Association of Vitamin D, Zinc and Selenium Related Genetic Variants With COVID-19 Disease Severity
Kotur et al.,
Association of Vitamin D, Zinc and Selenium Related Genetic Variants With COVID-19 Disease Severity,
Frontiers in Nutrition, doi:10.3389/fnut.2021.689419
Analysis of variants in genes significant for the status of vitamin D in 120 Serbian COVID-19 patients, showing that vitamin D related genetic variants DHCR7/NADSYN rs12785878 and CYP2R1 rs10741657 were associated with severe COVID-19 in adults.
Kotur et al., 4 Jun 2021, peer-reviewed, 13 authors.
Abstract: ORIGINAL RESEARCH
published: 04 June 2021
doi: 10.3389/fnut.2021.689419
Association of Vitamin D, Zinc and
Selenium Related Genetic Variants
With COVID-19 Disease Severity
Nikola Kotur 1 , Anita Skakic 1 , Kristel Klaassen 1 , Vladimir Gasic 1 , Branka Zukic 1 ,
Vesna Skodric-Trifunovic 2,3 , Mihailo Stjepanovic 2,3 , Zorica Zivkovic 4,5 , Olivera Ostojic 4 ,
Goran Stevanovic 3,6 , Lidija Lavadinovic 6 , Sonja Pavlovic 1 and Biljana Stankovic 1*
1
Laboratory for Molecular Biomedicine, Institute of Molecular Genetics and Genetic Engineering, University of Belgrade,
Belgrade, Serbia, 2 Clinic of Pulmonology, Clinical Center of Serbia, Belgrade, Serbia, 3 Medical Faculty, University of
Belgrade, Belgrade, Serbia, 4 Children’s Hospital for Lung Diseases and Tbc, MC Dr Dragisa Misovic, Belgrade, Serbia,
5
Faculty of Pharmacy Novi Sad, Business Academy, Novi Sad, Serbia, 6 Clinic for Infectious and Tropical Diseases, Clinical
Centre of Serbia, Belgrade, Serbia
Edited by:
Manja Zec,
University of Arizona, United States
Reviewed by:
Matina Kouvari,
Harokopio University, Greece
Janaina Donadio,
University of São Paulo, Brazil
*Correspondence:
Biljana Stankovic
biljana.stankovic@imgge.bg.ac.rs
Specialty section:
This article was submitted to
Nutrigenomics,
a section of the journal
Frontiers in Nutrition
Received: 31 March 2021
Accepted: 11 May 2021
Published: 04 June 2021
Citation:
Kotur N, Skakic A, Klaassen K,
Gasic V, Zukic B, Skodric-Trifunovic V,
Stjepanovic M, Zivkovic Z, Ostojic O,
Stevanovic G, Lavadinovic L,
Pavlovic S and Stankovic B (2021)
Association of Vitamin D, Zinc and
Selenium Related Genetic Variants
With COVID-19 Disease Severity.
Front. Nutr. 8:689419.
doi: 10.3389/fnut.2021.689419
Frontiers in Nutrition | www.frontiersin.org
Background: COVID-19 pandemic has proved to be an unrelenting health threat for
more than a year now. The emerging amount of data indicates that vitamin D, zinc and
selenium could be important for clinical presentation of COVID-19. Here, we investigated
association of genetic variants related to the altered level and bioavailability of vitamin D,
zinc and selenium with clinical severity of COVID-19.
Methods: We analyzed variants in genes significant for the status of vitamin D
(DHCR7/NADSYN1 rs12785878, GC rs2282679, CYP2R1 rs10741657, and VDR
rs2228570), zinc (PPCDC rs2120019) and selenium (DMGDH rs17823744) in 120
Serbian adult and pediatric COVID-19 patients using allelic discrimination. Furthermore,
we carried out comparative population genetic analysis among European and other
worldwide populations to investigate variation in allelic frequencies of selected variants.
Results: Study showed that DHCR7/NADSYN rs12785878 and CYP2R1 rs10741657
variants were associated with severe COVID-19 in adults (p = 0.03, p = 0.017,
respectively); carriers of DHCR7/NADSYN TG+GG and CYP2R1 GG genotypes had
0.21 and 5.9 the odds for developing severe disease, OR 0.21 (0.05–0.9) and OR 5.9
(1.4–25.2), respectively. There were no associations between selected genetic variants
and disease severity in pediatric patients. Comparative population genetic analysis
revealed that Serbian population had the lowest frequency of CYP2R1 rs10741657 G
allele compared to other non-Finish Europeans (0.58 compared to 0.69 and 0.66 in
Spanish and Italian population, respectively), suggesting that other populations should
also investigate the relationship of CYP2R1 variant and the COVID-19 disease course.
Conclusion: The results of the..
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