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Synbiotic for Prevention of SARS-Cov2 Infection in High Risk Hospital Staffs: A Randomized Controlled Trial

Ahanchian et al., Open Journal of Nursing, doi:10.4236/ojn.2021.115025 , IRCT20101020004976N6
May 2021  
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0 0.5 1 1.5 2+ Respiratory symptoms 73% Improvement Relative Risk Case 85% Probiotics  Ahanchian et al.  Prophylaxis  DB RCT Is prophylaxis with probiotics beneficial for COVID-19? Double-blind RCT 60 patients in Iran (July - August 2020) Fewer symptomatic cases (p=0.35) and cases (p=0.24), not sig. Ahanchian et al., Open J. Nursing, May 2021 Favors probiotics Favors control
Probiotics for COVID-19
17th treatment shown to reduce risk in March 2021
*, now known with p = 0.0000013 from 26 studies.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,200+ studies for 70+ treatments.
Small RCT 60 healthcare workers in Iran, showing lower cases with treatment but without statistical significance. Once daily oral synbiotic capsule (Lactocare®) containing 1 billion CFU L. (Lactobacillus) casei, L. rhamnosus, Streptococcus thermophilus, Bifidobacterium breve, L. acidophilus, Bifidobacterium infantis, L. bulgaricus, and Fructooligosacharide.
The immune effects of probiotics are strain-specific.
respiratory symptoms, 73.3% lower, RR 0.27, p = 0.35, treatment 1 of 29 (3.4%), control 4 of 31 (12.9%), NNT 11.
risk of case, 85.3% lower, RR 0.15, p = 0.24, treatment 0 of 29 (0.0%), control 3 of 31 (9.7%), NNT 10, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Ahanchian et al., 31 May 2021, Double Blind Randomized Controlled Trial, placebo-controlled, Iran, peer-reviewed, 14 authors, study period July 2020 - August 2020, trial IRCT20101020004976N6.
This PaperProbioticsAll
Synbiotic for Prevention of SARS-Cov2 Infection in High Risk Hospital Staffs: A Randomized Controlled Trial
Hamid Ahanchian, Alireza Ranjbar, Hamidreza Reihani, Arash Peivandi Yazdi, Seyed Ali Jafari, Mohammad Ali Kiani, Rana Tafrishi, Nasrinsadat Motevalli Haghi, Nasrin Moazzen, Ali Khalshour, Faezeh Mirzaei, Zahra Abbasi Shaye, Sadegh Ebrahimi, Hamidreza Kianifar
Open Journal of Nursing, doi:10.4236/ojn.2021.115025
Introduction: COVID-19 pandemic caused by the novel coronavirus SARS-CoV-2 increasingly involves people worldwide. Probiotics can improve immune system functions via different mechanisms. We proposed that Synbiotic Lactocare ® may also reduce SARS-Cov2 infection in high-risk medical staff working in COVID-19 hospital wards. Method: In a randomized, controlled trial, 60 hospital staff without any history of clinical or laboratory evidence of SARS-Cov2 infection were received either once-daily oral synbiotic capsule (Lactocare ® ) that contains 1 billion CFU/Cap of L. (Lactobacillus) casei, L.
Conflicts of Interest The authors declare no conflicts of interest regarding the publication of this paper.
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