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0 0.5 1 1.5 2+ Mortality 27% Improvement Relative Risk Death/intubation 6% Mortality, 5.9ng/mL 15% levels Death/intubation, 5.9ng/mL 40% levels Vitamin B9 for COVID-19  Meisel et al.  Prophylaxis Is prophylaxis with vitamin B9 beneficial for COVID-19? Retrospective 334 patients in Israel (January - November 2020) Lower mortality with vitamin B9 (not stat. sig., p=0.54) c19early.org Meisel et al., Nutrients, March 2021 Favors vitamin B9 Favors control

Folate Levels in Patients Hospitalized with Coronavirus Disease 2019

Meisel et al., Nutrients, doi:10.3390/nu13030812
Mar 2021  
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Retrospective 333 hospitalized patients in Israel, showing no significant difference in outcomes with low folate levels or with folic acid supplementation.
risk of death, 27.0% lower, OR 0.73, p = 0.54, treatment 23, control 310, RR approximated with OR.
risk of death/intubation, 6.0% lower, OR 0.94, p = 0.88, treatment 23, control 310, RR approximated with OR.
risk of death, 15.3% lower, OR 0.85, p = 0.66, high vitamin B9 levels (≥5.9ng/mL) 296, low vitamin B9 levels (<5.9ng/mL) 38, inverted to make OR<1 favor high vitamin B9 levels (≥5.9ng/mL), RR approximated with OR, outcome based on serum levels.
risk of death/intubation, 40.1% lower, OR 0.60, p = 0.09, high vitamin B9 levels (≥5.9ng/mL) 296, low vitamin B9 levels (<5.9ng/mL) 38, inverted to make OR<1 favor high vitamin B9 levels (≥5.9ng/mL), RR approximated with OR, outcome based on serum levels.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Meisel et al., 2 Mar 2021, retrospective, Israel, peer-reviewed, 8 authors, study period 27 January, 2020 - 23 November, 2020. Contact: eshcarme@gmail.com (corresponding author), orlyefros@gmail.com, jobleier@gmail.com, talbh142@gmail.com, avshalom.leibowitz@sheba.health.gov.il, gad.segal@sheba.health.gov.il, galia.rahav@sheba.health.gov.il, ehud.grossman@sheba.health.gov.il.
This PaperVitamin B9All
Folate Levels in Patients Hospitalized with Coronavirus Disease 2019
Eshcar Meisel, Orly Efros, Jonathan Bleier, Tal Beit Halevi, Gad Segal, Galia Rahav, Avshalom Leibowitz, Ehud Grossman
Nutrients, doi:10.3390/nu13030812
We aimed to investigate the prevalence of decreased folate levels in patients hospitalized with Coronavirus Disease 2019 (COVID-19) and evaluate their outcome and the prognostic significance associated with its different levels. In this retrospective cohort study, data were obtained from the electronic medical records at the Sheba Medical Center. Folic acid levels were available in 333 out of 1020 consecutive patients diagnosed with COVID-19 infection hospitalized from January 2020 to November 2020. Thirty-eight (11.4%) of the 333 patients comprising the present study population had low folate levels. No significant difference was found in the incidence of acute kidney injury, hypoxemia, invasive ventilation, length of hospital stay, and mortality be-tween patients with decreased and normal-range folate levels. When sub-dividing the study population according to quartiles of folate levels, similar findings were observed. In conclusion, decreased serum folate levels are common among hospitalized patients with COVID-19, but there was no association between serum folate levels and clinical outcomes. Due to the important role of folate in cell metabolism and the potential pathologic impact when deficient, a follow-up of folate levels or possible supplementation should be encouraged in hospitalized COVID-19 patients. Fur-ther studies are required to assess the prevalence and consequences of folate deficiency in COVID-19 patients.
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