Conv. Plasma
Nigella Sativa

All vitamin D studies
Meta analysis
study COVID-19 treatment researchVitamin DVitamin D (more..)
Melatonin Meta
Metformin Meta
Azvudine Meta
Bromhexine Meta Molnupiravir Meta
Budesonide Meta
Colchicine Meta
Conv. Plasma Meta Nigella Sativa Meta
Curcumin Meta Nitazoxanide Meta
Famotidine Meta Paxlovid Meta
Favipiravir Meta Quercetin Meta
Fluvoxamine Meta Remdesivir Meta
Hydroxychlor.. Meta Thermotherapy Meta
Ivermectin Meta

All Studies   Meta Analysis    Recent:   
0 0.5 1 1.5 2+ Severe case 68% Improvement Relative Risk Vitamin D for COVID-19  Al-Anouti et al.  Sufficiency Are vitamin D levels associated with COVID-19 outcomes? Retrospective 288 patients in United Arab Emirates Lower severe cases with higher vitamin D levels (p=0.00072) Al-Anouti et al., Nutrients, October 2021 Favors vitamin D Favors control

Associations between Genetic Variants in the Vitamin D Metabolism Pathway and Severity of COVID-19 among UAE Residents

Al-Anouti et al., Nutrients, doi:10.3390/nu13113680
Oct 2021  
  Source   PDF   All   Meta
Vitamin D for COVID-19
8th treatment shown to reduce risk in October 2020
*, now known with p < 0.00000000001 from 119 studies, recognized in 7 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
3,800+ studies for 60+ treatments.
Retrospective 646 COVID-19 patients in the UAE, showing significant associations between genetic determinants of vitamin D metabolism and COVID-19 severity, and an association with vitamin D deficiency and COVID-19 severity. Patients in this study overlap with AlSafar. DOH/DQD/2020/538.
risk of severe case, 68.1% lower, RR 0.32, p < 0.001, high D levels 56 of 146 (38.4%), low D levels 52 of 142 (36.6%), adjusted per study, inverted to make RR<1 favor high D levels, odds ratio converted to relative risk, <12ng/ml vs. >20ng/ml.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Al-Anouti et al., 20 Oct 2021, retrospective, United Arab Emirates, peer-reviewed, 11 authors.
This PaperVitamin DAll
Associations between Genetic Variants in the Vitamin D Metabolism Pathway and Severity of COVID-19 among UAE Residents
Fatme Al-Anouti, Mira Mousa, Spyridon N Karras, William B Grant, Zainab Alhalwachi, Laila Abdel-Wareth, Maimunah Uddin, Nawal Alkaabi, Guan K Tay, Bassam Mahboub, Habiba Alsafar
Nutrients, doi:10.3390/nu13113680
Vitamin D has many effects on cells in the immune system. Many studies have linked low vitamin D status with severity of COVID-19. Genetic variants involved in vitamin D metabolism have been implicated as potential risk factors for severe COVID-19 outcomes. This study investigated how genetic variations in humans affected the clinical presentation of COVID-19. In total, 646 patients with SARS-CoV-2 infection were divided into two groups: noncritical COVID-19 (n = 453; 70.12%) and a critical group (n = 193; 29.87%). Genotype data on the GC, NADSYN1, VDR, and CYP2R1 genes along with data on serum 25-hydroxyvitamin D levels were compiled in patients admitted to a major hospital in the United Arab Emirates between April 2020 and January 2021. We identified 12 single-nucleotide polymorphisms associated with the critical COVID-19 condition: rs59241277, rs113574864, rs182901986, rs60349934, and rs113876500; rs4944076, rs4944997, rs4944998, rs4944979, and rs10898210; and rs11574018 and rs11574024. We report significant associations between genetic determinants of vitamin D metabolism and COVID-19 severity in the UAE population. Further research needed to clarify the mechanism of action against viral infection in vitamin D deficiency. These variants could be used with vaccination to manage the spread of SARS-CoV-2 and could be particularly valuable in populations in which vitamin D deficiency is common.
Ahn, Yu, Stolzenberg-Solomon, Simon, Mccullough et al., Genome-wide association study of circulating vitamin D levels, Hum. Mol. Genet, doi:10.1093/hmg/ddq155
Al Anouti, Chehadeh, Osman, Elghazali, Al Safar, Investigating the association of vitamin D metabolism genes CYP2R1, CYP24A1 and CYP27B1 with vitamin D status in young adult Emiratis, J. Food Nutr. Res
Alsafar, Grant, Hijazi, Uddin, Alkaabi et al., COVID-19 disease severity and death in relation to vitamin D status among SARS-CoV-2-positive UAE residents, Nutrients, doi:10.3390/nu13051714
Bouillon, Genetic and environmental determinants of vitamin D status, Lancet, doi:10.1016/S0140-6736(10)60635-6
Castillo, Costa, Barrios, Díaz, Miranda et al., Effect of calcifediol treatment and best available therapy versus best available therapy on intensive care unit admission and mortality among patients hospitalized for COVID-19: A pilot randomized clinical study, J. Steroid Biochem. Mol. Biol, doi:10.1016/j.jsbmb.2020.105751
Charoenngam, Shirvani, Reddy, Vodopivec, Apovian et al., Association of Vitamin D Status with Hospital Morbidity and Mortality in adult hospitalized patients with COVID-19, Endocr. Pract, doi:10.1016/j.eprac.2021.02.013
