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All Studies   Meta Analysis    Recent:   
0 0.5 1 1.5 2+ Severe case 68% Improvement Relative Risk Vitamin D for COVID-19  Al-Anouti et al.  Sufficiency Are vitamin D levels associated with COVID-19 outcomes? Retrospective 288 patients in United Arab Emirates Lower severe cases with higher vitamin D levels (p=0.00072) c19early.org Al-Anouti et al., Nutrients, October 2021 Favors vitamin D Favors control

Associations between Genetic Variants in the Vitamin D Metabolism Pathway and Severity of COVID-19 among UAE Residents

Al-Anouti et al., Nutrients, doi:10.3390/nu13113680
Oct 2021  
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Vitamin D for COVID-19
8th treatment shown to reduce risk in October 2020
 
*, now known with p < 0.00000000001 from 119 studies, recognized in 7 countries.
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Retrospective 646 COVID-19 patients in the UAE, showing significant associations between genetic determinants of vitamin D metabolism and COVID-19 severity, and an association with vitamin D deficiency and COVID-19 severity. Patients in this study overlap with AlSafar. DOH/DQD/2020/538.
risk of severe case, 68.1% lower, RR 0.32, p < 0.001, high D levels 56 of 146 (38.4%), low D levels 52 of 142 (36.6%), adjusted per study, inverted to make RR<1 favor high D levels, odds ratio converted to relative risk, <12ng/ml vs. >20ng/ml.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Al-Anouti et al., 20 Oct 2021, retrospective, United Arab Emirates, peer-reviewed, 11 authors.
This PaperVitamin DAll
Associations between Genetic Variants in the Vitamin D Metabolism Pathway and Severity of COVID-19 among UAE Residents
Fatme Al-Anouti, Mira Mousa, Spyridon N Karras, William B Grant, Zainab Alhalwachi, Laila Abdel-Wareth, Maimunah Uddin, Nawal Alkaabi, Guan K Tay, Bassam Mahboub, Habiba Alsafar
Nutrients, doi:10.3390/nu13113680
Vitamin D has many effects on cells in the immune system. Many studies have linked low vitamin D status with severity of COVID-19. Genetic variants involved in vitamin D metabolism have been implicated as potential risk factors for severe COVID-19 outcomes. This study investigated how genetic variations in humans affected the clinical presentation of COVID-19. In total, 646 patients with SARS-CoV-2 infection were divided into two groups: noncritical COVID-19 (n = 453; 70.12%) and a critical group (n = 193; 29.87%). Genotype data on the GC, NADSYN1, VDR, and CYP2R1 genes along with data on serum 25-hydroxyvitamin D levels were compiled in patients admitted to a major hospital in the United Arab Emirates between April 2020 and January 2021. We identified 12 single-nucleotide polymorphisms associated with the critical COVID-19 condition: rs59241277, rs113574864, rs182901986, rs60349934, and rs113876500; rs4944076, rs4944997, rs4944998, rs4944979, and rs10898210; and rs11574018 and rs11574024. We report significant associations between genetic determinants of vitamin D metabolism and COVID-19 severity in the UAE population. Further research needed to clarify the mechanism of action against viral infection in vitamin D deficiency. These variants could be used with vaccination to manage the spread of SARS-CoV-2 and could be particularly valuable in populations in which vitamin D deficiency is common.
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