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Repurposing 0.5% povidone iodine solution in otorhinolaryngology practice in Covid 19 pandemic

Khan et al., Am J Otolaryngol, doi:10.1016/j.amjoto.2020.102618
Jun 2020  
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PVP-I for COVID-19
13th treatment shown to reduce risk in February 2021
 
*, now with p = 0.000000004 from 21 studies.
Lower risk for mortality, cases, and viral clearance.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,400+ studies for 79 treatments. c19early.org
Study of the use of PVP-I gargles and nasal drops before ENT appointments finding good tolerability.
Khan et al., 18 Jun 2020, peer-reviewed, 3 authors.
This PaperPovidone-Iod..All
Repurposing 0.5% povidone iodine solution in otorhinolaryngology practice in Covid 19 pandemic
Mubarak Muhamed Khan, Sapna Ramkrishna Parab, Mandar Paranjape
American Journal of Otolaryngology, doi:10.1016/j.amjoto.2020.102618
Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre -including this research content -immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
References
Ader, Paul, Reinhardt, Effect of mouth rinsing with two polyvinylpyrrolidone-iodine mixtures on iodine absorption and thyroid function, J Clin Endocrinol Metabol, doi:10.1210/jcem-66-3-632
Berkelman, Holland, Anderson, Increased bactericidal activity of dilute preparations of povidone-iodine solutions, J Clin Microbiol
Da Silveira Teixeira, De Figueiredo, Cherubini, De Oliveira, Salum, The topical effect of chlorhexidine and povidone-iodine in the repair of oral wounds. A review, Stomatologija
Domingo, Farrales, Loya, Pura, Uy, The effect of 1% povidone iodine as a pre-procedural mouthrinse in 20 patients with varying degrees of oral hygiene, J Philipp Dent Assoc
Eggers, Eickmann, Zorn, Rapid and effective virucidal activity of povidoneiodine products against Middle East Respiratory Syndrome Coronavirus (MERS-CoV) and modified vaccinia virus Ankara (MVA), Infect Dis Ther, doi:10.1007/s40121-015-0091-9
Eggers, Koburger-Janssen, Eickmann, Zorn, In vitro bactericidal and virucidal efficacy of povidone-iodine gargle/mouthwash against respiratory and oral tract pathogens, Infect Dis Ther, doi:10.1007/s40121-018-0200-7
González-Martín-Moro, Gallardo, Iodine povidone. A new paradigm in the treatment of adenoviral conjunctivitis? Povidona yodada. ¿Un nuevo paradigma en el tratamiento de la conjuntivitis adenovírica?, Arch Soc Esp Oftalmol, doi:10.1016/j.oftal.2019.07.013
He, Lau, Wu, Deng, Wang et al., Temporal dynamics in viral shedding and transmissibility of COVID-19, Nat Med
Kariwa, Fujii, Takashima, Inactivation of SARS coronavirus by means of povidone-iodine, physical conditions and chemical reagents, Dermatology, doi:10.1159/000089211
Kawana, Kudo, A trial of povidone-iodine (PVP-I) nasal inhalation and gargling to remove potentially pathogenic bacteria colonized in the pharynx, Kansenshogaku zasshi The Journal of the Japanese Association for Infectious Diseases, doi:10.11150/kansenshogakuzasshi1970.73.429
Koerner, George, Meyer, Rosco, Habib, Povidone-iodine concentration and dosing in cataract surgery, Surv Ophthalmol, doi:10.1016/j.survophthal.2018.05.002
Kunze, Kaiser, Petres, Relevanz einer Jodallergie bei handelsüblichen Polyvidon-Jod-Zubereitungen [Relevance of an iodine allergy to commercial polyvidone-iodine preparations
Lachapelle, Allergic contact dermatitis from povidone-iodine: a re-evaluation study, Contact Dermatitis, doi:10.1111/j.0105-1873.2005.00479.x
Mullings, Panchmatia, Samoy, Topical povidone-iodine as an adjunctive treatment for recalcitrant chronic rhinosinusitis, European Journal of Rhinology and Allergy, doi:10.5152/ejra.2019.166
Panchmatia, Payandeh, Al-Salman, The efficacy of diluted topical povidone-iodine rinses in the management of recalcitrant chronic rhinosinusitis: a prospective cohort study, Eur Arch Otorhinolaryngol, doi:10.1007/s00405-019-05628-w
Rahn, Review presentation on povidone-iodine antisepsis in the oral cavity, Postgrad Med J
Rezapoor, Nicholson, Tabatabaee, Chen, Maltenfort et al., Povidone-iodine-based solutions for decolonization of nasal Staphylococcus aureus: a randomized, prospective, placebo-controlled study, J Arthroplasty, doi:10.1016/j.arth.2017.04.039
Silas, Schroeder, Thomson, Myers, Optimizing the antisepsis protocol: effectiveness of 3 povidone-iodine 1.0% applications versus a single application of povidone-iodine 5.0, J Cataract Refract Surg, doi:10.1016/j.jcrs.2017.01.007
To, Tsang, Yip, Chan, Wu et al., Consistent detection of 2019 novel coronavirus in saliva, Clin Infect Dis
Urias, Varghese, Simunich, Morrissey, Dumire, Preoperative decolonization to reduce infections in urgent lower extremity repairs, Eur J Trauma Emerg Surg, doi:10.1007/s00068-017-0896-1
Wada, Nojima, Ogawa, Relationship between virucidal efficacy and free iodine concentration of povidone-iodine in buffer solution, Biocontrol Sci, doi:10.4265/bio.21.21
Zheng, SARS-CoV-2: an emerging coronavirus that causes a global threat, Int J Biol Sci
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