Real-world effectiveness and safety of oral Azvudine versus Paxlovid for COVID-19 in patients with kidney disease: a multicenter, retrospective, cohort study

DOI record: { "DOI": "10.1186/s12879-025-10643-w", "ISSN": [ "1471-2334" ], "URL": "http://dx.doi.org/10.1186/s12879-025-10643-w", "alternative-id": [ "10643" ], "article-number": "275", "assertion": [ { "group": { "label": "Article History", "name": "ArticleHistory" }, "label": "Received", "name": "received", "order": 1, "value": "13 July 2024" }, { "group": { "label": "Article History", "name": "ArticleHistory" }, "label": "Accepted", "name": "accepted", "order": 2, "value": "14 February 2025" }, { "group": { "label": "Article History", "name": "ArticleHistory" }, "label": "First Online", "name": "first_online", "order": 3, "value": "25 February 2025" }, { "group": { "label": "Declarations", "name": "EthicsHeading" }, "name": "Ethics", "order": 1 }, { "group": { "label": "Ethics approval and consent to participate", "name": "EthicsHeading" }, "name": "Ethics", "order": 2, "value": "The ethics committee of The First Affiliated Hospital of Zhengzhou University approved this study (2023-KY-0865-001). Considering that this study was a retrospective study, and all patients were anonymous, the ethics committee of the First Affiliated Hospital of Zhengzhou University waived individual informed consent." }, { "group": { "label": "Consent for publication", "name": "EthicsHeading" }, "name": "Ethics", "order": 3, "value": "Not applicable." }, { "group": { "label": "Competing interests", "name": "EthicsHeading" }, "name": "Ethics", "order": 4, "value": "The authors declare no competing interests." } ], "author": [ { "affiliation": [], "family": "Rao", "given": "Benchen", "sequence": "first" }, { "affiliation": [], "family": "Wang", "given": "Daming", "sequence": "additional" }, { "affiliation": [], "family": "Yang", "given": "Mengzhao", "sequence": "additional" }, { "affiliation": [], "family": "Zhao", "given": "Chunyu", "sequence": "additional" }, { "affiliation": [], "family": "Cheng", "given": "Ming", "sequence": "additional" }, { "affiliation": [], "family": "Li", "given": "Silin", "sequence": "additional" }, { "affiliation": [], "family": "Zhang", "given": "Donghua", "sequence": "additional" }, { "affiliation": [], "family": "Luo", "given": "Hong", "sequence": "additional" }, { "affiliation": [], "family": "Qian", "given": "Guowu", "sequence": "additional" }, { "affiliation": [], "family": "Wang", "given": "Ling", "sequence": "additional" }, { "affiliation": [], "family": "Zhang", "given": "Shixi", "sequence": "additional" }, { "affiliation": [], "family": "Li", "given": "Guotao", "sequence": "additional" }, { "affiliation": [], "family": "Li", "given": "Guangming", "sequence": "additional" }, { "affiliation": [], "family": "Yu", "given": "Zujiang", "sequence": "additional" }, { "affiliation": [], "family": "Ren", "given": "Zhigang", "sequence": "additional" } ], "container-title": "BMC Infectious Diseases", "container-title-short": "BMC Infect Dis", "content-domain": { "crossmark-restriction": false, "domain": [ "link.springer.com" ] }, "created": { "date-parts": [ [ 2025, 2, 25 ] ], "date-time": "2025-02-25T19:30:51Z", "timestamp": 1740511851000 }, "deposited": { "date-parts": [ [ 2025, 2, 25 ] ], "date-time": "2025-02-25T19:31:00Z", "timestamp": 1740511860000 }, "funder": [ { "award": [ "2023YFC3043514", "2022YFC2303100" ], "name": "National Key Research and Development Program of China" }, { "award": [ "ZYCXTD2023002", "QNCXTD2023002" ], "name": "Funding for Scientific Research and Innovation Team of The First Affiliated Hospital of Zhengzhou University" }, { "award": [ "HNSWJW-2022013" ], "name": "Young and middle-aged academic leaders of Henan Provincial Health Commission" }, { "award": [ "24HASTIT063" ], "name": "University Science and Technology Innovation Talent Support Plan of Henan Province" } ], "indexed": { "date-parts": [ [ 2025, 2, 26 ] ], "date-time": "2025-02-26T05:32:21Z", "timestamp": 1740547941720, "version": "3.38.0" }, "is-referenced-by-count": 0, "issue": "1", "issued": { "date-parts": [ [ 2025, 2, 25 ] ] }, "journal-issue": { "issue": "1", "published-online": { "date-parts": [ [ 2025, 12 ] ] } }, "language": "en", "license": [ { "URL": "https://creativecommons.org/licenses/by-nc-nd/4.0", "content-version": "tdm", "delay-in-days": 0, "start": { "date-parts": [ [ 2025, 2, 25 ] ], "date-time": "2025-02-25T00:00:00Z", "timestamp": 1740441600000 } }, { "URL": "https://creativecommons.org/licenses/by-nc-nd/4.0", "content-version": "vor", "delay-in-days": 0, "start": { "date-parts": [ [ 2025, 2, 25 ] ], "date-time": "2025-02-25T00:00:00Z", "timestamp": 1740441600000 } } ], "link": [ { "URL": "https://link.springer.com/content/pdf/10.1186/s12879-025-10643-w.pdf", "content-type": "application/pdf", "content-version": "vor", "intended-application": "text-mining" }, { "URL": "https://link.springer.com/article/10.1186/s12879-025-10643-w/fulltext.html", "content-type": "text/html", "content-version": "vor", "intended-application": "text-mining" }, { "URL": "https://link.springer.com/content/pdf/10.1186/s12879-025-10643-w.pdf", "content-type": "application/pdf", "content-version": "vor", "intended-application": "similarity-checking" } ], "member": "297", "original-title": [], "prefix": "10.1186", "published": { "date-parts": [ [ 2025, 2, 25 ] ] }, "published-online": { "date-parts": [ [ 2025, 2, 25 ] ] }, "publisher": "Springer Science and Business Media LLC", "reference": [ { "DOI": "10.1038/ki.2008.107", "author": "CY Hsu", "doi-asserted-by": "publisher", "first-page": "101", "issue": "1", "journal-title": "Kidney Int", "key": "10643_CR1", "unstructured": "Hsu CY, Ordonez JD, Chertow GM, Fan D, McCulloch CE, Go AS. 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