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0 0.5 1 1.5 2+ PASC, sleep 17% Improvement Relative Risk PASC, healthy lifestyle 49% Hospitalization, healthy l.. 78% Sleep  Wang et al.  Prophylaxis  LONG COVID Does better sleep reduce the risk of Long COVID (PASC)? Prospective study of 1,981 patients in the USA (Apr 2020 - Nov 2021) Lower PASC with higher quality sleep (p=0.0084) Wang et al., JAMA Internal Medicine, Feb 2023 Favors good sleep Favors control

Adherence to Healthy Lifestyle Prior to Infection and Risk of Post–COVID-19 Condition

Wang et al., JAMA Internal Medicine, doi:10.1001/jamainternmed.2022.6555
Feb 2023  
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Sleep for COVID-19
16th treatment shown to reduce risk in March 2021
*, now known with p = 0.0000000019 from 15 studies.
Lower risk for mortality, hospitalization, and cases.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
3,800+ studies for 60+ treatments.
Prospective analysis of 32,249 women, showing lower risk of PASC with a healthy lifestyle, in a dose-dependent manner. Participants with 5 or 6 healthy lifestyle factors had significantly lower COVID-19 hospitalization and PASC. BMI and sleep were independently associated with risk of PASC.
Study covers diet, exercise, and sleep.
risk of PASC, 17.0% lower, RR 0.83, p = 0.008, higher quality sleep 541 of 1,334 (40.6%), lower quality sleep 330 of 647 (51.0%), NNT 9.6, adjusted per study, 7-9 hours vs. <7 or >9, multivariable, model b.
risk of PASC, 49.0% lower, RR 0.51, p = 0.002, higher quality sleep 188, lower quality sleep 66, 5 or 6 healthy lifestyle factors vs. 0.
risk of hospitalization, 78.1% lower, RR 0.22, p = 0.006, higher quality sleep 5 of 188 (2.7%), lower quality sleep 8 of 66 (12.1%), NNT 11, 5 or 6 healthy lifestyle factors vs. 0.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Wang et al., 6 Feb 2023, prospective, USA, peer-reviewed, survey, mean age 64.7, 8 authors, study period April 2020 - November 2021. Contact: siwenwang@hsph.harvard.
This PaperSleepAll
Adherence to Healthy Lifestyle Prior to Infection and Risk of Post–COVID-19 Condition
MD Siwen Wang, PhD Yanping Li, MS Yiyang Yue, ScD Changzheng Yuan, ScD Jae Hee Kang, MD, ScD Jorge E Chavarro, PhD Shilpa N Bhupathiraju, PhD Andrea L Roberts
JAMA Internal Medicine, doi:10.1001/jamainternmed.2022.6555
Few modifiable risk factors for post-COVID-19 condition (PCC) have been identified. OBJECTIVE To investigate the association between healthy lifestyle factors prior to SARS-CoV-2 infection and risk of PCC. DESIGN, SETTING, AND PARTICIPANTS In this prospective cohort study, 32 249 women in the Nurses' Health Study II cohort reported preinfection lifestyle habits in 2015 and 2017. Healthy lifestyle factors included healthy body mass index (BMI, 18.5-24.9; calculated as weight in kilograms divided by height in meters squared), never smoking, at least 150 minutes per week of moderate to vigorous physical activity, moderate alcohol intake (5 to 15 g/d), high diet quality (upper 40% of Alternate Healthy Eating Index-2010 score), and adequate sleep (7 to 9 h/d). MAIN OUTCOMES AND MEASURES SARS-CoV-2 infection (confirmed by test) and PCC (at least 4 weeks of symptoms) were self-reported on 7 periodic surveys administered from April 2020 to November 2021. Among participants with SARS-CoV-2 infection, the relative risk (RR) of PCC in association with the number of healthy lifestyle factors (0 to 6) was estimated using Poisson regression and adjusting for demographic factors and comorbidities. RESULTS A total of 1981 women with a positive SARS-CoV-2 test over 19 months of follow-up were documented. Among those participants, mean age was 64.7 years (SD, 4.6; range, 55-75); 97.4% (n = 1929) were White; and 42.8% (n = 848) were active health care workers. Among these, 871 (44.0%) developed PCC. Healthy lifestyle was associated with lower risk of PCC in a dose-dependent manner. Compared with women without any healthy lifestyle factors, those with 5 to 6 had 49% lower risk (RR, 0.51; 95% CI, 0.33-0.78) of PCC. In a model mutually adjusted for all lifestyle factors, BMI and sleep were independently associated with risk of PCC (BMI, 18.5-24.9 vs others, RR, 0.85; 95% CI, 0.73-1.00, P = .046; sleep, 7-9 h/d vs others, RR, 0.83; 95% CI, 0.72-0.95, P = .008). If these associations were causal, 36.0% of PCC cases would have been prevented if all participants had 5 to 6 healthy lifestyle factors (population attributable risk percentage, 36.0%; 95% CI, 14.1%-52.7%). Results were comparable when PCC was defined as symptoms of at least 2-month duration or having ongoing symptoms at the time of PCC assessment. CONCLUSIONS AND RELEVANCE In this prospective cohort study, pre-infection healthy lifestyle was associated with a substantially lower risk of PCC. Future research should investigate whether lifestyle interventions may reduce risk of developing PCC or mitigate symptoms among individuals with PCC or possibly other postinfection syndromes.
