Vitamin D 25OH Deficiency and Mortality in Moderate to Severe COVID-19: A Multi-Center Prospective Observational Study
Laura Bogliolo, Emanuele Cereda, Catherine Klersy, Ludovico De Stefano, Federica Lobascio, Sara Masi, Silvia Crotti, Serena Bugatti, Carlomaurizio Montecucco, Stefania Demontis, Annalisa Mascheroni, Nadia Cerutti, Alberto Malesci, Salvatore Corrao, Riccardo Caccialanza
Frontiers in Nutrition, doi:10.3389/fnut.2022.934258
Discussion: The prevalence of vitamin D 25OH deficiency was confirmed to be very high in hospitalized patients with COVID-19. The use of a propensity score demonstrate an absence of significant association between vitamin D deficiency and mortality in hospitalized patients.
ETHICS STATEMENT The studies involving human participants were reviewed and approved by Comitato Etico referente Area di Pavia, Fondazione IRCCS Policlinico San Matteo, Pavia. The patients/participants provided their written informed consent to participate in this study.
AUTHOR CONTRIBUTIONS LB, EC, and RC had full access to all the data in the study and take responsibility for the integrity of the data and the accuracy of data analysis. RC is chief investigators and act as guarantors for this work. Concept and design: LB, CK, RC, and EC. Acquisition, analysis, or interpretation of data: RC, EC, LB, CK, LD, FL, SM, SC, SB, SD, AM, NC, AM, and SC. Drafting of the manuscript: LB, RC, EC, CK, and LD. Statistical analysis: CK. All authors contributed to the article and approved the submitted version.
Conflict of Interest: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Publisher's Note: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.
References
Alguwaihes, Sabico, Hasanato, Megdad, Albader, Severe vitamin D deficiency is not related to SARS-CoV-2 infection but may increase mortality risk in hospitalized adults: a retrospective casecontrol study in an Arab Gulf country, Aging Clin Exp Res,
doi:10.1007/s40520-021-01831-0Bassatne, Basbous, Chakhtoura, El Zein, Rahme et al., The link between COVID-19 and VItamin D (VIVID): A systematic review and meta-analysis, Metabolism,
doi:10.1016/j.metabol.2021.154753Caccialanza, Formisano, Klersy, Ferretti, Ferrari et al., Nutritional parameters associated with prognosis in non-critically ill hospitalized COVID-19 patients: the NUTRI-COVID19 study, Clin Nut,
doi:10.1016/j.clnu.2021.06.020Cereda, Bogliolo, De Stefano, Caccialanza, brief discussion of the benefit and mechanism of vitamin D supplementation on coronavirus disease 2019, Curr Opin Clin Nutr Metab Care,
doi:10.1097/MCO.0000000000000701~Cereda, Bogliolo, Klersy, Lobascio, Masi et al., Vitamin D 25(OH)D deficiency in COVID-19 patients admitted to a tertiary referral hospital, Clin Nutr,
doi:10.1016/j.clnu.2020.10.055Cereda, Bogliolo, Lobascio, Barichella, Zecchinelli et al., Vitamin D supplementation and outcomes in coronavirus disease 2019 (COVID19) patients from the outbreak area of Lombardy, Italy, Nutrition,
doi:10.1016/j.nut.2020.111055Dissanayake, Silva, Sumanatilleke, Prognostic and therapeutic role of vitamin D in COVID-19: systematic review and metaanalysis
Ghasemian, Shamshirian, Heydari, Malekan, Alizadeh-Navaei et al., The role of vitamin D in the age of COVID-19: a systematic review and meta-analysis, Int J Clin Pract,
doi:10.1111/ijcp.14675Murai, Fernandes, Sales, Pinto, Goessler et al., Effect of a single high dose of vitamin D3 on hospital length of stay in patients with moderate to Severe COVID-19 a randomized clinical trial, JAMA,
doi:10.1001/jama.2020.26848Panagiotou, Tee, Ihsan, Athar, Marchitelli et al., Low serum 25-hydroxyvitamin D (25[OH]D) levels in patients hospitalized with COVID-19 are associated with greater disease severity, Clin Endocrinol (Oxf),
doi:10.1111/cen.14276Radujkovic, Hippchen, Tiwari-Heckler, Dreher, Boxberger, Vitamin D deficiency and outcome of COVID-19 patients, Nutrients,
doi:10.3390/nu12092757Rhodes, Subramanian, Laird, Griffin, Kenny, Perspective: vitamin D deficiency and COVID-19 severity -plausibly linked by latitude, ethnicity, impacts on cytokines, ACE2 and thrombosis, J Intern Med,
doi:10.1111/joim.13149Sabico, Enani, Sheshah, Aljohani, Aldisi et al., Effects of a 2-Week 5000 IU versus 1000 IU Vitamin D3 supplementation on recovery of symptoms in patients with mild to moderate Covid-19: a randomized clinical trial, Nat Rev Immunol,
doi:10.1038/s41577-020-0331-4Smet, Smet, Herroelen, Gryspeerdt, Martens, Serum 25(OH)D Level on Hospital Admission Associated With COVID-19 Stage and Mortality, Am J Clin Pathol,
doi:10.1093/ajcp/aqaa252Teshome, Adane, Girma, Mekonnen, The impact of vitamin D level on COVID-19 infection: systematic review and meta-analysis, Front Public Health,
doi:10.3389/fpubh.2021.624559
