activity levels, above guidelines vs. meeting guidelines, multivariable, RR approximated with OR.
risk of case, 22.7% lower, OR 0.77, p = 0.02, high activity levels 3,658, low activity levels 1,680, adjusted per study, inverted to make OR<1 favor high activity levels, exercise vs. no exercise, multivariable, RR approximated with OR.
risk of case, 21.6% lower, OR 0.78, p = 0.03, high activity levels 3,371, low activity levels 1,716, adjusted per study, inverted to make OR<1 favor high activity levels, moderate-to-vigorous vs. low intensity, multivariable, RR approximated with OR.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Schmidt et al., 21 Jun 2023, retrospective, Germany, peer-reviewed, 8 authors, CoCo-Fakt trial.
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Self-Reported Pre-Pandemic Physical Activity and Likelihood of COVID-19 Infection: Data from the First Wave of the CoCo-Fakt Survey
Nikola Schmidt, Andreas Gehlhar, Barbara Grüne, Annelene Kossow, Thomas Kraus, Johannes Nießen, Stefanie Wessely, Christine Joisten
Sports Medicine - Open, doi:10.1186/s40798-023-00592-6
Objectives To investigate the potential protective role of exercise on the odds of COVID-19 infection in unvaccinated contact persons (CPs) who were at higher risk of infection due to confirmed contact with infected persons. Methods Before the onset of the vaccination campaign, the first wave of the CoCo-Fakt online survey was conducted with SARS-CoV-2-positive persons and their confirmed contacts who were isolated/quarantined between 1 March 2020 and 9 December 2020. Within this analysis, 5338 CPs were included and divided into those who subsequently tested positive (CP-P) and those who remained negative (CP-N). We assessed demographics as well as prepandemic lifestyle characteristics including physical activity (PA; type, frequency, time, intensity; duration clustered as 'below PA guidelines' , 'meeting PA guidelines' , and 'above PA guidelines'; intensity clustered as 'low intensity' and 'moderate-to-vigorous intensity') and sedentary behaviour. Results A greater percentage of CP-Ns reported being active before the pandemic compared to CP-Ps (69% vs. 63%; p = .004). Moreover, CP-Ns reported higher PA duration (164.1 min/week vs. 143.2 min/week; p = .038) and higher PA intensities than CP-Ps (67% vs. 60% moderate-to-vigorous intensity, 33% vs. 40% low intensity; p = .003). Adjusting for age, sex, socioeconomic status, migration background, and pre-existing chronic diseases, the odds of infection were negatively associated with exercise (yes/no) (Nagelkerke R 2 = 1.9%), PA levels above PA guidelines (Nagelkerke R 2 = 2.0%), and PA intensity (Nagelkerke R 2 = 1.8%). Conclusion Due to the beneficial effects of PA on the odds of infection, an active lifestyle should be promoted especially during possible subsequent pandemics (while taking into account necessary hygiene measures). Moreover, inactive and chronically ill persons should be especially encouraged to adopt a healthier lifestyle.
Abbreviations Supplementary Information The online version contains supplementary material available at https:// doi. org/ 10. 1186/ s40798-023-00592-6. Additional file 1. Online survey of the first wave of the CoCo-Fakt cohort study. Author Contributions NS wrote the manuscript. CJ, BG, AK and JN conceived and conducted the study. NS, SW and CJ ran all data analyses. AG conducted the questions regarding physical activity and sedentary lifestyle. TK contributed to the application at the Ethics Committee of the Medical Faculty of RWTH Aachen University as well as the evaluation and interpretation of this analysis. All authors read the manuscript and agreed to publication. Declarations Ethics Approval and Consent to Participate Participants were asked to actively consent to their participation in the online survey. Human Ethics Research Committee ethics approval was obtained from the Rheinisch-Westfälische Technische Hochschule Aachen Human Ethics Research Committee (351/20) and the research was conducted in accordance with the approved protocol. Consent for Publication Not applicable. Competing Interests Nikola Schmidt, Andreas Gehlhar, Barbara Grüne, Annelene Kossow, Thomas Kraus, Johannes Nießen, Stefanie Wessely and Christine Joisten declare that they have no competing interests. Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Ainsworth, Haskell, Herrmann, Meckes, Bassett et al., 2011 compendium of physical activities: a second update of codes and MET values, Med Sci Sports Exerc, doi:10.1249/mss.0b013e31821ece12
Book, Broichhaus, Grüne, Nießen, Wiesmüller et al., Adherence to stay-at-home orders: awareness, implementation and difficulties of officially ordered quarantine measures in the context of the COVID-19 pandemic in Cologne-a retrospective cohort study, BMJ Open, doi:10.1136/bmjopen-2022-063358
Brooks, Webster, Smith, The psychological impact of quarantine and how to reduce it: rapid review of the evidence, Lancet, doi:10.1016/s0140-6736(20)30460-8
