Prophylaxis for patients at risk of COVID-19 infection: results from the intranasal niclosamide randomised, double blinded, placebo controlled arm of the PROTECT-V platform trial
Toby Jl Humphrey, Wendi Qian, Michael Chen-Xu, Francis Dowling, Katrina Gatley, Rakshya Adhikari, Tracey Hensman, Louise Stockley, Abhinav Bassi, Nikita Bathla, Indranil Dasgupta, Davinder Ps Dosanjh, Mads Jellingsø, Morten Lind Jensen, Anne Weibel Callesen, John R Bradley, Vivekanand Jha, Morten Oa Sommer, Thomas F Hiemstra, Rona M Smith
Background PROTECT-V (PROphylaxis for paTiEnts at risk of COVID-19 infecTion) is a platform trial testing multiple pre-exposure COVID-19 prophylactic agents in vulnerable patient cohorts. The aim is to determine if these agents can confer additional protection, over and above vaccination, in patients who typically mount sub-optimal vaccine responses or are at particular risk of adverse clinical outcomes from COVID-19 infection. This paper reports the results from the intranasal niclosamide arm of the trial.
This preprint research paper has not been peer reviewed. Electronic copy available at: https://ssrn.com/abstract=4519538 P r e p r i n t n o t p e e r r e v i e w e d Supplementary Figure 2 : Participant withdrawal according to treatment allocation
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