Supplementary Data — Niclosamide reduces COVID-19 risk: real-time meta analysis of 7 studies

@CovidAnalysis, December 2025, Version 7V7
0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Cairns (DB RCT) 66% 0.34 [0.01-7.98] severe case 0/33 1/34 Improvement, RR [CI] Treatment Control Cairns (DB RCT) 18% 0.82 [0.58-1.17] recov. time 33 (n) 34 (n) Cairns (DB RCT) 24% 0.76 [0.41-1.39] viral+ 11/33 15/34 FINCOV Siripongbo.. (RCT) 0% 1.00 [0.07-15.3] progression 1/30 1/30 CT​1​ FINCOV Siripongbo.. (RCT) 67% 0.33 [0.01-7.87] progression 0/30 1/30 CT​1​ FINCOV Siripongbo.. (RCT) 39% 0.61 [0.28-1.29] symp. score 30 (n) 30 (n) CT​1​ FINCOV Siripongbo.. (RCT) 70% 0.30 [0.09-0.99] symp. score 30 (n) 30 (n) CT​1​ FINCOV Siripongbo.. (RCT) 14% 0.86 [0.61-1.20] symp. score 30 (n) 30 (n) CT​1​ FINCOV Siripongbo.. (RCT) 67% 0.33 [0.03-4.37] symp. score 30 (n) 30 (n) CT​1​ FINCOV Siripongbo.. (RCT) 50% 0.50 [0.13-1.95] symp. score 30 (n) 30 (n) CT​1​ FINCOV Siripongbo.. (RCT) 6% 0.94 [0.65-1.35] viral+ 30 (n) 30 (n) CT​1​ Kim (DB RCT) 29% 0.71 [0.55-0.92] recov. time 99 (n) 98 (n) Kim (DB RCT) 33% 0.67 [0.46-0.97] recov. time 99 (n) 98 (n) Kim (DB RCT) 25% 0.75 [0.53-1.07] recov. time 96 (n) 98 (n) Kim (DB RCT) 4% 0.96 [0.71-1.30] recov. time 99 (n) 98 (n) Kim (DB RCT) 22% 0.78 [0.50-1.22] recov. time 99 (n) 98 (n) Kim (DB RCT) -7% 1.07 [0.80-1.44] recov. time 96 (n) 98 (n) Kim (DB RCT) 56% 0.44 [0.14-1.39] viral load 99 (n) 98 (n) Kim (DB RCT) 26% 0.74 [0.10-5.35] viral load 99 (n) 98 (n) Kim (DB RCT) 66% 0.34 [0.08-1.39] viral load 96 (n) 98 (n) Abdulamir (RCT) 0% 1.00 [0.21-4.80] death 3/75 3/75 Abdulamir (RCT) 39% 0.61 [0.43-0.87] no recov. 75 (n) 75 (n) RESERVOIR First Wa.. (DB RCT) 23% 0.77 [0.33-1.82] viral+ 8/60 10/58 RESERVOIR First Wa.. (DB RCT) 33% 0.67 [0.31-1.44] viral+ 9/60 13/58 RESERVOIR First Wa.. (DB RCT) 42% 0.58 [0.28-1.22] viral+ 9/60 15/58 RESERVOIR First Wa.. (DB RCT) 28% 0.72 [0.38-1.40] viral+ 12/60 16/58 RESERVOIR First Wa.. (DB RCT) 23% 0.77 [0.49-1.23] viral+ 20/60 25/58 RESERVOIR First Wa.. (DB RCT) 1% 0.99 [0.76-1.29] viral+ 39/60 38/58 RESERVOIR First Wa.. (DB RCT) -3% 1.03 [0.88-1.19] viral+ 52/60 49/58 Rank (DB RCT) 30% 0.70 [0.13-3.78] death 2/22 3/23 Rank (DB RCT) 70% 0.3 [0.00-9e+23] recov. time 23 (n) 23 (n) Rank (DB RCT) -6% 1.06 [0.46-2.47] recov. time 23 (n) 23 (n) Rank (DB RCT) 57% 0.4 [0.00-4e+20] no disch. 23 (n) 23 (n) Rank (DB RCT) 0% 1.00 [0.90-1.11] viral time 23 (n) 23 (n) PROTECT-V Humphrey (DB RCT) 0% 1.00 [0.14-7.07] death 2/826 2/825 PROTECT-V Humphrey (DB RCT) 80% 0.20 [0.01-4.16] ventilation 0/826 2/825 PROTECT-V Humphrey (DB RCT) 13% 0.87 [0.41-1.81] hosp. 13/826 15/825 PROTECT-V Humphrey (DB RCT) -2% 1.02 [0.79-1.32] symp. case 103/826 133/825 Niclosamide COVID-19 outcomes c19early.org December 2025 ​1​ CT: study uses combined treatment Favors niclosamide Favors control
Fig. S1. All outcomes.