Bull, Ss, Biddle, World Health Organization 2020 guidelines on physical activity and sedentary behaviour, Br J Sports Med, doi:10.1136/bjsports-2020-102955
Cunningham, Physical activity and its relationship with COVID-19 cases and deaths: analysis of U.S. counties, J Sport Health Sci, doi:10.1016/j.jshs.2021.03.008
Ezzatvar, Ramírez-Vélez, Izquierdo, Physical activity and risk of infection, severity and mortality of COVID-19: a systematic review and non-linear dose-response meta-analysis of data from 1 853 610 adults, Br J Sports Med, doi:10.1136/bjsports-2022-105733
Graf, Schlepper, Bauer, Ferrari, Frank et al., Feasibility and acceptance of exercise recommendations (10,000 steps a day) within routine German health check (check-up 35/GOÄ29)-study protocol, Pilot Feasibility Stud, doi:10.1186/s40814-016-0092-9
Jimeno-Almazán, Martínez-Cava, Buendía-Romero, Relationship between the severity of persistent symptoms, physical fitness, and cardiopulmonary function in post-COVID-19 condition. A populationbased analysis, Intern Emerg Med, doi:10.1007/s11739-022-03039-0
Joisten, Kossow, Book, Broichhaus, Daum et al., How to manage quarantine-adherence, psychosocial consequences, coping strategies and lifestyle of patients with COVID-19 and their confirmed contacts: study protocol of the CoCo-Fakt surveillance study, BMJ Open, doi:10.1136/bmjopen-2020-048001
Lampert, Kroll, Müters, Messung des sozioökonomischen Status in der Studie zur Gesundheit Erwachsener in Deutschland (DEGS1), Bundesgesundheitsbl, doi:10.1007/s00103-012-1663-4
Lee, Lee, Moon, Physical activity and the risk of SARS-CoV-2 infection, severe COVID-19 illness and COVID-19 related mortality in South Korea: a nationwide cohort study, Br J Sports Med, doi:10.1136/bjsports-2021-104203
Mathieu, Ritchie, Rodés-Guirao, Appel, Giattino et al., Coronavirus Pandemic (COVID-19)
Mishra, Parveen, Bajpai, Agarwal, Vitamin D deficiency and comorbidities as risk factors of COVID-19 infection: a systematic review and meta-analysis, J Prev Med Public Health, doi:10.3961/jpmph.21.640
Neuhann, Buess, Wolff, Entwicklung einer Software zur Unterstützung der Prozesse im Gesundheitsamt der Stadt Köln in der SARS-CoV-2-Pandemie, Digitales Kontaktmanagement (DiKoMa). Epidemiol Bull, doi:10.25646/6923
Ng, Marimuthu, Koh, Pang, Linn et al., SARS-CoV-2 seroprevalence and transmission risk factors among high-risk close contacts: a retrospective cohort study, Lancet Infect Dis, doi:10.1016/s1473-3099(20)30833-1
Nieman, Henson, Austin, Upper respiratory tract infection is reduced in physically fit and active adults, Br J Sports Med, doi:10.1136/bjsm.2010.077875
Nieman, Wentz, The compelling link between physical activity and the body's defense system, J Sport Health Sci, doi:10.1016/j.jshs.2018.09.009
Nieman, exercise is medicine for immune function: implication for COVID-19, Curr Sports Med Rep, doi:10.1249/jsr.0000000000000867
Richter, Schienkiwitz, Starker, Krug, Domanska et al., Gesundheitsfördernde Verhaltensweisen bei Erwachsenen in Deutschland-Ergebnisse der Studie GEDA 2019/2020-EHIS, J Health Monit, doi:10.25646/8460
Sallis, Young, Tartof, Physical inactivity is associated with a higher risk for severe COVID-19 outcomes: a study in 48 440 adult patients, Br J Sports Med, doi:10.1136/bjsports-2021-104080
Saß, Lange, Finger, Allen, Born et al., Gesundheit in Deutschland aktuell"-Neue Daten für Deutschland und Europa Hintergrund und Studienmethodik von GEDA 2014/2015-EHIS, J Health Monit, doi:10.17886/RKI-GBE-2017-012
Simons, Shahab, Brown, Perski, The association of smoking status with SARS-CoV-2 infection, hospitalization and mortality from COVID-19: a living rapid evidence review with Bayesian meta-analyses (version 7), Addiction, doi:10.1111/add.15276
Steenkamp, Saggers, Bandini, Small steps, strong shield: directly measured, moderate physical activity in 65 361 adults is associated with significant protective effects from severe COVID-19 outcomes, Br J Sports Med, doi:10.1136/bjsports-2021-105159
Tian, Huo, Secondary attack rates of COVID-19 in diverse contact settings, a meta-analysis, J Infect Dev Ctries, doi:10.3855/jidc.13256
Tison, Avram, Kuhar, Abreau, Marcus et al., Worldwide effect of COVID-19 on physical activity: a descriptive study, Ann Intern Med, doi:10.7326/m20-2665
Tivian, Startseite|unipark, None
Trabelsi, Ammar, Masmoudi, Globally altered sleep patterns and physical activity levels by confinement in 5056 individuals: ECLB COVID-19 international online survey, Biol Sport, doi:10.5114/biolsport.2021.101605
Washif, Farooq, Krug, Training during the COVID-19 lockdown: knowledge, beliefs, and practices of 12,526 athletes from 142 countries and six continents, Sports Med, doi:10.1007/s40279-021-01573-z
Wessely, Tappiser, Eisenburger, Feddern, Gehlhar et al., Changes in alcohol consumption, eating behaviors, and body weight during quarantine measures: analysis of the CoCo-Fakt study, Obes Facts, doi:10.1159/000524352
Woods, Hutchinson, Powers, The COVID-19 pandemic and physical activity, Sports Med Health Sci, doi:10.1016/j.smhs.2020.05.006
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