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All Studies   Meta Analysis    Recent:   
0 0.5 1 1.5 2+ Severe case 68% Improvement Relative Risk Vitamin D for COVID-19  Al-Anouti et al.  Sufficiency Are vitamin D levels associated with COVID-19 outcomes? Retrospective 288 patients in United Arab Emirates Lower severe cases with higher vitamin D levels (p=0.00072) c19early.org Al-Anouti et al., Nutrients, October 2021 Favors vitamin D Favors control

Associations between Genetic Variants in the Vitamin D Metabolism Pathway and Severity of COVID-19 among UAE Residents

Al-Anouti et al., Nutrients, doi:10.3390/nu13113680
Oct 2021  
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Vitamin D for COVID-19
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Retrospective 646 COVID-19 patients in the UAE, showing significant associations between genetic determinants of vitamin D metabolism and COVID-19 severity, and an association with vitamin D deficiency and COVID-19 severity. Patients in this study overlap with AlSafar. DOH/DQD/2020/538.
risk of severe case, 68.1% lower, RR 0.32, p < 0.001, high D levels 56 of 146 (38.4%), low D levels 52 of 142 (36.6%), adjusted per study, inverted to make RR<1 favor high D levels, odds ratio converted to relative risk, <12ng/ml vs. >20ng/ml.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Al-Anouti et al., 20 Oct 2021, retrospective, United Arab Emirates, peer-reviewed, 11 authors.
This PaperVitamin DAll
Associations between Genetic Variants in the Vitamin D Metabolism Pathway and Severity of COVID-19 among UAE Residents
Fatme Al-Anouti, Mira Mousa, Spyridon N Karras, William B Grant, Zainab Alhalwachi, Laila Abdel-Wareth, Maimunah Uddin, Nawal Alkaabi, Guan K Tay, Bassam Mahboub, Habiba Alsafar
Nutrients, doi:10.3390/nu13113680
Vitamin D has many effects on cells in the immune system. Many studies have linked low vitamin D status with severity of COVID-19. Genetic variants involved in vitamin D metabolism have been implicated as potential risk factors for severe COVID-19 outcomes. This study investigated how genetic variations in humans affected the clinical presentation of COVID-19. In total, 646 patients with SARS-CoV-2 infection were divided into two groups: noncritical COVID-19 (n = 453; 70.12%) and a critical group (n = 193; 29.87%). Genotype data on the GC, NADSYN1, VDR, and CYP2R1 genes along with data on serum 25-hydroxyvitamin D levels were compiled in patients admitted to a major hospital in the United Arab Emirates between April 2020 and January 2021. We identified 12 single-nucleotide polymorphisms associated with the critical COVID-19 condition: rs59241277, rs113574864, rs182901986, rs60349934, and rs113876500; rs4944076, rs4944997, rs4944998, rs4944979, and rs10898210; and rs11574018 and rs11574024. We report significant associations between genetic determinants of vitamin D metabolism and COVID-19 severity in the UAE population. Further research needed to clarify the mechanism of action against viral infection in vitamin D deficiency. These variants could be used with vaccination to manage the spread of SARS-CoV-2 and could be particularly valuable in populations in which vitamin D deficiency is common.
References
Ahn, Yu, Stolzenberg-Solomon, Simon, Mccullough et al., Genome-wide association study of circulating vitamin D levels, Hum. Mol. Genet, doi:10.1093/hmg/ddq155
Al Anouti, Chehadeh, Osman, Elghazali, Al Safar, Investigating the association of vitamin D metabolism genes CYP2R1, CYP24A1 and CYP27B1 with vitamin D status in young adult Emiratis, J. Food Nutr. Res
Alsafar, Grant, Hijazi, Uddin, Alkaabi et al., COVID-19 disease severity and death in relation to vitamin D status among SARS-CoV-2-positive UAE residents, Nutrients, doi:10.3390/nu13051714
Bouillon, Genetic and environmental determinants of vitamin D status, Lancet, doi:10.1016/S0140-6736(10)60635-6
Castillo, Costa, Barrios, Díaz, Miranda et al., Effect of calcifediol treatment and best available therapy versus best available therapy on intensive care unit admission and mortality among patients hospitalized for COVID-19: A pilot randomized clinical study, J. Steroid Biochem. Mol. Biol, doi:10.1016/j.jsbmb.2020.105751
Charoenngam, Shirvani, Reddy, Vodopivec, Apovian et al., Association of Vitamin D Status with Hospital Morbidity and Mortality in adult hospitalized patients with COVID-19, Endocr. Pract, doi:10.1016/j.eprac.2021.02.013
Chehadeh, Osman, Nazar, Jerman, Alghafri et al., Implication of genetic variants in overweight and obesity susceptibility among the young Arab population of the United Arab Emirates, Gene, doi:10.1016/j.gene.2020.144509
