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Probiotics for preventing acute upper respiratory tract infections

Hao et al., Cochrane Database of Systematic Reviews, doi:10.1002/14651858.CD006895.pub3
Feb 2015  
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Meta analysis of 12 RCTs with 3,720 patients showing probiotics reduced acute upper respiratory tract infections.
Currently there are 23 probiotics studies and meta analysis shows:
Mortality61% lower [37‑76%]
Ventilation38% lower [-87‑79%]
ICU admission21% lower [-20‑48%]
Hospitalization13% lower [5‑21%]
Cases31% fewer [-1‑53%]
Hao et al., 3 Feb 2015, preprint, 3 authors.
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This PaperProbioticsAll
Probiotics for preventing acute upper respiratory tract infections
Qiukui Hao, Bi Rong Dong, Taixiang Wu
Cochrane Database of Systematic Reviews, doi:10.1002/14651858.cd006895.pub3
Trusted evidence. Informed decisions. Better health.
Cochrane Library Trusted evidence. Informed decisions. Better health. Cochrane Database of Systematic Reviews Age: aged 18 to 65 Inclusion criteria: healthy volunteers Exclusion criteria: known intolerance or allergy to any ingredient included in the formulations, medically treated allergy, current treatment for severe gastrointestinal disorders, pregnancy or lactation, vaccination against influenza within the last 12 months or smoking Interventions Treatment group: Lactobacillus plantarum HEAL 9 and Lactobacillus paracasei 8700:2 (1 × 10 9 CFU/day) for 12 weeks Control group: placebo: an identical-looking and tasting control product Cochrane Database of Systematic Reviews 3. Symptom score (burden) Notes - Risk of bias C O N T R I B U T I O N S O F A U T H O R S Qiukui Hao (QH) searched for trials, assessed the quality of trials, extracted data, analysed data and dra ed the review. Bi Rong Dong (BD) advised and assisted in writing the protocol and the review, searched for trials and developed the review. Cochrane Library Trusted evidence. Informed decisions. Better health. Cochrane Database of Systematic Reviews Taixiang Wu (TW) contributed to the development of the methods of the review and assisted with data extraction and analysis. D E C L A R A T I O N S O F I N T E R E S T Qiukui Hao: none known. Bi Rong Dong: none known. Taixiang Wu: none known. S O U R C E S O F S U P P O R T Internal sources • Chinese Cochrane Center, West China Hospital of..
Agustina, Kok, Van De Rest, Fahmida, Firmansyah et al., Early dietary intervention with a mixture of prebiotic oligosaccharides reduces the incidence of allergic manifestations and infections during the first two years of life, Journal of Nutrition
Gil-Campos, López, Rodriguez-Benítez, Romero, Roncero et al., Consumption of a fermented dairy product containing the probiotic Lactobacillus casei DN-114001 reduces the duration of respiratory infections in the elderly in a randomised controlled trial, International Journal of Sport Nutrition and Exercise Metabolism
Gutierrez-Castrellon ; Gutierrez-Castrellon, Lopez-Velazquez, Diaz-Garcia, Jimenez-Gutierrez, Mancilla-Ramirez et al., Long-term safety and impact on infection rates of postnatal probiotic and prebiotic (synbiotic) treatment: randomized, double-blind, placebo-controlled trial, International Journal of Sport Nutrition & Exercise Metabolism, doi:10.1002/14651858.CD000022.pub2
H A R A C T E R I S T I C S O F S T U D I E S, with 2 parallel arms Method of randomisation: not clearly stated Blinding: double-blind
Hao, Lu, Dong, Huang, Wu, Probiotics for preventing acute upper respiratory tract infections, Cochrane Database of Systematic Reviews, doi:10.1002/14651858.CD006895.pub2
Link-Amster, Rochat, Saudan, Mignot, Aeschlimann et al., Lactobacillus rhamnosus GG supplementation for preventing respiratory infections in children: a meta-analysis of randomized, placebo-controlled trials, Journal of Pediatric Gastroenterology and Nutrition
Lu 2008 Lu, Dong, Huang, Wu, Probiotics for preventing acute upper respiratory tract infections, Cochrane Database of Systematic Reviews, doi:10.1002/14651858.CD006895
Othman ; Othman, Meilson, Alfirevic, Pelto, Isolauri et al., Probiotic bacteria down-regulate the milk-induced inflammatory response in milk-hypersensitive subjects but have an immunostimulatory e ect in healthy subjects, Cochrane Database of Systematic Reviews, doi:10.1002/14651858
Perdigon, Alvarez, Rachid, Aguero, Gobbato et al., New scientific paradigms for probiotics and prebiotics, Journal of Clinical Gastroenterology
Pierro, Colombo, Zanvit, Risso, Rottoli, Use of Streptococcus salivarius K12 in the prevention of streptococcal and viral pharyngotonsillitis in children, Drug, Healthcare and Patient Safety
Valente 2009 Valente, Jr, Alexander, Tomas, Evancho-Chapman et al., Immunologic function in the elderly a er injury--the neutrophil and innate immunity, Journal of Trauma
Witard ; Witard, Turner, Jackman, Tipton, Jeukendrup et al., High-intensity training reduces CD8+ T-cell redistribution in response to exercise, Medicine and Science in Sports and Exercise
Wu 2007 Wu, Liu, The concepts, design, practice and reports of allocation concealment and blinding, Chinese Journal of Evidence-Based Medicine
Yamanaka, Hotomi, Shimada, Togawa, Immunological deficiency in "otitis-prone" children, Annals of the New York Academy of Sciences
Yasui 1999 Yasui, Kiyosima, Hori, Shida, Protection against influenza infection of mice fed Bifido bacterium breve YIT 4064, Clinical and Diagnostic Laboratory Immunology
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