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All Studies   Meta Analysis    Recent:   
0 0.5 1 1.5 2+ Mortality 15% Improvement Relative Risk Vitamin D for COVID-19  Bogliolo et al.  Sufficiency Are vitamin D levels associated with COVID-19 outcomes? Prospective study of 361 patients in Italy (March - August 2020) Lower mortality with higher vitamin D levels (not stat. sig., p=0.29) c19early.org Bogliolo et al., Frontiers in Nutrition, Jul 2022 Favors vitamin D Favors control

Vitamin D 25OH Deficiency and Mortality in Moderate to Severe COVID-19: A Multi-Center Prospective Observational Study

Bogliolo et al., Frontiers in Nutrition, doi:10.3389/fnut.2022.934258
Jul 2022  
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Vitamin D for COVID-19
8th treatment shown to reduce risk in October 2020
 
*, now known with p < 0.00000000001 from 120 studies, recognized in 8 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,200+ studies for 70+ treatments. c19early.org
Prospective 361 consecutive hospitalized patients in Italy, showing 77% had vitamin D deficiency. There was no statistically significant difference in mortality with deficiency.
This is the 139th of 196 COVID-19 sufficiency studies for vitamin D, which collectively show higher levels reduce risk with p<0.0000000001 (1 in 11,637 vigintillion).
risk of death, 15.3% lower, HR 0.85, p = 0.29, cutoff 20ng/mL, inverted to make HR<1 favor high D levels (≥20ng/mL).
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Bogliolo et al., 5 Jul 2022, prospective, Italy, peer-reviewed, median age 73.0, 16 authors, study period March 2020 - August 2020. Contact: l.bogliolo@smatteo.pv.it.
This PaperVitamin DAll
Vitamin D 25OH Deficiency and Mortality in Moderate to Severe COVID-19: A Multi-Center Prospective Observational Study
Laura Bogliolo, Emanuele Cereda, Catherine Klersy, Ludovico De Stefano, Federica Lobascio, Sara Masi, Silvia Crotti, Serena Bugatti, Carlomaurizio Montecucco, Stefania Demontis, Annalisa Mascheroni, Nadia Cerutti, Alberto Malesci, Salvatore Corrao, Riccardo Caccialanza
Frontiers in Nutrition, doi:10.3389/fnut.2022.934258
Discussion: The prevalence of vitamin D 25OH deficiency was confirmed to be very high in hospitalized patients with COVID-19. The use of a propensity score demonstrate an absence of significant association between vitamin D deficiency and mortality in hospitalized patients.
ETHICS STATEMENT The studies involving human participants were reviewed and approved by Comitato Etico referente Area di Pavia, Fondazione IRCCS Policlinico San Matteo, Pavia. The patients/participants provided their written informed consent to participate in this study. AUTHOR CONTRIBUTIONS LB, EC, and RC had full access to all the data in the study and take responsibility for the integrity of the data and the accuracy of data analysis. RC is chief investigators and act as guarantors for this work. Concept and design: LB, CK, RC, and EC. Acquisition, analysis, or interpretation of data: RC, EC, LB, CK, LD, FL, SM, SC, SB, SD, AM, NC, AM, and SC. Drafting of the manuscript: LB, RC, EC, CK, and LD. Statistical analysis: CK. All authors contributed to the article and approved the submitted version. Conflict of Interest: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Publisher's Note: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.
References
Alguwaihes, Sabico, Hasanato, Megdad, Albader, Severe vitamin D deficiency is not related to SARS-CoV-2 infection but may increase mortality risk in hospitalized adults: a retrospective casecontrol study in an Arab Gulf country, Aging Clin Exp Res, doi:10.1007/s40520-021-01831-0
Bassatne, Basbous, Chakhtoura, El Zein, Rahme et al., The link between COVID-19 and VItamin D (VIVID): A systematic review and meta-analysis, Metabolism, doi:10.1016/j.metabol.2021.154753
Caccialanza, Formisano, Klersy, Ferretti, Ferrari et al., Nutritional parameters associated with prognosis in non-critically ill hospitalized COVID-19 patients: the NUTRI-COVID19 study, Clin Nut, doi:10.1016/j.clnu.2021.06.020
Cereda, Bogliolo, De Stefano, Caccialanza, brief discussion of the benefit and mechanism of vitamin D supplementation on coronavirus disease 2019, Curr Opin Clin Nutr Metab Care, doi:10.1097/MCO.0000000000000701~
Cereda, Bogliolo, Klersy, Lobascio, Masi et al., Vitamin D 25(OH)D deficiency in COVID-19 patients admitted to a tertiary referral hospital, Clin Nutr, doi:10.1016/j.clnu.2020.10.055
Cereda, Bogliolo, Lobascio, Barichella, Zecchinelli et al., Vitamin D supplementation and outcomes in coronavirus disease 2019 (COVID19) patients from the outbreak area of Lombardy, Italy, Nutrition, doi:10.1016/j.nut.2020.111055
Dissanayake, Silva, Sumanatilleke, Prognostic and therapeutic role of vitamin D in COVID-19: systematic review and metaanalysis
Ghasemian, Shamshirian, Heydari, Malekan, Alizadeh-Navaei et al., The role of vitamin D in the age of COVID-19: a systematic review and meta-analysis, Int J Clin Pract, doi:10.1111/ijcp.14675
