Vitamin D 25OH Deficiency and Mortality in Moderate to Severe COVID-19: A Multi-Center Prospective Observational Study
Bogliolo et al.,
Vitamin D 25OH Deficiency and Mortality in Moderate to Severe COVID-19: A Multi-Center Prospective..,
Frontiers in Nutrition, doi:10.3389/fnut.2022.934258
Prospective 361 consecutive hospitalized patients in Italy, showing 77% had vitamin D deficiency. There was no statistically significant difference in mortality with deficiency.
risk of death, 15.3% lower, HR 0.85, p = 0.29, cutoff 20ng/mL, inverted to make HR<1 favor high D levels (≥20ng/mL).
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Bogliolo et al., 5 Jul 2022, prospective, Italy, peer-reviewed, median age 73.0, 16 authors, study period March 2020 - August 2020.
Contact:
l.bogliolo@smatteo.pv.it.
Abstract: BRIEF RESEARCH REPORT
published: 05 July 2022
doi: 10.3389/fnut.2022.934258
Vitamin D 25OH Deficiency and
Mortality in Moderate to Severe
COVID-19: A Multi-Center
Prospective Observational Study
Laura Bogliolo 1*† , Emanuele Cereda 2† , Catherine Klersy 3 , Ludovico De Stefano 1 ,
Federica Lobascio 2 , Sara Masi 2 , Silvia Crotti 2 , Serena Bugatti 1 ,
Carlomaurizio Montecucco 1 , Stefania Demontis 4 , Annalisa Mascheroni 5 , Nadia Cerutti 6 ,
Alberto Malesci 7 , Salvatore Corrao 8,9 , Riccardo Caccialanza 2† and
the NUTRI-COVID19 Collaborative Working Group 9
1
Edited by:
Kuo-Cheng Lu,
Fu Jen Catholic University
Hospital, Taiwan
Reviewed by:
Guoxun Chen,
The University of Tennessee,
United States
Nasser M. Al-Daghri,
King Saud University, Saudi Arabia
*Correspondence:
Laura Bogliolo
l.bogliolo@smatteo.pv.it
† These authors have contributed
equally to this work
Specialty section:
This article was submitted to
Clinical Nutrition,
a section of the journal
Frontiers in Nutrition
Received: 02 May 2022
Accepted: 15 June 2022
Published: 05 July 2022
Citation:
Bogliolo L, Cereda E, Klersy C,
Stefano LD, Lobascio F, Masi S,
Crotti S, Bugatti S, Montecucco C,
Demontis S, Mascheroni A, Cerutti N,
Malesci A, Corrao S, Caccialanza R
and the NUTRI-COVID19
Collaborative Working Group (2022)
Vitamin D 25OH Deficiency and
Mortality in Moderate to Severe
COVID-19: A Multi-Center Prospective
Observational Study.
Front. Nutr. 9:934258.
doi: 10.3389/fnut.2022.934258
Frontiers in Nutrition | www.frontiersin.org
Division of Rheumatology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy, 2 Clinical Nutrition and Dietetics Unit,
Fondazione IRCCS Policlinico San Matteo, Pavia, Italy, 3 Clinical Epidemiology & Biostatistics Unit, Fondazione IRCCS
Policlinico San Matteo, Pavia, Italy, 4 Nutritional Unit, Giovanni Borea Civil Hospital, Sanremo, Italy, 5 Clinical Nutrition and
Dietetics Unit–ASST Melegnano e Martesana, Melegnano (Milano), Italy, 6 Medicine and Dietetics Unit, ASST Pavia, Pavia,
Italy, 7 Division of Gastroenterology and Digestive Endoscopy, Department of Gastroenterology, Humanitas Research
Hospital, Milano, Italy, 8 Department of Health Promotion Sciences, Maternal and Infant Care, Internal Medicine and Medical
Specialties (PROMISE), University of Palermo, Palermo, Italy, 9 COVID Unit, Department of Internal Medicine, National
Relevance and High Specialization Hospital Trust ARNAS Civico, Di Cristina, Benfratelli, Palermo, Italy
Introduction: Several studies and meta-analyses suggested the role of vitamin D 25OH
in preventing severe forms of coronavirus disease 2019 (COVID-19). However, the
evidence on the clinical benefits of vitamin D 25OH adequacy in patients hospitalized for
COVID-19 remain conflicting and speculative. We aimed to investigate the association
between vitamin D 25OH serum levels and mortality in hospitalized patients with
moderate to severe COVID-19.
Method: This prospective observational multicentre study included 361 consecutive
patients with moderate to severe COVID-19 admitted to the Italian hospitals involved in
the NUTRI-COVID19 trial from March to August 2020. For each patient, serum vitamin D
25OH levels were assessed 48 h since admission and classified as deficient (<20 ng/mL)
or adequate (≥20 ng/mL). We built a propensity score for low/adequate vitamin D 25OH
levels to balance the clinical and demographic properties of the cohort, which resulted
in 261 patients with good common support used for the survival..
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