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All Studies   Meta Analysis    Recent:   
0 0.5 1 1.5 2+ Mortality 16% Improvement Relative Risk N-acetylcysteine  Gamarra-Morales et al.  ICU PATIENTS  RCT Is very late treatment with N-acetylcysteine beneficial for COVID-19? RCT 140 patients in Spain (March - June 2020) Lower mortality with N-acetylcysteine (not stat. sig., p=0.49) c19early.org Gamarra-Morales et al., Nutrients, May 2023 Favors N-acetylcysteine Favors control

Response to Intravenous N-Acetylcysteine Supplementation in Critically Ill Patients with COVID-19

Gamarra-Morales et al., Nutrients, doi:10.3390/nu15092235
May 2023  
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13th treatment shown to reduce risk in February 2021
 
*, now known with p = 0.000034 from 24 studies, recognized in 3 countries.
Lower risk for mortality, hospitalization, and cases.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,200+ studies for 70+ treatments. c19early.org
RCT 140 ICU patients in Spain, 72 treated with N-acetylcysteine (NAC). NAC patients showed improved PaO2/FiO2, CRP, D-dimer, and LDH, and there were associations between glutathione and clinical outcomes and severity biomarkers in NAC-treated patients. There was no significant difference in mortality.
risk of death, 15.7% lower, RR 0.84, p = 0.49, treatment 25 of 72 (34.7%), control 28 of 68 (41.2%), NNT 15.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Gamarra-Morales et al., 8 May 2023, Randomized Controlled Trial, Spain, peer-reviewed, 8 authors, study period 1 March, 2020 - 1 June, 2020. Contact: jennifer_gamo@hotmail.com (corresponding author), jorge.molina@ddi.uhu.es.
This PaperN-acetylcys..All
Response to Intravenous N-Acetylcysteine Supplementation in Critically Ill Patients with COVID-19
Yenifer Gamarra-Morales, Lourdes Herrera-Quintana, Jorge Molina-López, Héctor Vázquez-Lorente, Juan Francisco Machado-Casas, José Castaño-Pérez, José Miguel Pérez-Villares, Elena Planells
Nutrients, doi:10.3390/nu15092235
Administering N-acetylcysteine (NAC) could counteract the effect of free radicals, improving the clinical evolution of patients admitted to the Intensive Care Unit (ICU). This study aimed to investigate the clinical and biochemical effects of administering NAC to critically ill patients with COVID-19. A randomized controlled clinical trial was conducted on ICU patients (n = 140) with COVID-19 and divided into two groups: patients treated with NAC (NAC-treated group) and patients without NAC treatment (control group). NAC was administered as a continuous infusion with a loading dose and a maintenance dose during the study period (from admission until the third day of ICU stay). NAC-treated patients showed higher PaO 2 /FiO 2 (p ≤ 0.014) after 3 days in ICU than their control group counterparts. Moreover, C-reactive protein (p ≤ 0.001), D-dimer (p ≤ 0.042), and lactate dehydrogenase (p ≤ 0.001) levels decreased on the third day in NAC-treated patients. Glutathione concentrations decreased in both NAC-treated (p ≤ 0.004) and control (p ≤ 0.047) groups after 3 days in ICU; whereas glutathione peroxidase did not change during the ICU stay. The administration of NAC manages to improve the clinical and analytical response of seriously ill patients with COVID-19 compared to the control group. NAC is able to stop the decrease in glutathione concentrations.
Conflicts of Interest: The authors declare no conflict of interest.
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{ 'DOI': '10.3390/nu15092235', 'ISSN': ['2072-6643'], 'URL': 'http://dx.doi.org/10.3390/nu15092235', 'abstract': '<jats:p>Administering N-acetylcysteine (NAC) could counteract the effect of free radicals, ' 'improving the clinical evolution of patients admitted to the Intensive Care Unit (ICU). This ' 'study aimed to investigate the clinical and biochemical effects of administering NAC to ' 'critically ill patients with COVID-19. A randomized controlled clinical trial was conducted ' 'on ICU patients (n = 140) with COVID-19 and divided into two groups: patients treated with ' 'NAC (NAC-treated group) and patients without NAC treatment (control group). NAC was ' 'administered as a continuous infusion with a loading dose and a maintenance dose during the ' 'study period (from admission until the third day of ICU stay). NAC-treated patients showed ' 'higher PaO2/FiO2 (p ≤ 0.014) after 3 days in ICU than their control group counterparts. ' 'Moreover, C-reactive protein (p ≤ 0.001), D-dimer (p ≤ 0.042), and lactate dehydrogenase (p ≤ ' '0.001) levels decreased on the third day in NAC-treated patients. Glutathione concentrations ' 'decreased in both NAC-treated (p ≤ 0.004) and control (p ≤ 0.047) groups after 3 days in ICU; ' 'whereas glutathione peroxidase did not change during the ICU stay. The administration of NAC ' 'manages to improve the clinical and analytical response of seriously ill patients with ' 'COVID-19 compared to the control group. 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Late treatment
is less effective
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
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