{ 'indexed': { 'date-parts': [[2024, 11, 23]],
'date-time': '2024-11-23T05:32:07Z',
'timestamp': 1732339927539,
'version': '3.28.0'},
'reference-count': 0,
'publisher': 'Wiley',
'license': [ { 'start': { 'date-parts': [[2024, 11, 22]],
'date-time': '2024-11-22T00:00:00Z',
'timestamp': 1732233600000},
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'abstract': '<jats:p>Hyperinflammation is significant factor in long COVID, impacting over 65 million '
'post‐COVID‐19 individuals globally. Herbal remedies, including propolis, show promise in '
'reducing severity and pro‐inflammatory cytokines. However, the natural pharmacological role '
'of propolis in COVID‐19 management remains underexplored. Employing network pharmacology and '
"in silico techniques, we assessed propolis extract's potential in countering "
'SARS‐CoV‐2‐induced inflammation. We identified 80 flavonoids via LC‐MS/MS QTOF and employed '
'11 anti‐inflammatory drugs as references for inflammation target fishing. Utilizing in silico '
'techniques encompassing target fishing, molecular docking, and dynamics, we examined '
"propolis' effects. We identified 1105 gene targets connected to inflammation through multiple "
'validated target predictors. By integrating SARS‐CoV‐2 DEGs from GSE147507 with these '
'targets, we Identify precisely 25 inflammation‐COVID‐19‐associated propolis targets, '
'including STAT1, NOS2, CFB, EIF2K2, NPY5R, and BTK. Enrichment analyses highlighted primary '
'pharmacological pathways related to Epstein‐Barr virus infection and COVID‐19. Molecular '
'docking validated Isokaempferide, Iristectorigenin B, 3’‐Methoxypuerarin, Cosmosin, and '
'Baicalein‐7‐O‐β‐D glucopyranoside, which exhibited strong binding affinity and stability with '
'relevant genes. Moreover, our findings indicate that propolis ligands could potentially '
'suppress reactivation of Epstein‐Barr Virus infections in post‐COVID‐19 cases. These findings '
'highlight propolis as potential supplement to alleviate inflammation in COVID‐19 patients and '
'those with prolonged symptoms, requiring additional clinical validation for '
'confirmation.</jats:p>',
'DOI': '10.1002/cbdv.202401947',
'type': 'journal-article',
'created': { 'date-parts': [[2024, 11, 22]],
'date-time': '2024-11-22T14:04:14Z',
'timestamp': 1732284254000},
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'source': 'Crossref',
'is-referenced-by-count': 0,
'title': 'Uncovering the Therapeutic Potential of Propolis Extract in Managing Hyperinflammation and Long '
'COVID‐19: A Comprehensive Bioinformatics Study',
'prefix': '10.1002',
'author': [ { 'given': 'Isa',
'family': 'Anshori',
'sequence': 'first',
'affiliation': [ { 'name': 'Institut Teknologi Bandung School of Electrical Engineering and '
'Informatics Jl. Ganesa No. 10 40132 Bandung INDONESIA'}]},
{ 'given': 'Donny',
'family': 'Marcius',
'sequence': 'additional',
'affiliation': [ { 'name': 'Institut Teknologi Bandung School of Electrical Engineering and '
'Informatics Jalan Ganeca 10 Bandung 40132 Bandung INDONESIA'}]},
{ 'given': 'Putri Hawa',
'family': 'Syaifie',
'sequence': 'additional',
'affiliation': [ { 'name': 'Nano Center Indonesia Nano Center Indonesia Jalan PUSPIPTEK '
'15314 South Tangerang INDONESIA'}]},
{ 'given': 'Khalish Arsy Al Khairy',
'family': 'Siregar',
'sequence': 'additional',
'affiliation': [ { 'name': 'Universitas Muhammadiyah Kalimantan Timur Faculty of Pharmacy '
'Jl. Ir. H. Juanda No.15 75124 Samarinda INDONESIA'}]},
{ 'given': 'Luqman Abdan',
'family': 'Syakuran',
'sequence': 'additional',
'affiliation': [ { 'name': 'Nano Center Indonesia Nano Center Indonesia Jalan PUSPIPTEK '
'South Tangerang 15314 South Tangerang INDONESIA'}]},
{ 'given': 'Muhammad Miftah',
'family': 'Jauhar',
'sequence': 'additional',
'affiliation': [ { 'name': 'Nano Center Indonesia Nano Center Indonesia Jalan PUSPIPTEK '
'South Tangerang 15314 South Tangerang INDONESIA'}]},
{ 'given': 'Adzani Gaisani',
'family': 'Arda',
'sequence': 'additional',
'affiliation': [ { 'name': 'Nano Center Indonesia Nano Center Indonesia Jalan PUSPIPTEK '
'South Tangerang 15314 South Tangerang INDONESIA'}]},
{ 'given': 'Wervyan',
'family': 'Shalannanda',
'sequence': 'additional',
'affiliation': [ { 'name': 'Institut Teknologi Bandung School of Electrical Engineering and '
'Informatics Jalan Ganeca 10 40132 Bandung INDONESIA'}]},
{ 'given': 'Etik',
'family': 'Mardliyati',
'sequence': 'additional',
'affiliation': [ { 'name': 'National Research and Innovation Agency Republic of Indonesia '
'Research Center for Vaccine and Drug Jalan Raya Bogor 16911 '
'Cibinong INDONESIA'}]}],
'member': '311',
'published-online': {'date-parts': [[2024, 11, 22]]},
'container-title': 'Chemistry & Biodiversity',
'original-title': [],
'language': 'en',
'link': [ { 'URL': 'https://onlinelibrary.wiley.com/doi/pdf/10.1002/cbdv.202401947',
'content-type': 'unspecified',
'content-version': 'vor',
'intended-application': 'similarity-checking'}],
'deposited': { 'date-parts': [[2024, 11, 22]],
'date-time': '2024-11-22T14:04:16Z',
'timestamp': 1732284256000},
'score': 1,
'resource': {'primary': {'URL': 'https://onlinelibrary.wiley.com/doi/10.1002/cbdv.202401947'}},
'subtitle': [],
'short-title': [],
'issued': {'date-parts': [[2024, 11, 22]]},
'references-count': 0,
'alternative-id': ['10.1002/cbdv.202401947'],
'URL': 'http://dx.doi.org/10.1002/cbdv.202401947',
'relation': {},
'ISSN': ['1612-1872', '1612-1880'],
'subject': [],
'container-title-short': 'Chemistry & Biodiversity',
'published': {'date-parts': [[2024, 11, 22]]},
'assertion': [ { 'value': '2024-08-13',
'order': 0,
'name': 'received',
'label': 'Received',
'group': {'name': 'publication_history', 'label': 'Publication History'}},
{ 'value': '2024-11-19',
'order': 2,
'name': 'accepted',
'label': 'Accepted',
'group': {'name': 'publication_history', 'label': 'Publication History'}},
{ 'value': '2024-11-22',
'order': 3,
'name': 'published',
'label': 'Published',
'group': {'name': 'publication_history', 'label': 'Publication History'}}]}