Murai, Fernandes, Sales, Pinto, Goessler et al., Effect of a single high dose of vitamin D3 on hospital length of stay in patients with moderate to Severe COVID-19 a randomized clinical trial, JAMA, doi:10.1001/jama.2020.26848
Panagiotou, Tee, Ihsan, Athar, Marchitelli et al., Low serum 25-hydroxyvitamin D (25[OH]D) levels in patients hospitalized with COVID-19 are associated with greater disease severity, Clin Endocrinol (Oxf), doi:10.1111/cen.14276
Radujkovic, Hippchen, Tiwari-Heckler, Dreher, Boxberger, Vitamin D deficiency and outcome of COVID-19 patients, Nutrients, doi:10.3390/nu12092757
Reijven, Soeters, Vitamin D: a magic bullet or a myth?, Clin Nutr, doi:10.1016/j.clnu.2019.12.028
Rhodes, Subramanian, Laird, Griffin, Kenny, Perspective: vitamin D deficiency and COVID-19 severity -plausibly linked by latitude, ethnicity, impacts on cytokines, ACE2 and thrombosis, J Intern Med, doi:10.1111/joim.13149
Sabico, Enani, Sheshah, Aljohani, Aldisi et al., Effects of a 2-Week 5000 IU versus 1000 IU Vitamin D3 supplementation on recovery of symptoms in patients with mild to moderate Covid-19: a randomized clinical trial, Nat Rev Immunol, doi:10.1038/s41577-020-0331-4
Smet, Smet, Herroelen, Gryspeerdt, Martens, Serum 25(OH)D Level on Hospital Admission Associated With COVID-19 Stage and Mortality, Am J Clin Pathol, doi:10.1093/ajcp/aqaa252
Teshome, Adane, Girma, Mekonnen, The impact of vitamin D level on COVID-19 infection: systematic review and meta-analysis, Front Public Health, doi:10.3389/fpubh.2021.624559
{ 'DOI': '10.3389/fnut.2022.934258', 'ISSN': ['2296-861X'], 'URL': 'http://dx.doi.org/10.3389/fnut.2022.934258', 'abstract': '<jats:sec><jats:title>Introduction</jats:title><jats:p>Several studies and meta-analyses ' 'suggested the role of vitamin D 25OH in preventing severe forms of coronavirus disease 2019 ' '(COVID-19). However, the evidence on the clinical benefits of vitamin D 25OH adequacy in ' 'patients hospitalized for COVID-19 remain conflicting and speculative. We aimed to ' 'investigate the association between vitamin D 25OH serum levels and mortality in hospitalized ' 'patients with moderate to severe ' 'COVID-19.</jats:p></jats:sec><jats:sec><jats:title>Method</jats:title><jats:p>This ' 'prospective observational multicentre study included 361 consecutive patients with moderate ' 'to severe COVID-19 admitted to the Italian hospitals involved in the NUTRI-COVID19 trial from ' 'March to August 2020. For each patient, serum vitamin D 25OH levels were assessed 48 h since ' 'admission and classified as deficient (&amp;lt;20 ng/mL) or adequate (≥20 ng/mL). We built a ' 'propensity score for low/adequate vitamin D 25OH levels to balance the clinical and ' 'demographic properties of the cohort, which resulted in 261 patients with good common support ' 'used for the survival ' 'analysis.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Two ' 'Hundred-seventy-seven (77%) of the 361 enrolled patients (207 [57%] males, median age 73 ± ' '15.6 years) had vitamin D 25OH deficiency. Fifty-two (20%) of the 261 matched patients died ' 'during the hospital stay, corresponding to a hazard ratio of 1.18 for vitamin D 25OH ' 'deficiency (95% confidence interval: 0.86–1.62; <jats:italic>p</jats:italic> = ' '0.29).</jats:p></jats:sec><jats:sec><jats:title>Discussion</jats:title><jats:p>The prevalence ' 'of vitamin D 25OH deficiency was confirmed to be very high in hospitalized patients with ' 'COVID-19. The use of a propensity score demonstrate an absence of significant association ' 'between vitamin D deficiency and mortality in hospitalized patients.</jats:p></jats:sec>', 'alternative-id': ['10.3389/fnut.2022.934258'], 'author': [ {'affiliation': [], 'family': 'Bogliolo', 'given': 'Laura', 'sequence': 'first'}, {'affiliation': [], 'family': 'Cereda', 'given': 'Emanuele', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Klersy', 'given': 'Catherine', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Stefano', 'given': 'Ludovico De', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Lobascio', 'given': 'Federica', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Masi', 'given': 'Sara', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Crotti', 'given': 'Silvia', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Bugatti', 'given': 'Serena', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Montecucco', 'given': 'Carlomaurizio', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Demontis', 'given': 'Stefania', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Mascheroni', 'given': 'Annalisa', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Cerutti', 'given': 'Nadia', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Malesci', 'given': 'Alberto', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Corrao', 'given': 'Salvatore', 'sequence': 'additional'}, {'affiliation': [], 'family': 'Caccialanza', 'given': 'Riccardo', 'sequence': 'additional'}, { 'affiliation': [], 'name': 'The NUTRI-COVID19 Collaborative Working Group', 'sequence': 'additional'}], 'container-title': 'Frontiers in Nutrition', 'container-title-short': 'Front. 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