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Colostrum Lactoferrin Following Active and Recovered SARS-CoV-2 Infections during Pregnancy

Gaweł et al., Biomedicines, doi:10.3390/biomedicines12051120
May 2024  
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Analysis of 69 lactating mothers showing higher colostrum lactoferrin concentrations in mothers with a history of COVID-19 infection during pregnancy or delivery compared to pre-pandemic controls. The highest lactoferrin concentrations were found in mothers with active infection at delivery. Lactoferrin has demonstrated antiviral activity against SARS-CoV-2 in vitro, suggesting it may provide protection to breastfed infants.
Gaweł et al., 17 May 2024, Poland, peer-reviewed, 6 authors, study period 15 February, 2021 - 1 May, 2021. Contact: pszczygiol@usk.wroc.pl (corresponding author), barbara.krolak-olejnik@umw.edu.pl, lukianowski.blazej@gmail.com, katarzyna.koscielska-kasprzak@umw.edu.pl, dorota.bartoszek@umw.edu.pl, magdalena.krajewska@umw.edu.pl.
This PaperLactoferrinAll
Colostrum Lactoferrin Following Active and Recovered SARS-CoV-2 Infections during Pregnancy
Paulina Gaweł, Błażej Łukianowski, Katarzyna Kościelska-Kasprzak, Dorota Bartoszek, Magdalena Krajewska, Barbara Królak-Olejnik
Biomedicines, doi:10.3390/biomedicines12051120
Lactoferrin (Lf) , which is particularly abundant in human breast milk during the early stages of lactation, provides protection against a variety of infections, including viral infections, and has demonstrated activity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The objective of this study was to measure the concentrations of Lf in the colostrum of mothers with active coronavirus disease 2019 (COVID-19) infections during delivery, in mothers with a history of COVID-19 during pregnancy, and in non-infected controls. In this cross-sectional study, colostrum samples from 41 lactating mothers with a confirmed history of SARS-CoV-2 infection (asymptomatic or symptomatic) (both active and past infections) were collected. Twenty-eight colostrum samples collected during the pre-pandemic period served as a control group. An enzymelinked immunosorbent assay was performed to analyze the Lf concentrations. Concentrations of Lf in the colostrum samples were closely related to virus infection. Colostrum samples from mothers with confirmed SARS-CoV-2 infections contained higher concentrations of lactoferrin compared with samples from mothers from the control group. The highest concentrations of Lf were found in the colostrum samples of mothers with active SARS-CoV-2 infection during delivery when compared with the post-infection and control samples. This observed increase in lactoferrin suggests that it may be an important protective factor for breastfed infants, a finding which was particularly relevant during the pandemic period and remains relevant whenever a breastfeeding mother is infected.
Conflicts of Interest: The authors declare no conflicts of interest.
References
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