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An investigation of the correlation of vitamin D status and management outcomes in patients with severe COVID-19 at a South African tertiary hospital

Jalavu et al., IJID Regions, doi:10.1016/j.ijregi.2023.05.007

Jun 2023

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Vitamin D for COVID-19

8th treatment shown to reduce risk in October 2020

^*, now known with p < 0.00000000001 from 120 studies, recognized in 8 countries.

Lower risk for mortality, ICU admission, hospitalization, progression, recovery, cases, and viral clearance.

No treatment is 100% effective. Protocols combine complementary and synergistic treatments. ^* >10% efficacy in meta analysis with ≥3 clinical studies.

4,100+ studies for 60+ treatments. c19early.org

Prospective analysis of 68 COVID-19 ICU patients in South Africa, showing a high prevalence of vitamin D deficiency/insufficiency. There was no significant difference in mortality based on vitamin D sufficiency, however this result does not account for the different risk of being admitted to the ICU, or potential supplementation during the course of COVID-19 prior to ICU admission.

This is the 181st of 196 COVID-19 sufficiency studies for vitamin D, which collectively show higher levels reduce risk with p<0.0000000001 (1 in 11,637 vigintillion).

Important missing comments or errors? Let us know.

risk of death, 1.0% lower, HR 0.99, p = 0.97, high D levels (≥50nmol/L) 16 of 31 (51.6%), low D levels (<50nmol/L) 38 of 55 (69.1%), NNT 5.7, Kaplan–Meier.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates

Jalavu et al., 1 Jun 2023, prospective, South Africa, peer-reviewed, 16 authors, study period 29 October, 2020 - 10 February, 2021. Contact: pnyasulu@sun.ac.za.

This Paper Vitamin D All

An investigation of the correlation of vitamin D status and management outcomes in patients with severe COVID-19 at a South African tertiary hospital

Thumeka P Jalavu, Lovemore N Sigwadhi, Maritha J Kotze, Anteneh Yalew, Vera Ngah, Jacques L Tamuzi, Zivanai C Chapanduka, Brian W Allwood, Coenraad F Koegelenberg, Elvis M Irusen, Usha Lalla, Tandi E Matsha, Rajiv T Erasmus, Ali Zumla, Annalise E Zemlin, Peter S Nyasulu

IJID Regions, doi:10.1016/j.ijregi.2023.05.007

investigation of the correlation of vitamin D status and management outcomes in patients with severe COVID-19 at a South African tertiary hospital, IJID Regions (2023),

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