Ahmadi, Huang, Inan-Eroglu, Hamer, Stamatakis, Lifestyle risk factors and infectious disease mortality, including COVID-19, among middle aged and older adults: evidence from a community-based cohort study in the United Kingdom, Brain Behav Immun, doi:10.1016/j.bbi.2021.04.022
Akbaraly, Shipley, Ferrie, Long-term adherence to healthy dietary guidelines and chronic inflammation in the prospective Whitehall II study, Am J Med, doi:10.1016/j.amjmed.2014.10.002
Al-Delaimy, Willett, Measurement of tobacco smoke exposure: comparison of toenail nicotine biomarkers and self-reports, Cancer Epidemiol Biomarkers Prev, doi:10.1158/1055-9965.EPI-07-2695
Aldabal, Bahammam, Metabolic, endocrine, and immune consequences of sleep deprivation, Open Respir Med J, doi:10.2174/1874306401105010031
Antonelli, Pujol, Spector, Ourselin, Steves, Risk of long COVID associated with delta versus omicron variants of SARS-CoV-2, Lancet, doi:10.1016/S0140-6736(22)00941-2
Azzolini, Levi, Sarti, Association between BNT162b2 vaccination and long COVID after infections not requiring hospitalization in health care workers, JAMA, doi:10.1001/jama.2022.11691?utm_campaign=articlePDF%26utm_medium=articlePDFlink%26utm_source=articlePDF%26utm_content=jamainternmed.2022.6555
Bao, Bertoia, Lenart, Origin, methods, and evolution of the three Nurses' Health Studies, Am J Public Health, doi:10.2105/AJPH.2016.303338
Beavers, Brinkley, Nicklas, Effect of exercise training on chronic inflammation, Clin Chim Acta, doi:10.1016/j.cca.2010.02.069
Behan, Behan, Gow, Cavanagh, Gillespie, Enteroviruses and postviral fatigue syndrome, Ciba Found Symp, doi:10.1002/9780470514382.ch9
Bouton, Why behavior change is difficult to sustain, Prev Med, doi:10.1016/j.ypmed.2014.06.010
Childs, Calder, Miles, Diet and immune function, Nutrients, doi:10.3390/nu11081933
Chiuve, Fung, Rimm, Reproducibility and validity of a self-administered physical activity questionnaire, Int J Epidemiol, doi:10.1093/sleep/27.3.440
Chiva-Blanch, Badimon, Benefits and risks of moderate alcohol consumption on cardiovascular disease: current findings and controversies, Nutrients, doi:10.3390/nu12010108
Choutka, Jansari, Hornig, Iwasaki, Author correction: unexplained post-acute infection syndromes, Nat Med, doi:10.1038/s41591-022-01952-7
Cobre, Surek, Vilhena, Influence of foods and nutrients on COVID-19 recovery: a multivariate analysis of data from 170 countries using a generalized linear model, Clin Nutr, doi:10.1016/j.clnu.2021.03.018
Corrao, Bagnardi, Zambon, Vecchia, A meta-analysis of alcohol consumption and the risk of 15 diseases, Prev Med, doi:10.1016/j.ypmed.2003.11.027
Costenbader, Karlson, Cigarette smoking and autoimmune disease: what can we learn from epidemiology?, Lupus, doi:10.1177/0961203306069344
Crook, Raza, Nowell, Young, Long COVID-mechanisms, risk factors, and management, BMJ, doi:10.1136/bmj.n1648
Evans, Mcauley, Harrison, Physical, cognitive, and mental health impacts of COVID-19 after hospitalisation (PHOSP-COVID): a UK multicentre, prospective cohort study, Lancet Respir Med, doi:10.1016/S2213-2600(21)00383-0
For, Control, Nearly one in five american adults who have had COVID-19 still have "long COVID
Go, COVID-19 for health professionals: post COVID-19 condition
Goldhaber, Fanikos, Stämpfli, Anderson, How cigarette smoke skews immune responses to promote infection, lung disease and cancer, Nat Rev Immunol, doi:10.1038/nri2530
Hamer, Kivimäki, Gale, Batty, Lifestyle risk factors, inflammatory mechanisms, and COVID-19 hospitalization: a community-based cohort study of 387,109 adults in UK, Brain Behav Immun, doi:10.1016/j.bbi.2020.05.059
Huang, Goodman, Li, COVID-19 and diabetes mellitus: from pathophysiology to clinical management, Nat Rev Endocrinol, doi:10.1038/s41574-020-00435-4
Huang, Tobias, Hruby, Rifai, Tworoger et al., An increase in dietary quality is associated with favorable plasma biomarkers of the brain-adipose axis in apparently healthy US women, J Nutr, doi:10.3945/jn.115.229666
Ibarra-Coronado, Pantaleón-Martínez, Velazquéz-Moctezuma, The bidirectional relationship between sleep and immunity against infections, J Immunol Res, doi:10.1155/2015/678164
Imhof, Froehlich, Brenner, Boeing, Pepys et al., Effect of alcohol consumption on systemic markers of inflammation, Lancet, doi:10.1016/S0140-6736(00)04170-2
Iqbal, Lam, Sounderajah, Clarke, Ashrafian et al., Characteristics and predictors of acute and chronic post-COVID syndrome: a systematic review and meta-analysis, EClinicalMedicine, doi:10.1016/j.eclinm.2021.100899
Khunti, Davies, Kosiborod, Nauck, Long COVID-metabolic risk factors and novel therapeutic management, Nat Rev Endocrinol, doi:10.1038/s41574-021-00495-0
Korakas, Ikonomidis, Kousathana, Obesity and COVID-19: immune and metabolic derangement as a possible link to adverse clinical outcomes, Am J Physiol Endocrinol Metab, doi:10.1152/ajpendo.00198.2020
Lee, Chakladar, Li, Tobacco, but not nicotine and flavor-less electronic cigarettes, induces ACE2 and immune dysregulation, Int J Mol Sci, doi:10.3390/ijms21155513
Lee, Taneja, Vassallo, Cigarette smoking and inflammation: cellular and molecular mechanisms, J Dent Res, doi:10.1177/0022034511421200
Li, Pan, Wang, Impact of healthy lifestyle factors on life expectancies in the US population, doi:10.1161/CIRCULATIONAHA.117.032047
Lu, Solomon, Costenbader, Keenan, Chibnik et al., Alcohol consumption and markers of inflammation in women with preclinical rheumatoid arthritis, Arthritis Rheum, doi:10.1002/art.27739
Manzel, Muller, Hafler, Erdman, Linker et al., Role of "Western diet" in inflammatory autoimmune diseases, Curr Allergy Asthma Rep, doi:10.1007/s11882-013-0404-6
Mehandru, Merad, Pathological sequelae of long-haul COVID, Nat Immunol, doi:10.1038/s41590-021-01104-y
Milner, Beck, The impact of obesity on the immune response to infection, Proc Nutr Soc, doi:10.1017/S0029665112000158
Molina, Happel, Zhang, Kolls, Nelson, Focus on: alcohol and the immune system, Alcohol Res Health
Monteiro, Azevedo, Chronic inflammation in obesity and the metabolic syndrome, Mediators Inflamm, doi:10.1155/2010/289645
Mullington, Simpson, Meier-Ewert, Haack, Sleep loss and inflammation, Best Pract Res Clin Endocrinol Metab, doi:10.1016/j.beem.2010.08.014
Munblit, Hara, Akrami, Perego, Olliaro et al., Long COVID: aiming for a consensus, Lancet Respir Med, doi:10.1016/S2213-2600(22)00135-7
Nalbandian, Sehgal, Gupta, Post-acute COVID-19 syndrome, Nat Med, doi:10.1038/s41591-021-01283-z
Pinto, Roschel, De, Pinto, Physical inactivity and sedentary behavior: overlooked risk factors in autoimmune rheumatic diseases?, Autoimmun Rev, doi:10.1016/j.autrev.2017.05.001
Pischon, Hankinson, Hotamisligil, Rifai, Rimm, Leisure-time physical activity and reduced plasma levels of obesity-related inflammatory markers, Obes Res, doi:10.1038/oby.2003.145
Prasannan, Heightman, Hillman, Impaired exercise capacity in post-COVID-19 syndrome: the role of VWF-ADAMTS13 axis, Blood Adv, doi:10.1182/bloodadvances.2021006944
Rothman, Greenland, Lash, Modern Epidemiology
Subramanian, Nirantharakumar, Hughes, Symptoms and risk factors for long COVID in non-hospitalized adults, Nat Med, doi:10.1038/s41591-022-01909-w
Sudre, Murray, Varsavsky, Attributes and predictors of long COVID, Nat Med, doi:10.1038/s41591-021-01292-y
Tenforde, Kim, Lindsell, Symptom duration and risk factors for delayed return to usual health among outpatients with COVID-19 in a multistate health care systems network-United States, March, MMWR Morb Mortal Wkly Rep, doi:10.15585/mmwr.mm6930e1
Thompson, Williams, Walker, Long COVID burden and risk factors in 10 UK longitudinal studies and electronic health records, Nat Commun, doi:10.1038/s41467-022-30836-0
Troy, Hunter, Manson, Colditz, Stampfer et al., The validity of recalled weight among younger women, Int J Obes Relat Metab Disord
Versini, Jeandel, Rosenthal, Shoenfeld, Zielinski et al., Obesity in autoimmune diseases: not a passive bystander, Autoimmun Rev, doi:10.3389/fimmu.2019.01827
Wang, Quan, Chavarro, Associations of depression, anxiety, worry, perceived stress, and loneliness prior to infection with risk of post-COVID-19 conditions, JAMA Psychiatry, doi:10.1001/jamapsychiatry.2022.2640?utm_campaign=articlePDF%26utm_medium=articlePDFlink%26utm_source=articlePDF%26utm_content=jamainternmed.2022.6555
Watson, Badr, Belenky, Consensus Conference Panel. Joint Consensus Statement of the American Academy of Sleep Medicine and Sleep Research Society on the recommended amount of sleep for a healthy adult: methodology and discussion, Sleep, doi:10.5665/sleep.4886
Woods, Ceddia, Wolters, Evans, Lu et al., Effects of 6 months of moderate aerobic exercise training on immune function in the elderly, Mech Ageing Dev, doi:10.1016/S0047-6374(99)00014-7
Yu, Rohli, Yang, Jia, Impact of obesity on COVID-19 patients, J Diabetes Complications, doi:10.1016/j.jdiacomp.2020.107817
Yuan, Spiegelman, Rimm, Relative validity of nutrient intakes assessed by questionnaire, 24-hour recalls, and diet records as compared with urinary recovery and plasma concentration biomarkers: findings for women, Am J Epidemiol, doi:10.1093/aje/kwx328
Yuan, Spiegelman, Rimm, Validity of a dietary questionnaire assessed by comparison with multiple weighed dietary records or 24-hour recalls, Am J Epidemiol, doi:10.1093/aje/kww104
Zhang, Xu, Xie, Poor-sleep is associated with slow recovery from lymphopenia and an increased need for ICU care in hospitalized patients with COVID-19: a retrospective cohort study, Brain Behav Immun, doi:10.1016/j.bbi.2020.05.075
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