De Lucena, Da Silva Santos, De Lima, De Albuquerque Borborema, De Azevêdo et al., Mechanism of inflammatory response in associated comorbidities in COVID-19, Diabetes Metab. Syndr. Clin. Res. Rev
Di Maria, Latini, Borgiani, Novelli, Genetic variants of the human host influencing the coronavirus-associated phenotypes (SARS, MERS and COVID-19): Rapid systematic review and field synopsis, Hum. Genom, doi:10.1186/s40246-020-00280-6
Elkum, Alkayal, Noronha, Ali, Melhem et al., Vitamin D insufficiency in Arabs and South Asians positively associates with polymorphisms in GC and CYP2R1 genes, PLoS ONE, doi:10.1371/journal.pone.0113102
Enlund-Cerullo, Koljonen, Holmlund-Suila, Hauta-Alus, Rosendahl et al., Genetic Variation of the Vitamin D Binding Protein Affects Vitamin D Status and Response to Supplementation in Infants, J. Clin. Endocrinol. Metab, doi:10.1210/jc.2019-00630
Evans, Lippman, Shining Light on the COVID-19 Pandemic: A Vitamin D Receptor Checkpoint in Defense of Unregulated Wound Healing, Cell Metab, doi:10.1016/j.cmet.2020.09.007
Gallelli, Michniewicz, Cione, Squillace, Colosimo et al., 25-Hydroxy Vitamin D detection using different analytic methods in patients with migraine, J. Clin. Med, doi:10.3390/jcm8060895
Gasmi, Tippairote, Mujawdiya, Peana, Menzel et al., Micronutrients as immunomodulatory tools for COVID-19 management, Clin. Immunol, doi:10.1016/j.clim.2020.108545
Glinsky, Tripartite Combination of Candidate Pandemic Mitigation Agents: Vitamin, D.; Quercetin, and Estradiol Manifest Properties of Medicinal Agents for Targeted Mitigation of the COVID-19 Pandemic Defined by Genomics-Guided Tracing of SARS-CoV-2 Targets in Human Cells, Biomedicines
Grant, Lahore, Mcdonnell, Baggerly, French et al., Evidence that vitamin D supplementation could reduce risk of influenza and COVID-19 infections and deaths, Nutrients, doi:10.3390/nu12040988
Holick, Vitamin, Photobiology, metabolism, and clinical application, Endocrinology
Hossein-Nezhad, Spira, Holick, Influence of vitamin D status and vitamin D3 supplementation on genome wide expression of white blood cells: A randomized double-blind clinical trial, PLoS ONE, doi:10.1371/journal.pone.0058725
Jolliffe, Greiller, Mein, Hoti, Bakhsoliani et al., Vitamin D receptor genotype influences risk of upper respiratory infection, Br. J. Nutr, doi:10.1017/S000711451800209X
Karcioglu Batur, Hekim, The role of DBP gene polymorphisms in the prevalence of new coronavirus disease 2019 infection and mortality rate, J. Med Virol, doi:10.1002/jmv.26409
Kotur, Skakic, Klaassen, Gasic, Zukic et al., Association of Vitamin, D, Zinc and Selenium Related Genetic Variants With COVID-19 Disease Severity, Front. Nutr, doi:10.3389/fnut.2021.689419
Luciani, Caroleo, Cannataro, Mirra, D'agostino et al., Immunological Response to SARS-CoV-2 Is Sustained by Vitamin D: A Case Presentation of One-Year Follow-Up, Reports, doi:10.3390/reports4020018
Mcnally, Sampson, Matheson, Hutton, Little, Vitamin D receptor (VDR) polymorphisms and severe RSV bronchiolitis: A systematic review and meta-analysis, Pediatric Pulmonol, doi:10.1002/ppul.22877
Mercola, Grant, Wagner, Evidence regarding vitamin D and risk of COVID-19 and its severity, Nutrients, doi:10.3390/nu12113361
Rahmadhani, Zaharan, Mohamed, Moy, Jalaludin, The associations between VDR BsmI polymorphisms and risk of vitamin D deficiency, obesity and insulin resistance in adolescents residing in a tropical country, PLoS ONE, doi:10.1371/journal.pone.0178695
Safar, Chehadeh, Abdel-Wareth, Haq, Jelinek et al., Vitamin D receptor gene polymorphisms among Emirati patients with type 2 diabetes mellitus, J. Steroid Biochem. Mol. Biol
Sattar, Mcinnes, Mcmurray, Obesity is a risk factor for severe COVID-19 infection: Multiple potential mechanisms, Circulation, doi:10.1161/CIRCULATIONAHA.120.047659
Valle, Kim-Schulze, Huang, Beckmann, Nirenberg et al., An inflammatory cytokine signature predicts COVID-19 severity and survival, Nat. Med, doi:10.1038/s41591-020-1051-9
Weiss, Murdoch, Clinical course and mortality risk of severe COVID-19, Lancet, doi:10.1016/S0140-6736(20)30633-4
Xie, Wang, Bikle, Vitamin D Binding Protein, Total and Free Vitamin D Levels in Different Physiological and Pathophysiological Conditions, Front. Endocrinol, doi:10.3389/fendo.2020.00040
Zhao, Hu, Wang, Mao, Chen et al., Relationship between rs7041 polymorphism of GC gene and serum vitamin D status in Chinese women of childbearing age, J. Hyg. Res
Zhu, Ochalek, Kaufmann, Jones, Deluca, CYP2R1 is a major, but not exclusive, contributor to 25-hydroxyvitamin D production in vivo, doi:10.1073/pnas.1315006110
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