Chehadeh, Osman, Nazar, Jerman, Alghafri et al., Implication of genetic variants in overweight and obesity susceptibility among the young Arab population of the United Arab Emirates, Gene, doi:10.1016/j.gene.2020.144509
De Lucena, Da Silva Santos, De Lima, De Albuquerque Borborema, De Azevêdo et al., Mechanism of inflammatory response in associated comorbidities in COVID-19, Diabetes Metab. Syndr. Clin. Res. Rev
Di Maria, Latini, Borgiani, Novelli, Genetic variants of the human host influencing the coronavirus-associated phenotypes (SARS, MERS and COVID-19): Rapid systematic review and field synopsis, Hum. Genom, doi:10.1186/s40246-020-00280-6
Elkum, Alkayal, Noronha, Ali, Melhem et al., Vitamin D insufficiency in Arabs and South Asians positively associates with polymorphisms in GC and CYP2R1 genes, PLoS ONE, doi:10.1371/journal.pone.0113102
Enlund-Cerullo, Koljonen, Holmlund-Suila, Hauta-Alus, Rosendahl et al., Genetic Variation of the Vitamin D Binding Protein Affects Vitamin D Status and Response to Supplementation in Infants, J. Clin. Endocrinol. Metab, doi:10.1210/jc.2019-00630
Evans, Lippman, Shining Light on the COVID-19 Pandemic: A Vitamin D Receptor Checkpoint in Defense of Unregulated Wound Healing, Cell Metab, doi:10.1016/j.cmet.2020.09.007
Gallelli, Michniewicz, Cione, Squillace, Colosimo et al., 25-Hydroxy Vitamin D detection using different analytic methods in patients with migraine, J. Clin. Med, doi:10.3390/jcm8060895
Gasmi, Tippairote, Mujawdiya, Peana, Menzel et al., Micronutrients as immunomodulatory tools for COVID-19 management, Clin. Immunol, doi:10.1016/j.clim.2020.108545
Glinsky, Tripartite Combination of Candidate Pandemic Mitigation Agents: Vitamin, D.; Quercetin, and Estradiol Manifest Properties of Medicinal Agents for Targeted Mitigation of the COVID-19 Pandemic Defined by Genomics-Guided Tracing of SARS-CoV-2 Targets in Human Cells, Biomedicines
Grant, Lahore, Mcdonnell, Baggerly, French et al., Evidence that vitamin D supplementation could reduce risk of influenza and COVID-19 infections and deaths, Nutrients, doi:10.3390/nu12040988
Holick, Vitamin, Photobiology, metabolism, and clinical application, Endocrinology
Hossein-Nezhad, Spira, Holick, Influence of vitamin D status and vitamin D3 supplementation on genome wide expression of white blood cells: A randomized double-blind clinical trial, PLoS ONE, doi:10.1371/journal.pone.0058725
Jolliffe, Greiller, Mein, Hoti, Bakhsoliani et al., Vitamin D receptor genotype influences risk of upper respiratory infection, Br. J. Nutr, doi:10.1017/S000711451800209X
Karcioglu Batur, Hekim, The role of DBP gene polymorphisms in the prevalence of new coronavirus disease 2019 infection and mortality rate, J. Med Virol, doi:10.1002/jmv.26409
Kotur, Skakic, Klaassen, Gasic, Zukic et al., Association of Vitamin, D, Zinc and Selenium Related Genetic Variants With COVID-19 Disease Severity, Front. Nutr, doi:10.3389/fnut.2021.689419
Luciani, Caroleo, Cannataro, Mirra, D'agostino et al., Immunological Response to SARS-CoV-2 Is Sustained by Vitamin D: A Case Presentation of One-Year Follow-Up, Reports, doi:10.3390/reports4020018
Mcnally, Sampson, Matheson, Hutton, Little, Vitamin D receptor (VDR) polymorphisms and severe RSV bronchiolitis: A systematic review and meta-analysis, Pediatric Pulmonol, doi:10.1002/ppul.22877
Mercola, Grant, Wagner, Evidence regarding vitamin D and risk of COVID-19 and its severity, Nutrients, doi:10.3390/nu12113361
Rahmadhani, Zaharan, Mohamed, Moy, Jalaludin, The associations between VDR BsmI polymorphisms and risk of vitamin D deficiency, obesity and insulin resistance in adolescents residing in a tropical country, PLoS ONE, doi:10.1371/journal.pone.0178695
Safar, Chehadeh, Abdel-Wareth, Haq, Jelinek et al., Vitamin D receptor gene polymorphisms among Emirati patients with type 2 diabetes mellitus, J. Steroid Biochem. Mol. Biol
Sattar, Mcinnes, Mcmurray, Obesity is a risk factor for severe COVID-19 infection: Multiple potential mechanisms, Circulation, doi:10.1161/CIRCULATIONAHA.120.047659
Valle, Kim-Schulze, Huang, Beckmann, Nirenberg et al., An inflammatory cytokine signature predicts COVID-19 severity and survival, Nat. Med, doi:10.1038/s41591-020-1051-9
Weiss, Murdoch, Clinical course and mortality risk of severe COVID-19, Lancet, doi:10.1016/S0140-6736(20)30633-4
Xie, Wang, Bikle, Vitamin D Binding Protein, Total and Free Vitamin D Levels in Different Physiological and Pathophysiological Conditions, Front. Endocrinol, doi:10.3389/fendo.2020.00040
Zhao, Hu, Wang, Mao, Chen et al., Relationship between rs7041 polymorphism of GC gene and serum vitamin D status in Chinese women of childbearing age, J. Hyg. Res
Zhu, Ochalek, Kaufmann, Jones, Deluca, CYP2R1 is a major, but not exclusive, contributor to 25-hydroxyvitamin D production in vivo, doi:10.1073/pnas.1315006110
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Vaccines and treatments are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment, vaccine, or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop