Preprocedural Viral Load Effects of Oral Antiseptics on SARS-CoV-2 in Patients with COVID-19: A Systematic Review

{ 'indexed': {'date-parts': [[2023, 6, 14]], 'date-time': '2023-06-14T04:20:28Z', 'timestamp': 1686716428194}, 'reference-count': 144, 'publisher': 'MDPI AG', 'issue': '6', 'license': [ { 'start': { 'date-parts': [[2023, 6, 12]], 'date-time': '2023-06-12T00:00:00Z', 'timestamp': 1686528000000}, 'content-version': 'vor', 'delay-in-days': 0, 'URL': 'https://creativecommons.org/licenses/by/4.0/'}], 'content-domain': {'domain': [], 'crossmark-restriction': False}, 'abstract': '<jats:p>(1) There are limited clinical trials to support the effectiveness of mouth rinses ' 'when used as a preprocedural rinse against severe acute respiratory syndrome coronavirus 2 ' '(SARS-CoV-2). This systematic review aims to evaluate the efficacy of antiseptic mouth rinses ' 'as a preprocedural rinse in reducing SARS-CoV-2 oral viral load in-vivo. (2) Methods: A ' 'literature search was conducted through November 2022 for the following databases: PubMed, ' 'Web of Science, Cochrane Library, and Google Scholar. The evaluated outcomes were ' 'quantitative changes in viral load and the statistical significance of that change after ' 'using antiseptic mouth rinses. (3) Results: 14 randomized controlled trials (RCT) were ' 'selected for risk of bias assessment and data extraction. (4) Conclusion: Within the limits ' 'of this systematic review, preprocedural mouth rinses may significantly reduce SARS-CoV-2 in ' 'the mouth, thus, reducing the viral particles available for airborne dispersion. ' 'Preprocedural mouth rinses may be an effective strategy for reducing airborne SARS-CoV-2 ' 'dispersion in the environment. Their use may be a preventive strategy to reduce the spread of ' 'COVID-19 in selected medical and healthcare facilities, including dental clinics. Potential ' 'preprocedural mouth rinses are identified for use as an integral part of safe practice for ' 'healthcare protocols. This systematic review was registered with the National Institute for ' 'Health Research, international prospective register of systematic reviews (PROSPERO): ' 'CRD42022315177.</jats:p>', 'DOI': '10.3390/biomedicines11061694', 'type': 'journal-article', 'created': {'date-parts': [[2023, 6, 13]], 'date-time': '2023-06-13T05:35:30Z', 'timestamp': 1686634530000}, 'page': '1694', 'source': 'Crossref', 'is-referenced-by-count': 0, 'title': 'Preprocedural Viral Load Effects of Oral Antiseptics on SARS-CoV-2 in Patients with COVID-19: A ' 'Systematic Review', 'prefix': '10.3390', 'volume': '11', 'author': [ { 'ORCID': 'http://orcid.org/0000-0001-8503-2279', 'authenticated-orcid': False, 'given': 'Miriam', 'family': 'Ting', 'sequence': 'first', 'affiliation': [ { 'name': 'Department of Periodontics, University of Pennsylvania, ' 'Philadelphia, PA 19104, USA'}, { 'name': 'General Practice Residency, Albert Einstein Medical Center, ' 'Philadelphia, PA 19141, USA'}, {'name': 'Think Dental Learning Institute, Paoli, PA 19301, USA'}]}, { 'ORCID': 'http://orcid.org/0000-0003-1009-244X', 'authenticated-orcid': False, 'given': 'Alex', 'family': 'Dahlkemper', 'sequence': 'additional', 'affiliation': [ { 'name': 'General Practice Residency, Albert Einstein Medical Center, ' 'Philadelphia, PA 19141, USA'}]}, { 'given': 'Jeremy J.', 'family': 'Schwartz', 'sequence': 'additional', 'affiliation': [ { 'name': 'General Practice Residency, Albert Einstein Medical Center, ' 'Philadelphia, PA 19141, USA'}]}, { 'given': 'Manzel', 'family': 'Woodfork', 'sequence': 'additional', 'affiliation': [ { 'name': 'General Practice Residency, Albert Einstein Medical Center, ' 'Philadelphia, PA 19141, USA'}]}, { 'ORCID': 'http://orcid.org/0000-0003-3348-8893', 'authenticated-orcid': False, 'given': 'Jon B.', 'family': 'Suzuki', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Graduate Periodontics, University of Maryland, ' 'Baltimore, MD 21201, USA'}, { 'name': 'Department of Graduate Prosthodontics, University of Washington, ' 'Seattle, WA 98015, USA'}, { 'name': 'Department of Graduate Periodontics, Nova Southeastern ' 'University, Ft. Lauderdale, FL 33314, USA'}]}], 'member': '1968', 'published-online': {'date-parts': [[2023, 6, 12]]}, 'reference': [ { 'key': 'ref_1', 'doi-asserted-by': 'crossref', 'first-page': '2063', 'DOI': '10.1056/NEJMc2009324', 'article-title': 'Droplets and Aerosols in the Transmission of SARS-CoV-2', 'volume': '382', 'author': 'Meselson', 'year': '2020', 'journal-title': 'N. Engl. J. Med.'}, { 'key': 'ref_2', 'doi-asserted-by': 'crossref', 'first-page': '1177', 'DOI': '10.1056/NEJMc2001737', 'article-title': 'SARS-CoV-2 Viral Load in Upper Respiratory Specimens of Infected ' 'Patients', 'volume': '382', 'author': 'Zou', 'year': '2020', 'journal-title': 'N. Engl. J. Med.'}, { 'key': 'ref_3', 'doi-asserted-by': 'crossref', 'unstructured': 'Ting, M., and Suzuki, J.B. (2021). SARS-CoV-2: Overview and Its Impact ' 'on Oral Health. Biomedicines, 9.', 'DOI': '10.3390/biomedicines9111690'}, { 'key': 'ref_4', 'unstructured': 'Ting, M., and Suzuki, J.B. (2022). 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